JP5894717B2 - 乱用抑止性製剤 - Google Patents

乱用抑止性製剤 Download PDF

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Publication number
JP5894717B2
JP5894717B2 JP2012544825A JP2012544825A JP5894717B2 JP 5894717 B2 JP5894717 B2 JP 5894717B2 JP 2012544825 A JP2012544825 A JP 2012544825A JP 2012544825 A JP2012544825 A JP 2012544825A JP 5894717 B2 JP5894717 B2 JP 5894717B2
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Japan
Prior art keywords
granules
hydromorphone
weight
viscosity modifier
ethylcellulose
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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JP2012544825A
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English (en)
Japanese (ja)
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JP2013514386A (ja
JP2013514386A5 (https=
Inventor
ハメド、エハブ
ゼペダ、マニュエル エー． べガ
ゼペダ、マニュエル エー． べガ
Original Assignee
シマ ラブス インク．
シマ ラブス インク．
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Publication of JP2013514386A publication Critical patent/JP2013514386A/ja
Publication of JP2013514386A5 publication Critical patent/JP2013514386A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012544825A 2009-12-17 2010-12-16 乱用抑止性製剤 Expired - Fee Related JP5894717B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28751509P 2009-12-17 2009-12-17
US61/287,515 2009-12-17
PCT/US2010/060755 WO2011084593A2 (en) 2009-12-17 2010-12-16 Abuse-resistant formulations

Publications (3)

Publication Number Publication Date
JP2013514386A JP2013514386A (ja) 2013-04-25
JP2013514386A5 JP2013514386A5 (https=) 2014-02-13
JP5894717B2 true JP5894717B2 (ja) 2016-03-30

Family

ID=43618139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012544825A Expired - Fee Related JP5894717B2 (ja) 2009-12-17 2010-12-16 乱用抑止性製剤

Country Status (10)

Country Link
US (2) US20120225122A1 (https=)
EP (1) EP2512456A2 (https=)
JP (1) JP5894717B2 (https=)
CN (1) CN102665694A (https=)
AU (1) AU2010339882B2 (https=)
CA (1) CA2784407A1 (https=)
IL (1) IL219961A (https=)
MX (1) MX348361B (https=)
NZ (1) NZ600640A (https=)
WO (1) WO2011084593A2 (https=)

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US10751509B2 (en) 2007-11-26 2020-08-25 C. R. Bard, Inc. Iconic representations for guidance of an indwelling medical device
US10449330B2 (en) 2007-11-26 2019-10-22 C. R. Bard, Inc. Magnetic element-equipped needle assemblies
US8781555B2 (en) 2007-11-26 2014-07-15 C. R. Bard, Inc. System for placement of a catheter including a signal-generating stylet
US10524691B2 (en) 2007-11-26 2020-01-07 C. R. Bard, Inc. Needle assembly including an aligned magnetic element
US8849382B2 (en) 2007-11-26 2014-09-30 C. R. Bard, Inc. Apparatus and display methods relating to intravascular placement of a catheter
US9649048B2 (en) 2007-11-26 2017-05-16 C. R. Bard, Inc. Systems and methods for breaching a sterile field for intravascular placement of a catheter
EP2992825B1 (en) 2007-11-26 2017-11-01 C.R. Bard Inc. Integrated system for intravascular placement of a catheter
US9521961B2 (en) 2007-11-26 2016-12-20 C. R. Bard, Inc. Systems and methods for guiding a medical instrument
US8478382B2 (en) 2008-02-11 2013-07-02 C. R. Bard, Inc. Systems and methods for positioning a catheter
US9901714B2 (en) 2008-08-22 2018-02-27 C. R. Bard, Inc. Catheter assembly including ECG sensor and magnetic assemblies
US8437833B2 (en) 2008-10-07 2013-05-07 Bard Access Systems, Inc. Percutaneous magnetic gastrostomy
NZ594207A (en) 2009-02-06 2013-03-28 Egalet Ltd Immediate release composition resistant to abuse by intake of alcohol
RU2691318C2 (ru) 2009-06-12 2019-06-11 Бард Аксесс Системс, Инк. Способ позиционирования конца катетера
US9532724B2 (en) 2009-06-12 2017-01-03 Bard Access Systems, Inc. Apparatus and method for catheter navigation using endovascular energy mapping
NZ597283A (en) 2009-06-24 2013-07-26 Egalet Ltd Controlled release formulations
EP2464407A4 (en) 2009-08-10 2014-04-02 Bard Access Systems Inc Devices and methods for endovascular electrography
CN102665541B (zh) 2009-09-29 2016-01-13 C·R·巴德股份有限公司 与用于导管的血管内放置的设备一起使用的探针
WO2011044421A1 (en) 2009-10-08 2011-04-14 C. R. Bard, Inc. Spacers for use with an ultrasound probe
BR112012019354B1 (pt) 2010-02-02 2021-09-08 C.R.Bard, Inc Método para localização de um dispositivo médico implantável
EP4122385A1 (en) 2010-05-28 2023-01-25 C. R. Bard, Inc. Insertion guidance system for needles and medical components
WO2011150376A1 (en) 2010-05-28 2011-12-01 C.R. Bard, Inc. Apparatus for use with needle insertion guidance system
CN103228219B (zh) 2010-08-09 2016-04-27 C·R·巴德股份有限公司 用于超声探测器头的支撑和覆盖结构
JP5845260B2 (ja) 2010-08-20 2016-01-20 シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ Ｅｃｇ支援カテーテル先端配置の再確認
WO2012058461A1 (en) 2010-10-29 2012-05-03 C.R.Bard, Inc. Bioimpedance-assisted placement of a medical device
JP6008960B2 (ja) 2011-07-06 2016-10-19 シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ 挿入案内システムのためのニードル長決定および較正
USD699359S1 (en) 2011-08-09 2014-02-11 C. R. Bard, Inc. Ultrasound probe head
US9211107B2 (en) 2011-11-07 2015-12-15 C. R. Bard, Inc. Ruggedized ultrasound hydrogel insert
US20150086626A1 (en) * 2012-04-17 2015-03-26 Mylan, Inc Stable dosage forms of skeletal muscle relaxants with extended release coating
WO2013188833A2 (en) 2012-06-15 2013-12-19 C.R. Bard, Inc. Apparatus and methods for detection of a removable cap on an ultrasound probe
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US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
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US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
AU2015336065A1 (en) 2014-10-20 2017-05-04 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
US10973584B2 (en) 2015-01-19 2021-04-13 Bard Access Systems, Inc. Device and method for vascular access
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US9943513B1 (en) 2015-10-07 2018-04-17 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US11000207B2 (en) 2016-01-29 2021-05-11 C. R. Bard, Inc. Multiple coil system for tracking a medical device
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition
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Also Published As

Publication number Publication date
CN102665694A (zh) 2012-09-12
AU2010339882A1 (en) 2012-07-05
IL219961A (en) 2017-06-29
NZ600640A (en) 2014-11-28
AU2010339882B2 (en) 2016-10-27
WO2011084593A3 (en) 2012-03-29
JP2013514386A (ja) 2013-04-25
US20140294953A1 (en) 2014-10-02
MX348361B (es) 2017-06-07
US9474721B2 (en) 2016-10-25
IL219961A0 (en) 2012-07-31
US20120225122A1 (en) 2012-09-06
CA2784407A1 (en) 2011-07-14
WO2011084593A2 (en) 2011-07-14
MX2012006829A (es) 2012-07-10
EP2512456A2 (en) 2012-10-24

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