JP5709530B2 - マイクロニードルデバイス - Google Patents
マイクロニードルデバイス Download PDFInfo
- Publication number
- JP5709530B2 JP5709530B2 JP2010548491A JP2010548491A JP5709530B2 JP 5709530 B2 JP5709530 B2 JP 5709530B2 JP 2010548491 A JP2010548491 A JP 2010548491A JP 2010548491 A JP2010548491 A JP 2010548491A JP 5709530 B2 JP5709530 B2 JP 5709530B2
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- Prior art keywords
- microneedle
- polymer
- coating
- active ingredient
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
(操作手法)
高分子活性成分のモデルとしてBSA(牛血清アルブミン)、OVA(ovalbumin)及びTI(トリプシンインヒビター)を採用し、各種ポリマーとBSA、OVA又はTIとの混合水溶液を下記の表1〜7の条件にしたがって調製した。そして、凝集物の発生の有無や遠心脱泡後(遠心条件は表に記載)の相分離発生の有無を確認することで、相溶性を評価した(均一な液性=○、不均一な液性=×)。表1〜7において、○印は相溶性を有することを示し、×印は相溶性を有しないことを示す。なお、以下の記載における%表記は、コーティング剤中に含まれる重量%である。図3に示す方法でコーティングを行った後に1mL精製水で抽出し、BSA、OVA又はTIの含量(付着量)をBCA法により測定すると同時に、その時のpHも測定した。表中における「不可」の記載は、ポリマーの針への付着が認められなかったことを示す。
Claims (3)
- 基板と、
前記基板に設けられた、皮膚を穿孔可能なマイクロニードルと、
を備え、
前記マイクロニードルの表面上および/または前記基板上の少なくとも一部には、高分子活性成分とカルボキシビニルポリマーとを含むコーティング剤がコーティングされており、前記コーティング剤はpH5.2〜5.4の条件下でコーティングされており、
前記コーティング剤におけるカルボキシビニルポリマーの含量が0.1〜30重量%であり、
前記コーティング剤におけるカルボキシビニルポリマーと前記高分子活性成分との含量の比が5:1〜1:100である、
マイクロニードルデバイス。 - 前記コーティング剤におけるカルボキシビニルポリマーの含量が0.5〜10重量%である、請求項1に記載のマイクロニードルデバイス。
- 前記コーティング剤におけるカルボキシビニルポリマーと前記高分子活性成分との含量の比が1:3〜1:80である、請求項1に記載のマイクロニードルデバイス。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010548491A JP5709530B2 (ja) | 2009-01-30 | 2010-01-25 | マイクロニードルデバイス |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009020672 | 2009-01-30 | ||
JP2009020672 | 2009-01-30 | ||
PCT/JP2010/050892 WO2010087300A1 (ja) | 2009-01-30 | 2010-01-25 | マイクロニードルデバイス |
JP2010548491A JP5709530B2 (ja) | 2009-01-30 | 2010-01-25 | マイクロニードルデバイス |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2010087300A1 JPWO2010087300A1 (ja) | 2012-08-02 |
JP5709530B2 true JP5709530B2 (ja) | 2015-04-30 |
Family
ID=42395561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010548491A Active JP5709530B2 (ja) | 2009-01-30 | 2010-01-25 | マイクロニードルデバイス |
Country Status (7)
Country | Link |
---|---|
US (1) | US20120004626A1 (ja) |
EP (1) | EP2392378B1 (ja) |
JP (1) | JP5709530B2 (ja) |
KR (1) | KR101634838B1 (ja) |
CN (1) | CN102300601A (ja) |
SG (1) | SG173160A1 (ja) |
WO (1) | WO2010087300A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101774803B1 (ko) * | 2016-12-02 | 2017-09-05 | (주)엔앤비랩 | 마이크로 니들을 이용한 롤러형 피부 미용기기 및 이를 위한 롤러의 제작방법 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5615814B2 (ja) | 2009-06-10 | 2014-10-29 | 久光製薬株式会社 | マイクロニードルデバイス |
JP5873238B2 (ja) * | 2010-09-22 | 2016-03-01 | テルモ株式会社 | 生体接着シートおよびシート接着用デバイス |
KR101484161B1 (ko) | 2012-06-27 | 2015-01-22 | 연세대학교 산학협력단 | 코팅을 통한 고분자 기반의 나노 또는 마이크로 니들 및 그 제조방법 |
CA2882275A1 (en) * | 2012-08-30 | 2014-03-06 | Teijin Limited | Microneedle array coated with drug composition |
