JP5732471B2 - 溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体 - Google Patents

溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体 Download PDF

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Publication number
JP5732471B2
JP5732471B2 JP2012545092A JP2012545092A JP5732471B2 JP 5732471 B2 JP5732471 B2 JP 5732471B2 JP 2012545092 A JP2012545092 A JP 2012545092A JP 2012545092 A JP2012545092 A JP 2012545092A JP 5732471 B2 JP5732471 B2 JP 5732471B2
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Prior art keywords
composition according
composition
solvent
polyoxypropylene
calcipotriol
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Expired - Fee Related
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JP2012545092A
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Japanese (ja)
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JP2013515020A (ja
JP2013515020A5 (enExample
Inventor
カーステン・ペーターソン
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Leo Pharma AS
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Leo Pharma AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012545092A 2009-12-22 2010-12-22 溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体 Expired - Fee Related JP5732471B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPCT/DK2009/000264 2009-12-22
DK2009000264 2009-12-22
US29310810P 2010-01-07 2010-01-07
US61/293,108 2010-01-07
PCT/DK2010/000184 WO2011076209A2 (en) 2009-12-22 2010-12-22 Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue

Publications (3)

Publication Number Publication Date
JP2013515020A JP2013515020A (ja) 2013-05-02
JP2013515020A5 JP2013515020A5 (enExample) 2013-12-19
JP5732471B2 true JP5732471B2 (ja) 2015-06-10

Family

ID=43618136

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012545092A Expired - Fee Related JP5732471B2 (ja) 2009-12-22 2010-12-22 溶媒混合物およびビタミンｄ誘導体から成る医薬品組成物または類似体

Country Status (14)

Country Link
US (1) US20130023501A1 (enExample)
EP (1) EP2515866B1 (enExample)
JP (1) JP5732471B2 (enExample)
CN (1) CN102770121B (enExample)
AU (1) AU2010335656B2 (enExample)
BR (1) BR112012015437A2 (enExample)
CA (1) CA2785254A1 (enExample)
ES (1) ES2452872T3 (enExample)
IL (1) IL220517A (enExample)
MX (1) MX2012007225A (enExample)
NZ (1) NZ601001A (enExample)
RU (1) RU2559084C2 (enExample)
WO (1) WO2011076209A2 (enExample)
ZA (1) ZA201204622B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022553635A (ja) * 2019-10-25 2022-12-26 カーディオル セラピューティクス インコーポレイテッド 心臓病態の治療に使用するためのカンナビジオール組成物

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114903848A (zh) * 2013-02-27 2022-08-16 阿根塔创新有限公司 透皮制剂
KR102486797B1 (ko) * 2016-03-09 2023-01-11 삼성전자 주식회사 전자 장치 및 전자 장치의 디스플레이 구동 방법
CN107643354B (zh) * 2016-07-22 2022-02-01 重庆华邦胜凯制药有限公司 卡泊三醇起始原料a及相关杂质的分离与测定方法
CN106265485A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种稳定性改善的卡泊三醇组合物
CN106265511A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种性能优异的卡泊三醇倍他米松自微乳制剂
CN108904445A (zh) * 2018-08-06 2018-11-30 江苏知原药业有限公司 钙泊三醇纳米悬浮液
BR112023001283A2 (pt) 2020-07-28 2023-02-14 Arcutis Biotherapeutics Inc Composição farmacêutica tópica; método para tratar uma doença, distúrbio ou afecção inflamatória de pele em um indivíduo que necessita do mesmo; e método para intensificar a penetração em pele em um indivíduo de uma formulação farmacêutica tópica
EP4447930A1 (en) 2021-12-15 2024-10-23 Arcutis Biotherapeutics, Inc. Stable formulations of shr0302

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4083974A (en) * 1977-03-07 1978-04-11 The Upjohn Company Topical steroidal anti-inflammatory preparations containing polyoxypropylene 15 stearyl ether
DE4011682A1 (de) * 1990-04-06 1991-10-10 Schering Ag 24-oxa-derivate in der vitamin d-reihe
US5194431A (en) * 1992-07-08 1993-03-16 Wisconsin Alumni Research Foundation 24-cyclopropane vitamin D derivatives
USRE39706E1 (en) 1993-01-15 2007-06-26 Leo Pharma A/S Crystalline form of a vitamin D analogue
GB9611603D0 (en) * 1996-06-04 1996-08-07 Leo Pharm Prod Ltd Chemical compounds
US8263580B2 (en) * 1998-09-11 2012-09-11 Stiefel Research Australia Pty Ltd Vitamin formulation
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
CN1173703C (zh) * 1999-04-23 2004-11-03 里奥药物制品有限公司 药物组合物
CN100391464C (zh) * 2001-12-03 2008-06-04 诺瓦西股份有限公司 含活性维生素d化合物的药物组合物
RU2396250C2 (ru) 2003-07-24 2010-08-10 Лео Фарма А/С Новые производные аминобензофенона
US8741333B2 (en) * 2004-06-07 2014-06-03 Nuvo Research Inc. Compositions and methods for treating dermatitis or psoriasis
FR2871694B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises
EP1828148B1 (en) 2004-12-13 2010-01-20 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
FR2887150B1 (fr) * 2005-06-17 2007-08-03 Galderma Res & Dev Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
FR2909284B1 (fr) * 2006-11-30 2012-09-21 Galderma Sa Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien
US8148537B2 (en) 2006-12-22 2012-04-03 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
PL2114951T3 (pl) 2007-02-28 2014-10-31 Leo Pharma As Nowe inhibitory fosfodiesterazy
US7909624B2 (en) 2007-03-26 2011-03-22 Belkin International, Inc. Carabiner universal serial bus hub
CN101677979A (zh) 2007-04-19 2010-03-24 利奥制药有限公司 Src家族激酶抑制剂
KR101691876B1 (ko) * 2007-04-25 2017-01-02 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
JP2010526824A (ja) 2007-05-11 2010-08-05 ソネボーン インコーポレイテッド シリコーン類似の特性を有するワセリン
PL2379548T3 (pl) 2008-12-19 2016-08-31 Leo Pharma As Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022553635A (ja) * 2019-10-25 2022-12-26 カーディオル セラピューティクス インコーポレイテッド 心臓病態の治療に使用するためのカンナビジオール組成物
JP7818752B2 (ja) 2019-10-25 2026-02-24 カーディオル セラピューティクス インコーポレイテッド 心臓病態の治療に使用するためのカンナビジオール組成物

Also Published As

Publication number Publication date
MX2012007225A (es) 2012-07-30
NZ601001A (en) 2014-07-25
RU2559084C2 (ru) 2015-08-10
WO2011076209A2 (en) 2011-06-30
BR112012015437A2 (pt) 2016-03-15
ZA201204622B (en) 2013-09-25
RU2012130411A (ru) 2014-01-27
CN102770121A (zh) 2012-11-07
AU2010335656B2 (en) 2015-05-07
JP2013515020A (ja) 2013-05-02
IL220517A (en) 2016-08-31
EP2515866B1 (en) 2014-02-19
ES2452872T3 (es) 2014-04-03
EP2515866A2 (en) 2012-10-31
IL220517A0 (en) 2012-08-30
WO2011076209A3 (en) 2012-02-23
CN102770121B (zh) 2014-10-15
US20130023501A1 (en) 2013-01-24
AU2010335656A1 (en) 2012-07-19
CA2785254A1 (en) 2011-06-30
HK1177696A1 (en) 2013-08-30

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