JP5699157B2 - 長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物 - Google Patents

長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物 Download PDF

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JP5699157B2
JP5699157B2 JP2012537825A JP2012537825A JP5699157B2 JP 5699157 B2 JP5699157 B2 JP 5699157B2 JP 2012537825 A JP2012537825 A JP 2012537825A JP 2012537825 A JP2012537825 A JP 2012537825A JP 5699157 B2 JP5699157 B2 JP 5699157B2
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trpv1
maillard peptide
inflammation
activity
maillard
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JP2013510144A (ja
JP2013510144A5 (enExample
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リュ，ミ−ラ
ソン，ア−ヨン
キム，ウン−ヨン
ベ オ，ソク
ベ オ，ソク
イ，ヨンジュ
チョン イム，ウォン
チョン イム，ウォン
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SNU R&DB Foundation
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JP2012537825A 2009-11-06 2010-11-08 長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物 Expired - Fee Related JP5699157B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2009-0106912 2009-11-06
KR1020090106912A KR101126163B1 (ko) 2009-11-06 2009-11-06 장기 숙성 재래 간장에서 분리한 메일라드 펩타이드를 유효성분으로 함유하는 ｔｒｐｖ１ 활성 관련 질환 또는 염증 관련 질환의 예방 또는 치료용 약학적 조성물
PCT/KR2010/007845 WO2011056033A2 (ko) 2009-11-06 2010-11-08 장기 숙성 재래 간장에서 분리한 메일라드 펩타이드를 유효성분으로 함유하는 ｔｒｐｖ１ 활성 관련 질환 또는 염증 관련 질환의 예방 또는 치료용 약학적 조성물

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JP2014231805A Division JP2015061855A (ja) 2009-11-06 2014-11-14 長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物

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JP2013510144A JP2013510144A (ja) 2013-03-21
JP2013510144A5 JP2013510144A5 (enExample) 2014-04-03
JP5699157B2 true JP5699157B2 (ja) 2015-04-08

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JP2012537825A Expired - Fee Related JP5699157B2 (ja) 2009-11-06 2010-11-08 長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物
JP2014231805A Pending JP2015061855A (ja) 2009-11-06 2014-11-14 長期熟成在来式醤油から分離したメイラードペプチドを有効成分として含むｔｒｐｖ１活性関連疾患または炎症関連疾患の予防または治療のための薬学的組成物

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US (1) US8653032B2 (enExample)
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JP5916051B2 (ja) * 2011-04-24 2016-05-11 国立大学法人北海道大学 抗炎症剤および抗炎症剤の製造方法
KR101555357B1 (ko) 2013-11-15 2015-09-30 한국식품연구원 흑초 유래 펩타이드를 포함하는 염미 증강제
CN104664039B (zh) * 2015-03-03 2017-08-25 华南理工大学 一种具有降尿酸活性的秋刀鱼美拉德肽及其制法和应用
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CN104800749A (zh) * 2015-04-13 2015-07-29 青岛市第三人民医院 用于治疗糖尿病肾病的药物
CN104721632A (zh) * 2015-04-15 2015-06-24 晁东辉 一种临床医学中药麻醉剂
CN104784546A (zh) * 2015-04-23 2015-07-22 青岛市第三人民医院 用于防治甲型h1n1流感的药物
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CN106798865A (zh) * 2017-02-16 2017-06-06 成都市飞龙水处理技术研究所青白江第分所 一种治疗急慢性滑膜炎的中药组合物及其制备方法
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