JP5856059B2 - 虚血組織を治療するためのｓｄｆ−１送達 - Google Patents

虚血組織を治療するためのｓｄｆ−１送達 Download PDF

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JP5856059B2
JP5856059B2 JP2012527071A JP2012527071A JP5856059B2 JP 5856059 B2 JP5856059 B2 JP 5856059B2 JP 2012527071 A JP2012527071 A JP 2012527071A JP 2012527071 A JP2012527071 A JP 2012527071A JP 5856059 B2 JP5856059 B2 JP 5856059B2
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sdf
plasmid
administered
formulation
ischemic
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JP2013503202A5 (cg-RX-API-DMAC7.html
JP2013503202A (ja
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ペン，マーク，エス．
アラス，ラフル
パストーレ，ジョゼフ
ミラー，ティモシー，アール．
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Cleveland Clinic Foundation
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Cleveland Clinic Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2012527071A 2009-08-28 2010-08-30 虚血組織を治療するためのｓｄｆ−１送達 Active JP5856059B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23777509P 2009-08-28 2009-08-28
US61/237,775 2009-08-28
US33421610P 2010-05-13 2010-05-13
US61/334,216 2010-05-13
PCT/US2010/047175 WO2011026041A2 (en) 2009-08-28 2010-08-30 Sdf-1 delivery for treating ischemic tissue

Publications (3)

Publication Number Publication Date
JP2013503202A JP2013503202A (ja) 2013-01-31
JP2013503202A5 JP2013503202A5 (cg-RX-API-DMAC7.html) 2013-10-10
JP5856059B2 true JP5856059B2 (ja) 2016-02-09

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US (5) US20120283315A1 (cg-RX-API-DMAC7.html)
EP (1) EP2473196B1 (cg-RX-API-DMAC7.html)
JP (1) JP5856059B2 (cg-RX-API-DMAC7.html)
CN (1) CN102740894B (cg-RX-API-DMAC7.html)
AU (1) AU2010286511B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012004395B8 (cg-RX-API-DMAC7.html)
CA (1) CA2772610C (cg-RX-API-DMAC7.html)
MX (1) MX357779B (cg-RX-API-DMAC7.html)
WO (1) WO2011026041A2 (cg-RX-API-DMAC7.html)

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AU2010286511B2 (en) 2009-08-28 2016-05-26 Juventas Therapeutics, Inc. SDF-1 delivery for treating ischemic tissue
US9308277B2 (en) 2010-02-25 2016-04-12 Mesoblast International Sàrl Protease-resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
JP5921558B2 (ja) * 2010-10-14 2016-05-24 ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション，インコーポレイテッド 心臓人工多能性幹細胞ならびに心筋の修復および再生に使用する方法
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JP6461085B2 (ja) * 2013-03-15 2019-01-30 ザ クリーブランド クリニック ファウンデーション 虚血性組織を治療するためのｓｄｆ−１送達
JP2016516070A (ja) * 2013-03-15 2016-06-02 ザ クリーブランド クリニック ファウンデーション 心筋梗塞の処置のためのｓｄｆ−１の逆行性送達
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WO2011026041A2 (en) 2011-03-03
US20140135383A1 (en) 2014-05-15
AU2010286511A1 (en) 2012-04-12
BR112012004395A2 (pt) 2016-11-16
US8513213B2 (en) 2013-08-20
US8513007B2 (en) 2013-08-20
US20130303597A1 (en) 2013-11-14
EP2473196A2 (en) 2012-07-11
CA2772610A1 (en) 2011-03-03
US9844581B2 (en) 2017-12-19
US20120283315A1 (en) 2012-11-08
CA2772610C (en) 2018-01-23
WO2011026041A9 (en) 2011-07-21
US20120289586A1 (en) 2012-11-15
CN102740894A (zh) 2012-10-17
MX2012002610A (es) 2012-08-23
BR112012004395B8 (pt) 2021-05-25
CN102740894B (zh) 2015-07-15
BR112012004395B1 (pt) 2021-01-12
MX357779B (es) 2018-07-24
US8883756B2 (en) 2014-11-11
EP2473196A4 (en) 2015-01-07
JP2013503202A (ja) 2013-01-31
AU2010286511B2 (en) 2016-05-26
EP2473196B1 (en) 2017-05-31
US20120289585A1 (en) 2012-11-15

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