NZ596428A - Method of reducing intraocular pressure in humans - Google Patents
Method of reducing intraocular pressure in humansInfo
- Publication number
- NZ596428A NZ596428A NZ596428A NZ59642810A NZ596428A NZ 596428 A NZ596428 A NZ 596428A NZ 596428 A NZ596428 A NZ 596428A NZ 59642810 A NZ59642810 A NZ 59642810A NZ 596428 A NZ596428 A NZ 596428A
- Authority
- NZ
- New Zealand
- Prior art keywords
- intraocular pressure
- humans
- reducing intraocular
- purin
- dihydroxytetrahydrofuran
- Prior art date
Links
- 230000004410 intraocular pressure Effects 0.000 title abstract 2
- LRMHVVPPGGOAJQ-UHFFFAOYSA-N methyl nitrate Chemical compound CO[N+]([O-])=O LRMHVVPPGGOAJQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- SYHNGKRBPFJKCW-DNBRLMRSSA-M sodium;[(2r,3s,4r,5r)-5-[6-(cyclopentylamino)purin-9-yl]-3,4-dihydroxyoxolan-2-yl]methyl sulfate Chemical compound [Na+].O[C@@H]1[C@H](O)[C@@H](COS([O-])(=O)=O)O[C@H]1N1C2=NC=NC(NC3CCCC3)=C2N=C1 SYHNGKRBPFJKCW-DNBRLMRSSA-M 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17465509P | 2009-05-01 | 2009-05-01 | |
| US21999009P | 2009-06-24 | 2009-06-24 | |
| PCT/US2010/033112 WO2010127210A1 (en) | 2009-05-01 | 2010-04-30 | Method of reducing intraocular pressure in humans |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ596428A true NZ596428A (en) | 2014-03-28 |
Family
ID=43030847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ596428A NZ596428A (en) | 2009-05-01 | 2010-04-30 | Method of reducing intraocular pressure in humans |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8470800B2 (https=) |
| EP (1) | EP2424546B1 (https=) |
| JP (1) | JP5778663B2 (https=) |
| KR (1) | KR101757940B1 (https=) |
| CN (1) | CN102413832B (https=) |
| AU (1) | AU2010242943B2 (https=) |
| BR (1) | BRPI1009971A2 (https=) |
| CA (1) | CA2762064A1 (https=) |
| CL (1) | CL2011002675A1 (https=) |
| DK (1) | DK2424546T3 (https=) |
| EA (1) | EA024042B1 (https=) |
| ES (1) | ES2554684T3 (https=) |
| HR (1) | HRP20151200T1 (https=) |
| HU (1) | HUE028068T2 (https=) |
| IL (1) | IL216081A (https=) |
| MX (1) | MX2011011229A (https=) |
| MY (1) | MY159244A (https=) |
| NZ (1) | NZ596428A (https=) |
| PL (1) | PL2424546T3 (https=) |
| PT (1) | PT2424546E (https=) |
| RS (1) | RS54378B1 (https=) |
| SG (1) | SG175346A1 (https=) |
| SI (1) | SI2424546T1 (https=) |
| SM (1) | SMT201500295B (https=) |
| WO (1) | WO2010127210A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| CA2774704A1 (en) * | 2009-10-26 | 2011-05-05 | Inotek Pharmaceuticals Corporation | Ophthalmic formulation and method of manufacture thereof |
| SG182285A1 (en) * | 2010-01-11 | 2012-08-30 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
| PT2555775T (pt) * | 2010-03-19 | 2017-02-01 | Inotek Pharmaceuticals Corp | Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular |
| ES2613255T3 (es) * | 2010-03-19 | 2017-05-23 | Inotek Pharmaceuticals Corporation | Composiciones combinadas de agonistas de adenosina A1 y bloqueadores de receptores ß-adrenérgicos no selectivos para reducir la presión intraocular |
| EA201290958A1 (ru) | 2010-03-26 | 2013-04-30 | Инотек Фармасьютикалз Корпорейшн | Способ снижения внутриглазного давления у людей с применением n6-циклопентиладенозина (cpa), производных cpa или их пролекарств |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| US20120058983A1 (en) | 2010-09-02 | 2012-03-08 | Bayer Pharma Aktiengesellschaft | Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension |
| BR112014018413A8 (pt) * | 2012-01-26 | 2017-07-11 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo |
| CA2903114A1 (en) | 2013-03-15 | 2014-09-25 | Inotek Pharmaceuticals Corporation | Ophthalmic formulations |
