KR20140027090A - 연령-관련 황반 변성 (amd)의 치료에 유용한 인돌 화합물 또는 그의 유사체 - Google Patents

연령-관련 황반 변성 (amd)의 치료에 유용한 인돌 화합물 또는 그의 유사체 Download PDF

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KR20140027090A
KR20140027090A KR1020137020527A KR20137020527A KR20140027090A KR 20140027090 A KR20140027090 A KR 20140027090A KR 1020137020527 A KR1020137020527 A KR 1020137020527A KR 20137020527 A KR20137020527 A KR 20137020527A KR 20140027090 A KR20140027090 A KR 20140027090A
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Prior art keywords
amide
fluoro
indol
carbamoyl
chloro
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KR1020137020527A
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Korean (ko)
Inventor
에파 알트만
울리히 홈멜
에드위지 릴리안 잔느 로티오이
위르겐 클라우스 마이바움
닐스 오스터만
장 퀸카드
슈테판 안드레아스 란들
올리버 시믹
안나 불페티
베로니크 스타크-로겔
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노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20140027090A publication Critical patent/KR20140027090A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychology (AREA)
KR1020137020527A 2011-01-04 2012-01-02 연령-관련 황반 변성 (amd)의 치료에 유용한 인돌 화합물 또는 그의 유사체 Ceased KR20140027090A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161429730P 2011-01-04 2011-01-04
US61/429,730 2011-01-04
PCT/EP2012/050005 WO2012093101A1 (en) 2011-01-04 2012-01-02 Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (amd)

Publications (1)

Publication Number Publication Date
KR20140027090A true KR20140027090A (ko) 2014-03-06

Family

ID=45464587

Family Applications (1)

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KR1020137020527A Ceased KR20140027090A (ko) 2011-01-04 2012-01-02 연령-관련 황반 변성 (amd)의 치료에 유용한 인돌 화합물 또는 그의 유사체

Country Status (29)

Country Link
US (1) US9085555B2 (enExample)
EP (1) EP2661433B1 (enExample)
JP (1) JP5921572B2 (enExample)
KR (1) KR20140027090A (enExample)
CN (1) CN103402996B (enExample)
AP (1) AP2013006986A0 (enExample)
AR (1) AR084768A1 (enExample)
AU (1) AU2012204920B2 (enExample)
BR (1) BR112013017316A2 (enExample)
CA (1) CA2823665A1 (enExample)
CL (1) CL2013001891A1 (enExample)
CO (1) CO6791608A2 (enExample)
CR (1) CR20130333A (enExample)
CU (1) CU20130094A7 (enExample)
EA (1) EA023259B1 (enExample)
ES (1) ES2647664T3 (enExample)
GT (1) GT201300174A (enExample)
MA (1) MA34837B1 (enExample)
MX (1) MX347391B (enExample)
PE (1) PE20140471A1 (enExample)
PH (1) PH12013501436A1 (enExample)
PL (1) PL2661433T3 (enExample)
PT (1) PT2661433T (enExample)
SG (1) SG191844A1 (enExample)
TN (1) TN2013000275A1 (enExample)
TW (1) TW201242959A (enExample)
UY (1) UY33858A (enExample)
WO (1) WO2012093101A1 (enExample)
ZA (1) ZA201304684B (enExample)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180043343A (ko) * 2015-08-26 2018-04-27 아칠리온 파르마세우티칼스 인코포레이티드 의학적 질병의 치료를 위한 아릴, 헤테로아릴, 및 헤테로사이클릭 화합물
WO2023182871A1 (ko) * 2022-03-25 2023-09-28 바스테라 주식회사 3-페닐이속사졸 유도체 및 이를 유효성분으로 함유하는 안질환 예방 또는 치료용 약학 조성물
US11926617B2 (en) 2015-08-26 2024-03-12 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders
US12006307B2 (en) 2017-03-01 2024-06-11 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for treatment of medical disorders
US12076319B2 (en) 2017-08-02 2024-09-03 Achillion Pharmaceuticals, Inc. Therapeutic regimens for treatment of paroxysmal nocturnal hemoglobinuria
US12162860B2 (en) 2017-03-01 2024-12-10 Achillion Pharmaceuticals, Inc. Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders
US12239645B2 (en) 2018-12-17 2025-03-04 Achillion Pharmaceuticals, Inc. Targeted dosing for the treatment of complement mediated disorders
US12297205B2 (en) 2017-03-01 2025-05-13 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for treatment of medical disorders

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6155332B2 (ja) * 2012-06-28 2017-06-28 ノバルティス アーゲー ピロリジン誘導体、および補体経路調節因子としてのその使用
MX2014015738A (es) * 2012-06-28 2015-08-06 Novartis Ag Derivados de pirrolidina y su uso como moduladores de la senda del complemento.
WO2014002052A1 (en) * 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
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SG191844A1 (en) 2013-08-30
CN103402996A (zh) 2013-11-20
MX347391B (es) 2017-04-25
US9085555B2 (en) 2015-07-21
AU2012204920B2 (en) 2014-08-07
WO2012093101A1 (en) 2012-07-12
AU2012204920A1 (en) 2013-07-18
MX2013007867A (es) 2013-07-17
PT2661433T (pt) 2017-10-24
PH12013501436A1 (en) 2013-09-09
UY33858A (es) 2012-08-31
PE20140471A1 (es) 2014-04-13
JP2014506877A (ja) 2014-03-20
ES2647664T3 (es) 2017-12-26
CN103402996B (zh) 2015-02-11
MA34837B1 (fr) 2014-01-02
NZ612899A (en) 2015-07-31
EP2661433B1 (en) 2017-08-16
AP2013006986A0 (en) 2013-07-31
CR20130333A (es) 2013-09-04
TW201242959A (en) 2012-11-01
ZA201304684B (en) 2014-03-26
PL2661433T3 (pl) 2018-01-31
GT201300174A (es) 2014-06-06
EP2661433A1 (en) 2013-11-13
CU20130094A7 (es) 2013-10-29
CO6791608A2 (es) 2013-11-14

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