JP5866116B2 - 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途 - Google Patents

嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途 Download PDF

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JP5866116B2
JP5866116B2 JP2010250815A JP2010250815A JP5866116B2 JP 5866116 B2 JP5866116 B2 JP 5866116B2 JP 2010250815 A JP2010250815 A JP 2010250815A JP 2010250815 A JP2010250815 A JP 2010250815A JP 5866116 B2 JP5866116 B2 JP 5866116B2
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neratinib
maleate
spherical particles
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JP2011098965A (ja
JP2011098965A5 (https=
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リチャード ディオリオ クリストファー
リチャード ディオリオ クリストファー
マーフィ ユージーン
マーフィ ユージーン
ヴェンカタ ラマナ ラオ スリプリア
ヴェンカタ ラマナ ラオ スリプリア
マザファー シャフ シエド
マザファー シャフ シエド
ヴェンクル‐ジョンシック マジャ
ヴェンクル‐ジョンシック マジャ
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ワイス・エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2010250815A 2009-11-09 2010-11-09 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途 Active JP5866116B2 (ja)

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US25938709P 2009-11-09 2009-11-09
US61/259,387 2009-11-09

Related Child Applications (1)

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JP2015013685A Division JP5982020B2 (ja) 2009-11-09 2015-01-27 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途

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JP2011098965A JP2011098965A (ja) 2011-05-19
JP2011098965A5 JP2011098965A5 (https=) 2013-12-19
JP5866116B2 true JP5866116B2 (ja) 2016-02-17

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JP2010250815A Active JP5866116B2 (ja) 2009-11-09 2010-11-09 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途
JP2015013685A Active JP5982020B2 (ja) 2009-11-09 2015-01-27 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途
JP2016025515A Pending JP2016094478A (ja) 2009-11-09 2016-02-15 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途

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JP2016025515A Pending JP2016094478A (ja) 2009-11-09 2016-02-15 嘔吐および下痢などの状態を解消または軽減するためのコーティングされた薬物球状体およびその用途

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US (2) US8524281B2 (https=)
EP (1) EP2498751B1 (https=)
JP (3) JP5866116B2 (https=)
CN (4) CN107441058A (https=)
AR (1) AR078951A1 (https=)
AU (1) AU2010315362B2 (https=)
CA (1) CA2780332C (https=)
ES (1) ES2729677T3 (https=)
NZ (1) NZ599762A (https=)
TW (1) TWI429437B (https=)
WO (1) WO2011056741A2 (https=)

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CN107308130B (zh) 2021-06-15
JP2015078240A (ja) 2015-04-23
WO2011056741A2 (en) 2011-05-12
US20140004203A1 (en) 2014-01-02
CN107308130A (zh) 2017-11-03
JP2011098965A (ja) 2011-05-19
CA2780332A1 (en) 2011-05-12
CN107441058A (zh) 2017-12-08
EP2498751B1 (en) 2019-04-03
JP2016094478A (ja) 2016-05-26
AU2010315362A1 (en) 2012-05-24
CN106074445B (zh) 2018-12-21
CN102724962B (zh) 2017-05-17
WO2011056741A3 (en) 2011-06-30
AU2010315362B2 (en) 2015-01-22
NZ599762A (en) 2014-07-25
JP5982020B2 (ja) 2016-08-31
TW201138775A (en) 2011-11-16
ES2729677T3 (es) 2019-11-05
CA2780332C (en) 2018-01-30
EP2498751A2 (en) 2012-09-19
CN102724962A (zh) 2012-10-10
US8524281B2 (en) 2013-09-03
TWI429437B (zh) 2014-03-11
CN106074445A (zh) 2016-11-09
US20110165257A1 (en) 2011-07-07
US9211264B2 (en) 2015-12-15
AR078951A1 (es) 2011-12-14

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