JP2013520960A5 - - Google Patents

Download PDF

Info

Publication number
JP2013520960A5
JP2013520960A5 JP2012540193A JP2012540193A JP2013520960A5 JP 2013520960 A5 JP2013520960 A5 JP 2013520960A5 JP 2012540193 A JP2012540193 A JP 2012540193A JP 2012540193 A JP2012540193 A JP 2012540193A JP 2013520960 A5 JP2013520960 A5 JP 2013520960A5
Authority
JP
Japan
Prior art keywords
protein
amount
cell
human subject
degradation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012540193A
Other languages
English (en)
Japanese (ja)
Other versions
JP5846608B2 (ja
JP2013520960A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/JP2011/055570 external-priority patent/WO2011108766A1/en
Publication of JP2013520960A publication Critical patent/JP2013520960A/ja
Publication of JP2013520960A5 publication Critical patent/JP2013520960A5/ja
Application granted granted Critical
Publication of JP5846608B2 publication Critical patent/JP5846608B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012540193A 2010-03-03 2011-03-03 iPS細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法 Expired - Fee Related JP5846608B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30992710P 2010-03-03 2010-03-03
US61/309,927 2010-03-03
PCT/JP2011/055570 WO2011108766A1 (en) 2010-03-03 2011-03-03 METHOD FOR DIAGNOSING A PROTEIN MISFOLDING DISEASE USING NERVE CELLS DERIVED FROM iPS CELLS

Publications (3)

Publication Number Publication Date
JP2013520960A JP2013520960A (ja) 2013-06-10
JP2013520960A5 true JP2013520960A5 (enExample) 2014-06-26
JP5846608B2 JP5846608B2 (ja) 2016-01-20

Family

ID=44542394

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012540193A Expired - Fee Related JP5846608B2 (ja) 2010-03-03 2011-03-03 iPS細胞由来の神経細胞を用いた蛋白質ミスフォールディング病の診断方法

Country Status (3)

Country Link
US (1) US9097727B2 (enExample)
JP (1) JP5846608B2 (enExample)
WO (1) WO2011108766A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8642334B2 (en) 2009-02-17 2014-02-04 Memorial Sloan Kettering Cancer Center Methods of neural conversion of human embryonic stem cells
DK2577318T3 (da) 2010-05-25 2019-10-07 Memorial Sloan Kettering Cancer Center Fremgangsmåde til nociceptor-differentiering af humane embryoniske stamceller og anvendelser deraf
CN110684734A (zh) 2011-11-04 2020-01-14 纪念斯隆-凯特琳癌症中心 用于植入的中脑多巴胺(da)神经元
JP6335117B2 (ja) * 2012-03-21 2018-05-30 国立大学法人京都大学 アルツハイマー病の治療薬および/または予防薬のスクリーニング方法
EP3498824A1 (en) 2013-04-26 2019-06-19 Memorial Sloan-Kettering Cancer Center Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
JP6698626B2 (ja) 2014-08-04 2020-05-27 ユニバーシティ・オブ・カンザス 哺乳動物多能性幹細胞、それらの調製のための方法、およびその使用
WO2016208755A1 (ja) 2015-06-25 2016-12-29 株式会社カネカ 液体注入方法
WO2020007878A1 (en) * 2018-07-03 2020-01-09 Universidad Del País Vasco - Euskal Herriko Unibertsitatea Cellular aggregates for use in vascularisation therapy
WO2020165615A1 (en) 2019-02-14 2020-08-20 Omnion Research International D.O.O. Method of transformation of hair folicle cells into neurons, method and scale for estimating risk for onset of a particular brain disease
JP7333579B2 (ja) * 2019-05-08 2023-08-25 国立大学法人東京工業大学 アルツハイマー疾患モデル神経細胞及びその製造方法、並びにその神経細胞を用いたアルツハイマー病作用薬物のスクリーニング方法
WO2020241772A1 (ja) * 2019-05-31 2020-12-03 国立大学法人京都大学 情報処理装置、スクリーニング装置、情報処理方法、スクリーニング方法、及びプログラム
SG11202113100TA (en) * 2019-05-31 2021-12-30 Univ Kyoto Information processing device, screening device, information processing method, screening method, and program

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003091449A1 (fr) 2002-04-26 2003-11-06 Riken Methode de mesure de l'activite de la neprilysine
ZA200401646B (en) * 2003-03-12 2004-06-07 Reliance Life Sciences Pvt Ltd Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells.
KR100763477B1 (ko) 2003-03-12 2007-10-04 리라이언스 라이프 사이언시스 프라이빗. 리미티드 사람 배아 줄기세포로부터 최종적으로 분화된 도파민작용성 뉴런의 유도
US8669048B2 (en) 2008-06-24 2014-03-11 Parkinson's Institute Pluripotent cell lines and methods of use thereof

Similar Documents

Publication Publication Date Title
JP2013520960A5 (enExample)
Frontzkowski et al. Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
Buccellato et al. The role of glymphatic system in Alzheimer’s and Parkinson’s disease pathogenesis
Ayton et al. Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study
Gaiteri et al. Genetic variants in Alzheimer disease—molecular and brain network approaches
Moya-Alvarado et al. Neurodegeneration and Alzheimer's disease (AD). What can proteomics tell us about the Alzheimer's brain?
Marras et al. Parkinson's disease subtypes: lost in translation?
Bennett et al. Relation of neuropathology to cognition in persons without cognitive impairment
Naudí et al. Lipidomics of human brain aging and Alzheimer's disease pathology
Niemelä et al. Tau or neurofilament light—Which is the more suitable biomarker for Huntington’s disease?
CN103961113A (zh) 用于基于用户的行为测量压力的设备和方法
Hartl et al. Presymptomatic alterations in energy metabolism and oxidative stress in the APP23 mouse model of Alzheimer disease
Hoos et al. Longitudinal study of differential protein expression in an Alzheimer’s mouse model lacking inducible nitric oxide synthase
JP2015511721A5 (enExample)
Riedel et al. Uncovering biologically coherent peripheral signatures of health and risk for Alzheimer’s disease in the aging brain
Parente et al. Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus
Mohamet et al. Familial Alzheimer’s disease modelling using induced pluripotent stem cell technology
TW201606304A (zh) 測定治療反應之方法
Castillo-Mariqueo et al. Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging
Jarek et al. Evaluating p-tau217 and p-tau231 as biomarkers for early diagnosis and differentiation of Alzheimer’s disease: a narrative review
Falkenhain et al. A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease
Zimova et al. Human truncated tau induces mature neurofibrillary pathology in a mouse model of human tauopathy
Faisal et al. Preclinical trials in Alzheimer’s disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice
Priori et al. JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model
Cao et al. Age-correlated gene expression in normal and neurodegenerative human brain tissues