JP5906302B2 - 作用剤層および作用剤変換層を含む経皮組成物 - Google Patents

作用剤層および作用剤変換層を含む経皮組成物 Download PDF

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Publication number
JP5906302B2
JP5906302B2 JP2014501251A JP2014501251A JP5906302B2 JP 5906302 B2 JP5906302 B2 JP 5906302B2 JP 2014501251 A JP2014501251 A JP 2014501251A JP 2014501251 A JP2014501251 A JP 2014501251A JP 5906302 B2 JP5906302 B2 JP 5906302B2
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Japan
Prior art keywords
agent
transdermal composition
layer
transdermal
carboxylated
Prior art date
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Expired - Fee Related
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JP2014501251A
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English (en)
Japanese (ja)
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JP2014508810A5 (enExample
JP2014508810A (ja
Inventor
ハムリン，リチャード
ウェン，ジャニェ
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Teikoku Pharma USA Inc
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Teikoku Pharma USA Inc
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Application filed by Teikoku Pharma USA Inc filed Critical Teikoku Pharma USA Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014501251A 2011-03-24 2012-03-22 作用剤層および作用剤変換層を含む経皮組成物 Expired - Fee Related JP5906302B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161467337P 2011-03-24 2011-03-24
US61/467,337 2011-03-24
PCT/US2012/030171 WO2012129429A2 (en) 2011-03-24 2012-03-22 Transdermal compositions comprising an active agent layer and an active agent conversion layer

Publications (3)

Publication Number Publication Date
JP2014508810A JP2014508810A (ja) 2014-04-10
JP2014508810A5 JP2014508810A5 (enExample) 2014-12-11
JP5906302B2 true JP5906302B2 (ja) 2016-04-20

Family

ID=46880045

Family Applications (1)

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JP2014501251A Expired - Fee Related JP5906302B2 (ja) 2011-03-24 2012-03-22 作用剤層および作用剤変換層を含む経皮組成物

Country Status (7)

Country Link
US (2) US9119799B2 (enExample)
EP (1) EP2688561B1 (enExample)
JP (1) JP5906302B2 (enExample)
KR (1) KR101853082B1 (enExample)
CN (1) CN103476404B (enExample)
TW (1) TWI442948B (enExample)
WO (1) WO2012129429A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA023786B1 (ru) 2010-04-30 2016-07-29 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Трансдермальные композиции на основе пропиниламиноиндана
BR112015007872A2 (pt) 2012-11-02 2017-07-04 Teikoku Pharma Usa Inc composições transdermais de propinilaminoindano
HK1220109A1 (zh) * 2013-03-15 2017-04-28 Nal Pharmaceutical Group Limited 含卡巴拉汀的经皮给药系统
GB201317718D0 (en) * 2013-10-07 2013-11-20 Buzzz Pharmaceuticals Ltd Novel formulation
TWI709417B (zh) * 2013-10-07 2020-11-11 美商帝國製藥美國股份有限公司 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物
US20170291020A1 (en) * 2016-04-12 2017-10-12 Mylan Inc. Double disk transdermal system
CN107789628B (zh) * 2016-12-29 2021-07-23 天津键凯科技有限公司 一种聚乙二醇和局部麻醉药的结合物在非麻醉镇痛中的应用
WO2020084065A1 (en) * 2018-10-24 2020-04-30 Saniona A/S Transdermal tropane compositions and methods for using the same
EP3725306A1 (en) * 2019-04-17 2020-10-21 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system
WO2020212596A1 (en) * 2019-04-17 2020-10-22 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
US11752114B2 (en) 2019-04-17 2023-09-12 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
KR102155108B1 (ko) * 2019-11-27 2020-09-11 주식회사 우신라보타치 라사길린 또는 그의 약학적으로 허용가능한 염을 함유하는 경피흡수제제
CN117860708A (zh) * 2022-10-11 2024-04-12 姜钦治 含有普拉克索和雷沙吉兰的透皮贴片

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4452808A (en) 1982-12-07 1984-06-05 Smithkline Beckman Corporation 4-Aminoalkyl-2(3H)-indolones
US4588740A (en) 1982-12-07 1986-05-13 Smithkline Beckman Corporation Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones
JPS61280426A (ja) * 1985-06-04 1986-12-11 Ikeda Mohandou:Kk 消炎鎮痛用貼付剤
GB8712073D0 (en) 1987-05-21 1987-06-24 Smith Kline French Lab Medicament
EP0387751B1 (en) 1989-03-15 1994-06-08 Nitto Denko Corporation Medicated plasters
IT1237904B (it) 1989-12-14 1993-06-18 Ubaldo Conte Compresse a rilascio a velocita' controllata delle sostanze attive
US5744500A (en) 1990-01-03 1998-04-28 Teva Pharmaceutical Industries, Ltd. Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof
IL92952A (en) 1990-01-03 1994-06-24 Teva Pharma R-enantiomers of n-propargyl-1-aminoindan compounds, their preparation and pharmaceutical compositions containing them
JP2849937B2 (ja) 1990-04-18 1999-01-27 日東電工株式会社 医療用貼付剤
EP0593807A1 (en) * 1992-10-22 1994-04-27 LTS Lohmann Therapie-Systeme GmbH & Co. KG Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation
US5462746A (en) 1992-11-02 1995-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation
JP2539330B2 (ja) 1993-05-11 1996-10-02 日東電工株式会社 医療用粘着剤及びこれを用いて形成された医療用外用材
US5877218A (en) 1994-01-10 1999-03-02 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5391406A (en) 1994-03-25 1995-02-21 National Starch And Chemical Investment Holding Corporation Process of preparing hot melt pressure sensitive adhesives on a substrate
JP3604177B2 (ja) 1994-09-14 2004-12-22 日東電工株式会社 経皮吸収製剤
JP3576608B2 (ja) 1994-11-15 2004-10-13 日東電工株式会社 貼付剤および貼付製剤
DE19533772C1 (de) 1995-09-12 1998-01-02 Hexal Ag Tacrin/Selegilin-Pflaster
IL115357A (en) 1995-09-20 2000-01-31 Teva Pharma Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols
US5807570A (en) 1995-09-29 1998-09-15 Cygnus, Inc. Transdermal administration of ropinirole and analogs thereof
US6929801B2 (en) 1996-02-19 2005-08-16 Acrux Dds Pty Ltd Transdermal delivery of antiparkinson agents
DE19628999C1 (de) 1996-07-18 1998-03-12 Lohmann Gmbh & Co Kg Medizinische Haftklebstoffe mit hoher Wasserdampfdurchlässigkeit und Klebkraft und damit versehene Pflaster und ihre Verwendung
US7150881B2 (en) 1997-06-26 2006-12-19 Mylan Technologies, Inc. Adhesive mixture for transdermal delivery of highly plasticizing drugs
US6132761A (en) 1997-09-05 2000-10-17 Nitto Denko Corporation Percutaneous absorption preparation
IT1294748B1 (it) 1997-09-17 1999-04-12 Permatec Tech Ag Formulazione per un dispositivo transdermico
NZ504108A (en) 1997-09-26 2002-06-28 Noven Pharma Bioadhesive compositions comprising a polyvinylpyrrolidone polymer and methods for topical administration of active agents
US6809120B1 (en) 1998-01-13 2004-10-26 University Of Saskatchewan Technologies Inc. Composition containing propargylamine for enhancing cancer therapy
US6146656A (en) 1998-01-22 2000-11-14 Nitto Denko Corporation Percutaneous absorption preparation
DE19814087A1 (de) 1998-03-30 1999-10-14 Lohmann Therapie Syst Lts Feuchtigkeitsaktivierbares therapeutisches System
DE69916424T2 (de) 1998-12-02 2005-05-19 Nichiban Co. Ltd. Druckempfindliches klebeband zur befestigung auf der haut und grundmaterial zu seiner benutzung
JP2002531488A (ja) 1998-12-07 2002-09-24 エラン コーポレーシヨン ピーエルシー 揮発性液体薬剤を送出するための経皮パッチ
DE19918106A1 (de) 1999-04-22 2000-10-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit neutralisierten Acrylathaftklebern
US6218421B1 (en) 1999-07-01 2001-04-17 Smithkline Beecham P.L.C. Method of promoting smoking cessation
DE19950066A1 (de) * 1999-10-16 2001-04-26 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit einem Gehalt an Tulobuterol-hydrochlorid zur Verabreichung des Bronchodilatators Tulobuterol über die Haut
WO2001052823A2 (en) 2000-01-20 2001-07-26 Noven Pharmaceuticals, Inc. Compositions to effect the release profile in the transdermal administration of drugs
US6277875B1 (en) 2000-07-17 2001-08-21 Andrew J. Holman Use of dopamine D2/D3 receptor agonists to treat fibromyalgia
DE10035891A1 (de) 2000-07-24 2002-02-14 Lohmann Therapie Syst Lts Medizinischer Haftkleber mit einer zweiphasigen Klebermatrix aus Polyacrylaten und Polyaminsalzen
US20070225379A1 (en) 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US20040028724A1 (en) 2000-11-07 2004-02-12 Takaaki Terahara Pharmaceutical preparation of percutaneous absorption type
DE10060852A1 (de) 2000-12-06 2002-06-20 Hexal Ag Absorptionsmittel und Kanalbildner enthaltende wirkstoffundurchlässige Deckschicht oder abziehbare Schutzschicht eines transdermalen therapeutischen Systems
WO2002069974A1 (en) 2001-03-05 2002-09-12 Andrew Holman Administration of sleep restorative agents
US20030212085A1 (en) 2001-04-17 2003-11-13 Mccall Robert B. Treatment of fibromyalgia and chronic fatigue syndrome
DE10137162A1 (de) 2001-07-30 2003-02-20 Hexal Ag Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol
KR20050045946A (ko) 2002-06-25 2005-05-17 애크럭스 디디에스 피티와이 리미티드 비정질 약학적 조성물을 이용한 경피전달속도의 제어
US20050186141A1 (en) 2002-06-25 2005-08-25 Acrux Dds Pty Ltd. Transdermal aerosol compositions
EP1386605A1 (en) 2002-07-30 2004-02-04 Schwarz Pharma Ag Improved transdermal delivery system for the administration of rotigotine
SI1567152T1 (sl) 2002-11-15 2013-10-30 Teva Pharmaceutical Industries Ltd. Uporaba rasagilina z riluzolom za zdravljenje amiotrofične lateralne skleroze
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
US20040242669A1 (en) 2003-05-27 2004-12-02 Filippo Drago Method of treating deficits associated with brain injury
EP1663179A1 (en) 2003-07-21 2006-06-07 Noven Pharmaceuticals, Inc. Composition and method for controlling drug delivery from silicone adhesive blends
DE10338174A1 (de) 2003-08-20 2005-03-24 Lts Lohmann Therapie-Systeme Ag Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit
PT1670433E (pt) 2003-10-10 2012-02-08 Ferring Bv Fórmula farmacológica transdérmica para a minimização de resíduos na pele
US7378439B2 (en) 2004-01-20 2008-05-27 Usv, Ltd. Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride
JP2005232148A (ja) 2004-02-03 2005-09-02 Technion Research & Development Foundation Ltd 神経保護剤としてプロパルギルアミンの使用
ES2337700T3 (es) 2004-02-18 2010-04-28 Sepracor, Inc. Terapia combinada de agonista de dopamina con sedantes para mejorar la calidad del sueño.
JP4961207B2 (ja) * 2004-04-21 2012-06-27 久光製薬株式会社 粘着基剤中の吸収促進剤の含有率を高めた外用貼付剤
ITMI20041628A1 (it) 2004-08-06 2004-11-06 Bouty S P A Sistema terapeutico a rilascio controllato per uso topico transdermico
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
ES2596809T3 (es) 2004-10-08 2017-01-12 Noven Pharmaceuticals, Inc. Dispositivo de administración transdérmica de fármacos que incluye un refuerzo oclusivo
AU2006245349A1 (en) 2005-02-22 2006-11-16 Teva Pharmaceutical Industries Ltd. Improved process for the synthesis of enantiomeric indanylamine derivatives
CA2600011C (en) 2005-02-23 2015-11-10 Teva Pharmaceutical Industries Ltd. Rasagiline formulations of improved content uniformity
WO2006138475A2 (en) 2005-06-16 2006-12-28 Jenrin Discovery Mao-b inhibitors useful for treating obesity
US20070134310A1 (en) * 2005-09-23 2007-06-14 Nedberge Diane E Transdermal risperidone delivery system
KR100663163B1 (ko) 2005-10-24 2007-01-02 (주)아모레퍼시픽 비스테로이드성 소염진통제를 함유하는 경피 투여 제제
EP1954667B1 (en) 2005-11-17 2017-02-08 Teva Pharmaceutical Industries Ltd Methods for isolating propargylated aminoindans
US7572834B1 (en) 2005-12-06 2009-08-11 Teva Pharmaceutical Industries, Ltd. Rasagiline formulations and processes for their preparation
CN101032474B (zh) 2006-03-06 2011-02-16 重庆医药工业研究院有限责任公司 一种治疗或预防神经系统疾病的雷沙吉兰透皮贴片及其制备方法
MX2008012265A (es) 2006-03-24 2009-02-20 Auxilium Int Holdings Inc Procedimiento para la preparacion de un laminado extruido por fusion en caliente.
RU2008144405A (ru) * 2006-04-11 2010-05-20 Нитибан Ко, Лтд (Jp) Содержащий тамсулозин трансдермальный пластырь
US20070254941A1 (en) 2006-04-21 2007-11-01 Glenmark Pharmaceuticals Limited Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation
TW200815045A (en) 2006-06-29 2008-04-01 Jazz Pharmaceuticals Inc Pharmaceutical compositions of ropinirole and methods of use thereof
NZ576992A (en) * 2006-10-27 2011-02-25 Noven Pharma Transdermal delivery of ketoprofen polar derivatives
PT2101569E (pt) 2006-12-14 2012-01-13 Teva Pharma Base de rasagilina sólida cristalina
US20090043111A1 (en) 2007-08-06 2009-02-12 Meizheng Liu Novel process for ropinirole preparation
DE102007041557B4 (de) 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend längliche Hohlkörper
US20090062400A1 (en) 2007-09-05 2009-03-05 Laurence Oron Method of treating glaucoma using rasagiline
US8188149B2 (en) 2007-09-17 2012-05-29 Teva Pharmaceutical Industries, Ltd. Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss
EP2258355B1 (en) * 2008-02-27 2020-01-22 Hisamitsu Pharmaceutical Co., Inc. Patch
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
CA2727021A1 (en) 2008-06-19 2009-12-23 Teva Pharmaceutical Industries Ltd. Process for purifying rasagiline base
CN101606923B (zh) 2008-06-20 2013-01-09 重庆医药工业研究院有限责任公司 一种稳定的控释释放的雷沙吉兰透皮贴片及其制备方法
CA2730787A1 (en) 2008-07-16 2010-01-21 David M. Cohen Topical drug delivery system
US20100029987A1 (en) 2008-07-29 2010-02-04 Dipharma Francis S.R.I. Crystalline Form of Rasagiline and Process for the Preparation Thereof
US20100087768A1 (en) 2008-10-02 2010-04-08 Forlano Paula Transdermal drug delivery system for liquid active ingredient
US20110008413A1 (en) 2009-07-08 2011-01-13 Msk Pharma, Llc Compositions and Methods of Topical Drug Delivery for the Treatment of Carpal Tunnel Syndrome
EP2298277A1 (en) 2009-09-09 2011-03-23 Labtec GmbH Transdermal patch formulation
EA023786B1 (ru) * 2010-04-30 2016-07-29 ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. Трансдермальные композиции на основе пропиниламиноиндана
CN102475692A (zh) 2010-11-29 2012-05-30 重庆医药工业研究院有限责任公司 一种防止雷沙吉兰挥发的透皮贴片

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EP2688561A2 (en) 2014-01-29
TWI442948B (zh) 2014-07-01
US20160184240A1 (en) 2016-06-30
US9119799B2 (en) 2015-09-01
US20130072884A1 (en) 2013-03-21
TW201309350A (zh) 2013-03-01
KR101853082B1 (ko) 2018-04-27
JP2014508810A (ja) 2014-04-10
KR20140016293A (ko) 2014-02-07
CN103476404A (zh) 2013-12-25
EP2688561A4 (en) 2014-08-20

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