MX348361B - Formulaciones resistentes al abuso. - Google Patents
Formulaciones resistentes al abuso.Info
- Publication number
- MX348361B MX348361B MX2012006829A MX2012006829A MX348361B MX 348361 B MX348361 B MX 348361B MX 2012006829 A MX2012006829 A MX 2012006829A MX 2012006829 A MX2012006829 A MX 2012006829A MX 348361 B MX348361 B MX 348361B
- Authority
- MX
- Mexico
- Prior art keywords
- dosage form
- abuse
- hydromorphone
- resistant formulations
- sustained
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Esta revelación se refiere a una forma farmacéutica oral de liberación sostenida para la administración de una vez al día que comprende una matriz que contiene un modificador de la viscosidad y gránulos revestidos que contienen hidromorfona. La forma farmacéutica puede tener un perfil de liberación de modo tal que 16 horas después de la administración, se libera menos de alrededor de 85 por ciento de la hidromorfona. Además, la forma farmacéutica puede tener resistencia al alcohol y/o a la trituración.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28751509P | 2009-12-17 | 2009-12-17 | |
PCT/US2010/060755 WO2011084593A2 (en) | 2009-12-17 | 2010-12-16 | Abuse-resistant formulations |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2012006829A MX2012006829A (es) | 2012-07-10 |
MX348361B true MX348361B (es) | 2017-06-07 |
Family
ID=43618139
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012006829A MX348361B (es) | 2009-12-17 | 2010-12-16 | Formulaciones resistentes al abuso. |
Country Status (10)
Country | Link |
---|---|
US (2) | US20120225122A1 (es) |
EP (1) | EP2512456A2 (es) |
JP (1) | JP5894717B2 (es) |
CN (1) | CN102665694A (es) |
AU (1) | AU2010339882B2 (es) |
CA (1) | CA2784407A1 (es) |
IL (1) | IL219961A (es) |
MX (1) | MX348361B (es) |
NZ (1) | NZ600640A (es) |
WO (1) | WO2011084593A2 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
WO2008148798A2 (en) | 2007-06-04 | 2008-12-11 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
US9456766B2 (en) | 2007-11-26 | 2016-10-04 | C. R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
WO2009070616A2 (en) | 2007-11-26 | 2009-06-04 | C. R. Bard, Inc. | Integrated system for intravascular placement of a catheter |
US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
EP2313143B1 (en) | 2008-08-22 | 2014-09-24 | C.R. Bard, Inc. | Catheter assembly including ecg sensor and magnetic assemblies |
US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
US9005660B2 (en) | 2009-02-06 | 2015-04-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
BRPI1010773B1 (pt) | 2009-06-12 | 2021-06-01 | Bard Access Systems, Inc | Adaptador para eletrocardiografia endovascular referência cruzada para pedidos relacionados |
US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
CA2766179A1 (en) | 2009-06-24 | 2010-12-29 | Egalet Ltd. | Controlled release formulations |
WO2011019760A2 (en) | 2009-08-10 | 2011-02-17 | Romedex International Srl | Devices and methods for endovascular electrography |
WO2011041450A1 (en) | 2009-09-29 | 2011-04-07 | C. R. Bard, Inc. | Stylets for use with apparatus for intravascular placement of a catheter |
WO2011044421A1 (en) | 2009-10-08 | 2011-04-14 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
WO2011097312A1 (en) | 2010-02-02 | 2011-08-11 | C.R. Bard, Inc. | Apparatus and method for catheter navigation and tip location |
WO2011150358A1 (en) | 2010-05-28 | 2011-12-01 | C.R. Bard, Inc. | Insertion guidance system for needles and medical components |
EP2603145A2 (en) | 2010-08-09 | 2013-06-19 | C.R. Bard, Inc. | Support and cover structures for an ultrasound probe head |
WO2012024577A2 (en) | 2010-08-20 | 2012-02-23 | C.R. Bard, Inc. | Reconfirmation of ecg-assisted catheter tip placement |
EP2632360A4 (en) | 2010-10-29 | 2014-05-21 | Bard Inc C R | IMPROVED ASSISTED BY BIO-IMPEDANCE OF A MEDICAL DEVICE |
