JP5715340B2 - Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体 - Google Patents

Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体 Download PDF

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JP5715340B2
JP5715340B2 JP2009554036A JP2009554036A JP5715340B2 JP 5715340 B2 JP5715340 B2 JP 5715340B2 JP 2009554036 A JP2009554036 A JP 2009554036A JP 2009554036 A JP2009554036 A JP 2009554036A JP 5715340 B2 JP5715340 B2 JP 5715340B2
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optionally substituted
pyrazolo
pyridine
dione
methyl
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JP2010521522A (ja
JP2010521522A5 (enExample
Inventor
パージュ，パトリック
オーチャード，マイク
フィオラゾ・カルティエ，ラエティシィア
モッティロニ，ビアンカ
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Calliditas Therapeutics Suisse SA
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Genkyotex Suisse SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
JP2009554036A 2007-03-22 2008-03-20 Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体 Active JP5715340B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
US60/896,284 2007-03-22
EP07109555.8 2007-06-04
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
PCT/EP2008/053390 WO2008113856A1 (en) 2007-03-22 2008-03-20 Pyrazolo pyridine derivatives as nadph oxidase inhibitors

Related Child Applications (1)

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JP2015050104A Division JP6047189B2 (ja) 2007-03-22 2015-03-13 Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体を含有する医薬組成物

Publications (3)

Publication Number Publication Date
JP2010521522A JP2010521522A (ja) 2010-06-24
JP2010521522A5 JP2010521522A5 (enExample) 2013-08-08
JP5715340B2 true JP5715340B2 (ja) 2015-05-07

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JP2009554036A Active JP5715340B2 (ja) 2007-03-22 2008-03-20 Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体
JP2015050104A Active JP6047189B2 (ja) 2007-03-22 2015-03-13 Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体を含有する医薬組成物

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Country Status (17)

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US (2) US8389518B2 (enExample)
EP (3) EP2002835A1 (enExample)
JP (2) JP5715340B2 (enExample)
CN (2) CN101686967B (enExample)
AU (1) AU2008228186C1 (enExample)
BR (1) BRPI0808824B8 (enExample)
CA (1) CA2676954C (enExample)
CY (2) CY1113556T1 (enExample)
DK (2) DK2545918T3 (enExample)
ES (2) ES2398994T3 (enExample)
HR (2) HRP20130143T1 (enExample)
IL (1) IL201009A (enExample)
PL (2) PL2545918T3 (enExample)
PT (2) PT2139477E (enExample)
RS (2) RS52640B (enExample)
SI (2) SI2139477T1 (enExample)
WO (1) WO2008113856A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015134805A (ja) * 2007-03-22 2015-07-27 ゲンキョ テックス エスアー Ｎａｄｐｈオキシダーゼインヒビターとしてのピラゾロピリジン誘導体を含有する医薬組成物

Families Citing this family (38)

* Cited by examiner, † Cited by third party
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EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166010A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
US20120141461A1 (en) * 2009-07-17 2012-06-07 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating fibrotic disorders
EP2305679A1 (en) * 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
EP2512242B8 (en) * 2009-12-18 2015-12-09 GlaxoSmithKline Intellectual Property Limited Novel compounds
EP2361911A1 (en) 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361912A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
WO2012173952A1 (en) 2011-06-13 2012-12-20 Emory University Piperazine derivatives, compositions, and uses related thereto
GB2494679A (en) * 2011-09-15 2013-03-20 Univ Jw Goethe Frankfurt Main Treatment of neuropathic pain and nerve injury by Nox4 inhibition
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
WO2014153227A1 (en) * 2013-03-14 2014-09-25 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting nox-1
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
TW201713650A (en) * 2015-06-22 2017-04-16 Actelion Pharmaceuticals Ltd NADPH oxidase 4 inhibitors
CA3027097C (en) * 2016-05-10 2023-11-28 Georgia State University Research Foundation, Inc. Bicyclic fused pyrazole derivatives for the treatment of rsv
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