JP5868862B2 - 双性イオンポリマーバイオコンジュゲートおよび関連する方法 - Google Patents

双性イオンポリマーバイオコンジュゲートおよび関連する方法 Download PDF

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JP5868862B2
JP5868862B2 JP2012538070A JP2012538070A JP5868862B2 JP 5868862 B2 JP5868862 B2 JP 5868862B2 JP 2012538070 A JP2012538070 A JP 2012538070A JP 2012538070 A JP2012538070 A JP 2012538070A JP 5868862 B2 JP5868862 B2 JP 5868862B2
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polymer
conjugate
pcb
biomolecule
protein
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JP2013510181A (ja
JP2013510181A5 (https=
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ジャング、シャオイ
キーフェ、アンドリュー
シュ、ホン
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ユニヴァーシティ・オブ・ワシントン・スルー・イッツ・センター・フォー・コマーシャリゼーション
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • External Artificial Organs (AREA)
JP2012538070A 2009-11-06 2010-11-08 双性イオンポリマーバイオコンジュゲートおよび関連する方法 Expired - Fee Related JP5868862B2 (ja)

Applications Claiming Priority (3)

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US25908809P 2009-11-06 2009-11-06
US61/259,088 2009-11-06
PCT/US2010/055886 WO2011057224A2 (en) 2009-11-06 2010-11-08 Zwitterionic polymer bioconjugates and related methods

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JP2013510181A JP2013510181A (ja) 2013-03-21
JP2013510181A5 JP2013510181A5 (https=) 2013-12-26
JP5868862B2 true JP5868862B2 (ja) 2016-02-24

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US (3) US8877172B2 (https=)
EP (1) EP2496267A4 (https=)
JP (1) JP5868862B2 (https=)
CN (1) CN102905730A (https=)
WO (1) WO2011057224A2 (https=)

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US10031138B2 (en) 2012-01-20 2018-07-24 University Of Washington Through Its Center For Commercialization Hierarchical films having ultra low fouling and high recognition element loading properties
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EP3191016B1 (en) 2014-09-09 2021-10-27 University of Washington Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use
US20170096637A1 (en) * 2015-03-20 2017-04-06 Chung Yuan Christian University Zwitterionic-Bias Material for Blood Cell Selection and Application Thereof
CN109563199A (zh) 2016-06-13 2019-04-02 麻省理工学院 用于减少异物反应和纤维化的生物相容性两性离子聚合物涂层和水凝胶
DK3570874T3 (da) * 2017-01-17 2023-04-11 Univ Wayne State Zwitterionisk polymer-insulin-sammensætninger og dertil relaterede fremgangsmåder
DE102017101057A1 (de) * 2017-01-20 2018-07-26 Fraunhofer-Institut für Angewandte Polymerforschung IAP Zwitterionische Nanopartikel
AU2018306910A1 (en) * 2017-07-24 2020-02-20 Rohm And Haas Company Chloride-free cationic polymers using acetate anions
AU2018306909A1 (en) * 2017-07-24 2020-02-20 Rohm And Haas Company Chloride-free cationic polymers using acetate anions
WO2019022866A1 (en) * 2017-07-24 2019-01-31 Union Carbide Chemicals & Plastics Technology Llc COUNTER-IONS MONOMERS AND POLYMERS WITH MIXED LOAD PRODUCTS THEREFROM
WO2019183637A1 (en) * 2018-03-23 2019-09-26 University Of Washington Immunosuppressive materials and related methods
WO2021022198A1 (en) * 2019-08-01 2021-02-04 Carnegie Mellon University (CMU) Tuning protein solubility by polymer surface modification
WO2021072281A1 (en) * 2019-10-11 2021-04-15 University Of Washington Modified endonucleases and related methods
CN114605577B (zh) * 2022-03-21 2023-05-26 长春中医药大学 一种抗肿瘤两性聚合物及其制备方法与应用

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Also Published As

Publication number Publication date
EP2496267A4 (en) 2016-02-17
US8877172B2 (en) 2014-11-04
US20190070300A1 (en) 2019-03-07
JP2013510181A (ja) 2013-03-21
EP2496267A2 (en) 2012-09-12
CN102905730A (zh) 2013-01-30
US20120315239A1 (en) 2012-12-13
WO2011057224A3 (en) 2011-09-15
WO2011057224A2 (en) 2011-05-12
US10130716B2 (en) 2018-11-20
US20150157732A1 (en) 2015-06-11

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