CN101963579B - 用于测量来自液体样品的散射光信号的改善的方法和设备 - Google Patents

用于测量来自液体样品的散射光信号的改善的方法和设备 Download PDF

Info

Publication number
CN101963579B
CN101963579B CN201010205250.0A CN201010205250A CN101963579B CN 101963579 B CN101963579 B CN 101963579B CN 201010205250 A CN201010205250 A CN 201010205250A CN 101963579 B CN101963579 B CN 101963579B
Authority
CN
China
Prior art keywords
light
sample unit
scattering
light beam
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201010205250.0A
Other languages
English (en)
Chinese (zh)
Other versions
CN101963579A (zh
Inventor
S·P·特兰奥弗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyatt Technology LLC
Original Assignee
Wyatt Technology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyatt Technology LLC filed Critical Wyatt Technology LLC
Publication of CN101963579A publication Critical patent/CN101963579A/zh
Application granted granted Critical
Publication of CN101963579B publication Critical patent/CN101963579B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4709—Backscatter
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G01N2021/513—Cuvettes for scattering measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
CN201010205250.0A 2009-06-15 2010-06-13 用于测量来自液体样品的散射光信号的改善的方法和设备 Active CN101963579B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/456,470 US7982875B2 (en) 2009-06-15 2009-06-15 Method and apparatus for measuring the scattered light signals from a liquid sample
US12/456,470 2009-06-15

Publications (2)

Publication Number Publication Date
CN101963579A CN101963579A (zh) 2011-02-02
CN101963579B true CN101963579B (zh) 2016-01-20

Family

ID=42734803

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201010205250.0A Active CN101963579B (zh) 2009-06-15 2010-06-13 用于测量来自液体样品的散射光信号的改善的方法和设备

Country Status (4)

Country Link
US (1) US7982875B2 (enExample)
EP (1) EP2264437B1 (enExample)
JP (2) JP5859187B2 (enExample)
CN (1) CN101963579B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2584353B1 (de) * 2011-10-18 2018-01-24 Postnova Analytics GmbH Blendensystem für Vielwinkellichtstreudetektoren
DE202014102634U1 (de) 2014-06-05 2014-07-01 Postnova Analytics Gmbh Zweiteilige Messzelle für die statische Lichtstreuung
CN105527224B (zh) * 2014-09-29 2019-02-22 安东帕有限公司 一种用于分析样品的设备和方法
WO2017053478A1 (en) 2015-09-22 2017-03-30 Wyatt Technology Corporation Method and apparatus to measure multiple signals from a liquid sample
EP3420338B1 (en) * 2016-02-26 2023-05-03 Single Technologies AB Method and apparatus for high throughput imaging
WO2018054852A1 (en) * 2016-09-22 2018-03-29 Imec Vzw Particle detection using thin lenses
US20180156717A1 (en) * 2016-12-05 2018-06-07 Bill & Melinda Gates Foundation Multi-test assay systems and methods of using the same
US20190383726A1 (en) * 2016-12-27 2019-12-19 National Institute Of Advanced Industrial Science And Technology Flow cell for optical measurement
US10466173B2 (en) 2017-10-06 2019-11-05 Wyatt Technology Corporation Optical flow cell assembly incorporating a replaceable transparent flow cell
JP7140193B2 (ja) * 2018-08-01 2022-09-21 株式会社島津製作所 光散乱検出装置
JP7187874B2 (ja) * 2018-08-02 2022-12-13 株式会社島津製作所 光散乱検出装置
CN108760686B (zh) * 2018-08-07 2024-05-14 天津诺迈科技有限公司 散射比浊法检测微流控芯片及使用该芯片的生化免疫机
WO2020142096A1 (en) 2019-01-02 2020-07-09 M & J Scientific, Llc Light scattering detectors and methods for the same
JP7307495B2 (ja) 2019-01-02 2023-07-12 エム アンド ジェイ サイエンティフィック エルエルシー 光散乱検出器及び光散乱検出器のサンプルセル
CN109932450B (zh) * 2019-04-03 2022-01-25 安徽皖仪科技股份有限公司 流通池和具有其的液相色谱仪
US11733144B2 (en) * 2020-12-14 2023-08-22 Caterpillar Inc. Convertible housing assembly for a particle sensor
US11555776B2 (en) 2021-02-03 2023-01-17 Shimadzu Corporation Light scattering detection apparatus

