JP5925383B2 - 光クロスリンク能を有する光応答性ヌクレオチドアナログ - Google Patents

光クロスリンク能を有する光応答性ヌクレオチドアナログ Download PDF

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JP5925383B2
JP5925383B2 JP2015508725A JP2015508725A JP5925383B2 JP 5925383 B2 JP5925383 B2 JP 5925383B2 JP 2015508725 A JP2015508725 A JP 2015508725A JP 2015508725 A JP2015508725 A JP 2015508725A JP 5925383 B2 JP5925383 B2 JP 5925383B2
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group
hydrogen atom
formula
bind
nucleic acid
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JPWO2014157565A1 (ja
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健造 藤本
健造 藤本
坂本　隆
坂本　　隆
佑弥 田中
佑弥 田中
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Japan Science and Technology Agency
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/121—Coherent waves, e.g. laser beams
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/12—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing electromagnetic waves
    • B01J19/122—Incoherent waves
    • B01J19/123—Ultraviolet light
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F232/00—Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system
    • C08F232/08—Copolymers of cyclic compounds containing no unsaturated aliphatic radicals in a side chain, and having one or more carbon-to-carbon double bonds in a carbocyclic ring system having condensed rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Optics & Photonics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Indole Compounds (AREA)
JP2015508725A 2013-03-28 2014-03-27 光クロスリンク能を有する光応答性ヌクレオチドアナログ Active JP5925383B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013070381 2013-03-28
JP2013070381 2013-03-28
PCT/JP2014/058988 WO2014157565A1 (ja) 2013-03-28 2014-03-27 光クロスリンク能を有する光応答性ヌクレオチドアナログ

Related Child Applications (1)

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JP2016041446A Division JP6312729B2 (ja) 2013-03-28 2016-03-03 光クロスリンク能を有する光応答性ヌクレオチドアナログ

Publications (2)

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JP5925383B2 true JP5925383B2 (ja) 2016-05-25
JPWO2014157565A1 JPWO2014157565A1 (ja) 2017-02-16

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JP2016041446A Active JP6312729B2 (ja) 2013-03-28 2016-03-03 光クロスリンク能を有する光応答性ヌクレオチドアナログ

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Country Link
US (1) US10450334B2 (enrdf_load_stackoverflow)
EP (1) EP2980073B1 (enrdf_load_stackoverflow)
JP (2) JP5925383B2 (enrdf_load_stackoverflow)
CN (1) CN105579437B (enrdf_load_stackoverflow)
CA (1) CA2908379C (enrdf_load_stackoverflow)
WO (1) WO2014157565A1 (enrdf_load_stackoverflow)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016145229A (ja) * 2013-03-28 2016-08-12 国立研究開発法人科学技術振興機構 光クロスリンク能を有する光応答性ヌクレオチドアナログ
US11078211B2 (en) 2017-07-26 2021-08-03 Japan Advanced Institute Of Science And Technology Photoresponsive nucleotide analog capable of photocrosslinking in visible light region
US11214590B2 (en) 2017-07-26 2022-01-04 Japan Advanced Institute Of Science And Technology Photoresponsive nucleotide analog capable of photocrosslinking in visible light region

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10844087B2 (en) 2013-10-30 2020-11-24 Japan Science And Technology Agency Method of suppressing formation of photocrosslink, and photoreactive nucleic acid in which auto-crosslink formation is suppressed
IL291323B2 (en) 2016-07-15 2023-09-01 Am Chemicals Llc Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
JP7104399B2 (ja) * 2018-04-04 2022-07-21 国立大学法人北陸先端科学技術大学院大学 光反応性人工アミノ酸、及び光架橋性人工ポリペプチド
JPWO2021215428A1 (enrdf_load_stackoverflow) 2020-04-22 2021-10-28
CN117105996B (zh) * 2023-10-24 2024-02-06 北京瑞博奥医药科技有限公司 一种脱氧核糖衍生物的制备的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05507419A (ja) * 1990-08-09 1993-10-28 ジンタ・インコーポレイテッド オリゴマーのための改善された非ヌクレオチド系リンカー試薬
WO2005083073A1 (ja) * 2004-02-27 2005-09-09 Japan Science And Technology Agency Ｄｎａエンザイムおよびその活性制御方法
WO2009066447A1 (ja) * 2007-11-19 2009-05-28 Japan Advanced Institute Of Science And Technology 光クロスリンク能を有する光応答性人工ヌクレオチド
WO2010147673A2 (en) * 2009-06-19 2010-12-23 University Of Florida Research Foundation, Inc. Single-dna molecule nanomotor regulated by photons

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3753942B2 (ja) 2000-03-10 2006-03-08 独立行政法人科学技術振興機構 ５−ピリミジン含有核酸、それを用いた可逆的連結方法
JP3753938B2 (ja) 2000-12-15 2006-03-08 独立行政法人科学技術振興機構 光連結性ヌクレオシド含有ｄｎａを用いて塩基を点変異する方法
JP4814904B2 (ja) 2008-04-16 2011-11-16 国立大学法人北陸先端科学技術大学院大学 核酸類の配列選択的な精製方法
CN102171234A (zh) * 2008-08-05 2011-08-31 康奈尔大学 光交联核酸水凝胶
US10450334B2 (en) * 2013-03-28 2019-10-22 Japan Science And Technology Agency Photoresponsive nucleotide analogue having photocrosslinking ability
US10844087B2 (en) * 2013-10-30 2020-11-24 Japan Science And Technology Agency Method of suppressing formation of photocrosslink, and photoreactive nucleic acid in which auto-crosslink formation is suppressed

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05507419A (ja) * 1990-08-09 1993-10-28 ジンタ・インコーポレイテッド オリゴマーのための改善された非ヌクレオチド系リンカー試薬
WO2005083073A1 (ja) * 2004-02-27 2005-09-09 Japan Science And Technology Agency Ｄｎａエンザイムおよびその活性制御方法
WO2009066447A1 (ja) * 2007-11-19 2009-05-28 Japan Advanced Institute Of Science And Technology 光クロスリンク能を有する光応答性人工ヌクレオチド
WO2010147673A2 (en) * 2009-06-19 2010-12-23 University Of Florida Research Foundation, Inc. Single-dna molecule nanomotor regulated by photons

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016145229A (ja) * 2013-03-28 2016-08-12 国立研究開発法人科学技術振興機構 光クロスリンク能を有する光応答性ヌクレオチドアナログ
US11078211B2 (en) 2017-07-26 2021-08-03 Japan Advanced Institute Of Science And Technology Photoresponsive nucleotide analog capable of photocrosslinking in visible light region
US11214590B2 (en) 2017-07-26 2022-01-04 Japan Advanced Institute Of Science And Technology Photoresponsive nucleotide analog capable of photocrosslinking in visible light region

Also Published As

Publication number Publication date
CA2908379A1 (en) 2014-10-02
CN105579437A (zh) 2016-05-11
EP2980073B1 (en) 2020-05-13
JP2016145229A (ja) 2016-08-12
JPWO2014157565A1 (ja) 2017-02-16
CN105579437B (zh) 2019-03-08
WO2014157565A1 (ja) 2014-10-02
US20160031918A1 (en) 2016-02-04
JP6312729B2 (ja) 2018-04-18
US10450334B2 (en) 2019-10-22
CA2908379C (en) 2021-03-30
EP2980073A4 (en) 2016-11-30
EP2980073A1 (en) 2016-02-03

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