JP5846608B2 - iPS細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法 - Google Patents
iPS細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法 Download PDFInfo
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- JP5846608B2 JP5846608B2 JP2012540193A JP2012540193A JP5846608B2 JP 5846608 B2 JP5846608 B2 JP 5846608B2 JP 2012540193 A JP2012540193 A JP 2012540193A JP 2012540193 A JP2012540193 A JP 2012540193A JP 5846608 B2 JP5846608 B2 JP 5846608B2
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/90—Polysaccharides
- C12N2501/91—Heparin
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- C12N2503/00—Use of cells in diagnostics
- C12N2503/02—Drug screening
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96486—Metalloendopeptidases (3.4.24)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30992710P | 2010-03-03 | 2010-03-03 | |
| US61/309,927 | 2010-03-03 | ||
| PCT/JP2011/055570 WO2011108766A1 (en) | 2010-03-03 | 2011-03-03 | METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM iPS CELLS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013520960A JP2013520960A (ja) | 2013-06-10 |
| JP2013520960A5 JP2013520960A5 (enExample) | 2014-06-26 |
| JP5846608B2 true JP5846608B2 (ja) | 2016-01-20 |
Family
ID=44542394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540193A Expired - Fee Related JP5846608B2 (ja) | 2010-03-03 | 2011-03-03 | iPS細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US9097727B2 (enExample) |
| JP (1) | JP5846608B2 (enExample) |
| WO (1) | WO2011108766A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8642334B2 (en) | 2009-02-17 | 2014-02-04 | Memorial Sloan Kettering Cancer Center | Methods of neural conversion of human embryonic stem cells |
| DK2577318T3 (da) | 2010-05-25 | 2019-10-07 | Memorial Sloan Kettering Cancer Center | Fremgangsmåde til nociceptor-differentiering af humane embryoniske stamceller og anvendelser deraf |
| CN110684734A (zh) | 2011-11-04 | 2020-01-14 | 纪念斯隆-凯特琳癌症中心 | 用于植入的中脑多巴胺(da)神经元 |
| JP6335117B2 (ja) * | 2012-03-21 | 2018-05-30 | 国立大学法人京都大学 | アルツハイマー病の治療薬および/または予防薬のスクリーニング方法 |
| EP3498824A1 (en) | 2013-04-26 | 2019-06-19 | Memorial Sloan-Kettering Cancer Center | Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells |
| JP6698626B2 (ja) | 2014-08-04 | 2020-05-27 | ユニバーシティ・オブ・カンザス | 哺乳動物多能性幹細胞、それらの調製のための方法、およびその使用 |
| WO2016208755A1 (ja) | 2015-06-25 | 2016-12-29 | 株式会社カネカ | 液体注入方法 |
| WO2020007878A1 (en) * | 2018-07-03 | 2020-01-09 | Universidad Del País Vasco - Euskal Herriko Unibertsitatea | Cellular aggregates for use in vascularisation therapy |
| WO2020165615A1 (en) | 2019-02-14 | 2020-08-20 | Omnion Research International D.O.O. | Method of transformation of hair folicle cells into neurons, method and scale for estimating risk for onset of a particular brain disease |
| JP7333579B2 (ja) * | 2019-05-08 | 2023-08-25 | 国立大学法人東京工業大学 | アルツハイマー疾患モデル神経細胞及びその製造方法、並びにその神経細胞を用いたアルツハイマー病作用薬物のスクリーニング方法 |
| WO2020241772A1 (ja) * | 2019-05-31 | 2020-12-03 | 国立大学法人京都大学 | 情報処理装置、スクリーニング装置、情報処理方法、スクリーニング方法、及びプログラム |
| SG11202113100TA (en) * | 2019-05-31 | 2021-12-30 | Univ Kyoto | Information processing device, screening device, information processing method, screening method, and program |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003091449A1 (fr) | 2002-04-26 | 2003-11-06 | Riken | Methode de mesure de l'activite de la neprilysine |
| ZA200401646B (en) * | 2003-03-12 | 2004-06-07 | Reliance Life Sciences Pvt Ltd | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells. |
| KR100763477B1 (ko) | 2003-03-12 | 2007-10-04 | 리라이언스 라이프 사이언시스 프라이빗. 리미티드 | 사람 배아 줄기세포로부터 최종적으로 분화된 도파민작용성 뉴런의 유도 |
| US8669048B2 (en) | 2008-06-24 | 2014-03-11 | Parkinson's Institute | Pluripotent cell lines and methods of use thereof |
-
2011
- 2011-03-03 WO PCT/JP2011/055570 patent/WO2011108766A1/en not_active Ceased
- 2011-03-03 JP JP2012540193A patent/JP5846608B2/ja not_active Expired - Fee Related
- 2011-03-03 US US13/582,403 patent/US9097727B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9097727B2 (en) | 2015-08-04 |
| JP2013520960A (ja) | 2013-06-10 |
| US20130034858A1 (en) | 2013-02-07 |
| WO2011108766A1 (en) | 2011-09-09 |
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