JP5859187B2 - 粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法 - Google Patents

粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法 Download PDF

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JP5859187B2
JP5859187B2 JP2010135191A JP2010135191A JP5859187B2 JP 5859187 B2 JP5859187 B2 JP 5859187B2 JP 2010135191 A JP2010135191 A JP 2010135191A JP 2010135191 A JP2010135191 A JP 2010135191A JP 5859187 B2 JP5859187 B2 JP 5859187B2
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light
sample cell
hole
cell
light beam
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JP2010286491A (ja
JP2010286491A5 (enExample
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スティーブン・ピィ・トレイノフ
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Wyatt Technology LLC
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G01N2021/513—Cuvettes for scattering measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
JP2010135191A 2009-06-15 2010-06-14 粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法 Active JP5859187B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/456,470 US7982875B2 (en) 2009-06-15 2009-06-15 Method and apparatus for measuring the scattered light signals from a liquid sample
US12/456,470 2009-06-15

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JP2015054737A Division JP5886994B2 (ja) 2009-06-15 2015-03-18 粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法

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JP2010286491A JP2010286491A (ja) 2010-12-24
JP2010286491A5 JP2010286491A5 (enExample) 2013-03-28
JP5859187B2 true JP5859187B2 (ja) 2016-02-10

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JP2010135191A Active JP5859187B2 (ja) 2009-06-15 2010-06-14 粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法
JP2015054737A Active JP5886994B2 (ja) 2009-06-15 2015-03-18 粒子の懸濁液の光散乱特性を測定するための円形の試料セルおよびシステム、ならびに粒子の懸濁液によって散乱された光を測定する方法

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US (1) US7982875B2 (enExample)
EP (1) EP2264437B1 (enExample)
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CN (1) CN101963579B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2584353B1 (de) * 2011-10-18 2018-01-24 Postnova Analytics GmbH Blendensystem für Vielwinkellichtstreudetektoren
DE202014102634U1 (de) 2014-06-05 2014-07-01 Postnova Analytics Gmbh Zweiteilige Messzelle für die statische Lichtstreuung
CN105527224B (zh) * 2014-09-29 2019-02-22 安东帕有限公司 一种用于分析样品的设备和方法
WO2017053478A1 (en) 2015-09-22 2017-03-30 Wyatt Technology Corporation Method and apparatus to measure multiple signals from a liquid sample
EP3420338B1 (en) * 2016-02-26 2023-05-03 Single Technologies AB Method and apparatus for high throughput imaging
WO2018054852A1 (en) * 2016-09-22 2018-03-29 Imec Vzw Particle detection using thin lenses
US20180156717A1 (en) * 2016-12-05 2018-06-07 Bill & Melinda Gates Foundation Multi-test assay systems and methods of using the same
US20190383726A1 (en) * 2016-12-27 2019-12-19 National Institute Of Advanced Industrial Science And Technology Flow cell for optical measurement
US10466173B2 (en) 2017-10-06 2019-11-05 Wyatt Technology Corporation Optical flow cell assembly incorporating a replaceable transparent flow cell
JP7140193B2 (ja) * 2018-08-01 2022-09-21 株式会社島津製作所 光散乱検出装置
JP7187874B2 (ja) * 2018-08-02 2022-12-13 株式会社島津製作所 光散乱検出装置
CN108760686B (zh) * 2018-08-07 2024-05-14 天津诺迈科技有限公司 散射比浊法检测微流控芯片及使用该芯片的生化免疫机
WO2020142096A1 (en) 2019-01-02 2020-07-09 M & J Scientific, Llc Light scattering detectors and methods for the same
JP7307495B2 (ja) 2019-01-02 2023-07-12 エム アンド ジェイ サイエンティフィック エルエルシー 光散乱検出器及び光散乱検出器のサンプルセル
CN109932450B (zh) * 2019-04-03 2022-01-25 安徽皖仪科技股份有限公司 流通池和具有其的液相色谱仪
US11733144B2 (en) * 2020-12-14 2023-08-22 Caterpillar Inc. Convertible housing assembly for a particle sensor
US11555776B2 (en) 2021-02-03 2023-01-17 Shimadzu Corporation Light scattering detection apparatus

