JP5841064B2 - 血液流量低下の検出 - Google Patents
血液流量低下の検出 Download PDFInfo
- Publication number
- JP5841064B2 JP5841064B2 JP2012547081A JP2012547081A JP5841064B2 JP 5841064 B2 JP5841064 B2 JP 5841064B2 JP 2012547081 A JP2012547081 A JP 2012547081A JP 2012547081 A JP2012547081 A JP 2012547081A JP 5841064 B2 JP5841064 B2 JP 5841064B2
- Authority
- JP
- Japan
- Prior art keywords
- blood
- impedance value
- controller
- blood flow
- dialysis system
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000017531 blood circulation Effects 0.000 title claims description 89
- 238000001514 detection method Methods 0.000 title claims description 10
- 230000003247 decreasing effect Effects 0.000 title description 9
- 239000008280 blood Substances 0.000 claims description 109
- 210000004369 blood Anatomy 0.000 claims description 109
- 239000012530 fluid Substances 0.000 claims description 72
- 238000000502 dialysis Methods 0.000 claims description 64
- 238000000034 method Methods 0.000 claims description 41
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 37
- 239000011780 sodium chloride Substances 0.000 claims description 36
- 238000004891 communication Methods 0.000 claims description 17
- 230000002829 reductive effect Effects 0.000 claims description 10
- 238000005259 measurement Methods 0.000 claims description 9
- 230000002572 peristaltic effect Effects 0.000 claims description 7
- 230000004044 response Effects 0.000 claims description 6
- 230000003213 activating effect Effects 0.000 claims description 4
- 239000002504 physiological saline solution Substances 0.000 claims description 2
- 230000002745 absorbent Effects 0.000 description 19
- 239000002250 absorbent Substances 0.000 description 19
- 239000000385 dialysis solution Substances 0.000 description 16
- 230000006870 function Effects 0.000 description 14
- 230000009977 dual effect Effects 0.000 description 12
- 239000000243 solution Substances 0.000 description 9
- 208000007536 Thrombosis Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- 239000011575 calcium Substances 0.000 description 5
- 229910052791 calcium Inorganic materials 0.000 description 5
- 238000001631 haemodialysis Methods 0.000 description 5
- 230000000322 hemodialysis Effects 0.000 description 5
- 229960002897 heparin Drugs 0.000 description 5
- 229920000669 heparin Polymers 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000011591 potassium Substances 0.000 description 5
- 229910052700 potassium Inorganic materials 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
- 239000003978 infusion fluid Substances 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 239000003146 anticoagulant agent Substances 0.000 description 3
- 229940127219 anticoagulant drug Drugs 0.000 description 3
- 230000003292 diminished effect Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 108700012359 toxins Proteins 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 230000004872 arterial blood pressure Effects 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 206010018873 Haemoconcentration Diseases 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000008321 arterial blood flow Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000007485 conventional hemodialysis Methods 0.000 description 1
- 238000013500 data storage Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
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- 230000002441 reversible effect Effects 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 230000008320 venous blood flow Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3656—Monitoring patency or flow at connection sites; Detecting disconnections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3659—Cannulae pertaining to extracorporeal circulation
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/650,745 US8529491B2 (en) | 2009-12-31 | 2009-12-31 | Detecting blood flow degradation |
| US12/650,745 | 2009-12-31 | ||
| PCT/US2010/057581 WO2011081740A1 (en) | 2009-12-31 | 2010-11-22 | Detecting blood flow degradation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013516225A JP2013516225A (ja) | 2013-05-13 |
| JP2013516225A5 JP2013516225A5 (enExample) | 2014-01-16 |
| JP5841064B2 true JP5841064B2 (ja) | 2016-01-06 |
Family
ID=43618316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547081A Expired - Fee Related JP5841064B2 (ja) | 2009-12-31 | 2010-11-22 | 血液流量低下の検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8529491B2 (enExample) |
| EP (2) | EP2519275B1 (enExample) |
| JP (1) | JP5841064B2 (enExample) |
| AU (1) | AU2010337269B2 (enExample) |
| CA (1) | CA2785806C (enExample) |
| WO (1) | WO2011081740A1 (enExample) |
Families Citing this family (42)
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| US8152751B2 (en) | 2007-02-09 | 2012-04-10 | Baxter International Inc. | Acoustic access disconnection systems and methods |
| DE102008035742B3 (de) * | 2008-07-04 | 2010-01-14 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung zur Peritonealdialyse |
| US8753515B2 (en) | 2009-12-05 | 2014-06-17 | Home Dialysis Plus, Ltd. | Dialysis system with ultrafiltration control |
| US8501009B2 (en) | 2010-06-07 | 2013-08-06 | State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Fluid purification system |
