JP5855239B2 - ラクトフェリン融合タンパク質及びその製造方法 - Google Patents

ラクトフェリン融合タンパク質及びその製造方法 Download PDF

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JP5855239B2
JP5855239B2 JP2014512737A JP2014512737A JP5855239B2 JP 5855239 B2 JP5855239 B2 JP 5855239B2 JP 2014512737 A JP2014512737 A JP 2014512737A JP 2014512737 A JP2014512737 A JP 2014512737A JP 5855239 B2 JP5855239 B2 JP 5855239B2
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fusion protein
hlf
lactoferrin
hinge
variant
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JPWO2013162050A1 (ja
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佐藤　淳
佐藤　　淳
伸治 加賀谷
伸治 加賀谷
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NRL Pharma Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/09—Recombinant DNA-technology
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    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Genetics & Genomics (AREA)
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  • Diabetes (AREA)
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  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Animal Husbandry (AREA)
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JP2014512737A 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法 Active JP5855239B2 (ja)

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JP2012098085 2012-04-23
JP2012098085 2012-04-23
JP2014512737A JP5855239B2 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法
PCT/JP2013/062685 WO2013162050A1 (ja) 2012-04-23 2013-04-23 ラクトフェリン融合タンパク質及びその製造方法

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US (2) US9809641B2 (OSRAM)
EP (1) EP2842969B1 (OSRAM)
JP (2) JP5855239B2 (OSRAM)
KR (1) KR102177252B1 (OSRAM)
BR (1) BR112014026162A2 (OSRAM)
CA (1) CA2871468C (OSRAM)
ES (1) ES2671631T3 (OSRAM)
IN (1) IN2014DN09815A (OSRAM)
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
US10562959B2 (en) 2012-04-23 2020-02-18 Nrl Pharma, Inc. Lactoferrin fusion protein and method for preparation thereof
US11041014B2 (en) 2016-10-28 2021-06-22 S & K Biopharma, Inc. Lactoferrin/albumin fusion protein and production method therefor

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SI3110434T1 (sl) * 2014-02-24 2019-02-28 Takeda Gmbh UTI fuzijski proteini
JP2018515073A (ja) * 2015-05-04 2018-06-14 ラボラトワール フランセ デュ フラクショヌマン エ デ ビオテクノロジーＬａｂｏｒａｔｏｉｒｅ Ｆｒａｎｃａｉｓ ｄｕ Ｆｒａｃｔｉｏｎｎｅｍｅｎｔ ｅｔ ｄｅｓ Ｂｉｏｔｅｃｈｎｏｌｏｇｉｅｓ Ｆｃ融合タンパク質のトランスジェニック産生
EP3313875A4 (en) * 2015-06-24 2018-12-26 Board of Regents of the University of Texas System Methods and compositions for treatment of symptoms associated with intracranial hemorrhage
AU2016329197B2 (en) * 2015-09-30 2021-01-21 Igm Biosciences, Inc. Binding molecules with modified J-chain
JPWO2018079701A1 (ja) * 2016-10-28 2019-09-19 株式会社Ｎｒｌファーマ ラクトフェリン活性を有するタンパク質を含む、抗ガン治療補助剤
UA127985C2 (uk) 2017-02-17 2024-03-06 Деналі Терап'Ютікс Інк. Сконструйований поліпептид, який зв'язує трансфериновий рецептор
KR20200058510A (ko) 2017-10-02 2020-05-27 데날리 테라퓨틱스 인크. 효소 대체 요법 효소를 포함하는 융합 단백질
JP7527638B2 (ja) * 2018-06-26 2024-08-05 株式会社Ｓ＆Ｋバイオファーマ グリコサミノグリカン阻害剤および促進剤
US20200024329A1 (en) * 2018-07-17 2020-01-23 Bradley G. Thompson Methods for regulating endogenous production of lactoferrin and sub-peptides thereof
IL293994A (en) 2019-12-23 2022-08-01 Denali Therapeutics Inc Progranulin variants, compositions comprising same and uses thereof
CA3169647A1 (en) * 2020-11-25 2022-06-02 Jang Hyun Han Methods and compositions for treating sars-cov-2 infection

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US6111081A (en) 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
JP3681982B2 (ja) 1998-07-15 2005-08-10 サムヤン ジェネックス コーポレイション 酵母からラクトフェリンポリペプチドを大量生産する方法及びそれに有用な微生物菌株
US6660843B1 (en) * 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
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CA2871468C (en) 2021-09-21
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CA2871468A1 (en) 2013-10-31
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IN2014DN09815A (OSRAM) 2015-07-31
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KR20150008870A (ko) 2015-01-23
US20150093382A1 (en) 2015-04-02
JP6356115B2 (ja) 2018-07-11
US20180072794A1 (en) 2018-03-15
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