JP5921572B2 - 加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ - Google Patents

加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ Download PDF

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JP5921572B2
JP5921572B2 JP2013547843A JP2013547843A JP5921572B2 JP 5921572 B2 JP5921572 B2 JP 5921572B2 JP 2013547843 A JP2013547843 A JP 2013547843A JP 2013547843 A JP2013547843 A JP 2013547843A JP 5921572 B2 JP5921572 B2 JP 5921572B2
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fluoro
amide
indol
carbamoyl
chloro
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JP2014506877A5 (enExample
JP2014506877A (ja
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エヴァ・アルトマン
ウルリッヒ・ホンメル
エドウィジュ・リリアーヌ・ジャンヌ・ロルティオワ
ユルゲン・クラウス・マイバウム
ニルス・オステルマン
ジャン・カンカール
シュテファン・アンドレアス・ランドル
オリヴァー・ジミック
アンナ・ヴルペッティ
オリヴィエ・ロジェル
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ノバルティス アーゲー
ノバルティス アーゲー
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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JP2013547843A 2011-01-04 2012-01-02 加齢性黄斑変性症（ａｍｄ）の処置に有用なインドール化合物またはそのアナログ Expired - Fee Related JP5921572B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161429730P 2011-01-04 2011-01-04
US61/429,730 2011-01-04
PCT/EP2012/050005 WO2012093101A1 (en) 2011-01-04 2012-01-02 Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)

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JP2014506877A JP2014506877A (ja) 2014-03-20
JP2014506877A5 JP2014506877A5 (enExample) 2015-02-19
JP5921572B2 true JP5921572B2 (ja) 2016-05-24

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US (1) US9085555B2 (enExample)
EP (1) EP2661433B1 (enExample)
JP (1) JP5921572B2 (enExample)
KR (1) KR20140027090A (enExample)
CN (1) CN103402996B (enExample)
AP (1) AP2013006986A0 (enExample)
AR (1) AR084768A1 (enExample)
AU (1) AU2012204920B2 (enExample)
BR (1) BR112013017316A2 (enExample)
CA (1) CA2823665A1 (enExample)
CL (1) CL2013001891A1 (enExample)
CO (1) CO6791608A2 (enExample)
CR (1) CR20130333A (enExample)
CU (1) CU20130094A7 (enExample)
EA (1) EA023259B1 (enExample)
ES (1) ES2647664T3 (enExample)
GT (1) GT201300174A (enExample)
MA (1) MA34837B1 (enExample)
MX (1) MX347391B (enExample)
PE (1) PE20140471A1 (enExample)
PH (1) PH12013501436A1 (enExample)
PL (1) PL2661433T3 (enExample)
PT (1) PT2661433T (enExample)
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TN (1) TN2013000275A1 (enExample)
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CN104619698B (zh) * 2012-06-28 2016-08-31 诺华股份有限公司 吡咯烷衍生物及其作为补体途径调节剂的用途
JP6209605B2 (ja) * 2012-06-28 2017-10-04 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
WO2014002051A2 (en) * 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
CN104640855B (zh) * 2012-06-28 2017-08-29 诺华股份有限公司 补体途经调节剂及其用途
EP2867229B1 (en) * 2012-06-28 2017-07-26 Novartis AG Pyrrolidine derivatives and their use as complement pathway modulators
US20150191462A1 (en) * 2012-06-28 2015-07-09 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
WO2014005150A1 (en) * 2012-06-29 2014-01-03 Novartis Ag Crystalline forms of l-(2-((lr,3s,5r)-3-( (2 -fluoro-3 - (trifluoromethoxy) phenyl) carbamoyl) - 2 -azabicycl o [3.1.0] hexan- 2 -yl) - 2 -oxoethyl) - 5 -methyl - 1h - pyrazolo [3, 4 -c] pyridine - 3 - carboxami de and salts thereof
WO2014002059A1 (en) * 2012-06-29 2014-01-03 Novartis Ag CRYSTALLINE FORMS OF 1-(2-((1R,3S,5R)-3-(((R)-1-(3-chloro-2-fluorophenyl)ethyl)carbamoyl)-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)-1Hpyrazolo[3,4-c]pyridine-3-carboxamide
US9550755B2 (en) * 2012-07-12 2017-01-24 Novartis Ag Complement pathway modulators and uses thereof
WO2014017643A1 (ja) * 2012-07-27 2014-01-30 佐藤製薬株式会社 ジフルオロメチレン化合物
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WO2012093101A1 (en) 2012-07-12
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PH12013501436A1 (en) 2013-09-09
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