| US8784668B2 (en) * | 2010-10-12 | 2014-07-22 | Fresenius Medical Care Holdings, Inc. | Systems and methods for compensation of compliant behavior in regenerative dialysis systems |
| US10695481B2 (en) | 2011-08-02 | 2020-06-30 | Medtronic, Inc. | Hemodialysis system having a flow path with a controlled compliant volume |
| US10857277B2 (en) | 2011-08-16 | 2020-12-08 | Medtronic, Inc. | Modular hemodialysis system |
| US9328969B2 (en) | 2011-10-07 | 2016-05-03 | Outset Medical, Inc. | Heat exchange fluid purification for dialysis system |
| US8992777B2 (en) | 2011-11-18 | 2015-03-31 | Fresenius Medical Care Holdings, Inc. | Systems and methods for providing notifications in dialysis systems |
| US9165112B2 (en) | 2012-02-03 | 2015-10-20 | Fresenius Medical Care Holdings, Inc. | Systems and methods for displaying objects at a medical treatment apparatus display screen |
| ES2534477T5 (es) | 2012-05-09 | 2018-07-20 | D_Med Consulting Ag | Procedimiento para la cebadura de un dispositivo de hemodiálisis |
| AU2013201556B2 (en) | 2012-07-13 | 2014-06-05 | Gambro Lundia Ab | Filtering of pressure signals for suppression of periodic pulses |
| US10905816B2 (en) | 2012-12-10 | 2021-02-02 | Medtronic, Inc. | Sodium management system for hemodialysis |
| US10543052B2 (en) | 2013-02-01 | 2020-01-28 | Medtronic, Inc. | Portable dialysis cabinet |
| US10850016B2 (en) | 2013-02-01 | 2020-12-01 | Medtronic, Inc. | Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection |
| US9623164B2 (en) * | 2013-02-01 | 2017-04-18 | Medtronic, Inc. | Systems and methods for multifunctional volumetric fluid control |
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| DE102013213390A1 (de) * | 2013-07-09 | 2015-01-15 | Rwth Aachen | Verfahren und Vorrichtung zur Detektion eines Ansaugens einer Entnahmekanüle |
| US20150314055A1 (en) | 2014-04-29 | 2015-11-05 | Michael Edward HOGARD | Dialysis system and methods |
| US10172989B2 (en) | 2014-09-12 | 2019-01-08 | Easydial Inc. | Portable hemodialysis machine and disposable cartridge with blood leak sensor |
| US10980929B2 (en) | 2014-09-12 | 2021-04-20 | Diality Inc. | Hemodialysis system with ultrafiltration controller |
| CN104383619B (zh) * | 2014-12-03 | 2016-08-24 | 佟博弘 | 透析液流量智能调节装置与方法、透析机 |
| US9713665B2 (en) | 2014-12-10 | 2017-07-25 | Medtronic, Inc. | Degassing system for dialysis |
| US10874787B2 (en) | 2014-12-10 | 2020-12-29 | Medtronic, Inc. | Degassing system for dialysis |
| US9895479B2 (en) | 2014-12-10 | 2018-02-20 | Medtronic, Inc. | Water management system for use in dialysis |
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| JP2016174752A (ja) * | 2015-03-20 | 2016-10-06 | ソニー株式会社 | 血液状態監視装置、血液状態を監視する方法、血液状態監視システム、及び血液状態改善用プログラム |
| US10413654B2 (en) * | 2015-12-22 | 2019-09-17 | Baxter International Inc. | Access disconnection system and method using signal metrics |
| JP2019521750A (ja) | 2016-06-13 | 2019-08-08 | ヘンリー フォード ヘルス システム | 血液透析時の血管内容量減少を検知するための方法 |
| JP7025408B2 (ja) | 2016-08-19 | 2022-02-24 | アウトセット・メディカル・インコーポレイテッド | 腹膜透析システム及び方法 |
| US10272187B2 (en) | 2017-02-22 | 2019-04-30 | Fresenius Medical Care Holdings, Inc. | System and methods for dialyzer flow rates estimation using measured dialyzer pressures |
| US11278654B2 (en) | 2017-12-07 | 2022-03-22 | Medtronic, Inc. | Pneumatic manifold for a dialysis system |
| US11033667B2 (en) | 2018-02-02 | 2021-06-15 | Medtronic, Inc. | Sorbent manifold for a dialysis system |
| US11110215B2 (en) | 2018-02-23 | 2021-09-07 | Medtronic, Inc. | Degasser and vent manifolds for dialysis |
| CA3109237A1 (en) | 2018-08-23 | 2020-02-27 | Outset Medical, Inc. | Systems and methods for priming dialysis tubing sets |
| AU2020266584B2 (en) | 2019-04-30 | 2025-10-23 | Outset Medical, Inc. | Dialysis system and methods |
| US12128165B2 (en) | 2020-04-27 | 2024-10-29 | Mozarc Medical Us Llc | Dual stage degasser |
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| US12318528B2 (en) | 2020-10-30 | 2025-06-03 | Mozarc Medical Us Llc | Variable orifice fistula graft |
| EP4329643A4 (en) | 2021-04-27 | 2025-03-12 | Contego Medical, Inc. | Thrombus aspiration system and methods for controlling blood loss |
| DE102022133981A1 (de) | 2022-12-12 | 2024-06-13 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung, System und Verfahren zur Erkennung von Blutgerinnseln |
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| US8512553B2 (en) * | 2007-07-05 | 2013-08-20 | Baxter International Inc. | Extracorporeal dialysis ready peritoneal dialysis machine |
| ES2446543T3 (es) * | 2008-05-26 | 2014-03-10 | Gambro Lundia Ab | Aparato de hemodiálisis o hemo(dia)filtración |
| DE102008035742B3 (de) * | 2008-07-04 | 2010-01-14 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung zur Peritonealdialyse |
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| AU2010337269B2 (en) | 2014-08-28 |
| EP2529771A3 (en) | 2013-02-20 |
| US8529491B2 (en) | 2013-09-10 |
| JP2013516225A (ja) | 2013-05-13 |
| EP2519275A1 (en) | 2012-11-07 |
| AU2010337269A1 (en) | 2012-07-05 |
| WO2011081740A1 (en) | 2011-07-07 |
| EP2529771B1 (en) | 2020-01-01 |
| EP2519275B1 (en) | 2020-03-04 |
| EP2529771A2 (en) | 2012-12-05 |
| US20110160637A1 (en) | 2011-06-30 |
| CA2785806A1 (en) | 2011-07-07 |
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