JP5912126B2 - 医薬投与形態 - Google Patents

医薬投与形態 Download PDF

Info

Publication number
JP5912126B2
JP5912126B2 JP2013540480A JP2013540480A JP5912126B2 JP 5912126 B2 JP5912126 B2 JP 5912126B2 JP 2013540480 A JP2013540480 A JP 2013540480A JP 2013540480 A JP2013540480 A JP 2013540480A JP 5912126 B2 JP5912126 B2 JP 5912126B2
Authority
JP
Japan
Prior art keywords
polymer
layer
mucoadhesive
pharmaceutical formulation
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013540480A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013544259A5 (enExample
JP2013544259A (ja
Inventor
ルビナ・ペルビーン・シャイク
ビネス・ピレイ
ヤヒャ・エソップ・チョーナラ
リサ・クレア・デュ・トイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of the Witwatersrand
Original Assignee
University of the Witwatersrand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of the Witwatersrand filed Critical University of the Witwatersrand
Publication of JP2013544259A publication Critical patent/JP2013544259A/ja
Publication of JP2013544259A5 publication Critical patent/JP2013544259A5/ja
Application granted granted Critical
Publication of JP5912126B2 publication Critical patent/JP5912126B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013540480A 2010-11-26 2011-11-28 医薬投与形態 Active JP5912126B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ZA201003740 2010-11-26
ZA2010/03740 2010-11-26
PCT/IB2011/055331 WO2012070028A1 (en) 2010-11-26 2011-11-28 A pharmaceutical dosage form

Publications (3)

Publication Number Publication Date
JP2013544259A JP2013544259A (ja) 2013-12-12
JP2013544259A5 JP2013544259A5 (enExample) 2014-03-13
JP5912126B2 true JP5912126B2 (ja) 2016-04-27

Family

ID=46145444

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013540480A Active JP5912126B2 (ja) 2010-11-26 2011-11-28 医薬投与形態

Country Status (6)

Country Link
US (1) US9808418B2 (enExample)
EP (1) EP2646006B1 (enExample)
JP (1) JP5912126B2 (enExample)
CN (1) CN103338756B (enExample)
WO (1) WO2012070028A1 (enExample)
ZA (1) ZA201304709B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022014811A1 (ko) * 2020-07-17 2022-01-20 엠엑스바이오 주식회사 의료용 나노 섬유 필름

