JP5791512B2 - 組織因子経路阻害因子（ｔｆｐｉ）に対する抗体 - Google Patents
組織因子経路阻害因子（ｔｆｐｉ）に対する抗体 Download PDFInfo
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08172522.8 | 2008-12-22 | ||
| EP08172522 | 2008-12-22 | ||
| PCT/EP2009/067566 WO2010072687A1 (en) | 2008-12-22 | 2009-12-18 | Antibodies against tissue factor pathway inhibitor (tfpi) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012513193A JP2012513193A (ja) | 2012-06-14 |
| JP2012513193A5 JP2012513193A5 (enExample) | 2012-12-13 |
| JP5791512B2 true JP5791512B2 (ja) | 2015-10-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541487A Expired - Fee Related JP5791512B2 (ja) | 2008-12-22 | 2009-12-18 | 組織因子経路阻害因子（ｔｆｐｉ）に対する抗体 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8618263B2 (enExample) |
| EP (1) | EP2379599B1 (enExample) |
| JP (1) | JP5791512B2 (enExample) |
| CN (1) | CN102300876A (enExample) |
| TW (1) | TW201026329A (enExample) |
| WO (1) | WO2010072687A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2379600E (pt) * | 2008-12-22 | 2014-04-29 | Novo Nordisk As | Anticorpos contra inibidor da via de fator tecidual |
| DK3345615T3 (da) | 2010-03-01 | 2020-01-20 | Bayer Healthcare Llc | Optimerede monoklonale antistoffer mod inhibitor af vævsfaktoraktiveringsvejen (tfpi) |
| EP2588499B1 (en) * | 2010-06-30 | 2020-04-08 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
| US9228022B2 (en) | 2010-06-30 | 2016-01-05 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
| ES2926773T3 (es) | 2013-03-15 | 2022-10-28 | Novo Nordisk As | Anticuerpos capaces de unirse específicamente a dos epítopos en el inhibidor de la ruta del factor tisular |
| US10231993B2 (en) | 2013-06-27 | 2019-03-19 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
| JP6584397B2 (ja) * | 2013-07-19 | 2019-10-02 | ノヴォ ノルディスク アー／エス | 凝血促進活性を誘発することができる組織因子経路インヒビターのｎ末端部分を認識する抗体 |
| WO2016042093A1 (en) * | 2014-09-17 | 2016-03-24 | Novo Nordisk A/S | Antibodies capable of binding two epitopes on tissue factor pathway inhibitor (1-161) |
| EA036490B1 (ru) * | 2015-02-25 | 2020-11-17 | Могам Инститьют Фор Байомедикал Рисерч | Антитела, связывающиеся с tfpi, и содержащая их композиция |
| SG10201912817YA (en) | 2015-08-19 | 2020-02-27 | Pfizer | Tissue factor pathway inhibitor antibodies and uses thereof |
| US20210395391A1 (en) | 2018-10-11 | 2021-12-23 | Pfizer Inc. | Dosage Regimen for TFPI Antagonists |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
| WO2025124481A1 (zh) * | 2023-12-13 | 2025-06-19 | 苏州康宁杰瑞生物科技有限公司 | Tfpi抗体用于治疗血友病 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0539975A1 (en) * | 1991-10-31 | 1993-05-05 | Teijin Limited | Method for immunological assay of free lipoprotein-associated coagulation inhibitor (LACI) and kit therefor |
| JPH0875736A (ja) | 1994-09-06 | 1996-03-22 | Chemo Sero Therapeut Res Inst | ヒト組織因子凝固系インヒビターの定量法 |
-
2009
- 2009-12-18 JP JP2011541487A patent/JP5791512B2/ja not_active Expired - Fee Related
- 2009-12-18 WO PCT/EP2009/067566 patent/WO2010072687A1/en not_active Ceased
- 2009-12-18 CN CN2009801555207A patent/CN102300876A/zh not_active Withdrawn
- 2009-12-18 EP EP09793538.1A patent/EP2379599B1/en not_active Not-in-force
- 2009-12-18 US US13/140,840 patent/US8618263B2/en not_active Expired - Fee Related
- 2009-12-22 TW TW098144131A patent/TW201026329A/zh unknown
-
2013
- 2013-08-28 US US14/012,204 patent/US20130344090A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20130344090A1 (en) | 2013-12-26 |
| WO2010072687A1 (en) | 2010-07-01 |
| US8618263B2 (en) | 2013-12-31 |
| JP2012513193A (ja) | 2012-06-14 |
| CN102300876A (zh) | 2011-12-28 |
| TW201026329A (en) | 2010-07-16 |
| EP2379599A1 (en) | 2011-10-26 |
| US20110268745A1 (en) | 2011-11-03 |
| EP2379599B1 (en) | 2015-09-02 |
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