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705771A (en) * 1970-01-14 1972-12-12 Bio Physics Systems Inc Photoanalysis apparatus
US4490042A (en) * 1981-06-04 1984-12-25 Wyatt Philip J Method for determining the properties of wine
US4541719A (en) * 1982-07-20 1985-09-17 Wyatt Philip J Method and apparatus for characterizing microparticles and measuring their response to their environment
US4616927A (en) * 1984-11-15 1986-10-14 Wyatt Technology Corporation Sample cell for light scattering measurements

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57208439A (en) * 1981-06-18 1982-12-21 Olympus Optical Co Ltd Particle coagulation discriminating vessel
US4565448A (en) * 1983-03-11 1986-01-21 E. I. Du Pont De Nemours And Company Particle counting apparatus
JPS60161548A (ja) * 1984-01-31 1985-08-23 Canon Inc 流動微小粒子状物体の散乱光測定装置
FR2566543B1 (fr) * 1984-06-20 1988-02-26 Commissariat Energie Atomique Dispositif optique a rendement de collection eleve et cytofluorimetre en faisant application
US4907884A (en) 1984-11-15 1990-03-13 Wyatt Technology Corporation Sample cell monitoring system
US4591268A (en) * 1984-11-23 1986-05-27 Lew Hyok S Accumulative absorption-dispersion spectrophotometer
US4952055A (en) 1988-10-03 1990-08-28 Wyatt Technology Corporation Differential refractometer
USD329821S (en) 1989-02-21 1992-09-29 Wyatt Technology Corporation Apparatus for the measurement of fine particles in liquid suspension by the light scattering procedure
US5175596A (en) * 1990-10-23 1992-12-29 Venturedyne, Ltd. Liquid nephelometer
US5495333A (en) * 1992-07-24 1996-02-27 Sumitomo Electric Industries, Ltd. Method and apparatus of detecting impurities in fluid
US5404217A (en) * 1993-08-26 1995-04-04 Janik; Gary R. Laser liquid flow cell manifold system and method for assembly
US5530540A (en) 1994-08-03 1996-06-25 Wyatt Technology Corporation Light scattering measurement cell for very small volumes
JP3124989B2 (ja) * 1994-12-19 2001-01-15 リオン株式会社 光散乱式粒子検出装置
US5734468A (en) * 1995-08-18 1998-03-31 Beckman Instruments, Inc. Probe and method for determining serum indices of a serum sample
JP3567949B2 (ja) * 1995-10-24 2004-09-22 石川島播磨重工業株式会社 レーザレーダ装置
US6052184A (en) * 1996-11-13 2000-04-18 The Administrators Of The Tulane Educational Fund Miniature, submersible, versatile, light scattering probe for absolute equilibrium and non-equilibrium characterization of macromolecular and colloidal solutions
US20040004717A1 (en) * 1996-11-13 2004-01-08 Reed Wayne F. Automatic mixing and dilution methods and apparatus for online characterization of equilibrium and non-equilibrium properties of solutions containing polymers and/or colloids
US6452672B1 (en) * 2000-03-10 2002-09-17 Wyatt Technology Corporation Self cleaning optical flow cell
JP4439765B2 (ja) * 2001-07-23 2010-03-24 株式会社堀場製作所 粒子径分布測定装置
US6590652B2 (en) * 2001-11-02 2003-07-08 Pointsource Technologies, Inc. Flow through light scattering device
US7057724B1 (en) * 2002-03-21 2006-06-06 Institute Of Critical Care Medicine Particulate info to field units
US6651009B1 (en) 2002-07-24 2003-11-18 Wyatt Technology Corporation Method for determining average solution properties of macromolecules by the injection method
GB2403815A (en) * 2003-07-10 2005-01-12 Ocuity Ltd Birefringent lens array structure
US6774994B1 (en) 2003-08-13 2004-08-10 Wyatt Technology Corporation Method and apparatus for determining absolute number densities of particles in suspension
DE10341520A1 (de) * 2003-09-09 2005-04-07 Schupp, Wolfgang, Dr. Verfahren und Vorrichtung zur Durchführung einer Lichtstreuung
US7386427B2 (en) 2003-09-18 2008-06-10 Wyatt Technology Corporation Method for correcting the effects of interdetector band broadening
US7151604B2 (en) * 2004-03-05 2006-12-19 Honeywell International Inc. Optical system and method for particle detection
JP2006066736A (ja) 2004-08-27 2006-03-09 Orion Denki Kk コード結束用フックを備えた液晶型テレビ
US7113266B1 (en) * 2005-03-30 2006-09-26 Beckman Coulter, Inc. Flow cytometer for differentiating small particles in suspension
JP2008039539A (ja) * 2006-08-04 2008-02-21 Shimadzu Corp 光散乱検出装置
WO2010036736A2 (en) * 2008-09-25 2010-04-01 Varian, Inc Light scattering flow cell device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3705771A (en) * 1970-01-14 1972-12-12 Bio Physics Systems Inc Photoanalysis apparatus
US4490042A (en) * 1981-06-04 1984-12-25 Wyatt Philip J Method for determining the properties of wine
US4541719A (en) * 1982-07-20 1985-09-17 Wyatt Philip J Method and apparatus for characterizing microparticles and measuring their response to their environment
US4616927A (en) * 1984-11-15 1986-10-14 Wyatt Technology Corporation Sample cell for light scattering measurements