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103611187A (zh) * 2013-11-15 2014-03-05 无锡中科光远生物材料有限公司 一种时序性释放药物的组织工程支架的制备方法
WO2015186108A1 (en) * 2014-06-05 2015-12-10 University Of The Witwatersrand, Johannesburg 2 layers tablet oral dosage form for various drug release
CZ308594B6 (cs) * 2014-09-29 2020-12-23 VÝZKUMNÝ ÚSTAV VETERINÁRNÍHO LÉKAŘSTVÍ, v.v.i. Mukoadhezivní nosiče částic, způsob přípravy a použití
CN113197851A (zh) 2015-05-06 2021-08-03 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
US11090354B2 (en) 2015-08-06 2021-08-17 The Johns Hopkins University Composition and method for treatment of metabolic disorders
CN106822007B (zh) 2015-09-11 2021-12-31 西姆莱斯股份公司 口服制剂
US11129798B2 (en) * 2016-08-19 2021-09-28 Aron H. Blaesi Fibrous dosage form
CN108697637A (zh) * 2016-01-27 2018-10-23 因斯塔尔科技股份公司 用于治疗性处理的口腔粘膜纳米纤维载体
US12427121B2 (en) 2016-05-05 2025-09-30 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine compositions
CN122182527A (zh) 2016-05-05 2026-06-12 阿奎斯蒂弗医疗股份有限公司 增强递送的肾上腺素组合物
US11273131B2 (en) 2016-05-05 2022-03-15 Aquestive Therapeutics, Inc. Pharmaceutical compositions with enhanced permeation
US12433850B2 (en) 2016-05-05 2025-10-07 Aquestive Therapeutics, Inc. Enhanced delivery epinephrine and prodrug compositions
GB201614100D0 (en) * 2016-08-17 2016-09-28 Globalacorn Ltd Carriers
CA3050026A1 (en) * 2017-01-23 2018-07-26 Afyx Therapeutics A/S Method for preparing electrospun fibers with a high content of a bioadhesive substance
BR112019014236A2 (pt) 2017-01-23 2020-03-17 Afyx Therapeutics A/S Método para a fabricação de um produto de duas camadas à base de fibras eletrofiadas
CN107184560B (zh) * 2017-06-03 2021-02-02 寿光富康制药有限公司 二甲双胍胃滞留片及制备方法
US11654114B2 (en) * 2017-06-07 2023-05-23 Egy-Nano Pharma, Lp Oral prolonged drug delivery platforms
IL311142A (en) * 2017-09-26 2024-04-01 Aquestive Therapeutics Inc Delivery pharmaceutical compositions including permeation enhancers
GB2572566B (en) * 2018-04-03 2022-01-12 Zewail City Of Science And Tech Wound healing system comprising layers of nanofiber matrices separately carrying a mucoadhesive, a drug and a moisture indicator, and use thereof
CN108589045B (zh) * 2018-04-10 2021-06-08 华南理工大学 一种负载益生元和/或益生菌的纳米纤维膜及制备与应用
JP7040418B2 (ja) * 2018-11-21 2022-03-23 株式会社村田製作所 錠剤
US12194294B2 (en) * 2019-01-29 2025-01-14 The Regents Of The University Of California Oral drug delivery devices and methods using iontophoresis
CN109908108B (zh) * 2019-03-15 2022-05-03 深圳市光远生物材料有限责任公司 一种载药纳米复合纤维膜系统及其制备方法和应用
EP3968980A1 (en) 2019-05-14 2022-03-23 Clexio Biosciences Ltd. Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
EP3978234A4 (en) * 2019-05-29 2022-07-27 Mitsubishi Chemical Corporation NANOMESH MULTILAYER BODY, METHOD OF MAKING CONDUCTIVE CIRCUIT AND NANOMESH CONNECTION KIT
CN112107559B (zh) * 2019-06-20 2023-09-08 普济生物科技（台州）有限公司 口腔透粘膜药物剂型
CN110934894B (zh) * 2019-12-09 2021-11-30 西南交通大学 一种载两歧双歧杆菌的抗肿瘤纤维局部埋植剂及其制备方法和应用
WO2021151156A1 (en) * 2020-01-31 2021-08-05 Anders William James Sideris Drug delivery device
ES2876401B2 (es) * 2020-05-11 2024-04-05 Bioinicia S L Parches auto-adhesivos de fibras para la liberación controlada de bioactivos
WO2021228358A1 (en) 2020-05-11 2021-11-18 Symrise Ag A solid mucoadhesive composition
WO2022195476A1 (en) 2021-03-15 2022-09-22 Clexio Biosciences Ltd. Gastroretentive devices for assessment of intragastric conditions
JP7611783B2 (ja) * 2021-04-21 2025-01-10 順也 藤森 フィトケミカル組成物の製造方法
WO2023076281A1 (en) 2021-10-25 2023-05-04 Aquestive Therapeutics, Inc. Oral and nasal compositions and methods of treatment
CN114287634B (zh) 2022-01-07 2022-08-19 东北农业大学 包埋益生菌的阿拉伯胶复合纤维/胶囊及其制备方法和应用
CN121668141A (zh) * 2023-07-12 2026-03-17 哈尔滨商业大学 一种胃滞留形状记忆复合膜

