JP5694928B2 - ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用 - Google Patents

ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用 Download PDF

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Publication number
JP5694928B2
JP5694928B2 JP2011517819A JP2011517819A JP5694928B2 JP 5694928 B2 JP5694928 B2 JP 5694928B2 JP 2011517819 A JP2011517819 A JP 2011517819A JP 2011517819 A JP2011517819 A JP 2011517819A JP 5694928 B2 JP5694928 B2 JP 5694928B2
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cells
heme
hemoglobin
blood
oxidative stress
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JP2011517819A
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Japanese (ja)
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JP2012505154A5 (enExample
JP2012505154A (ja
Inventor
アケルストロム，ボー
ハンソン，ステファン
オルソン，マーティン，レナース
オルソン，マグナス
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Guard Therapeutics International AB
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A1M Pharma AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
JP2011517819A 2008-07-18 2009-07-17 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用 Expired - Fee Related JP5694928B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US13533808P 2008-07-18 2008-07-18
DKPA200801024 2008-07-18
DKPA200801024 2008-07-18
US61/135,338 2008-07-18
US18938108P 2008-08-18 2008-08-18
US61/189,381 2008-08-18
DKPA200801116 2008-08-18
DKPA200801116 2008-08-18
US19750608P 2008-10-27 2008-10-27
US61/197,506 2008-10-27
DKPA200801478 2008-10-27
DKPA200801478 2008-10-27
PCT/EP2009/005217 WO2010006809A2 (en) 2008-07-18 2009-07-17 Medical use of the radical scavenger and antioxidant alpha-1-microglobulin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014236500A Division JP6406987B2 (ja) 2008-07-18 2014-11-21 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用

Publications (3)

Publication Number Publication Date
JP2012505154A JP2012505154A (ja) 2012-03-01
JP2012505154A5 JP2012505154A5 (enExample) 2012-09-06
JP5694928B2 true JP5694928B2 (ja) 2015-04-01

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JP2011517819A Expired - Fee Related JP5694928B2 (ja) 2008-07-18 2009-07-17 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用
JP2014236500A Expired - Fee Related JP6406987B2 (ja) 2008-07-18 2014-11-21 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用
JP2015241096A Expired - Fee Related JP6175478B2 (ja) 2008-07-18 2015-12-10 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用

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JP2014236500A Expired - Fee Related JP6406987B2 (ja) 2008-07-18 2014-11-21 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用
JP2015241096A Expired - Fee Related JP6175478B2 (ja) 2008-07-18 2015-12-10 ラジカルスカベンジャー及び抗酸化剤アルファ−１−ミクログロブリンの医薬的使用

Country Status (12)

Country Link
US (1) US10350268B2 (enExample)
EP (2) EP2313106B1 (enExample)
JP (3) JP5694928B2 (enExample)
AU (1) AU2009270435B2 (enExample)
CA (1) CA2730531A1 (enExample)
DK (2) DK2638915T3 (enExample)
ES (2) ES2571956T3 (enExample)
HR (2) HRP20160760T1 (enExample)
HU (2) HUE027953T2 (enExample)
PL (2) PL2313106T3 (enExample)
PT (1) PT2638915T (enExample)
WO (1) WO2010006809A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004289252C1 (en) 2003-11-08 2013-06-20 Prothera Biologics, Inc. Preparation and composition of Inter-alpha inhibitor proteins from human plasma for therapeutic use
WO2008098734A1 (en) 2007-02-12 2008-08-21 Stefan Hansson Diagnosis and treatment of preeclampsia
AU2009260822B2 (en) 2008-05-28 2016-09-22 Prothera Biologics, Inc. Preparation and composition of Inter-alpha inhibitor proteins from blood
ES2599034T3 (es) * 2012-09-05 2017-01-31 A1M Pharma Ab Alfa-1-microglobulina para su uso en el tratamiento de enfermedades relacionadas con mitocondrias
WO2014039987A2 (en) 2012-09-09 2014-03-13 Prothera Biologics, Inc. Treatment of disease using inter-alpha inhibitor proteins
WO2015095553A1 (en) 2013-12-20 2015-06-25 Nephrogenesis, Llc Methods and apparatus for kidney dialysis
BR112018068522A2 (pt) * 2016-03-18 2019-01-22 A1M Pharma Ab novas proteínas derivadas de alfa-1-microglobulina e seu uso
EP3512539A4 (en) 2016-09-13 2020-07-29 Prothera Biologics, Inc. METHODS FOR TREATING LUNG DISEASE USING INTER-ALPHA INHIBITOR PROTEINS
WO2018094023A2 (en) * 2016-11-16 2018-05-24 Anand Prasad Cyclic dipeptides and wound healing
BR112019022358A2 (pt) 2017-04-25 2020-05-19 Prothera Biologics Inc métodos para quantificar proteínas inibidoras inter-alfa
CN111511386A (zh) * 2017-11-03 2020-08-07 卫士医疗国际公司 α-1-微球蛋白用于保护骨髓细胞的用途
JP6906807B2 (ja) * 2018-08-31 2021-07-21 一般社団法人クラインシュタイン医工学パースペクティブ 透析装置
WO2024165674A1 (en) 2023-02-08 2024-08-15 Guard Therapeutics International AB Alpha-1-microglobulin derived peptide fragments and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166133A (en) * 1991-04-17 1992-11-24 Cetus Corporation Method for inhibing adhesion of white blood cells to endothelial cells
US6103691A (en) * 1994-03-23 2000-08-15 Tschesche; Harald Utilisation of angiogenin and/or α1 -microglobulin and/or complement factor D in order to inhibit the secretion of proteins
US5910482A (en) 1996-03-19 1999-06-08 Board Of Regents, The University Of Texas System Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor
JP2001348342A (ja) 2001-04-12 2001-12-18 Nippon Zoki Pharmaceut Co Ltd 免疫調整・抗炎症剤
DE10125883A1 (de) 2001-05-28 2002-12-12 Serumwerk Bernburg Ag Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie
DE10237423A1 (de) 2002-08-16 2004-02-19 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
US20070060512A1 (en) * 2003-03-04 2007-03-15 Homayoun Sadeghi Dipeptidyl-peptidase protected protein
AR045074A1 (es) 2003-07-23 2005-10-12 Applied Research Systems Uso de cd164 soluble en desordenes inflamatorios y autoinmunes
ITMI20032528A1 (it) 2003-12-19 2005-06-20 Francesco Santangelo Uso di cistina o di cisteina per la prevenzione e il
US20060105419A1 (en) 2004-08-16 2006-05-18 Biosite, Inc. Use of a glutathione peroxidase 1 as a marker in cardiovascular conditions
JP2007001922A (ja) 2005-06-23 2007-01-11 Asahi Kasei Pharma Kk 透析患者における腎疾患改善剤、又は機能性食品
US20070292421A1 (en) 2005-07-28 2007-12-20 Feinberg Bruce B Method for treating preeclampsia
US20080133141A1 (en) 2005-12-22 2008-06-05 Frost Stephen J Weighted Scoring Methods and Use Thereof in Screening
WO2008098734A1 (en) * 2007-02-12 2008-08-21 Stefan Hansson Diagnosis and treatment of preeclampsia

Also Published As

Publication number Publication date
EP2638915A1 (en) 2013-09-18
DK2638915T3 (en) 2017-01-30
AU2009270435B2 (en) 2014-10-16
ES2614490T3 (es) 2017-05-31
CA2730531A1 (en) 2010-01-21
HRP20160760T1 (hr) 2016-08-12
PL2638915T3 (pl) 2017-04-28
WO2010006809A2 (en) 2010-01-21
PL2313106T3 (pl) 2016-08-31
JP6406987B2 (ja) 2018-10-17
PT2638915T (pt) 2017-01-10
JP6175478B2 (ja) 2017-08-02
EP2638915B1 (en) 2016-10-19
HUE027953T2 (en) 2017-01-30
JP2012505154A (ja) 2012-03-01
US10350268B2 (en) 2019-07-16
DK2313106T3 (en) 2016-07-25
JP2016102125A (ja) 2016-06-02
AU2009270435A1 (en) 2010-01-21
US20110190208A1 (en) 2011-08-04
EP2313106A2 (en) 2011-04-27
EP2313106B1 (en) 2016-03-30
JP2015071620A (ja) 2015-04-16
HUE030274T2 (en) 2017-05-29
HRP20161808T1 (hr) 2017-02-24
WO2010006809A3 (en) 2010-05-27
ES2571956T3 (es) 2016-05-27

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