JP5702366B2 - 蛍光リン脂質エーテル化合物、組成物、及びその使用 - Google Patents

蛍光リン脂質エーテル化合物、組成物、及びその使用 Download PDF

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JP5702366B2
JP5702366B2 JP2012510929A JP2012510929A JP5702366B2 JP 5702366 B2 JP5702366 B2 JP 5702366B2 JP 2012510929 A JP2012510929 A JP 2012510929A JP 2012510929 A JP2012510929 A JP 2012510929A JP 5702366 B2 JP5702366 B2 JP 5702366B2
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fluorescent phospholipid
ether compound
phospholipid ether
tissue
fluorescent
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JP2012526822A (ja
JP2012526822A5 (cg-RX-API-DMAC10.html
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ピンチュク アナトリー
ピンチュク アナトリー
ピー．ウェイチャート ジェイミー
ピー．ウェイチャート ジェイミー
ロンギーノ マルク
ロンギーノ マルク
カンデラ イラワティ
カンデラ イラワティ
アール．クラーク ウィリアム
アール．クラーク ウィリアム
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セレクター，インコーポレイティド
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Priority claimed from US12/463,970 external-priority patent/US7811548B1/en
Priority claimed from US12/463,990 external-priority patent/US20100284930A1/en
Priority claimed from US12/463,978 external-priority patent/US20100284929A1/en
Priority claimed from US12/463,998 external-priority patent/US20100284931A1/en
Priority claimed from US12/463,983 external-priority patent/US20100286510A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Endoscopes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2012510929A 2009-05-11 2010-05-11 蛍光リン脂質エーテル化合物、組成物、及びその使用 Active JP5702366B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US12/463,970 US7811548B1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds and compositions
US12/463,978 2009-05-11
US12/463,990 US20100284930A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of skin cancers using phospholipid ether compounds
US12/463,983 2009-05-11
US12/463,978 US20100284929A1 (en) 2009-05-11 2009-05-11 Fluorescent imaging of tumors using phospholipid ether compounds
US12/463,998 US20100284931A1 (en) 2009-05-11 2009-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use
US12/463,998 2009-05-11
US12/463,990 2009-05-11
US12/463,970 2009-05-11
US12/463,983 US20100286510A1 (en) 2009-05-11 2009-05-11 Use of fluorescent phospholipid ether compounds in biopsies
PCT/US2010/034361 WO2010132428A1 (en) 2009-05-11 2010-05-11 Fluorescent phospholipid ether compounds, compositions, and methods of use

Related Child Applications (1)

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JP2014183841A Division JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用

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JP2012526822A JP2012526822A (ja) 2012-11-01
JP2012526822A5 JP2012526822A5 (cg-RX-API-DMAC10.html) 2013-06-27
JP5702366B2 true JP5702366B2 (ja) 2015-04-15

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JP2014183841A Active JP6006271B2 (ja) 2009-05-11 2014-09-10 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

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JP2015098391A Active JP6073961B2 (ja) 2009-05-11 2015-05-13 蛍光リン脂質エーテル化合物、組成物、及びその使用
JP2016089336A Pending JP2016193907A (ja) 2009-05-11 2016-04-27 蛍光リン脂質エーテル化合物、組成物、及びその使用

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US (1) US9616140B2 (cg-RX-API-DMAC10.html)
EP (1) EP2429591B1 (cg-RX-API-DMAC10.html)
JP (4) JP5702366B2 (cg-RX-API-DMAC10.html)
ES (1) ES2549459T3 (cg-RX-API-DMAC10.html)
WO (1) WO2010132428A1 (cg-RX-API-DMAC10.html)

Cited By (2)

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JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

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JP2013032297A (ja) * 2011-08-01 2013-02-14 Univ Of Tsukuba バイオイメージングのための近赤外発光物質及びその合成方法
JP6260259B2 (ja) * 2013-12-24 2018-01-17 日油株式会社 ボロン酸含有ホスホリルコリン化合物及びその製造方法、並びにヨード基含有化合物修飾剤
CN107708702A (zh) 2014-11-17 2018-02-16 塞勒克塔生物科学有限公司 磷脂醚类似物作为靶向癌症的药物载体
WO2017079535A1 (en) 2015-11-06 2017-05-11 Wisconsin Alumni Research Foundation Long-lived gadolinium based tumor targeted imaging and therapy agents
CN109791152B (zh) 2016-06-14 2023-03-03 塞勒科塔生物科学公司 用于鉴定和分离循环肿瘤细胞的磷脂醚类似物
KR102148067B1 (ko) * 2016-09-02 2020-08-26 주식회사 엘지화학 화합물 및 이를 포함하는 색변환필름
JP2020066637A (ja) * 2017-02-27 2020-04-30 富士フイルム株式会社 病理診断用染色剤、細胞核染色方法、病理標本の製造方法、及び色素
JP6495989B1 (ja) 2017-10-02 2019-04-03 株式会社アマダホールディングス プログラム作成装置、溶接システム、及びプログラム作成方法
WO2019200017A1 (en) 2018-04-10 2019-10-17 Cellectar Biosciences, Inc. Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy
CN112204039A (zh) 2018-06-01 2021-01-08 富士胶片株式会社 荧光性化合物及使用了该荧光性化合物的荧光标记生物物质
KR102973364B1 (ko) 2019-10-10 2026-06-04 셀렉타 바이오사이언시스, 인코퍼레이티드 인지질-플라바글린 접합체 및 표적화된 암 치료를 위해 이를 사용하는 방법
IL299971B2 (en) * 2020-09-05 2026-02-01 Council Scient Ind Res Self-assembled thermoresponsive organic material as photonic ink and its fabrication process
CN114957330A (zh) * 2022-07-06 2022-08-30 南京师范大学 一种新型花菁染料中间体及其制备方法

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015166372A (ja) * 2009-05-11 2015-09-24 セレクター，インコーポレイティド 蛍光リン脂質エーテル化合物、組成物、及びその使用
WO2022025625A1 (ko) * 2020-07-28 2022-02-03 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물
KR20220014003A (ko) * 2020-07-28 2022-02-04 부산대학교 산학협력단 암 줄기세포 검출용 바이오 마커 조성물

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JP2012526822A (ja) 2012-11-01
JP2015007118A (ja) 2015-01-15
WO2010132428A1 (en) 2010-11-18
JP2016193907A (ja) 2016-11-17
JP6006271B2 (ja) 2016-10-12
EP2429591B1 (en) 2015-08-26
JP2015166372A (ja) 2015-09-24
US9616140B2 (en) 2017-04-11
ES2549459T3 (es) 2015-10-28
EP2429591A1 (en) 2012-03-21
US20150044142A1 (en) 2015-02-12
JP6073961B2 (ja) 2017-02-01
EP2429591A4 (en) 2013-02-20

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