| JP2018501219A (ja) * | 2014-12-03 | 2018-01-18 | イノテック ファーマシューティカルズ コーポレイション | 黄斑変性の予防、軽減または治療方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117910A2 (en) * | 2004-05-26 | 2005-12-15 | Inotek Pharmaceuticals Corporation | Purine derivatives as adenosine a1 receptor agonists and methods of use thereof |
| CN101010085B (zh) | 2004-05-26 | 2012-12-26 | 伊诺泰克制药公司 | 嘌呤衍生物作为腺苷a1受体激动剂及其用法 |
| EA015683B1 (ru) * | 2005-11-30 | 2011-10-31 | Инотек Фармасьютикалз Корпорейшн | Производные пурина и способы их применения |
| CA2774704A1 (en) * | 2009-10-26 | 2011-05-05 | Inotek Pharmaceuticals Corporation | Ophthalmic formulation and method of manufacture thereof |
| SG182285A1 (en) * | 2010-01-11 | 2012-08-30 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
| PT2555775T (pt) * | 2010-03-19 | 2017-02-01 | Inotek Pharmaceuticals Corp | Composições de combinação de agonistas de adenosina a1 e inibidores de anidrase carbónica para redução da pressão intra-ocular |
| ES2613255T3 (es) * | 2010-03-19 | 2017-05-23 | Inotek Pharmaceuticals Corporation | Composiciones combinadas de agonistas de adenosina A1 y bloqueadores de receptores ß-adrenérgicos no selectivos para reducir la presión intraocular |
-
2010
- 2010-04-30 BR BRPI1009971A patent/BRPI1009971A2/pt not_active IP Right Cessation
- 2010-04-30 PT PT107704025T patent/PT2424546E/pt unknown
- 2010-04-30 EA EA201171339A patent/EA024042B1/ru not_active IP Right Cessation
- 2010-04-30 JP JP2012508764A patent/JP5778663B2/ja not_active Expired - Fee Related
- 2010-04-30 HR HRP20151200TT patent/HRP20151200T1/hr unknown
- 2010-04-30 HU HUE10770402A patent/HUE028068T2/en unknown
- 2010-04-30 CN CN201080018539.XA patent/CN102413832B/zh not_active Expired - Fee Related
- 2010-04-30 SI SI201031070T patent/SI2424546T1/sl unknown
- 2010-04-30 DK DK10770402.5T patent/DK2424546T3/en active
- 2010-04-30 MX MX2011011229A patent/MX2011011229A/es unknown
- 2010-04-30 AU AU2010242943A patent/AU2010242943B2/en not_active Ceased
- 2010-04-30 CA CA2762064A patent/CA2762064A1/en not_active Abandoned
- 2010-04-30 RS RS20150782A patent/RS54378B1/sr unknown
- 2010-04-30 MY MYPI2011004858A patent/MY159244A/en unknown
- 2010-04-30 EP EP10770402.5A patent/EP2424546B1/en active Active
- 2010-04-30 US US12/771,289 patent/US8470800B2/en not_active Expired - Fee Related
- 2010-04-30 KR KR1020117025057A patent/KR101757940B1/ko not_active Expired - Fee Related
- 2010-04-30 NZ NZ596428A patent/NZ596428A/en not_active IP Right Cessation
- 2010-04-30 SG SG2011078151A patent/SG175346A1/en unknown
- 2010-04-30 PL PL10770402T patent/PL2424546T3/pl unknown
- 2010-04-30 WO PCT/US2010/033112 patent/WO2010127210A1/en not_active Ceased
- 2010-04-30 ES ES10770402.5T patent/ES2554684T3/es active Active
-
2011
- 2011-10-27 CL CL2011002675A patent/CL2011002675A1/es unknown
- 2011-11-01 IL IL216081A patent/IL216081A/en not_active IP Right Cessation
-
2013
- 2013-04-03 US US13/855,919 patent/US20130217643A1/en not_active Abandoned
-
2015
- 2015-11-30 SM SM201500295T patent/SMT201500295B/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ERR | Error or correction |
Free format text: THE AGENT HAS BEEN CORRECTED TO 1357371, IN-LEGAL LIMITED, 2 BUCHANAN STREET, WADESTOWN, WELLINGTON 6012, NZ; THE CONTACT HAS BEEN CORRECTED TO 1357371, IN-LEGAL LIMITED, 2 BUCHANAN STREET, WADESTOWN, WELLINGTON 6012, NZ Effective date: 20140226 |
|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 30 APR 2017 BY COMPUTER PACKAGES INC Effective date: 20140828 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 30 APR 2018 BY COMPUTER PACKAGES INC Effective date: 20170331 |
|
| LAPS | Patent lapsed |