JP5849045B2 - 試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 - Google Patents

試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 Download PDF

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JP5849045B2
JP5849045B2 JP2012513061A JP2012513061A JP5849045B2 JP 5849045 B2 JP5849045 B2 JP 5849045B2 JP 2012513061 A JP2012513061 A JP 2012513061A JP 2012513061 A JP2012513061 A JP 2012513061A JP 5849045 B2 JP5849045 B2 JP 5849045B2
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ion
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mass
group
compounds
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JP2012529010A (ja
JP2012529010A5 (enExample
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サブハカール デイ，
サブハカール デイ，
サシ ピライ，
サシ ピライ，
ブライアン エル． ウィリアムソン，
ブライアン エル． ウィリアムソン，
サブハシシュ プルカヤスタ，
サブハシシュ プルカヤスタ，
ミカル ウェインストック，
ミカル ウェインストック，
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ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/64—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving ketones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N2030/042—Standards
    • G01N2030/045—Standards internal
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/200833—Carbonyl, ether, aldehyde or ketone containing

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
JP2012513061A 2009-05-31 2010-06-01 試薬化合物、標識ストラテジーおよび質量分析ワークフローを用いたケトンおよびアルデヒド分析物の特異的分析 Expired - Fee Related JP5849045B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18274809P 2009-05-31 2009-05-31
US61/182,748 2009-05-31
PCT/US2010/001598 WO2010141075A1 (en) 2009-05-31 2010-06-01 Specific analysis of ketone and aldehyde analytes using reagent compounds labeling strategies, and mass spectrometry workflow

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JP2012529010A JP2012529010A (ja) 2012-11-15
JP2012529010A5 JP2012529010A5 (enExample) 2013-07-18
JP5849045B2 true JP5849045B2 (ja) 2016-01-27

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US (3) US20110003395A1 (enExample)
EP (1) EP2438448B1 (enExample)
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CA (1) CA2762277C (enExample)
WO (1) WO2010141075A1 (enExample)

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CN103782166B (zh) * 2011-06-06 2018-01-16 沃特世科技公司 用于定量样品中目标分析物的组合物、方法和试剂盒
CN104040343A (zh) * 2012-01-05 2014-09-10 Dh科技发展私人贸易有限公司 增强含有酮类固醇和酮基或醛的分析物的灵敏度和特异性
CN104040332B (zh) 2012-01-20 2017-10-20 Dh科技发展私人贸易有限公司 使用标记化学和lc‑msms工作流分析具有酚系oh的雌二醇和分析物
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WO2017087852A1 (en) * 2015-11-19 2017-05-26 The Arizona Board Of Regents On Behalf Of The University Of Arizona Stress biomarkers and related non-invasive detection methods
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CN107014846A (zh) * 2016-01-27 2017-08-04 沈阳药科大学 一种检测植物油过热处理的方法及其用途
CN107290459B (zh) * 2016-03-31 2019-12-06 中国科学院大连化学物理研究所 一种磷酸糖类物质的富集和固相衍生预处理方法
JP7153652B2 (ja) * 2017-01-31 2022-10-14 エフ．ホフマン－ラ ロシュ アーゲー 質量分析用の試薬
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CN108931603A (zh) * 2018-04-23 2018-12-04 国家烟草质量监督检验中心 一种基于稳定同位素标记质谱联用技术检测血浆中羧酸类代谢物的方法
JP7547313B2 (ja) 2018-07-24 2024-09-09 エフ． ホフマン－ラ ロシュ アーゲー 質量分析のための試薬
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EP2438448B1 (en) 2020-05-20
US20140004616A1 (en) 2014-01-02
CA2762277A1 (en) 2010-12-09
JP2012529010A (ja) 2012-11-15
EP2438448A1 (en) 2012-04-11
US20170115258A1 (en) 2017-04-27
US10094809B2 (en) 2018-10-09
CA2762277C (en) 2018-08-14
EP2438448A4 (en) 2015-05-06
US9500622B2 (en) 2016-11-22
WO2010141075A8 (en) 2011-10-27
US20110003395A1 (en) 2011-01-06
WO2010141075A1 (en) 2010-12-09

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