JP5933554B2 - 光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法 - Google Patents

光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法 Download PDF

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JP5933554B2
JP5933554B2 JP2013527249A JP2013527249A JP5933554B2 JP 5933554 B2 JP5933554 B2 JP 5933554B2 JP 2013527249 A JP2013527249 A JP 2013527249A JP 2013527249 A JP2013527249 A JP 2013527249A JP 5933554 B2 JP5933554 B2 JP 5933554B2
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methyl
fluorophenyl
pyrazol
quinazolin
pharmaceutical composition
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Japanese (ja)
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JP2013536854A5 (enExample
JP2013536854A (ja
Inventor
ダブリュー．ホルラダイ マルク
ダブリュー．ホルラダイ マルク
セトトイ エドウアルド
セトトイ エドウアルド
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アムビト ビオスシエンセス コルポラチオン
アムビト ビオスシエンセス コルポラチオン
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3833—Chiral chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013527249A 2010-09-01 2011-08-31 光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法 Expired - Fee Related JP5933554B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37928610P 2010-09-01 2010-09-01
US37928010P 2010-09-01 2010-09-01
US61/379,286 2010-09-01
US61/379,280 2010-09-01
PCT/US2011/049902 WO2012030917A1 (en) 2010-09-01 2011-08-31 An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2013536854A JP2013536854A (ja) 2013-09-26
JP2013536854A5 JP2013536854A5 (enExample) 2014-10-09
JP5933554B2 true JP5933554B2 (ja) 2016-06-15

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JP2013527248A Expired - Fee Related JP5932794B2 (ja) 2010-09-01 2011-08-31 光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法
JP2013527249A Expired - Fee Related JP5933554B2 (ja) 2010-09-01 2011-08-31 光学活性のあるピラゾリルアミノキナゾリン及びその医薬組成物及び使用方法

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US (5) US8912324B2 (enExample)
EP (2) EP2611796B1 (enExample)
JP (2) JP5932794B2 (enExample)
AR (2) AR082875A1 (enExample)
AU (2) AU2011296074B2 (enExample)
CA (2) CA2809994A1 (enExample)
ES (2) ES2579942T3 (enExample)
TW (2) TW201305143A (enExample)
WO (2) WO2012030917A1 (enExample)

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US8633209B2 (en) * 2010-09-01 2014-01-21 Ambit Biosciences Corporation Hydrobromide salts of a pyrazolylaminoquinazoline
WO2012030917A1 (en) * 2010-09-01 2012-03-08 Ambit Biosciences Corporation An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof
US9611253B2 (en) 2012-02-29 2017-04-04 Ambit Biosciences Corporation Solid forms comprising optically active pyrazolylaminoquinazoline, compositions thereof, and uses therewith
RS62713B1 (sr) 2014-08-11 2022-01-31 Acerta Pharma Bv Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora
SMT202200285T1 (it) 2014-08-11 2022-09-14 Acerta Pharma Bv Combinazioni terapeutiche di un inibitore di btk, un inibitore di pd-1 e/o un inibitore di pd-l1
TW201618773A (zh) 2014-08-11 2016-06-01 艾森塔製藥公司 Ｂｔｋ抑制劑、ｐｉ３ｋ抑制劑、ｊａｋ－２抑制劑、及／或ｃｄｋ４／６抑制劑的治療組合物
CN117858709A (zh) * 2022-08-08 2024-04-09 石药集团中奇制药技术（石家庄）有限公司 一种含有三环杂芳基的化合物的用途
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Also Published As

Publication number Publication date
AR082875A1 (es) 2013-01-16
US20120053194A1 (en) 2012-03-01
US20140194449A1 (en) 2014-07-10
US20150141443A1 (en) 2015-05-21
CA2809993A1 (en) 2012-03-08
TW201302732A (zh) 2013-01-16
JP5932794B2 (ja) 2016-06-08
US9295672B2 (en) 2016-03-29
ES2579942T3 (es) 2016-08-17
EP2611795A1 (en) 2013-07-10
JP2013536854A (ja) 2013-09-26
CA2809994A1 (en) 2012-03-08
AU2011296074A1 (en) 2013-03-28
WO2012030917A1 (en) 2012-03-08
JP2013536853A (ja) 2013-09-26
US20150353528A1 (en) 2015-12-10
AR082874A1 (es) 2013-01-16
WO2012030913A1 (en) 2012-03-08
EP2611796A1 (en) 2013-07-10
EP2611795B1 (en) 2016-05-04
EP2611796B1 (en) 2016-04-20
US8952020B2 (en) 2015-02-10
ES2581840T3 (es) 2016-09-07
AU2011296078B2 (en) 2015-06-18
US20120053193A1 (en) 2012-03-01
US8703943B2 (en) 2014-04-22
TW201305143A (zh) 2013-02-01
US8912324B2 (en) 2014-12-16
AU2011296078A1 (en) 2013-03-28
AU2011296074B2 (en) 2015-06-18

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