CN101686967B - 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 - Google Patents

作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 Download PDF

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Publication number
CN101686967B
CN101686967B CN200880009282.4A CN200880009282A CN101686967B CN 101686967 B CN101686967 B CN 101686967B CN 200880009282 A CN200880009282 A CN 200880009282A CN 101686967 B CN101686967 B CN 101686967B
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Prior art keywords
pyridine
pyrazolo
optionally substituted
dione
ethyl
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CN101686967A (zh
Inventor
P·帕日
M·奥查德
L·菲奥拉索-卡迪埃尔
B·莫迪洛尼
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Kailiditas Treatment Switzerland GmbH
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Genkyotex SA
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pulmonology (AREA)
  • Diabetes (AREA)
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  • Cardiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
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CN200880009282.4A 2007-03-22 2008-03-20 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 Active CN101686967B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201510477495.1A CN105061422B (zh) 2007-03-22 2008-03-20 吡唑并吡啶衍生物及其用途

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US89628407P 2007-03-22 2007-03-22
US60/896,284 2007-03-22
EP07109555.8 2007-06-04
EP07109555A EP2002835A1 (en) 2007-06-04 2007-06-04 Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
PCT/EP2008/053390 WO2008113856A1 (en) 2007-03-22 2008-03-20 Pyrazolo pyridine derivatives as nadph oxidase inhibitors

Related Child Applications (1)

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CN201510477495.1A Division CN105061422B (zh) 2007-03-22 2008-03-20 吡唑并吡啶衍生物及其用途

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CN101686967A CN101686967A (zh) 2010-03-31
CN101686967B true CN101686967B (zh) 2015-08-19

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CN200880009282.4A Active CN101686967B (zh) 2007-03-22 2008-03-20 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物
CN201510477495.1A Active CN105061422B (zh) 2007-03-22 2008-03-20 吡唑并吡啶衍生物及其用途

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US (2) US8389518B2 (enExample)
EP (3) EP2002835A1 (enExample)
JP (2) JP5715340B2 (enExample)
CN (2) CN101686967B (enExample)
AU (1) AU2008228186C1 (enExample)
BR (1) BRPI0808824B8 (enExample)
CA (1) CA2676954C (enExample)
CY (2) CY1113556T1 (enExample)
DK (2) DK2139477T3 (enExample)
ES (2) ES2512491T3 (enExample)
HR (2) HRP20130143T1 (enExample)
IL (1) IL201009A (enExample)
PL (2) PL2545918T3 (enExample)
PT (2) PT2545918E (enExample)
RS (2) RS53641B1 (enExample)
SI (2) SI2139477T1 (enExample)
WO (1) WO2008113856A1 (enExample)

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EP2000176A1 (en) 2007-06-04 2008-12-10 GenKyo Tex Tetrahydroindole derivatives as NADPH Oxidase inhibitors
EP2166010A1 (en) 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2165707A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166008A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as NADPH oxidase inhibitors
EP2166009A1 (en) * 2008-09-23 2010-03-24 Genkyo Tex Sa Pyrazolo pyridine derivatives as nadph oxidase inhibitors
US20120141461A1 (en) * 2009-07-17 2012-06-07 The Regents Of The University Of Michigan Compositions and methods for diagnosing and treating fibrotic disorders
EP2305679A1 (en) * 2009-09-28 2011-04-06 GenKyoTex SA Pyrazoline dione derivatives as nadph oxidase inhibitors
EP2512242B8 (en) * 2009-12-18 2015-12-09 GlaxoSmithKline Intellectual Property Limited Novel compounds
EP2361912A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
EP2361911A1 (en) * 2010-02-18 2011-08-31 GenKyoTex SA Pyrazolo piperidine derivatives as NADPH oxidase inhibitors
US9428478B2 (en) 2011-06-13 2016-08-30 Emory University Piperazine derivatives, compositions, and uses related thereto
GB2494679A (en) * 2011-09-15 2013-03-20 Univ Jw Goethe Frankfurt Main Treatment of neuropathic pain and nerve injury by Nox4 inhibition
EP2591782A1 (en) * 2011-11-11 2013-05-15 Johann Wolfgang Goethe-Universität Nadph oxidase 4 inhibitors and use thereof
US9688960B2 (en) 2013-03-14 2017-06-27 Eastern Virginia Medical School Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting NOX-1
EP2857399A1 (en) 2013-10-03 2015-04-08 GenKyoTex SA Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction
EP3098220A1 (en) 2015-05-28 2016-11-30 GenKyoTex SA Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof
CN107743483B (zh) * 2015-06-22 2022-01-28 埃科特莱茵药品有限公司 Nadph氧化酶4抑制剂
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US20180072741A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyrimidine compounds and uses thereof
AR109596A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos pirazolopiridina y sus usos
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