JP5849045B2 - 試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 - Google Patents

試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 Download PDF

Info

Publication number
JP5849045B2
JP5849045B2 JP2012513061A JP2012513061A JP5849045B2 JP 5849045 B2 JP5849045 B2 JP 5849045B2 JP 2012513061 A JP2012513061 A JP 2012513061A JP 2012513061 A JP2012513061 A JP 2012513061A JP 5849045 B2 JP5849045 B2 JP 5849045B2
Authority
JP
Japan
Prior art keywords
ion
analyte
mass
group
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2012513061A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012529010A (ja
JP2012529010A5 (enExample
Inventor
サブハカール デイ，
サブハカール デイ，
サシ ピライ，
サシ ピライ，
ブライアン エル． ウィリアムソン，
ブライアン エル． ウィリアムソン，
サブハシシュ プルカヤスタ，
サブハシシュ プルカヤスタ，
ミカル ウェインストック，
ミカル ウェインストック，
Original Assignee
ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド, ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド filed Critical ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
Publication of JP2012529010A publication Critical patent/JP2012529010A/ja
Publication of JP2012529010A5 publication Critical patent/JP2012529010A5/ja
Application granted granted Critical
Publication of JP5849045B2 publication Critical patent/JP5849045B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
JP2012513061A 2009-05-31 2010-06-01 試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 Expired - Fee Related JP5849045B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18274809P 2009-05-31 2009-05-31
US61/182,748 2009-05-31
PCT/US2010/001598 WO2010141075A1 (en) 2009-05-31 2010-06-01 Specific analysis of ketone and aldehyde analytes using reagent compounds labeling strategies, and mass spectrometry workflow

Publications (3)

Publication Number Publication Date
JP2012529010A JP2012529010A (ja) 2012-11-15
JP2012529010A5 JP2012529010A5 (enExample) 2013-07-18
JP5849045B2 true JP5849045B2 (ja) 2016-01-27

Family

ID=43298006

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012513061A Expired - Fee Related JP5849045B2 (ja) 2009-05-31 2010-06-01 試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析

Country Status (5)

Country Link
US (3) US20110003395A1 (enExample)
EP (1) EP2438448B1 (enExample)
JP (1) JP5849045B2 (enExample)
CA (1) CA2762277C (enExample)
WO (1) WO2010141075A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1868616A2 (en) * 2005-03-29 2007-12-26 The University of Maryland, Baltimore Inhibitors for extracellular signal-regulated kinase docking domains and uses therefor
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
US8309359B2 (en) * 2010-01-15 2012-11-13 California Institute Of Technology Isobaric tags for analyte detection and quantification
EP2526428B1 (en) * 2010-01-22 2016-03-30 DH Technologies Development Pte. Ltd. Mass tag reagents for simultaneous quantitation and identification of small molecules
WO2011091436A1 (en) 2010-01-25 2011-07-28 Dh Technologies Development Pte. Ltd. Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof
US9834578B2 (en) * 2010-05-27 2017-12-05 University Of Utah Research Foundation Enhanced sensitivity for analysis of ketosteroid compounds using mass spectrometry
EP2673631B1 (en) * 2011-02-07 2020-04-29 Laboratory Corporation of America Holdings Method for determining the presence or amount of testosterone in a sample
BR112013031284A2 (pt) * 2011-06-06 2016-12-06 Waters Technologies Corp composições, métodos, e kits para quantificar analitos alvo em uma amostra
CN104040343A (zh) * 2012-01-05 2014-09-10 Dh科技发展私人贸易有限公司 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性
US9874575B2 (en) 2012-01-20 2018-01-23 Dh Technologies Development Pte. Ltd. Analysis of estradiol and analytes with phenolic OH using labeling chemistry and LC-MSMS workflow
CN104603617B (zh) * 2012-05-18 2017-04-12 Dh科技发展私人贸易有限公司 使用定点衍生化和lc/ms/ms工作流程分析一组脑腱黄瘤病生物
GB201215924D0 (en) * 2012-09-06 2012-10-24 Univ Swansea Kit and method for quantitative detection of steroids
JP2017527822A (ja) 2014-06-27 2017-09-21 パルス ヘルス エルエルシー 蛍光検出アセンブリ
WO2017087852A1 (en) * 2015-11-19 2017-05-26 The Arizona Board Of Regents On Behalf Of The University Of Arizona Stress biomarkers and related non-invasive detection methods
GB201521903D0 (en) * 2015-12-11 2016-01-27 Electrophoretics Ltd Isorbaric mass labels
CN107014846A (zh) * 2016-01-27 2017-08-04 沈阳药科大学 一种检测植物油过热处理的方法及其用途
CN107290459B (zh) * 2016-03-31 2019-12-06 中国科学院大连化学物理研究所 一种磷酸糖类物质的富集和固相衍生预处理方法
CN110383071B (zh) * 2017-01-31 2023-10-03 豪夫迈·罗氏有限公司 用于质谱的试剂
US20190041332A1 (en) 2017-08-01 2019-02-07 Pulse Health Llc Methods and Systems for Aldehyde Detection
CN108931603A (zh) * 2018-04-23 2018-12-04 国家烟草质量监督检验中心 一种基于稳定同位素标记质谱联用技术检测血浆中羧酸类代谢物的方法
WO2020020850A1 (en) * 2018-07-24 2020-01-30 F. Hoffmann-La Roche Ag Reagent for mass spectrometry
JP7547314B2 (ja) 2018-07-24 2024-09-09 エフ． ホフマン－ラ ロシュ アーゲー 質量分析のための試薬
EP3826994A1 (en) * 2018-07-24 2021-06-02 F. Hoffmann-La Roche AG Reagent for mass spectrometry
EP4405687A1 (en) * 2021-09-22 2024-07-31 DH Technologies Development Pte. Ltd. Ms/ms-based identification of trisulfide bonds
WO2024110385A1 (en) * 2022-11-21 2024-05-30 F. Hoffmann-La Roche Ag Derivatisation agent for laser desorption ionization mass spectrometry

