CN102413832B - 降低人眼内压的方法 - Google Patents

降低人眼内压的方法 Download PDF

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Publication number
CN102413832B
CN102413832B CN201080018539.XA CN201080018539A CN102413832B CN 102413832 B CN102413832 B CN 102413832B CN 201080018539 A CN201080018539 A CN 201080018539A CN 102413832 B CN102413832 B CN 102413832B
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China
Prior art keywords
iop
compound
affected eye
reduced
hours
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Expired - Fee Related
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CN201080018539.XA
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English (en)
Chinese (zh)
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CN102413832A (zh
Inventor
施哈·巴曼
鲁道夫·A·鲍姆加特内尔
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Rocket Pharmaceuticals Inc
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Inotek Pharmaceuticals Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Prostheses (AREA)
CN201080018539.XA 2009-05-01 2010-04-30 降低人眼内压的方法 Expired - Fee Related CN102413832B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17465509P 2009-05-01 2009-05-01
US61/174,655 2009-05-01
US21999009P 2009-06-24 2009-06-24
US61/219,990 2009-06-24
PCT/US2010/033112 WO2010127210A1 (en) 2009-05-01 2010-04-30 Method of reducing intraocular pressure in humans

Publications (2)

Publication Number Publication Date
CN102413832A CN102413832A (zh) 2012-04-11
CN102413832B true CN102413832B (zh) 2015-11-25

Family

ID=43030847

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080018539.XA Expired - Fee Related CN102413832B (zh) 2009-05-01 2010-04-30 降低人眼内压的方法

Country Status (25)

Country Link
US (2) US8470800B2 (https=)
EP (1) EP2424546B1 (https=)
JP (1) JP5778663B2 (https=)
KR (1) KR101757940B1 (https=)
CN (1) CN102413832B (https=)
AU (1) AU2010242943B2 (https=)
BR (1) BRPI1009971A2 (https=)
CA (1) CA2762064A1 (https=)
CL (1) CL2011002675A1 (https=)
DK (1) DK2424546T3 (https=)
EA (1) EA024042B1 (https=)
ES (1) ES2554684T3 (https=)
HR (1) HRP20151200T1 (https=)
HU (1) HUE028068T2 (https=)
IL (1) IL216081A (https=)
MX (1) MX2011011229A (https=)
MY (1) MY159244A (https=)
NZ (1) NZ596428A (https=)
PL (1) PL2424546T3 (https=)
PT (1) PT2424546E (https=)
RS (1) RS54378B1 (https=)
SG (1) SG175346A1 (https=)
SI (1) SI2424546T1 (https=)
SM (1) SMT201500295B (https=)
WO (1) WO2010127210A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008062567A1 (de) 2008-12-16 2010-06-17 Bayer Schering Pharma Aktiengesellschaft Dipeptoid-Prodrugs und ihre Verwendung
DE102009006602A1 (de) * 2009-01-29 2010-08-05 Bayer Schering Pharma Aktiengesellschaft Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs
WO2011053569A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
LT2523669T (lt) * 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
US8455457B2 (en) * 2010-03-19 2013-06-04 Inotek Pharmaceuticals Corporation Combination compositions for reducing intraocular pressure
JP2013522322A (ja) * 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物
PH12012501906A1 (en) * 2010-03-26 2013-01-14 Inotek Pharmaceuticals Corp Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
DE102010030688A1 (de) 2010-06-30 2012-01-05 Bayer Schering Pharma Aktiengesellschaft Substituierte Dicyanopyridine und ihre Verwendung
US20120058983A1 (en) * 2010-09-02 2012-03-08 Bayer Pharma Aktiengesellschaft Adenosine A1 agonists for the treatment of glaucoma and ocular hypertension
PT2807178T (pt) 2012-01-26 2017-08-08 Inotek Pharmaceuticals Corp Polimorfos anidros de nitrato de (2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-dihidroxitetrahidrofuran-2-il)}metilo e seus processos de preparação
NZ630759A (en) 2013-03-15 2017-07-28 Inotek Pharmaceuticals Corp Ophthalmic formulations comprising an a1 agonist
WO2016090005A1 (en) * 2014-12-03 2016-06-09 Inotek Pharmaceuticals Corporation Methods of preventing, reducing or treating macular degeneration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085A (zh) * 2004-05-26 2007-08-01 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
CN101321460A (zh) * 2005-11-30 2008-12-10 伊诺泰克制药公司 嘌呤衍生物及其用法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103087133B (zh) * 2004-05-26 2016-09-14 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
WO2011053569A1 (en) * 2009-10-26 2011-05-05 Inotek Pharmaceuticals Corporation Ophthalmic formulation and method of manufacture thereof
LT2523669T (lt) * 2010-01-11 2017-04-25 Inotek Pharmaceuticals Corporation Akispūdžio mažinimo būdas, derinys ir rinkinys
US8455457B2 (en) * 2010-03-19 2013-06-04 Inotek Pharmaceuticals Corporation Combination compositions for reducing intraocular pressure
JP2013522322A (ja) * 2010-03-19 2013-06-13 イノテック ファーマシューティカルズ コーポレイション 眼内圧を下げるためのアデノシンａ１受容体アゴニストと炭酸脱水酵素阻害剤との組合せ組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101010085A (zh) * 2004-05-26 2007-08-01 伊诺泰克制药公司 嘌呤衍生物作为腺苷a1受体激动剂及其用法
CN101321460A (zh) * 2005-11-30 2008-12-10 伊诺泰克制药公司 嘌呤衍生物及其用法

Also Published As

Publication number Publication date
HUE028068T2 (en) 2016-11-28
JP5778663B2 (ja) 2015-09-16
WO2010127210A1 (en) 2010-11-04
MX2011011229A (es) 2011-11-18
SG175346A1 (en) 2011-11-28
EP2424546B1 (en) 2015-10-28
KR101757940B1 (ko) 2017-07-13
HRP20151200T1 (hr) 2016-01-15
NZ596428A (en) 2014-03-28
KR20120017026A (ko) 2012-02-27
SI2424546T1 (sl) 2016-02-29
US20100279970A1 (en) 2010-11-04
US20130217643A1 (en) 2013-08-22
CL2011002675A1 (es) 2012-06-01
EP2424546A4 (en) 2013-01-23
PT2424546E (pt) 2015-12-23
ES2554684T3 (es) 2015-12-22
PL2424546T3 (pl) 2016-04-29
EA201171339A1 (ru) 2012-05-30
CN102413832A (zh) 2012-04-11
AU2010242943A1 (en) 2011-12-01
IL216081A (en) 2015-11-30
HK1167599A1 (en) 2012-12-07
CA2762064A1 (en) 2010-11-04
JP2012525437A (ja) 2012-10-22
EA024042B1 (ru) 2016-08-31
IL216081A0 (en) 2012-01-31
DK2424546T3 (en) 2015-12-14
US8470800B2 (en) 2013-06-25
MY159244A (en) 2016-12-30
BRPI1009971A2 (pt) 2016-03-15
RS54378B1 (sr) 2016-04-28
SMT201500295B (it) 2016-01-08
EP2424546A1 (en) 2012-03-07
AU2010242943B2 (en) 2016-09-29

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C06 Publication
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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20120411

Assignee: Eno Tech Co. Ltd.

Assignor: Inotek Pharmaceuticals Corporation

Contract record no.: 2017990000148

Denomination of invention: Method of reducing intraocular pressure in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof

Granted publication date: 20151125

License type: Common License

Record date: 20170425

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Termination date: 20180430

CF01 Termination of patent right due to non-payment of annual fee