WO2015073919A1 (en) * | 2013-11-14 | 2015-05-21 | University Medical Pharmaceuticals Corporation | Microneedles for therapeutic agent delivery with improved mechanical properties |
US9943674B2 (en) * | 2014-02-14 | 2018-04-17 | Juvic Inc. | Microstructure-based drug delivery system comprising microporous structure |
US9719239B2 (en) | 2014-03-18 | 2017-08-01 | Kohler India Corporation Private Limited | Dual-jet toilet |
EP3119946A1 (en) | 2014-03-21 | 2017-01-25 | Kohler Co. | Toilet comprising a jet hole |
KR101676861B1 (ko) | 2015-04-10 | 2016-11-17 | 씨앤텍 주식회사 | 마이크로 니들 패치 제조장치와 방법, 및 이에 의해 제조되는 마이크로 니들 패치 |
KR102139336B1 (ko) * | 2015-04-20 | 2020-07-29 | 주식회사 엘지생활건강 | 유효 성분의 흡수속도가 개선된 용해성 마이크로니들 디바이스 및 이를 포함하는 키트 |
EP3294344A1 (en) * | 2015-05-11 | 2018-03-21 | ETH Zurich | Compositions for circulatory system visualization |
KR101785930B1 (ko) * | 2015-12-30 | 2017-10-16 | 주식회사 쿼드메디슨 | 수분 환경에서 변형 및 변성 억제를 위한 마이크로 니들 및 그 제작 방법 |
US20200230846A1 (en) * | 2016-04-12 | 2020-07-23 | Juvic Inc. | Rotating assembly and apparatus for manufacturing microstructure comprising same |
WO2018056584A1 (ko) | 2016-09-21 | 2018-03-29 | 삼성전자 주식회사 | 피부 상태 측정 방법 및 이를 위한 전자 장치 |
US11426571B2 (en) * | 2016-11-18 | 2022-08-30 | Industry-Academic Cooperation Foundation, Yonsei University | Microneedle array with composite formulation, and method for manufacturing same |
AU2018285954A1 (en) | 2017-06-13 | 2019-12-19 | Vaxxas Pty Limited | Quality control of substrate coatings |
KR102238033B1 (ko) * | 2018-01-18 | 2021-04-08 | 주식회사 에스엔비아 | 이식형 마이크로니들 및 이의 제조 방법 |
CN108310617A (zh) * | 2018-02-12 | 2018-07-24 | 苏州纳晶医药技术有限公司 | 可注射微针晶片套件 |
US11690799B2 (en) | 2018-04-19 | 2023-07-04 | Lts Lohmann Therapie-Systeme Ag | Microneedle system for applying interferon |
US11318292B2 (en) * | 2018-05-28 | 2022-05-03 | Microneedles Inc. | Microneedle patch for transdermal injections |
CA3135302A1 (en) * | 2019-03-29 | 2020-10-08 | Vaxxas Pty Limited | Vaccination using high-density microprojection array patch |
CN109876197B (zh) * | 2019-04-09 | 2024-05-10 | 珠海天威增材有限公司 | 一种3d打印皮肤及其制备方法 |
CN113877055A (zh) * | 2021-08-10 | 2022-01-04 | 中国人民解放军军事科学院军事医学研究院 | 辐射敏感可穿戴药物控释系统 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990357A (en) * | 1989-05-04 | 1991-02-05 | Becton, Dickinson And Company | Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings |
US20050153873A1 (en) * | 2004-01-09 | 2005-07-14 | Chan Keith T. | Frequency assisted transdermal agent delivery method and system |
JP2007061632A (ja) * | 2005-08-31 | 2007-03-15 | Cordis Corp | 薬物溶出用医療装置のための抗血栓性被膜 |
WO2007091608A1 (ja) * | 2006-02-10 | 2007-08-16 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードル付き経皮薬物投与装置 |
JP2008509746A (ja) * | 2004-08-11 | 2008-04-03 | アルザ・コーポレーシヨン | ナトリウム利尿ペプチドを経皮送達する器具および方法 |
JP2008520370A (ja) * | 2004-11-18 | 2008-06-19 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイのコーティングのためのマスキング方法 |
WO2008096732A1 (ja) * | 2007-02-06 | 2008-08-14 | Hisamitsu Pharmaceutical Co., Inc. | アレルギー診断用マイクロニードルデバイス |
WO2008139648A1 (ja) * | 2007-05-15 | 2008-11-20 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルのコーティング方法 |
Family Cites Families (4)
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KR100453132B1 (ko) | 1996-12-20 | 2004-10-15 | 앨자 코포레이션 | 경피 약제 플럭스를 향상시키기 위한 장치 및 방법 |
GB0017999D0 (en) | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
CA2562932A1 (en) | 2004-04-01 | 2005-10-27 | Alza Corporation | Apparatus and method for transdermal delivery of influenza vaccine |
CA2612005C (en) * | 2005-06-17 | 2013-10-29 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
-
2010
- 2010-01-25 JP JP2010548491A patent/JP5709530B2/ja active Active
- 2010-01-25 SG SG2011054277A patent/SG173160A1/en unknown
- 2010-01-25 KR KR1020117016137A patent/KR101634838B1/ko active IP Right Grant
- 2010-01-25 CN CN2010800056844A patent/CN102300601A/zh active Pending
- 2010-01-25 WO PCT/JP2010/050892 patent/WO2010087300A1/ja active Application Filing
- 2010-01-25 EP EP10735768.3A patent/EP2392378B1/en active Active
- 2010-01-25 US US13/147,014 patent/US20120004626A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4990357A (en) * | 1989-05-04 | 1991-02-05 | Becton, Dickinson And Company | Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings |
US20050153873A1 (en) * | 2004-01-09 | 2005-07-14 | Chan Keith T. | Frequency assisted transdermal agent delivery method and system |
JP2008509746A (ja) * | 2004-08-11 | 2008-04-03 | アルザ・コーポレーシヨン | ナトリウム利尿ペプチドを経皮送達する器具および方法 |
JP2008520370A (ja) * | 2004-11-18 | 2008-06-19 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロニードルアレイのコーティングのためのマスキング方法 |
JP2007061632A (ja) * | 2005-08-31 | 2007-03-15 | Cordis Corp | 薬物溶出用医療装置のための抗血栓性被膜 |
WO2007091608A1 (ja) * | 2006-02-10 | 2007-08-16 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードル付き経皮薬物投与装置 |
WO2008096732A1 (ja) * | 2007-02-06 | 2008-08-14 | Hisamitsu Pharmaceutical Co., Inc. | アレルギー診断用マイクロニードルデバイス |
WO2008139648A1 (ja) * | 2007-05-15 | 2008-11-20 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルのコーティング方法 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101774803B1 (ko) * | 2016-12-02 | 2017-09-05 | (주)엔앤비랩 | 마이크로 니들을 이용한 롤러형 피부 미용기기 및 이를 위한 롤러의 제작방법 |
WO2018101578A1 (ko) * | 2016-12-02 | 2018-06-07 | (주)엔앤비랩 | 마이크로 니들을 이용한 롤러형 피부 미용기기 |
Also Published As
Publication number | Publication date |
---|---|
EP2392378B1 (en) | 2017-03-15 |
SG173160A1 (en) | 2011-08-29 |
US20120004626A1 (en) | 2012-01-05 |
EP2392378A1 (en) | 2011-12-07 |
CN102300601A (zh) | 2011-12-28 |
WO2010087300A1 (ja) | 2010-08-05 |
KR101634838B1 (ko) | 2016-06-29 |
KR20110118627A (ko) | 2011-10-31 |
EP2392378A4 (en) | 2014-03-26 |
JPWO2010087300A1 (ja) | 2012-08-02 |
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