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040662A2 (en) * 1995-06-07 1996-12-19 Cellpro, Incorporated Aminooxy-containing linker compounds and their application in conjugates
EP1588145B1 (en) 2003-01-30 2011-07-06 Life Technologies Corporation Methods, mixtures, kits and compositions pertaining to analyte determination
WO2004097372A2 (en) * 2003-04-28 2004-11-11 The Regents Of The University Of California Element-coded affinity tags
US7309608B2 (en) * 2003-09-30 2007-12-18 Hoa Duc Nguyen Method of analysis of aldehyde and ketone by mass spectrometry
US7369712B2 (en) 2003-09-30 2008-05-06 Fotonation Vision Limited Automated statistical self-calibrating detection and removal of blemishes in digital images based on multiple occurrences of dust in images
JP4832312B2 (ja) * 2004-01-05 2011-12-07 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド 標識試薬および標識化分析物の混合物を含む、標識試薬、標識化分析物、およびそれらに由来するフラグメントイオン、ならびにそれらの分析方法
US7307169B2 (en) 2004-01-05 2007-12-11 Applera Corporation Isotopically enriched N-substituted piperazines and methods for the preparation thereof
JP4566604B2 (ja) * 2004-03-31 2010-10-20 塩野義製薬株式会社 糖鎖標識試薬
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
GB0518585D0 (en) * 2005-09-12 2005-10-19 Electrophoretics Ltd Mass labels
EP1951890A4 (en) * 2005-11-16 2009-06-24 Ambrx Inc PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
EP2054540B1 (en) * 2006-05-26 2014-11-26 DH Technologies Development Pte. Ltd. Tagging reagents and methods for hydroxylated compounds

Also Published As

Publication number Publication date
US20140004616A1 (en) 2014-01-02
US20170115258A1 (en) 2017-04-27
CA2762277A1 (en) 2010-12-09
WO2010141075A1 (en) 2010-12-09
CA2762277C (en) 2018-08-14
JP2012529010A (ja) 2012-11-15
EP2438448B1 (en) 2020-05-20
US9500622B2 (en) 2016-11-22
WO2010141075A8 (en) 2011-10-27
US10094809B2 (en) 2018-10-09
EP2438448A4 (en) 2015-05-06
US20110003395A1 (en) 2011-01-06
EP2438448A1 (en) 2012-04-11

Similar Documents

Publication Publication Date Title
US10094809B2 (en) Specific analysis of ketone and aldehyde analytes using reagent compounds, labeling strategies, and mass spectrometry workflow
US8236565B2 (en) Tagging reagents and methods for hydroxylated compounds
JP5548447B2 (ja) 検体の決定に関する方法、混合物、キットおよび組成物
US20140349885A1 (en) Enhancement of sensitivity and specificity of ketosteroids and keto or aldehyde containing analytes
EP2807482B1 (en) Analysis of estradiol and analytes with phenolic oh using labeling chemistry and lc-msms workflow
EP2467350B1 (en) Mass labels
JP2009543069A5 (enExample)
JP7799628B2 (ja) 質量分析のための試薬
US10078091B2 (en) Analysis of a panel of cerebrotendinous xanthomatosis biomarkers using site specific derivation and LC/MS/MS workflow
JP2022092263A (ja) 化合物、誘導体化試薬、分析方法、並びに分離及び／又は定量方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130531

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130531

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20140318

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140502

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20140718

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20140728

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141028

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150302

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150331

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150511

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20151102

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151130

R150 Certificate of patent or registration of utility model

Ref document number: 5849045

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees