JP5777115B2 - 多能性幹細胞から中胚葉細胞への分化誘導法 - Google Patents

多能性幹細胞から中胚葉細胞への分化誘導法 Download PDF

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JP5777115B2
JP5777115B2 JP2012542287A JP2012542287A JP5777115B2 JP 5777115 B2 JP5777115 B2 JP 5777115B2 JP 2012542287 A JP2012542287 A JP 2012542287A JP 2012542287 A JP2012542287 A JP 2012542287A JP 5777115 B2 JP5777115 B2 JP 5777115B2
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cells
cell
mesoderm
hematopoietic
stem cells
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JP2013521762A (ja
JP2013521762A5 (enExample
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明 丹羽
明 丹羽
中畑　龍俊
龍俊 中畑
俊男 平家
俊男 平家
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Kyoto University NUC
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012542287A 2010-03-18 2011-03-18 多能性幹細胞から中胚葉細胞への分化誘導法 Expired - Fee Related JP5777115B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31517010P 2010-03-18 2010-03-18
US61/315,170 2010-03-18
PCT/JP2011/057503 WO2011115308A1 (en) 2010-03-18 2011-03-18 Method for inducing differentiation of pluripotent stem cells into mesodermal cells

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JP2013521762A JP2013521762A (ja) 2013-06-13
JP2013521762A5 JP2013521762A5 (enExample) 2014-06-19
JP5777115B2 true JP5777115B2 (ja) 2015-09-09

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US (1) US8652845B2 (enExample)
EP (1) EP2547764B1 (enExample)
JP (1) JP5777115B2 (enExample)
WO (1) WO2011115308A1 (enExample)

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US9074186B2 (en) * 2012-08-15 2015-07-07 Boston Medical Center Corporation Production of red blood cells and platelets from stem cells
CA2896053A1 (en) * 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Methods for production of platelets from pluripotent stem cells and compositions thereof
JP6493881B2 (ja) 2013-06-12 2019-04-03 国立大学法人京都大学 人工多能性幹細胞の選別方法および血球への分化誘導方法
FR3024462A1 (fr) * 2014-07-29 2016-02-05 Univ Pierre Et Marie Curie Paris 6 Procede de production in vitro de progeniteurs adipocytaires et d'adipocytes
CA2968655C (en) 2014-11-25 2021-11-16 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
JP6800859B2 (ja) * 2015-01-26 2020-12-16 フェイト セラピューティクス，インコーポレイテッド 造血細胞分化を誘導するための方法および組成物
WO2017014165A1 (ja) 2015-07-17 2017-01-26 国立大学法人京都大学 血管内皮細胞の誘導方法
JP6646311B2 (ja) * 2015-07-17 2020-02-14 国立大学法人京都大学 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法
CN115927199A (zh) * 2015-11-04 2023-04-07 菲特治疗公司 用于诱导造血细胞分化的方法和组合物
EP4249074A3 (en) 2015-11-04 2024-01-10 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
WO2017164257A1 (ja) * 2016-03-23 2017-09-28 国立大学法人京都大学 血球分化能の高い中胚葉誘導方法
EP3597734A4 (en) 2017-03-14 2021-03-03 Kyoto University METHOD FOR PRODUCING HELPER T-CELLS FROM PLURIPOTENT STEM CELLS
SG11202106642YA (en) 2018-12-20 2021-07-29 Sumitomo Chemical Co Embryonic erythroblast-containing cell population and method for producing same, cell culture composition, and compound test method
GB201911957D0 (en) * 2019-08-20 2019-10-02 Adaptimmune Ltd Methods of producing haemogenic progenitor cells from pluripotent stem cells
WO2021107117A1 (ja) * 2019-11-28 2021-06-03 国立大学法人京都大学 多能性幹細胞からの造血細胞の製造法
JP7072756B2 (ja) * 2019-12-27 2022-05-23 国立大学法人京都大学 多能性幹細胞から中胚葉前駆細胞および血液血管前駆細胞への分化誘導法
CA3171960A1 (en) * 2020-02-28 2021-09-02 Purdue Research Foundation Generating aorta-gonad-mesonephros-like hematopoietic cells from human pluripotent stem cells under a defined condition
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
CN112574944A (zh) * 2020-12-14 2021-03-30 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 基于体外诱导eps发育形成类囊胚结构的方法
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
CN113249303B (zh) * 2021-05-07 2022-07-29 华中农业大学 血管内皮细胞生长因子在促进鸡原始生殖细胞增殖和迁移中的应用
CN114457006B (zh) * 2022-02-21 2023-07-28 广州华越肾科再生医学科技有限公司 一种通过不连续分化制备肾脏足细胞的方法
CN115247152B (zh) * 2022-09-21 2022-12-27 呈诺再生医学科技(北京)有限公司 制备造血干细胞或造血干祖细胞的方法及培养长期再生造血干细胞的方法
CN120826462A (zh) * 2023-03-02 2025-10-21 R.P.谢勒技术有限责任公司 多能干细胞分化为间充质基质细胞的方法

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US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
AU2002360424A1 (en) * 2001-11-26 2003-06-10 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
US7452718B2 (en) * 2004-03-26 2008-11-18 Geron Corporation Direct differentiation method for making cardiomyocytes from human embryonic stem cells
AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
US20110151554A1 (en) * 2006-11-09 2011-06-23 Akira Yuo Method for culturing and subculturing primate embryonic stem cell, as well as method for inducing differentiation thereof
EP2479260B1 (en) * 2008-03-17 2016-01-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
KR102242305B1 (ko) 2008-03-27 2021-04-19 아스테리아스 바이오세라퓨틱스, 인크. 영장류 다능성 줄기 세포의 조혈계 세포로의 분화
JPWO2010008100A1 (ja) * 2008-07-17 2012-01-05 国立大学法人名古屋大学 骨格筋細胞又は骨細胞の誘導法

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US20130011924A1 (en) 2013-01-10
EP2547764B1 (en) 2019-01-23
JP2013521762A (ja) 2013-06-13
US8652845B2 (en) 2014-02-18
EP2547764A1 (en) 2013-01-23
WO2011115308A1 (en) 2011-09-22
EP2547764A4 (en) 2014-01-22

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