JP5778663B2 - ヒトの眼圧を低下させるための医薬組成物 - Google Patents

ヒトの眼圧を低下させるための医薬組成物 Download PDF

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Publication number
JP5778663B2
JP5778663B2 JP2012508764A JP2012508764A JP5778663B2 JP 5778663 B2 JP5778663 B2 JP 5778663B2 JP 2012508764 A JP2012508764 A JP 2012508764A JP 2012508764 A JP2012508764 A JP 2012508764A JP 5778663 B2 JP5778663 B2 JP 5778663B2
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pharmaceutical composition
compound
iop
composition according
eye
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Japanese (ja)
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JP2012525437A5 (https=
JP2012525437A (ja
Inventor
バーマン、シーカ
エイ． バウムガートナー、ルドルフ
エイ． バウムガートナー、ルドルフ
Original Assignee
イノテック ファーマシューティカルズ コーポレイション
イノテック ファーマシューティカルズ コーポレイション
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
JP2012508764A 2009-05-01 2010-04-30 ヒトの眼圧を低下させるための医薬組成物 Expired - Fee Related JP5778663B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17465509P 2009-05-01 2009-05-01
US61/174,655 2009-05-01
US21999009P 2009-06-24 2009-06-24
US61/219,990 2009-06-24
PCT/US2010/033112 WO2010127210A1 (en) 2009-05-01 2010-04-30 Method of reducing intraocular pressure in humans

Publications (3)

Publication Number Publication Date
JP2012525437A JP2012525437A (ja) 2012-10-22
JP2012525437A5 JP2012525437A5 (https=) 2013-06-20
JP5778663B2 true JP5778663B2 (ja) 2015-09-16

Family

ID=43030847

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012508764A Expired - Fee Related JP5778663B2 (ja) 2009-05-01 2010-04-30 ヒトの眼圧を低下させるための医薬組成物

Country Status (25)

Country Link
US (2) US8470800B2 (https=)
EP (1) EP2424546B1 (https=)
JP (1) JP5778663B2 (https=)
KR (1) KR101757940B1 (https=)
CN (1) CN102413832B (https=)
AU (1) AU2010242943B2 (https=)
BR (1) BRPI1009971A2 (https=)
CA (1) CA2762064A1 (https=)
CL (1) CL2011002675A1 (https=)
DK (1) DK2424546T3 (https=)
EA (1) EA024042B1 (https=)
ES (1) ES2554684T3 (https=)
HR (1) HRP20151200T1 (https=)
HU (1) HUE028068T2 (https=)
IL (1) IL216081A (https=)
MX (1) MX2011011229A (https=)
MY (1) MY159244A (https=)
NZ (1) NZ596428A (https=)
PL (1) PL2424546T3 (https=)
PT (1) PT2424546E (https=)
RS (1) RS54378B1 (https=)
SG (1) SG175346A1 (https=)
SI (1) SI2424546T1 (https=)
SM (1) SMT201500295B (https=)
WO (1) WO2010127210A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
CA2774704A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
SG182285A1 (en) * 2010-01-11 2012-08-30 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
PT2555775T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular
ES2613255T3 (es) * 2010-03-19 2017-05-23 Inotek Pharmaceuticals Corporation Composiciones combinadas de agonistas de adenosina A1 y bloqueadores de receptores ß-adrenérgicos no selectivos para reducir la presión intraocular
EA201290958A1 (ru) 2010-03-26 2013-04-30 Инотек Фармасьютикалз Корпорейшн Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
BR112014018413A8 (pt) * 2012-01-26 2017-07-11 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo
CA2903114A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
JP2018501219A (ja) * 2014-12-03 2018-01-18 イノテック ファーマシューティカルズ コーポレイション 黄斑変性の予防、軽減または治療方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117910A2 (en) * 2004-05-26 2005-12-15 Inotek Pharmaceuticals Corporation Purine derivatives as adenosine a1 receptor agonists and methods of use thereof
CN101010085B (zh) 2004-05-26 2012-12-26 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
EA015683B1 (ru) * 2005-11-30 2011-10-31 Инотек Фармасьютикалз Корпорейшн Производные пурина и способы их применения
CA2774704A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
SG182285A1 (en) * 2010-01-11 2012-08-30 Inotek Pharmaceuticals Corp Combination, kit and method of reducing intraocular pressure
PT2555775T (pt) * 2010-03-19 2017-02-01 Inotek Pharmaceuticals Corp Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular
ES2613255T3 (es) * 2010-03-19 2017-05-23 Inotek Pharmaceuticals Corporation Composiciones combinadas de agonistas de adenosina A1 y bloqueadores de receptores ß-adrenérgicos no selectivos para reducir la presión intraocular

Also Published As

Publication number Publication date
EA201171339A1 (ru) 2012-05-30
SG175346A1 (en) 2011-11-28
AU2010242943A1 (en) 2011-12-01
DK2424546T3 (en) 2015-12-14
US20100279970A1 (en) 2010-11-04
US8470800B2 (en) 2013-06-25
RS54378B1 (sr) 2016-04-28
EP2424546A1 (en) 2012-03-07
WO2010127210A1 (en) 2010-11-04
EA024042B1 (ru) 2016-08-31
EP2424546B1 (en) 2015-10-28
IL216081A (en) 2015-11-30
HRP20151200T1 (hr) 2016-01-15
IL216081A0 (en) 2012-01-31
SMT201500295B (it) 2016-01-08
HUE028068T2 (en) 2016-11-28
CN102413832A (zh) 2012-04-11
MY159244A (en) 2016-12-30
HK1167599A1 (en) 2012-12-07
PT2424546E (pt) 2015-12-23
CN102413832B (zh) 2015-11-25
SI2424546T1 (sl) 2016-02-29
ES2554684T3 (es) 2015-12-22
BRPI1009971A2 (pt) 2016-03-15
EP2424546A4 (en) 2013-01-23
CA2762064A1 (en) 2010-11-04
MX2011011229A (es) 2011-11-18
PL2424546T3 (pl) 2016-04-29
KR20120017026A (ko) 2012-02-27
NZ596428A (en) 2014-03-28
JP2012525437A (ja) 2012-10-22
KR101757940B1 (ko) 2017-07-13
AU2010242943B2 (en) 2016-09-29
CL2011002675A1 (es) 2012-06-01
US20130217643A1 (en) 2013-08-22

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