JP5717634B2 - 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 - Google Patents
流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 Download PDFInfo
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- JP5717634B2 JP5717634B2 JP2011525300A JP2011525300A JP5717634B2 JP 5717634 B2 JP5717634 B2 JP 5717634B2 JP 2011525300 A JP2011525300 A JP 2011525300A JP 2011525300 A JP2011525300 A JP 2011525300A JP 5717634 B2 JP5717634 B2 JP 5717634B2
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
- G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/932—Specified use of nanostructure for electronic or optoelectronic application
- Y10S977/953—Detector using nanostructure
- Y10S977/957—Of chemical property or presence
Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9388508P | 2008-09-03 | 2008-09-03 | |
| US61/093,885 | 2008-09-03 | ||
| PCT/US2009/055876 WO2010028140A2 (en) | 2008-09-03 | 2009-09-03 | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014218935A Division JP2015064364A (ja) | 2008-09-03 | 2014-10-28 | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012501627A JP2012501627A (ja) | 2012-01-26 |
| JP5717634B2 true JP5717634B2 (ja) | 2015-05-13 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011525300A Active JP5717634B2 (ja) | 2008-09-03 | 2009-09-03 | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
| JP2014218935A Pending JP2015064364A (ja) | 2008-09-03 | 2014-10-28 | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014218935A Pending JP2015064364A (ja) | 2008-09-03 | 2014-10-28 | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8882980B2 (enExample) |
| EP (1) | EP2342362B1 (enExample) |
| JP (2) | JP5717634B2 (enExample) |
| CN (1) | CN102186989B (enExample) |
| WO (1) | WO2010028140A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070190542A1 (en) * | 2005-10-03 | 2007-08-16 | Ling Xinsheng S | Hybridization assisted nanopore sequencing |
| EP2201136B1 (en) | 2007-10-01 | 2017-12-06 | Nabsys 2.0 LLC | Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment |
| US10670559B2 (en) * | 2008-07-11 | 2020-06-02 | Cornell University | Nanofluidic channels with integrated charge sensors and methods based thereon |
| JP5717634B2 (ja) | 2008-09-03 | 2015-05-13 | ナブシス， インコーポレイテッド | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
| US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
| US9410196B2 (en) | 2008-09-03 | 2016-08-09 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| US10759824B2 (en) | 2008-09-03 | 2020-09-01 | Quantumdx Group Limited | Design, synthesis and use of synthetic nucleotides comprising charge mass tags |
| US9650668B2 (en) * | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
| US8455260B2 (en) | 2009-03-27 | 2013-06-04 | Massachusetts Institute Of Technology | Tagged-fragment map assembly |
| WO2010111605A2 (en) * | 2009-03-27 | 2010-09-30 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
| US8864969B2 (en) | 2009-06-25 | 2014-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction |
| US8715933B2 (en) * | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
| WO2012067911A1 (en) | 2010-11-16 | 2012-05-24 | Nabsys, Inc. | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
| KR20120065792A (ko) * | 2010-12-13 | 2012-06-21 | 삼성전자주식회사 | 나노 센서 및 그의 제조 방법 |
| US20120146162A1 (en) * | 2010-12-13 | 2012-06-14 | Samsung Electronics Co., Ltd. | Nanosensor and method of manufacturing the same |
| CN102169105A (zh) * | 2010-12-22 | 2011-08-31 | 东南大学 | 一种基于石墨烯的纳米孔单分子传感器及其介质辨识方法 |
| KR20140040697A (ko) | 2011-01-14 | 2014-04-03 | 키진 엔.브이. | 쌍 말단 무작위 서열 기반 유전자형 판별 |
| US9217132B2 (en) | 2011-01-20 | 2015-12-22 | Ibis Biosciences, Inc. | Microfluidic transducer |
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| JP2012501627A (ja) | 2012-01-26 |
| CN102186989B (zh) | 2021-06-29 |
| CN102186989A (zh) | 2011-09-14 |
| WO2010028140A3 (en) | 2010-08-19 |
| EP2342362A2 (en) | 2011-07-13 |
| JP2015064364A (ja) | 2015-04-09 |
| US8882980B2 (en) | 2014-11-11 |
| US20100096268A1 (en) | 2010-04-22 |
| EP2342362B1 (en) | 2017-03-01 |
| WO2010028140A2 (en) | 2010-03-11 |
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