JP5698237B2 - ステント用カバー部材及びステント装置 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/16—Materials with shape-memory or superelastic properties
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- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Description
Claims (14)
- 形状記憶特性を有する生体吸収性ポリマー材料により、当該ステントの内外周に亘って血流を確保する開口を周面に有する管状に形成されるとともに、脈管内に植え込まれたときに上記脈管を内部から支持可能とする大きさに形状記憶され、上記形状記憶された大きさより縮径されてバルーンカテーテルのバルーン上に装着され、上記バルーンの拡張により拡径されるステントを、上記ステントの外周側から上記縮径された状態に支持するステント用カバー部材であって、
上記ステント用カバー部材は、弾性力を有し一定量以上の拡張により塑性変形する生体吸収性ポリマー材料により、上記バルーンカテーテルのバルーン上に縮径された状態で装着される上記ステントを上記縮径された状態に支持する内周径を有する大きさの筒状に形成されるとともに、当該カバー部材の周面に上記カバー部材の内外に亘って血流を確保する複数の開口部が設けられてなり、上記バルーン上に装着された上記ステントが、上記バルーンの拡張により上記形状記憶された大きさに拡径されるとき、塑性変形して上記ステントの支持を解放することを特徴とするステント用カバー部材。 - 上記ステント用カバー部材を構成する生体吸収性ポリマー材料は、ポリL−ラクチド(PLLA)とポリε−カプロラクトン(PCL)との共重合体(LCL)であって、上記PLLAと上記PCLの組成比がモル比(mol%)で95〜20:5〜80の範囲にあることを特徴とする請求項1記載のステント用カバー部材。
- 上記ステント用カバー部材は、37℃における弾性率が2×107〜2×109パスカル(Pa)の範囲にあることを特徴とする請求項1記載のステント用カバー部材。
- 上記ステント用カバー部材は、表面積に対し10〜70%の開口率で複数の開口部が形成されていることを特徴とする請求項1〜3のいずれか1項に記載のステント用カバー部材。
- 上記ステント用カバー部材には、内膜増殖抑制効果を有する薬剤が含有されていることを特徴とする請求項1〜4のいずれか1項に記載のステント用カバー部材。
- 上記ステント用カバー部材を構成する生体吸収性ポリマー材料100重量部に対し、純度を94%以上とするエピガロカテキンガレード(EGCg)が1〜30重量部添加されていることを特徴とする請求項1〜4のいずれか1項に記載のステント用カバー部材。
- 形状記憶特性を有する生体吸収性ポリマー材料により、当該ステントの内外周に亘って血流を確保する開口を周面に有する管状に形成されるとともに、脈管内に植え込まれたときに上記脈管を内部から支持可能とする大きさに形状記憶され、上記形状記憶された大きさより縮径されてバルーンカテーテルのバルーン上に装着され、上記バルーンの拡張により拡径されるステントと、
上記形状記憶された大きさより縮径されたステントをその外周側から覆って上記縮径した状態に支持するステント用カバー部材とからなり、
上記ステント用カバー部材は、弾性力を有し一定量以上の拡張により塑性変形する生体吸収性ポリマー材料により、上記バルーンカテーテルのバルーン上に縮径された状態で装着される上記ステントを上記縮径された状態に支持する内周径を有する大きさの筒状に形成されるとともに、当該カバー部材の周面に上記カバー部材の内外に亘って血流を確保する複数の開口部が設けられてなり、上記バルーン上に装着された上記ステントが、上記バルーンの拡張により上記形状記憶された大きさに拡径されるとき、塑性変形して上記ステントの支持を解放することを特徴とするステント装置。 - 上記ステント用カバー部材は、37℃における弾性率が2×107〜2×109パスカル(Pa)の範囲にあることを特徴とする請求項7記載のステント装置。
- 上記ステント用カバー部材を構成する生体吸収性ポリマー材料は、ポリL−ラクチド(PLLA)とポリε−カプロラクトン(PCL)との共重合体(LCL)であって、上記PLLAと上記PCLの組成比がモル比(mol%)で95〜20:5〜80の範囲にあることを特徴とする請求項7記載のステント装置。
- 上記ステントは、一連に連続する線条体を直線部分と折り曲げ部とが順次連続するように折り曲げて形成された複数の管状体形成エレメントを組み合わせて構成され、上記折り曲げ部の開き角を変化させることによって拡径、縮径されることを特徴とする請求項7〜9のいずれか1項に記載のステント装置。
- 上記ステント用カバー部材には、脈管内に植え込まれ拡張されたステントによって支持脈管内壁の表面積に対し10〜70%の開口率で複数の開口部が形成されていることを特徴とする請求項7〜10のいずれか1項に記載のステント装置。
- 上記ステント用カバー部材には、内膜増殖抑制効果を有する薬剤が担持され、上記ステントには、血栓形成抑制効果を有する薬剤が担持されていることを特徴とする請求項7〜11のいずれか1項に記載のステント装置。
- 上記ステント用カバー部材を構成する生体吸収性ポリマー材料100重量部に対し、純度を94%以上とするエピガロカテキンガレード(EGCg)が1〜30重量部添加されていることを特徴とする請求項7〜11のいずれか1項に記載のステント装置。
- 上記ステント用カバー部材の外周面に、内膜増殖抑制効果を有する薬剤を含有したコーティング剤が被着されて薬剤担持層が形成されていることを特徴とする請求項7〜13のいずれか1項に記載のステント装置。
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JP2012525324A JP5698237B2 (ja) | 2010-07-20 | 2011-07-19 | ステント用カバー部材及びステント装置 |
PCT/JP2011/004080 WO2012011269A1 (ja) | 2010-07-20 | 2011-07-19 | ステント用カバー部材及びステント装置 |
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US (1) | US9668897B2 (ja) |
EP (1) | EP2596766A4 (ja) |
JP (1) | JP5698237B2 (ja) |
KR (1) | KR20130096645A (ja) |
AU (1) | AU2011280836A1 (ja) |
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US20130338762A1 (en) * | 2012-06-15 | 2013-12-19 | Abbott Cardiovascular Systems Inc. | Bioresorbable polymer peripheral scaffolds made from block copolymers of poly(l-lactide) and hydrophilic polymers |
US8968387B2 (en) | 2012-07-23 | 2015-03-03 | Abbott Cardiovascular Systems Inc. | Shape memory bioresorbable polymer peripheral scaffolds |
CA2911226C (en) | 2013-05-23 | 2024-02-20 | S.T.S. Medical Ltd. | Shape change structure |
WO2015157281A1 (en) | 2014-04-08 | 2015-10-15 | Boston Scientific Scimed, Inc. | Partially coated stents |
JP6711748B2 (ja) * | 2014-06-12 | 2020-06-17 | 国立研究開発法人国立循環器病研究センター | ステント |
US20150374485A1 (en) * | 2014-06-27 | 2015-12-31 | Cordis Corporation | Targeted perforations in endovascular device |
US10912663B2 (en) | 2014-11-26 | 2021-02-09 | S.T.S. Medical Ltd. | Shape change structure for treatment of nasal conditions including sinusitis |
CN108289747B (zh) * | 2015-11-26 | 2020-11-27 | 株式会社日本医疗机器技研 | 生物体吸收性支架 |
KR101821746B1 (ko) | 2016-08-24 | 2018-01-24 | 주식회사 엠아이텍 | 약물방출형 생분해성 스텐트 |
AU2017371223B2 (en) | 2016-12-09 | 2023-04-27 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment of an implant in the prostatic urethra |
KR101964635B1 (ko) * | 2017-07-25 | 2019-04-02 | 주식회사 엠아이텍 | 이탈 방지용 스텐트 및 그 제조방법 |
JP7283808B2 (ja) * | 2018-10-02 | 2023-05-30 | ティーエムディー ラブ カンパニー,リミテッド | 形状記憶高分子を含む血管吻合用部材 |
CN109568661B (zh) * | 2018-12-27 | 2020-02-11 | 郑州大学 | 一种高韧性组织工程血管支架及其制备方法 |
US11890213B2 (en) | 2019-11-19 | 2024-02-06 | Zenflow, Inc. | Systems, devices, and methods for the accurate deployment and imaging of an implant in the prostatic urethra |
WO2023127943A1 (ja) * | 2021-12-28 | 2023-07-06 | 日本ゼオン株式会社 | 消化器系ステント |
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2011
- 2011-07-19 US US13/811,190 patent/US9668897B2/en not_active Expired - Fee Related
- 2011-07-19 WO PCT/JP2011/004080 patent/WO2012011269A1/ja active Application Filing
- 2011-07-19 KR KR1020127034351A patent/KR20130096645A/ko not_active Application Discontinuation
- 2011-07-19 JP JP2012525324A patent/JP5698237B2/ja not_active Expired - Fee Related
- 2011-07-19 EP EP11809445.7A patent/EP2596766A4/en not_active Withdrawn
- 2011-07-19 AU AU2011280836A patent/AU2011280836A1/en not_active Abandoned
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WO2000013737A1 (fr) * | 1998-09-08 | 2000-03-16 | Kabushikikaisha Igaki Iryo Sekkei | Stent pour vaisseaux |
JP2005534425A (ja) * | 2002-08-05 | 2005-11-17 | ボストン サイエンティフィック リミテッド | 保持材を有する分離可能な医療装置 |
JP2010521211A (ja) * | 2007-03-15 | 2010-06-24 | メディノール リミテッド | カバードステントバルーン及びその使用方法 |
Also Published As
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JPWO2012011269A1 (ja) | 2013-09-09 |
KR20130096645A (ko) | 2013-08-30 |
US20130131778A1 (en) | 2013-05-23 |
CA2804261A1 (en) | 2012-01-26 |
AU2011280836A1 (en) | 2013-01-24 |
EP2596766A1 (en) | 2013-05-29 |
WO2012011269A1 (ja) | 2012-01-26 |
US9668897B2 (en) | 2017-06-06 |
EP2596766A4 (en) | 2014-01-08 |
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