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Absolute small angle light scattering measurements from weakly scattering systems in a shear flow apparatus;V.Weber and F.Schosseler;《REVIEW OF SCIENTIFIC INSTRUMENTS》;20020731;第73卷(第7期);图1，全文 *

Also Published As

Publication number Publication date
JP2010286491A (ja) 2010-12-24
US7982875B2 (en) 2011-07-19
JP2015111163A (ja) 2015-06-18
US20100315637A1 (en) 2010-12-16
JP5859187B2 (ja) 2016-02-10
EP2264437B1 (en) 2022-08-24
JP5886994B2 (ja) 2016-03-16
CN101963579A (zh) 2011-02-02
EP2264437A1 (en) 2010-12-22

Similar Documents

Publication Publication Date Title
CN101963579B (zh) 用于测量来自液体样品的散射光信号的改善的方法和设备
AU752985B2 (en) Optical apparatus
JP2010286491A5 (enExample)
EP2180306B1 (en) Focussing arrangement for a capillary cell
JP6691043B2 (ja) 粒子特性評価装置
US11221289B2 (en) Optical particle detector
JP5854621B2 (ja) 長光路長フローセル
CN106198490B (zh) 一种空间偏移拉曼光谱探测系统
CN1758052B (zh) 结合有光检测器阵列的灵敏度增强的差示折射计
CN105973772A (zh) 一种动态、静态光散射结合的激光粒度仪
CA2807630C (en) Annular optical device
US7336351B1 (en) Laser remote sensing of backscattered light from a target sample
WO1991003725A1 (en) Combined optical train for laser spectroscopy
CN205786213U (zh) 动态、静态光散射结合的激光粒度仪
CN106168711A (zh) 一种锥透镜环式激光辐照装置
CN206057182U (zh) 一种空间偏移拉曼光谱探测系统
CN104880469A (zh) 核聚变靶室及其原位在线检测装置和分析装置
CN206057694U (zh) 一种锥透镜环式激光辐照装置
AU2008200836B2 (en) Optical Apparatus
AU2002318853B2 (en) Optical Apparatus
NZ523347A (en) Optical apparatus with annular beam and focussing reflector for sperm particle irradiance analysis
AU2005203372A1 (en) Optical Apparatus
NZ522984A (en) Optical flow cytometry

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant