JP5758399B2 - 化合物、その一定の新形態、その医薬組成物ならびに製剤化および使用の方法 - Google Patents

化合物、その一定の新形態、その医薬組成物ならびに製剤化および使用の方法 Download PDF

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JP5758399B2
JP5758399B2 JP2012539175A JP2012539175A JP5758399B2 JP 5758399 B2 JP5758399 B2 JP 5758399B2 JP 2012539175 A JP2012539175 A JP 2012539175A JP 2012539175 A JP2012539175 A JP 2012539175A JP 5758399 B2 JP5758399 B2 JP 5758399B2
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ethyl
oxy
dimethylamino
methyl
phenyl
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JP2013511475A (ja
JP2013511475A5 (en:Method
Inventor
スー、ウェイ−グォ
チャン、ウェイハン
チア、ホン
ツイ、ユミン
レン、ヨンシン
サイ、ヤン
ウー、チェンピン
リー、ウェンチー
シャオ、チアンヨン
ティエン、チェンピン
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ハッチソン メディファーマ リミテッド
ハッチソン メディファーマ リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
JP2012539175A 2009-11-23 2010-11-23 化合物、その一定の新形態、その医薬組成物ならびに製剤化および使用の方法 Active JP5758399B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2009101992592A CN102070618B (zh) 2009-11-23 2009-11-23 一种化合物及其晶体
CN200910199259.2 2009-11-23
PCT/CN2010/078997 WO2011060746A1 (en) 2009-11-23 2010-11-23 Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

Publications (3)

Publication Number Publication Date
JP2013511475A JP2013511475A (ja) 2013-04-04
JP2013511475A5 JP2013511475A5 (en:Method) 2014-01-16
JP5758399B2 true JP5758399B2 (ja) 2015-08-05

Family

ID=44029398

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012539175A Active JP5758399B2 (ja) 2009-11-23 2010-11-23 化合物、その一定の新形態、その医薬組成物ならびに製剤化および使用の方法

Country Status (19)

Country Link
US (2) US8658658B2 (en:Method)
EP (1) EP2504331B1 (en:Method)
JP (1) JP5758399B2 (en:Method)
KR (1) KR101513784B1 (en:Method)
CN (2) CN102070618B (en:Method)
AU (1) AU2010321366B2 (en:Method)
BR (1) BR112012012138B1 (en:Method)
CA (1) CA2781066C (en:Method)
DK (1) DK2504331T3 (en:Method)
ES (1) ES2529105T3 (en:Method)
IN (1) IN2012DN04868A (en:Method)
MX (1) MX2012005926A (en:Method)
MY (1) MY161749A (en:Method)
NZ (1) NZ600266A (en:Method)
PH (1) PH12012500992A1 (en:Method)
PL (1) PL2504331T3 (en:Method)
PT (1) PT2504331E (en:Method)
RU (1) RU2507203C1 (en:Method)
WO (1) WO2011060746A1 (en:Method)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102070618B (zh) * 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 一种化合物及其晶体
EP3517524B1 (en) * 2014-06-19 2021-05-26 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
CN105985326B (zh) * 2015-02-16 2020-04-14 上海宣创生物科技有限公司 嘧啶衍生物晶型ⅲ及其制备方法和用途
WO2016187767A1 (en) * 2015-05-25 2016-12-01 Hutchison Medipharma Limited Pharmaceutical compositions and use thereof
EP3541808A4 (en) * 2016-11-18 2020-07-22 Hutchison Medipharma Limited SOLID TUMOR TREATMENT PROCESS
JP2020164434A (ja) * 2019-03-28 2020-10-08 上野製薬株式会社 ２，６−ナフタレンビス（２−オキサゾリン）の製造方法
CN115052605B (zh) * 2020-03-09 2024-07-05 和记黄埔医药（上海）有限公司 抗pd-1抗体和多受体酪氨酸激酶抑制剂的药物组合及其使用方法
KR102780533B1 (ko) * 2021-04-12 2025-03-18 주식회사 미토이뮨테라퓨틱스 5-[(1,1-디옥시도-4-티오몰포리닐)메틸]-2-페닐-n-(테트라하이드로-2h-피란-4-일)-1h-인돌-7-아민의 신규 결정형

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090036448A1 (en) * 2004-03-30 2009-02-05 Taisho Pharmecutical Co., Ltd. Pyrimidine derivatives and methods of treatment related to the use thereof
US20090149467A1 (en) 2005-09-15 2009-06-11 Merck & Co., Inc. Tyrosine Kinase Inhibitors
CN101289444B (zh) * 2007-04-16 2012-01-04 和记黄埔医药（上海）有限公司 一种嘧啶衍生物及其医药用途
CA2684470C (en) * 2007-04-16 2016-02-09 Hutchison Medipharma Enterprises Limited Pyrimidine derivatives
TW201008933A (en) * 2008-08-29 2010-03-01 Hutchison Medipharma Entpr Ltd Pyrimidine compounds
CN102070618B (zh) * 2009-11-23 2013-08-21 和记黄埔医药（上海）有限公司 一种化合物及其晶体

Also Published As

Publication number Publication date
AU2010321366A8 (en) 2012-07-05
AU2010321366B2 (en) 2014-07-24
ES2529105T3 (es) 2015-02-16
RU2507203C1 (ru) 2014-02-20
US8658658B2 (en) 2014-02-25
PT2504331E (pt) 2015-02-20
MX2012005926A (es) 2012-11-23
RU2012126112A (ru) 2013-12-27
JP2013511475A (ja) 2013-04-04
IN2012DN04868A (en:Method) 2015-09-25
KR20120097526A (ko) 2012-09-04
CN102648194A (zh) 2012-08-22
PL2504331T3 (pl) 2015-04-30
WO2011060746A1 (en) 2011-05-26
CA2781066A1 (en) 2011-05-26
EP2504331A1 (en) 2012-10-03
AU2010321366A1 (en) 2012-06-14
CA2781066C (en) 2014-09-16
CN102070618B (zh) 2013-08-21
CN102070618A (zh) 2011-05-25
US20140200232A1 (en) 2014-07-17
CN102648194B (zh) 2014-10-29
US20120270889A1 (en) 2012-10-25
BR112012012138B1 (pt) 2023-02-07
US8946249B2 (en) 2015-02-03
EP2504331B1 (en) 2014-11-12
BR112012012138A2 (pt) 2017-03-07
NZ600266A (en) 2014-06-27
MY161749A (en) 2017-05-15
PH12012500992A1 (en) 2016-09-09
KR101513784B1 (ko) 2015-04-20
EP2504331A4 (en) 2013-04-17
DK2504331T3 (en) 2014-12-08

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