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2352389C (en) * 1998-11-27 2009-01-20 Kanji Takada An oral formulation for gastrointestinal drug delivery
KR100806412B1 (ko) 2000-01-28 2008-02-21 스미스클라인 비참 코포레이션 전기방사 약제학적 조성물
EP1542662A1 (en) * 2002-09-28 2005-06-22 McNEIL-PPC, INC. Immediate release dosage form comprising shell having openings therein
NZ540318A (en) * 2002-10-31 2007-09-28 Umd Inc Therapeutic compositions for drug delivery to and through covering epithelia
US20100254961A1 (en) * 2007-09-05 2010-10-07 Taiyokagaku Co., Ltd. Water-soluble electrospun sheet
ZA200903858B (en) 2008-06-19 2013-10-30 Univ Of Witwatesrand Johannesburg Pharmaceutical dosage form
WO2010002418A2 (en) * 2008-07-01 2010-01-07 The Johns Hopkins University Quick-dissolving oral thin film for targeted delivery of therapeutic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022014811A1 (ko) * 2020-07-17 2022-01-20 엠엑스바이오 주식회사 의료용 나노 섬유 필름

Also Published As

Publication number Publication date
EP2646006A4 (en) 2014-06-25
EP2646006A1 (en) 2013-10-09
CN103338756B (zh) 2016-03-02
WO2012070028A1 (en) 2012-05-31
ZA201304709B (en) 2015-03-25
EP2646006B1 (en) 2015-02-25
US9808418B2 (en) 2017-11-07
US20130337022A1 (en) 2013-12-19
CN103338756A (zh) 2013-10-02
JP2013544259A (ja) 2013-12-12

Similar Documents

Publication Publication Date Title
JP2013544259A (ja) 医薬投与形態
Sun et al. pH-sensitive ZnO/carboxymethyl cellulose/chitosan bio-nanocomposite beads for colon-specific release of 5-fluorouracil
Torres-Martínez et al. Drugs loaded into electrospun polymeric nanofibers for delivery
Dai et al. Swelling characteristics and drug delivery properties of nifedipine‐loaded pH sensitive alginate–chitosan hydrogel beads
Khutoryanskiy Hydrogen-bonded interpolymer complexes as materials for pharmaceutical applications
Bertram et al. In situ gelling, bioadhesive nasal inserts for extended drug delivery: in vitro characterization of a new nasal dosage form
Aduba Jr et al. Semi-interpenetrating network (sIPN) gelatin nanofiber scaffolds for oral mucosal drug delivery
Nangare et al. Silk industry waste protein: isolation, purification and fabrication of electrospun silk protein nanofibers as a possible nanocarrier for floating drug delivery
JP2012503036A (ja) ビニルアルコールコポリマークリオゲル、ビニルアルコールコポリマー並びにそれらの方法及び製品
Zhao et al. Nanofiber orodispersible films based on carboxymethyl curdlan and PEO: New delivery system for amlodipine besylate
Hamori et al. Preparation and pharmaceutical evaluation of acetaminophen nano-fiber tablets: Application of a solvent-based electrospinning method for tableting
Pisani et al. Tableted hydrophilic electrospun nanofibers to promote meloxicam dissolution rate
CN101415442B (zh) 控释凝胶
Raval et al. Copolymers and block copolymers in drug delivery and therapy
CN112107559B (zh) 口腔透粘膜药物剂型
Cheaburu-Yilmaz et al. Polysaccharide containing gels for pharmaceutical applications
TWI619517B (zh) 凝膠組成物及凝膠組成物的製造方法
Shafi et al. Optimizing the fabrication of electrospun nanofibers of prochlorperazine for enhanced dissolution and permeation properties
CN111643719A (zh) 环γ-聚谷氨酸改性水凝胶负载纳米海绵解毒系统及其制备方法
CN105828812A (zh) 胃内滞留口服药物组合物
Dumitriu et al. A drug delivery system based on stimuli-responsive alginate/N-isopropylacryl amide hydrogel
Huang et al. Self-assembled particles of N-phthaloylchitosan-g-polycaprolactone molecular bottle brushes as carriers for controlled release of indometacin
US20220287981A1 (en) Adhesive drug delivery microparticles and a product comprising thereof
Vijayakumar et al. Drug carriers, polymers as: Synthesis, characterization, and in vitro evaluation
EP2219621B1 (en) Tri-molecular complexes and their use in drug delivery systems

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140124

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140124

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140919

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140924

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141222

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150126

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150421

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150717

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150831

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151020

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160112

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160315

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160331

R150 Certificate of patent or registration of utility model

Ref document number: 5912126

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250