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705771A (en) * 1970-01-14 1972-12-12 Bio Physics Systems Inc Photoanalysis apparatus
US4490042A (en) * 1981-06-04 1984-12-25 Wyatt Philip J Method for determining the properties of wine
JPS57208439A (en) * 1981-06-18 1982-12-21 Olympus Optical Co Ltd Particle coagulation discriminating vessel
US4541719A (en) * 1982-07-20 1985-09-17 Wyatt Philip J Method and apparatus for characterizing microparticles and measuring their response to their environment
US4565448A (en) * 1983-03-11 1986-01-21 E. I. Du Pont De Nemours And Company Particle counting apparatus
JPS60161548A (ja) * 1984-01-31 1985-08-23 Canon Inc 流動微小粒子状物体の散乱光測定装置
FR2566543B1 (fr) * 1984-06-20 1988-02-26 Commissariat Energie Atomique Dispositif optique a rendement de collection eleve et cytofluorimetre en faisant application
US4907884A (en) 1984-11-15 1990-03-13 Wyatt Technology Corporation Sample cell monitoring system
US4616927A (en) * 1984-11-15 1986-10-14 Wyatt Technology Corporation Sample cell for light scattering measurements
US4591268A (en) * 1984-11-23 1986-05-27 Lew Hyok S Accumulative absorption-dispersion spectrophotometer
US4952055A (en) 1988-10-03 1990-08-28 Wyatt Technology Corporation Differential refractometer
USD329821S (en) 1989-02-21 1992-09-29 Wyatt Technology Corporation Apparatus for the measurement of fine particles in liquid suspension by the light scattering procedure
US5175596A (en) * 1990-10-23 1992-12-29 Venturedyne, Ltd. Liquid nephelometer
US5495333A (en) * 1992-07-24 1996-02-27 Sumitomo Electric Industries, Ltd. Method and apparatus of detecting impurities in fluid
US5404217A (en) * 1993-08-26 1995-04-04 Janik; Gary R. Laser liquid flow cell manifold system and method for assembly
US5530540A (en) 1994-08-03 1996-06-25 Wyatt Technology Corporation Light scattering measurement cell for very small volumes
JP3124989B2 (ja) * 1994-12-19 2001-01-15 リオン株式会社 光散乱式粒子検出装置
US5734468A (en) * 1995-08-18 1998-03-31 Beckman Instruments, Inc. Probe and method for determining serum indices of a serum sample
JP3567949B2 (ja) * 1995-10-24 2004-09-22 石川島播磨重工業株式会社 レーザレーダ装置
US6052184A (en) * 1996-11-13 2000-04-18 The Administrators Of The Tulane Educational Fund Miniature, submersible, versatile, light scattering probe for absolute equilibrium and non-equilibrium characterization of macromolecular and colloidal solutions
US20040004717A1 (en) * 1996-11-13 2004-01-08 Reed Wayne F. Automatic mixing and dilution methods and apparatus for online characterization of equilibrium and non-equilibrium properties of solutions containing polymers and/or colloids
US6452672B1 (en) * 2000-03-10 2002-09-17 Wyatt Technology Corporation Self cleaning optical flow cell
JP4439765B2 (ja) * 2001-07-23 2010-03-24 株式会社堀場製作所 粒子径分布測定装置
US6590652B2 (en) * 2001-11-02 2003-07-08 Pointsource Technologies, Inc. Flow through light scattering device
US7057724B1 (en) * 2002-03-21 2006-06-06 Institute Of Critical Care Medicine Particulate info to field units
US6651009B1 (en) 2002-07-24 2003-11-18 Wyatt Technology Corporation Method for determining average solution properties of macromolecules by the injection method
GB2403815A (en) * 2003-07-10 2005-01-12 Ocuity Ltd Birefringent lens array structure
US6774994B1 (en) 2003-08-13 2004-08-10 Wyatt Technology Corporation Method and apparatus for determining absolute number densities of particles in suspension
DE10341520A1 (de) * 2003-09-09 2005-04-07 Schupp, Wolfgang, Dr. Verfahren und Vorrichtung zur Durchführung einer Lichtstreuung
US7386427B2 (en) 2003-09-18 2008-06-10 Wyatt Technology Corporation Method for correcting the effects of interdetector band broadening
US7151604B2 (en) * 2004-03-05 2006-12-19 Honeywell International Inc. Optical system and method for particle detection
JP2006066736A (ja) 2004-08-27 2006-03-09 Orion Denki Kk コード結束用フックを備えた液晶型テレビ
US7113266B1 (en) * 2005-03-30 2006-09-26 Beckman Coulter, Inc. Flow cytometer for differentiating small particles in suspension
JP2008039539A (ja) * 2006-08-04 2008-02-21 Shimadzu Corp 光散乱検出装置
WO2010036736A2 (en) * 2008-09-25 2010-04-01 Varian, Inc Light scattering flow cell device

Also Published As

Publication number Publication date
CN101963579B (zh) 2016-01-20
JP2010286491A (ja) 2010-12-24
US7982875B2 (en) 2011-07-19
JP2015111163A (ja) 2015-06-18
US20100315637A1 (en) 2010-12-16
EP2264437B1 (en) 2022-08-24
JP5886994B2 (ja) 2016-03-16
CN101963579A (zh) 2011-02-02
EP2264437A1 (en) 2010-12-22

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