WO2013006817A1 (en) | 2011-07-06 | 2013-01-10 | C.R. Bard, Inc. | Needle length determination and calibration for insertion guidance system |
USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
US9211107B2 (en) | 2011-11-07 | 2015-12-15 | C. R. Bard, Inc. | Ruggedized ultrasound hydrogel insert |
US20150086626A1 (en) * | 2012-04-17 | 2015-03-26 | Mylan, Inc | Stable dosage forms of skeletal muscle relaxants with extended release coating |
EP2861153A4 (en) | 2012-06-15 | 2016-10-19 | Bard Inc C R | APPARATUS AND METHODS FOR DETECTION OF A REMOVABLE CAP ON AN ULTRASONIC PROBE |
EP2893928B1 (en) | 2012-09-03 | 2018-10-24 | Daiichi Sankyo Company, Limited | Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition |
CA2817728A1 (en) * | 2013-05-31 | 2014-11-30 | Pharmascience Inc. | Abuse deterrent immediate release formulation |
US10195153B2 (en) | 2013-08-12 | 2019-02-05 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
CN105979868B (zh) | 2014-02-06 | 2020-03-10 | C·R·巴德股份有限公司 | 用于血管内装置的导向和放置的系统和方法 |
CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
EP3209282A4 (en) | 2014-10-20 | 2018-05-23 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
WO2016210325A1 (en) | 2015-06-26 | 2016-12-29 | C.R. Bard, Inc. | Connector interface for ecg-based catheter positioning system |
US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
WO2020081373A1 (en) | 2018-10-16 | 2020-04-23 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
AU2019386979B2 (en) | 2018-11-26 | 2023-03-16 | The Procter & Gamble Company | Solid pharmaceutical preparation containing lipoic acid and use thereof |
WO2021100728A1 (ja) | 2019-11-20 | 2021-05-27 | 塩野義製薬株式会社 | 6,7-不飽和-7-カルバモイルモルヒナン誘導体含有固形製剤 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
PE20001396A1 (es) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
US20030068375A1 (en) * | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
JP5259183B2 (ja) * | 2004-07-01 | 2013-08-07 | グリューネンタール・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 乱用に対して保護された経口剤形 |
US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
ES2611794T3 (es) * | 2007-09-13 | 2017-05-10 | Cima Labs Inc. | Formulación de medicamentos resistentes al abuso |
DE502007002695D1 (de) * | 2007-11-09 | 2010-03-11 | Acino Pharma Ag | Retardtabletten mit Hydromorphon |
US8927025B2 (en) * | 2010-05-11 | 2015-01-06 | Cima Labs Inc. | Alcohol-resistant metoprolol-containing extended-release oral dosage forms |
-
2010
- 2010-12-16 WO PCT/US2010/060755 patent/WO2011084593A2/en active Application Filing
- 2010-12-16 MX MX2012006829A patent/MX348361B/es active IP Right Grant
- 2010-12-16 EP EP10801741A patent/EP2512456A2/en not_active Withdrawn
- 2010-12-16 JP JP2012544825A patent/JP5894717B2/ja not_active Expired - Fee Related
- 2010-12-16 AU AU2010339882A patent/AU2010339882B2/en not_active Ceased
- 2010-12-16 CN CN2010800576355A patent/CN102665694A/zh active Pending
- 2010-12-16 CA CA2784407A patent/CA2784407A1/en not_active Abandoned
- 2010-12-16 NZ NZ600640A patent/NZ600640A/en not_active IP Right Cessation
-
2012
- 2012-05-14 US US13/470,963 patent/US20120225122A1/en not_active Abandoned
- 2012-05-23 IL IL219961A patent/IL219961A/en not_active IP Right Cessation
-
2014
- 2014-06-05 US US14/296,572 patent/US9474721B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
IL219961A0 (en) | 2012-07-31 |
MX2012006829A (es) | 2012-07-10 |
EP2512456A2 (en) | 2012-10-24 |
WO2011084593A3 (en) | 2012-03-29 |
AU2010339882B2 (en) | 2016-10-27 |
CN102665694A (zh) | 2012-09-12 |
US20120225122A1 (en) | 2012-09-06 |
US9474721B2 (en) | 2016-10-25 |
US20140294953A1 (en) | 2014-10-02 |
AU2010339882A1 (en) | 2012-07-05 |
CA2784407A1 (en) | 2011-07-14 |
IL219961A (en) | 2017-06-29 |
WO2011084593A2 (en) | 2011-07-14 |
NZ600640A (en) | 2014-11-28 |
JP2013514386A (ja) | 2013-04-25 |
JP5894717B2 (ja) | 2016-03-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |