HUE030274T2 - The therapeutic use of the root binding and antioxidant alpha-1 microglobulin - Google Patents

Info

Publication number

HUE030274T2

HUE030274T2 HUE13172049A HUE13172049A HUE030274T2 HU E030274 T2 HUE030274 T2 HU E030274T2 HU E13172049 A HUE13172049 A HU E13172049A HU E13172049 A HUE13172049 A HU E13172049A HU E030274 T2 HUE030274 T2 HU E030274T2

Authority

HU

Hungary

Prior art keywords

alpha

cells

heme

haemoglobin

blood

Prior art date

2008-07-18

Links

• Espacenet
• Global Dossier
• Discuss

• 102000003966 Alpha-1-microglobulin Human genes 0.000 title description 281
• 101800001761 Alpha-1-microglobulin Proteins 0.000 title description 277
• 239000003963 antioxidant agent Substances 0.000 title description 45
• 230000003078 antioxidant effect Effects 0.000 title description 35
• 239000002516 radical scavenger Substances 0.000 title description 5
• 241000282414 Homo sapiens Species 0.000 claims description 46
• 210000003734 kidney Anatomy 0.000 claims description 19
• 239000003795 chemical substances by application Substances 0.000 claims description 15
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
• 239000002904 solvent Substances 0.000 claims description 8
• 108010054147 Hemoglobins Proteins 0.000 claims description 3
• 102000001554 Hemoglobins Human genes 0.000 claims description 3
• 239000003995 emulsifying agent Substances 0.000 claims description 2
• 239000004094 surface-active agent Substances 0.000 claims description 2
• 102000029749 Microtubule Human genes 0.000 claims 1
• 108091022875 Microtubule Proteins 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 238000011888 autopsy Methods 0.000 claims 1
• JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 claims 1
• 210000000078 claw Anatomy 0.000 claims 1
• 235000019788 craving Nutrition 0.000 claims 1
• 210000004688 microtubule Anatomy 0.000 claims 1
• 239000002357 osmotic agent Substances 0.000 claims 1
• 210000004027 cell Anatomy 0.000 description 204
• 150000003278 haem Chemical class 0.000 description 122
• 230000036542 oxidative stress Effects 0.000 description 108
• 108090000623 proteins and genes Proteins 0.000 description 80
• 102000004169 proteins and genes Human genes 0.000 description 77
• 235000018102 proteins Nutrition 0.000 description 76
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 70
• 150000003254 radicals Chemical class 0.000 description 61
• 201000010099 disease Diseases 0.000 description 60
• 210000004369 blood Anatomy 0.000 description 59
• 239000008280 blood Substances 0.000 description 59
• 239000007800 oxidant agent Substances 0.000 description 52
• 238000011282 treatment Methods 0.000 description 52
• 238000007254 oxidation reaction Methods 0.000 description 50
• 230000003647 oxidation Effects 0.000 description 45
• 235000006708 antioxidants Nutrition 0.000 description 44
• 210000001519 tissue Anatomy 0.000 description 42
• 230000000694 effects Effects 0.000 description 41
• 108090000765 processed proteins & peptides Proteins 0.000 description 40
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 38
• 229920001184 polypeptide Polymers 0.000 description 37
• 102000004196 processed proteins & peptides Human genes 0.000 description 37
• 210000003743 erythrocyte Anatomy 0.000 description 34
• 238000000034 method Methods 0.000 description 34
• 230000001590 oxidative effect Effects 0.000 description 34
• 235000001014 amino acid Nutrition 0.000 description 33
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 32
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 32
• 229940024606 amino acid Drugs 0.000 description 31
• 150000001413 amino acids Chemical class 0.000 description 31
• 210000003491 skin Anatomy 0.000 description 31
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 30
• 238000006243 chemical reaction Methods 0.000 description 29
• 230000001965 increasing effect Effects 0.000 description 29
• 210000002381 plasma Anatomy 0.000 description 29
• 201000011461 pre-eclampsia Diseases 0.000 description 29
• 239000003642 reactive oxygen metabolite Substances 0.000 description 29
• 239000000306 component Substances 0.000 description 27
• 239000000203 mixture Substances 0.000 description 26
• 206010061218 Inflammation Diseases 0.000 description 25
• -1 organic compound heme Chemical class 0.000 description 24
• 230000015572 biosynthetic process Effects 0.000 description 23
• 238000000502 dialysis Methods 0.000 description 23
• 230000004054 inflammatory process Effects 0.000 description 23
• 238000006722 reduction reaction Methods 0.000 description 23
• 238000007792 addition Methods 0.000 description 22
• 230000009467 reduction Effects 0.000 description 22
• 102000008186 Collagen Human genes 0.000 description 21
• 108010035532 Collagen Proteins 0.000 description 21
• 206010018910 Haemolysis Diseases 0.000 description 21
• 108050006654 Lipocalin Proteins 0.000 description 21
• 229920001436 collagen Polymers 0.000 description 21
• 102000019298 Lipocalin Human genes 0.000 description 20
• 230000007246 mechanism Effects 0.000 description 20
• 230000004048 modification Effects 0.000 description 20
• 238000012986 modification Methods 0.000 description 20
• 230000006378 damage Effects 0.000 description 19
• 230000008439 repair process Effects 0.000 description 19
• 230000014509 gene expression Effects 0.000 description 18
• 229910052742 iron Inorganic materials 0.000 description 18
• 210000000056 organ Anatomy 0.000 description 18
• 125000003275 alpha amino acid group Chemical group 0.000 description 17
• 230000002255 enzymatic effect Effects 0.000 description 17
• 208000015181 infectious disease Diseases 0.000 description 17
• 230000004792 oxidative damage Effects 0.000 description 17
• 230000027455 binding Effects 0.000 description 16
• 239000002609 medium Substances 0.000 description 16
• 238000002054 transplantation Methods 0.000 description 16
• 208000027418 Wounds and injury Diseases 0.000 description 15
• 229940072107 ascorbate Drugs 0.000 description 15
• 235000010323 ascorbic acid Nutrition 0.000 description 15
• 239000011668 ascorbic acid Substances 0.000 description 15
• 239000000872 buffer Substances 0.000 description 15
• 239000003814 drug Substances 0.000 description 15
• 238000002474 experimental method Methods 0.000 description 15
• 210000002826 placenta Anatomy 0.000 description 15
• 238000006467 substitution reaction Methods 0.000 description 15
• 230000001684 chronic effect Effects 0.000 description 14
• 230000008588 hemolysis Effects 0.000 description 14
• 150000003573 thiols Chemical class 0.000 description 14
• 230000002292 Radical scavenging effect Effects 0.000 description 13
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
• 230000006870 function Effects 0.000 description 13
• 238000011534 incubation Methods 0.000 description 13
• 239000001301 oxygen Substances 0.000 description 13
• 229910052760 oxygen Inorganic materials 0.000 description 13
• 230000002829 reductive effect Effects 0.000 description 13
• 208000032843 Hemorrhage Diseases 0.000 description 12
• 206010052428 Wound Diseases 0.000 description 12
• 210000000172 cytosol Anatomy 0.000 description 12
• 238000000684 flow cytometry Methods 0.000 description 12
• 208000028867 ischemia Diseases 0.000 description 12
• 230000010412 perfusion Effects 0.000 description 12
• 239000000047 product Substances 0.000 description 12
• 230000001225 therapeutic effect Effects 0.000 description 12
• 238000002560 therapeutic procedure Methods 0.000 description 12
• 108010007622 LDL Lipoproteins Proteins 0.000 description 11
• 102000007330 LDL Lipoproteins Human genes 0.000 description 11
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 11
• 230000001413 cellular effect Effects 0.000 description 11
• 230000002949 hemolytic effect Effects 0.000 description 11
• 108020004999 messenger RNA Proteins 0.000 description 11
• 230000008569 process Effects 0.000 description 11
• 238000003860 storage Methods 0.000 description 11
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
• NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 10
• 102000003896 Myeloperoxidases Human genes 0.000 description 10
• 108090000235 Myeloperoxidases Proteins 0.000 description 10
• 230000003064 anti-oxidating effect Effects 0.000 description 10
• 210000004556 brain Anatomy 0.000 description 10
• 230000030833 cell death Effects 0.000 description 10
• 230000009089 cytolysis Effects 0.000 description 10
• 230000001605 fetal effect Effects 0.000 description 10
• 239000001963 growth medium Substances 0.000 description 10
• 230000005764 inhibitory process Effects 0.000 description 10
• 230000003834 intracellular effect Effects 0.000 description 10
• 239000012528 membrane Substances 0.000 description 10
• 238000003753 real-time PCR Methods 0.000 description 10
• 238000010186 staining Methods 0.000 description 10
• 201000001320 Atherosclerosis Diseases 0.000 description 9
• 102000004190 Enzymes Human genes 0.000 description 9
• 108090000790 Enzymes Proteins 0.000 description 9
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 9
• 108010018924 Heme Oxygenase-1 Proteins 0.000 description 9
• 206010022840 Intraventricular haemorrhage Diseases 0.000 description 9
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 9
• 125000000539 amino acid group Chemical group 0.000 description 9
• 230000004888 barrier function Effects 0.000 description 9
• 208000034158 bleeding Diseases 0.000 description 9
• 231100000319 bleeding Toxicity 0.000 description 9
• 230000000740 bleeding effect Effects 0.000 description 9
• 230000017531 blood circulation Effects 0.000 description 9
• 208000035475 disorder Diseases 0.000 description 9
• 238000009472 formulation Methods 0.000 description 9
• 238000000338 in vitro Methods 0.000 description 9
• 210000004072 lung Anatomy 0.000 description 9
• 230000001404 mediated effect Effects 0.000 description 9
• 210000004379 membrane Anatomy 0.000 description 9
• 239000002953 phosphate buffered saline Substances 0.000 description 9
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 8
• ZTOJFFHGPLIVKC-YAFCTCPESA-N (2e)-3-ethyl-2-[(z)-(3-ethyl-6-sulfo-1,3-benzothiazol-2-ylidene)hydrazinylidene]-1,3-benzothiazole-6-sulfonic acid Chemical compound S\1C2=CC(S(O)(=O)=O)=CC=C2N(CC)C/1=N/N=C1/SC2=CC(S(O)(=O)=O)=CC=C2N1CC ZTOJFFHGPLIVKC-YAFCTCPESA-N 0.000 description 8
• PXEZTIWVRVSYOK-UHFFFAOYSA-N 2-(3,6-diacetyloxy-2,7-dichloro-9h-xanthen-9-yl)benzoic acid Chemical compound C1=2C=C(Cl)C(OC(=O)C)=CC=2OC2=CC(OC(C)=O)=C(Cl)C=C2C1C1=CC=CC=C1C(O)=O PXEZTIWVRVSYOK-UHFFFAOYSA-N 0.000 description 8
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 8
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 8
• 239000003153 chemical reaction reagent Substances 0.000 description 8
• 150000001875 compounds Chemical class 0.000 description 8
• 229940079593 drug Drugs 0.000 description 8
• 210000002744 extracellular matrix Anatomy 0.000 description 8
• 235000013305 food Nutrition 0.000 description 8
• WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Chemical compound Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 description 8
• 235000018977 lysine Nutrition 0.000 description 8
• 238000004519 manufacturing process Methods 0.000 description 8
• 239000002245 particle Substances 0.000 description 8
• 230000001681 protective effect Effects 0.000 description 8
• 230000002000 scavenging effect Effects 0.000 description 8
• 239000000243 solution Substances 0.000 description 8
• 241000894007 species Species 0.000 description 8
• 239000000126 substance Substances 0.000 description 8
• 230000003827 upregulation Effects 0.000 description 8
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 7
• 108020004414 DNA Proteins 0.000 description 7
• 208000035186 Hemolytic Autoimmune Anemia Diseases 0.000 description 7
• XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 7
• DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 7
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 7
• 239000004472 Lysine Substances 0.000 description 7
• 230000001154 acute effect Effects 0.000 description 7
• 238000004458 analytical method Methods 0.000 description 7
• 206010003246 arthritis Diseases 0.000 description 7
• 201000000448 autoimmune hemolytic anemia Diseases 0.000 description 7
• 210000004204 blood vessel Anatomy 0.000 description 7
• 230000019522 cellular metabolic process Effects 0.000 description 7
• 210000003754 fetus Anatomy 0.000 description 7
• 239000012634 fragment Substances 0.000 description 7
• 210000002216 heart Anatomy 0.000 description 7
• 229940027941 immunoglobulin g Drugs 0.000 description 7
• 238000002513 implantation Methods 0.000 description 7
• 238000001802 infusion Methods 0.000 description 7
• 201000006370 kidney failure Diseases 0.000 description 7
• 230000008774 maternal effect Effects 0.000 description 7
• 230000035515 penetration Effects 0.000 description 7
• 230000035935 pregnancy Effects 0.000 description 7
• 238000011321 prophylaxis Methods 0.000 description 7
• XJMOSONTPMZWPB-UHFFFAOYSA-M propidium iodide Chemical compound [I-].[I-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CCC[N+](C)(CC)CC)=C1C1=CC=CC=C1 XJMOSONTPMZWPB-UHFFFAOYSA-M 0.000 description 7
• 239000000523 sample Substances 0.000 description 7
• 230000000451 tissue damage Effects 0.000 description 7
• 231100000827 tissue damage Toxicity 0.000 description 7
• 210000002700 urine Anatomy 0.000 description 7
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 6
• VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 6
• 206010020772 Hypertension Diseases 0.000 description 6
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 6
• 206010028980 Neoplasm Diseases 0.000 description 6
• 208000001647 Renal Insufficiency Diseases 0.000 description 6
• 238000002835 absorbance Methods 0.000 description 6
• 239000003633 blood substitute Substances 0.000 description 6
• 230000000981 bystander Effects 0.000 description 6
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 6
• 239000006285 cell suspension Substances 0.000 description 6
• 230000004087 circulation Effects 0.000 description 6
• 238000006731 degradation reaction Methods 0.000 description 6
• 230000001419 dependent effect Effects 0.000 description 6
• 239000000385 dialysis solution Substances 0.000 description 6
• 231100000673 dose–response relationship Toxicity 0.000 description 6
• 230000001771 impaired effect Effects 0.000 description 6
• YGPSJZOEDVAXAB-UHFFFAOYSA-N kynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-UHFFFAOYSA-N 0.000 description 6
• 210000000265 leukocyte Anatomy 0.000 description 6
• 239000000463 material Substances 0.000 description 6
• 230000017074 necrotic cell death Effects 0.000 description 6
• 230000003169 placental effect Effects 0.000 description 6
• 238000003127 radioimmunoassay Methods 0.000 description 6
• 230000006950 reactive oxygen species formation Effects 0.000 description 6
• 230000010410 reperfusion Effects 0.000 description 6
• 238000007619 statistical method Methods 0.000 description 6
• 239000006228 supernatant Substances 0.000 description 6
• 238000012384 transportation and delivery Methods 0.000 description 6
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 6
• 239000004475 Arginine Substances 0.000 description 5
• 102000014702 Haptoglobin Human genes 0.000 description 5
• 108050005077 Haptoglobin Proteins 0.000 description 5
• 206010022822 Intravascular haemolysis Diseases 0.000 description 5
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 5
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 5
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 5
• 241001465754 Metazoa Species 0.000 description 5
• GHAZCVNUKKZTLG-UHFFFAOYSA-N N-ethyl-succinimide Natural products CCN1C(=O)CCC1=O GHAZCVNUKKZTLG-UHFFFAOYSA-N 0.000 description 5
• HDFGOPSGAURCEO-UHFFFAOYSA-N N-ethylmaleimide Chemical compound CCN1C(=O)C=CC1=O HDFGOPSGAURCEO-UHFFFAOYSA-N 0.000 description 5
• 206010028851 Necrosis Diseases 0.000 description 5
• 102000004316 Oxidoreductases Human genes 0.000 description 5
• 108090000854 Oxidoreductases Proteins 0.000 description 5
• 238000000692 Student's t-test Methods 0.000 description 5
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 5
• 239000012503 blood component Substances 0.000 description 5
• 210000001772 blood platelet Anatomy 0.000 description 5
• 230000015556 catabolic process Effects 0.000 description 5
• 238000004590 computer program Methods 0.000 description 5
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 5
• 230000003247 decreasing effect Effects 0.000 description 5
• 239000007857 degradation product Substances 0.000 description 5
• 238000011161 development Methods 0.000 description 5
• 230000018109 developmental process Effects 0.000 description 5
• 230000005284 excitation Effects 0.000 description 5
• 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 5
• 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 5
• 229960001340 histamine Drugs 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• 208000014674 injury Diseases 0.000 description 5
• 230000002452 interceptive effect Effects 0.000 description 5
• 210000004185 liver Anatomy 0.000 description 5
• 230000004060 metabolic process Effects 0.000 description 5
• 210000000440 neutrophil Anatomy 0.000 description 5
• 210000000130 stem cell Anatomy 0.000 description 5
• 230000035882 stress Effects 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• 238000003786 synthesis reaction Methods 0.000 description 5
• 238000012360 testing method Methods 0.000 description 5
• 238000005406 washing Methods 0.000 description 5
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
• LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 4
• 241000251468 Actinopterygii Species 0.000 description 4
• 241000894006 Bacteria Species 0.000 description 4
• 241000283707 Capra Species 0.000 description 4
• 206010012438 Dermatitis atopic Diseases 0.000 description 4
• 102000002737 Heme Oxygenase-1 Human genes 0.000 description 4
• 102100028006 Heme oxygenase 1 Human genes 0.000 description 4
• QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 4
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 4
• 241000124008 Mammalia Species 0.000 description 4
• 108091028043 Nucleic acid sequence Proteins 0.000 description 4
• ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 4
• 201000004681 Psoriasis Diseases 0.000 description 4
• 108020004459 Small interfering RNA Proteins 0.000 description 4
• PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 4
• 102000019197 Superoxide Dismutase Human genes 0.000 description 4
• 108010012715 Superoxide dismutase Proteins 0.000 description 4
• 208000003441 Transfusion reaction Diseases 0.000 description 4
• KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 4
• UCTWMZQNUQWSLP-UHFFFAOYSA-N adrenaline Chemical compound CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 4
• 230000004075 alteration Effects 0.000 description 4
• 239000000427 antigen Substances 0.000 description 4
• 108091007433 antigens Proteins 0.000 description 4
• 102000036639 antigens Human genes 0.000 description 4
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
• 201000008937 atopic dermatitis Diseases 0.000 description 4
• 201000011510 cancer Diseases 0.000 description 4
• 238000010531 catalytic reduction reaction Methods 0.000 description 4
• 210000000170 cell membrane Anatomy 0.000 description 4
• 238000005119 centrifugation Methods 0.000 description 4
• 230000000875 corresponding effect Effects 0.000 description 4
• 235000018417 cysteine Nutrition 0.000 description 4
• 206010012601 diabetes mellitus Diseases 0.000 description 4
• VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 4
• 210000004696 endometrium Anatomy 0.000 description 4
• 230000003511 endothelial effect Effects 0.000 description 4
• 230000007613 environmental effect Effects 0.000 description 4
• 239000012737 fresh medium Substances 0.000 description 4
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 230000002209 hydrophobic effect Effects 0.000 description 4
• 210000000936 intestine Anatomy 0.000 description 4
• 229960000310 isoleucine Drugs 0.000 description 4
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
• 230000003902 lesion Effects 0.000 description 4
• 230000000670 limiting effect Effects 0.000 description 4
• 239000011159 matrix material Substances 0.000 description 4
• 230000002438 mitochondrial effect Effects 0.000 description 4
• 150000007523 nucleic acids Chemical class 0.000 description 4
• 239000002773 nucleotide Substances 0.000 description 4
• 125000003729 nucleotide group Chemical group 0.000 description 4
• 230000001575 pathological effect Effects 0.000 description 4
• 230000008823 permeabilization Effects 0.000 description 4
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 4
• 230000002028 premature Effects 0.000 description 4
• 229940002612 prodrug Drugs 0.000 description 4
• 239000000651 prodrug Substances 0.000 description 4
• 238000001959 radiotherapy Methods 0.000 description 4
• 108020003175 receptors Proteins 0.000 description 4
• 102000005962 receptors Human genes 0.000 description 4
• 230000001603 reducing effect Effects 0.000 description 4
• 230000028327 secretion Effects 0.000 description 4
• 239000007787 solid Substances 0.000 description 4
• 238000001356 surgical procedure Methods 0.000 description 4
• 125000003396 thiol group Chemical group [H]S* 0.000 description 4
• 231100000331 toxic Toxicity 0.000 description 4
• 230000002588 toxic effect Effects 0.000 description 4
• 235000019165 vitamin E Nutrition 0.000 description 4
• 239000011709 vitamin E Substances 0.000 description 4
• 230000029663 wound healing Effects 0.000 description 4
• DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 3
• 208000037260 Atherosclerotic Plaque Diseases 0.000 description 3
• 208000035143 Bacterial infection Diseases 0.000 description 3
• 206010057248 Cell death Diseases 0.000 description 3
• 102100030497 Cytochrome c Human genes 0.000 description 3
• 108010052832 Cytochromes Proteins 0.000 description 3
• 102000018832 Cytochromes Human genes 0.000 description 3
• 108010075031 Cytochromes c Proteins 0.000 description 3
• 201000004624 Dermatitis Diseases 0.000 description 3
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
• 239000004471 Glycine Substances 0.000 description 3
• 206010065973 Iron Overload Diseases 0.000 description 3
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
• YGPSJZOEDVAXAB-QMMMGPOBSA-N L-kynurenine Chemical compound OC(=O)[C@@H](N)CC(=O)C1=CC=CC=C1N YGPSJZOEDVAXAB-QMMMGPOBSA-N 0.000 description 3
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 3
• KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 3
• 229910019142 PO4 Inorganic materials 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 241000700159 Rattus Species 0.000 description 3
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 3
• 239000004473 Threonine Substances 0.000 description 3
• QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
• 208000025865 Ulcer Diseases 0.000 description 3
• 238000000862 absorption spectrum Methods 0.000 description 3
• 238000009825 accumulation Methods 0.000 description 3
• 230000009471 action Effects 0.000 description 3
• 230000002411 adverse Effects 0.000 description 3
• 235000004279 alanine Nutrition 0.000 description 3
• 208000007502 anemia Diseases 0.000 description 3
• 230000006907 apoptotic process Effects 0.000 description 3
• 238000013459 approach Methods 0.000 description 3
• 235000009582 asparagine Nutrition 0.000 description 3
• 229960001230 asparagine Drugs 0.000 description 3
• 208000022362 bacterial infectious disease Diseases 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 3
• 230000037396 body weight Effects 0.000 description 3
• 230000003915 cell function Effects 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 230000007423 decrease Effects 0.000 description 3
• 230000007547 defect Effects 0.000 description 3
• 230000007123 defense Effects 0.000 description 3
• 230000002939 deleterious effect Effects 0.000 description 3
• 230000008030 elimination Effects 0.000 description 3
• 238000003379 elimination reaction Methods 0.000 description 3
• 239000012530 fluid Substances 0.000 description 3
• 238000000799 fluorescence microscopy Methods 0.000 description 3
• 230000013595 glycosylation Effects 0.000 description 3
• 238000006206 glycosylation reaction Methods 0.000 description 3
• 238000001631 haemodialysis Methods 0.000 description 3
• 208000007475 hemolytic anemia Diseases 0.000 description 3
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 3
• 230000000642 iatrogenic effect Effects 0.000 description 3
• 208000000509 infertility Diseases 0.000 description 3
• 230000036512 infertility Effects 0.000 description 3
• 231100000535 infertility Toxicity 0.000 description 3
• 230000002757 inflammatory effect Effects 0.000 description 3
• 239000003112 inhibitor Substances 0.000 description 3
• 230000002401 inhibitory effect Effects 0.000 description 3
• 239000007924 injection Substances 0.000 description 3
• 238000002347 injection Methods 0.000 description 3
• 230000003993 interaction Effects 0.000 description 3
• 238000007914 intraventricular administration Methods 0.000 description 3
• 231100000518 lethal Toxicity 0.000 description 3
• 230000001665 lethal effect Effects 0.000 description 3
• 239000006210 lotion Substances 0.000 description 3
• 230000002101 lytic effect Effects 0.000 description 3
• 210000002540 macrophage Anatomy 0.000 description 3
• 206010025482 malaise Diseases 0.000 description 3
• 201000004792 malaria Diseases 0.000 description 3
• 239000003550 marker Substances 0.000 description 3
• 230000005906 menstruation Effects 0.000 description 3
• 239000002207 metabolite Substances 0.000 description 3
• 229930182817 methionine Natural products 0.000 description 3
• 230000000813 microbial effect Effects 0.000 description 3
• 230000003278 mimic effect Effects 0.000 description 3
• 210000001616 monocyte Anatomy 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• 201000003045 paroxysmal nocturnal hemoglobinuria Diseases 0.000 description 3
• 239000008194 pharmaceutical composition Substances 0.000 description 3
• 239000010452 phosphate Substances 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 230000002468 redox effect Effects 0.000 description 3
• 230000001105 regulatory effect Effects 0.000 description 3
• 230000004044 response Effects 0.000 description 3
• 210000001525 retina Anatomy 0.000 description 3
• 230000002441 reversible effect Effects 0.000 description 3
• 150000003839 salts Chemical class 0.000 description 3
• 210000002966 serum Anatomy 0.000 description 3
• 208000007056 sickle cell anemia Diseases 0.000 description 3
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 3
• 238000002798 spectrophotometry method Methods 0.000 description 3
• 208000024891 symptom Diseases 0.000 description 3
• 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 3
• 239000004474 valine Substances 0.000 description 3
• 230000035899 viability Effects 0.000 description 3
• 235000019154 vitamin C Nutrition 0.000 description 3
• 239000011718 vitamin C Substances 0.000 description 3
• AXFMEGAFCUULFV-BLFANLJRSA-N (2s)-2-[[(2s)-1-[(2s,3r)-2-amino-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]pentanedioic acid Chemical compound CC[C@@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O AXFMEGAFCUULFV-BLFANLJRSA-N 0.000 description 2
• DFZVZEMNPGABKO-ZETCQYMHSA-N (2s)-2-amino-3-pyridin-3-ylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CN=C1 DFZVZEMNPGABKO-ZETCQYMHSA-N 0.000 description 2
• FQFVANSXYKWQOT-ZETCQYMHSA-N (2s)-2-azaniumyl-3-pyridin-4-ylpropanoate Chemical compound OC(=O)[C@@H](N)CC1=CC=NC=C1 FQFVANSXYKWQOT-ZETCQYMHSA-N 0.000 description 2
• VCKPUUFAIGNJHC-UHFFFAOYSA-N 3-hydroxykynurenine Chemical compound OC(=O)C(N)CC(=O)C1=CC=CC(O)=C1N VCKPUUFAIGNJHC-UHFFFAOYSA-N 0.000 description 2
• FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 2
• 206010066181 Acute haemolytic transfusion reaction Diseases 0.000 description 2
• 239000012099 Alexa Fluor family Substances 0.000 description 2
• 241000224489 Amoeba Species 0.000 description 2
• LIJXJYGRSRWLCJ-IHRRRGAJSA-N Asp-Phe-Arg Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O LIJXJYGRSRWLCJ-IHRRRGAJSA-N 0.000 description 2
• 208000023275 Autoimmune disease Diseases 0.000 description 2
• 241000271566 Aves Species 0.000 description 2
• BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
• 102000004506 Blood Proteins Human genes 0.000 description 2
• 108010017384 Blood Proteins Proteins 0.000 description 2
• 208000024172 Cardiovascular disease Diseases 0.000 description 2
• 101710088194 Dehydrogenase Proteins 0.000 description 2
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 201000009273 Endometriosis Diseases 0.000 description 2
• 241000588724 Escherichia coli Species 0.000 description 2
• 206010015871 Extravascular haemolysis Diseases 0.000 description 2
• 208000001362 Fetal Growth Retardation Diseases 0.000 description 2
• AIGROOHQXCACHL-WDSKDSINSA-N Glu-Gly-Ala Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(O)=O AIGROOHQXCACHL-WDSKDSINSA-N 0.000 description 2
• ZHNHJYYFCGUZNQ-KBIXCLLPSA-N Glu-Ile-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CCC(O)=O ZHNHJYYFCGUZNQ-KBIXCLLPSA-N 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
• 108010024636 Glutathione Proteins 0.000 description 2
• 102000006587 Glutathione peroxidase Human genes 0.000 description 2
• 108700016172 Glutathione peroxidases Proteins 0.000 description 2
• RYAOJUMWLWUGNW-QMMMGPOBSA-N Gly-Val-Gly Chemical compound NCC(=O)N[C@@H](C(C)C)C(=O)NCC(O)=O RYAOJUMWLWUGNW-QMMMGPOBSA-N 0.000 description 2
• 102000016761 Haem oxygenases Human genes 0.000 description 2
• 108050006318 Haem oxygenases Proteins 0.000 description 2
• 208000018565 Hemochromatosis Diseases 0.000 description 2
• 102000013271 Hemopexin Human genes 0.000 description 2
• 108010026027 Hemopexin Proteins 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101500025164 Homo sapiens Alpha-1-microglobulin Proteins 0.000 description 2
• 101000797623 Homo sapiens Protein AMBP Proteins 0.000 description 2
• XLXPYSDGMXTTNQ-UHFFFAOYSA-N Ile-Phe-Leu Natural products CCC(C)C(N)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=CC=C1 XLXPYSDGMXTTNQ-UHFFFAOYSA-N 0.000 description 2
• 208000026350 Inborn Genetic disease Diseases 0.000 description 2
• 206010061216 Infarction Diseases 0.000 description 2
• 208000019693 Lung disease Diseases 0.000 description 2
• 108020004485 Nonsense Codon Proteins 0.000 description 2
• 108091060545 Nonsense suppressor Proteins 0.000 description 2
• 208000002193 Pain Diseases 0.000 description 2
• 244000046052 Phaseolus vulgaris Species 0.000 description 2
• 235000010627 Phaseolus vulgaris Nutrition 0.000 description 2
• 241000269907 Pleuronectes platessa Species 0.000 description 2
• 206010036590 Premature baby Diseases 0.000 description 2
• 206010037660 Pyrexia Diseases 0.000 description 2
• 240000001970 Raphanus sativus var. sativus Species 0.000 description 2
• 241000282898 Sus scrofa Species 0.000 description 2
• 208000002903 Thalassemia Diseases 0.000 description 2
• 102000002933 Thioredoxin Human genes 0.000 description 2
• VGYBYGQXZJDZJU-XQXXSGGOSA-N Thr-Glu-Ala Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(O)=O VGYBYGQXZJDZJU-XQXXSGGOSA-N 0.000 description 2
• 208000007536 Thrombosis Diseases 0.000 description 2
• 229940122618 Trypsin inhibitor Drugs 0.000 description 2
• UMPVMAYCLYMYGA-ONGXEEELSA-N Val-Leu-Gly Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(O)=O UMPVMAYCLYMYGA-ONGXEEELSA-N 0.000 description 2
• 229930003427 Vitamin E Natural products 0.000 description 2
• 108010093894 Xanthine oxidase Proteins 0.000 description 2
• XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
• 239000002253 acid Substances 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000000654 additive Substances 0.000 description 2
• 230000003321 amplification Effects 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000003110 anti-inflammatory effect Effects 0.000 description 2
• 108010009111 arginyl-glycyl-glutamic acid Proteins 0.000 description 2
• 108010038850 arginyl-isoleucyl-tyrosine Proteins 0.000 description 2
• 108010094001 arginyl-tryptophyl-arginine Proteins 0.000 description 2
• 210000001367 artery Anatomy 0.000 description 2
• 229940009098 aspartate Drugs 0.000 description 2
• 230000006399 behavior Effects 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• 230000033228 biological regulation Effects 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 210000000601 blood cell Anatomy 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 239000000969 carrier Substances 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000005779 cell damage Effects 0.000 description 2
• 210000003850 cellular structure Anatomy 0.000 description 2
• 206010008129 cerebral palsy Diseases 0.000 description 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
• 238000001311 chemical methods and process Methods 0.000 description 2
• 238000007385 chemical modification Methods 0.000 description 2
• PMMYEEVYMWASQN-IMJSIDKUSA-N cis-4-Hydroxy-L-proline Chemical compound O[C@@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-IMJSIDKUSA-N 0.000 description 2
• 230000001427 coherent effect Effects 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• 238000010924 continuous production Methods 0.000 description 2
• 230000008602 contraction Effects 0.000 description 2
• 230000002596 correlated effect Effects 0.000 description 2
• 125000004122 cyclic group Chemical group 0.000 description 2
• 239000000824 cytostatic agent Substances 0.000 description 2
• 230000001085 cytostatic effect Effects 0.000 description 2
• 230000000254 damaging effect Effects 0.000 description 2
• 230000016117 decidualization Effects 0.000 description 2
• 230000006735 deficit Effects 0.000 description 2
• 230000003111 delayed effect Effects 0.000 description 2
• 238000012217 deletion Methods 0.000 description 2
• 230000037430 deletion Effects 0.000 description 2
• 238000011033 desalting Methods 0.000 description 2
• 238000009792 diffusion process Methods 0.000 description 2
• 239000003085 diluting agent Substances 0.000 description 2
• 230000008034 disappearance Effects 0.000 description 2
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 2
• 230000009977 dual effect Effects 0.000 description 2
• 238000001493 electron microscopy Methods 0.000 description 2
• 239000000839 emulsion Substances 0.000 description 2
• 210000003617 erythrocyte membrane Anatomy 0.000 description 2
• 230000029142 excretion Effects 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 239000003925 fat Substances 0.000 description 2
• 230000004720 fertilization Effects 0.000 description 2
• 208000030941 fetal growth restriction Diseases 0.000 description 2
• 239000007850 fluorescent dye Substances 0.000 description 2
• 230000037406 food intake Effects 0.000 description 2
• 235000012631 food intake Nutrition 0.000 description 2
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
• 210000001035 gastrointestinal tract Anatomy 0.000 description 2
• 238000005227 gel permeation chromatography Methods 0.000 description 2
• 230000030279 gene silencing Effects 0.000 description 2
• 208000016361 genetic disease Diseases 0.000 description 2
• 230000002068 genetic effect Effects 0.000 description 2
• 229930195712 glutamate Natural products 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• 229960003180 glutathione Drugs 0.000 description 2
• 210000003714 granulocyte Anatomy 0.000 description 2
• 208000035474 group of disease Diseases 0.000 description 2
• 230000003394 haemopoietic effect Effects 0.000 description 2
• 230000009931 harmful effect Effects 0.000 description 2
• 230000035876 healing Effects 0.000 description 2
• 230000036541 health Effects 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 230000000322 hemodialysis Effects 0.000 description 2
• 201000001505 hemoglobinuria Diseases 0.000 description 2
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
• 230000013632 homeostatic process Effects 0.000 description 2
• 208000003906 hydrocephalus Diseases 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 230000006872 improvement Effects 0.000 description 2
• 230000006698 induction Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 230000007574 infarction Effects 0.000 description 2
• 230000004968 inflammatory condition Effects 0.000 description 2
• 208000027866 inflammatory disease Diseases 0.000 description 2
• 230000008798 inflammatory stress Effects 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• 238000001990 intravenous administration Methods 0.000 description 2
• 230000009545 invasion Effects 0.000 description 2
• 230000003907 kidney function Effects 0.000 description 2
• AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 238000004811 liquid chromatography Methods 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
• 238000005259 measurement Methods 0.000 description 2
• 208000030159 metabolic disease Diseases 0.000 description 2
• 229910052751 metal Inorganic materials 0.000 description 2
• 239000002184 metal Substances 0.000 description 2
• 229910021645 metal ion Inorganic materials 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 239000000178 monomer Substances 0.000 description 2
• 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
• 230000037434 nonsense mutation Effects 0.000 description 2
• 238000003199 nucleic acid amplification method Methods 0.000 description 2
• 229920001542 oligosaccharide Polymers 0.000 description 2
• 150000002482 oligosaccharides Chemical group 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 230000008816 organ damage Effects 0.000 description 2
• 244000045947 parasite Species 0.000 description 2
• 244000052769 pathogen Species 0.000 description 2
• 230000008506 pathogenesis Effects 0.000 description 2
• 230000001717 pathogenic effect Effects 0.000 description 2
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
• 230000002093 peripheral effect Effects 0.000 description 2
• 229940124531 pharmaceutical excipient Drugs 0.000 description 2
• 230000035790 physiological processes and functions Effects 0.000 description 2
• 235000015108 pies Nutrition 0.000 description 2
• 229920003023 plastic Polymers 0.000 description 2
• 239000004033 plastic Substances 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 108091033319 polynucleotide Proteins 0.000 description 2
• 102000040430 polynucleotide Human genes 0.000 description 2
• 239000002157 polynucleotide Substances 0.000 description 2
• 230000008092 positive effect Effects 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 230000011514 reflex Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 230000019254 respiratory burst Effects 0.000 description 2
• 230000000241 respiratory effect Effects 0.000 description 2
• 230000000284 resting effect Effects 0.000 description 2
• 230000002207 retinal effect Effects 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 230000005070 ripening Effects 0.000 description 2
• FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
• 239000012679 serum free medium Substances 0.000 description 2
• 108010071207 serylmethionine Proteins 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 238000001228 spectrum Methods 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• 239000000758 substrate Substances 0.000 description 2
• 230000002459 sustained effect Effects 0.000 description 2
• 150000007944 thiolates Chemical group 0.000 description 2
• 108060008226 thioredoxin Proteins 0.000 description 2
• 229940094937 thioredoxin Drugs 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• 238000012546 transfer Methods 0.000 description 2
• 238000013519 translation Methods 0.000 description 2
• 230000008733 trauma Effects 0.000 description 2
• 239000002753 trypsin inhibitor Substances 0.000 description 2
• 210000004881 tumor cell Anatomy 0.000 description 2
• 230000007306 turnover Effects 0.000 description 2
• 231100000397 ulcer Toxicity 0.000 description 2
• 239000006216 vaginal suppository Substances 0.000 description 2
• 238000007631 vascular surgery Methods 0.000 description 2
• 239000003981 vehicle Substances 0.000 description 2
• 210000004885 white matter Anatomy 0.000 description 2
• 229940075420 xanthine Drugs 0.000 description 2
• UJXJZOCXEZPHIE-YFKPBYRVSA-N (2s)-2-(2-hydroxyethylamino)-4-sulfanylbutanoic acid Chemical compound OCCN[C@H](C(O)=O)CCS UJXJZOCXEZPHIE-YFKPBYRVSA-N 0.000 description 1
• CNMAQBJBWQQZFZ-LURJTMIESA-N (2s)-2-(pyridin-2-ylamino)propanoic acid Chemical compound OC(=O)[C@H](C)NC1=CC=CC=N1 CNMAQBJBWQQZFZ-LURJTMIESA-N 0.000 description 1
• PDRJLZDUOULRHE-ZETCQYMHSA-N (2s)-2-amino-3-pyridin-2-ylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=N1 PDRJLZDUOULRHE-ZETCQYMHSA-N 0.000 description 1
• JQFLYFRHDIHZFZ-RXMQYKEDSA-N (2s)-3,3-dimethylpyrrolidine-2-carboxylic acid Chemical compound CC1(C)CCN[C@@H]1C(O)=O JQFLYFRHDIHZFZ-RXMQYKEDSA-N 0.000 description 1
• CNPSFBUUYIVHAP-AKGZTFGVSA-N (2s)-3-methylpyrrolidine-2-carboxylic acid Chemical compound CC1CCN[C@@H]1C(O)=O CNPSFBUUYIVHAP-AKGZTFGVSA-N 0.000 description 1
• FXGZFWDCXQRZKI-VKHMYHEASA-N (2s)-5-amino-2-nitramido-5-oxopentanoic acid Chemical compound NC(=O)CC[C@@H](C(O)=O)N[N+]([O-])=O FXGZFWDCXQRZKI-VKHMYHEASA-N 0.000 description 1
• CCAIIPMIAFGKSI-DMTCNVIQSA-N (2s,3r)-3-hydroxy-2-(methylazaniumyl)butanoate Chemical compound CN[C@@H]([C@@H](C)O)C(O)=O CCAIIPMIAFGKSI-DMTCNVIQSA-N 0.000 description 1
• CNPSFBUUYIVHAP-WHFBIAKZSA-N (2s,3s)-3-methylpyrrolidin-1-ium-2-carboxylate Chemical compound C[C@H]1CCN[C@@H]1C(O)=O CNPSFBUUYIVHAP-WHFBIAKZSA-N 0.000 description 1
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
• OMGHIGVFLOPEHJ-UHFFFAOYSA-N 2,5-dihydro-1h-pyrrol-1-ium-2-carboxylate Chemical compound OC(=O)C1NCC=C1 OMGHIGVFLOPEHJ-UHFFFAOYSA-N 0.000 description 1
• JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
• XEVFXAFXZZYFSX-UHFFFAOYSA-N 3-azabicyclo[2.1.1]hexane-4-carboxylic acid Chemical compound C1C2CC1(C(=O)O)NC2 XEVFXAFXZZYFSX-UHFFFAOYSA-N 0.000 description 1
• HQFLTUZKIRYQSP-UHFFFAOYSA-N 3-ethyl-2h-1,3-benzothiazole-6-sulfonic acid Chemical class OS(=O)(=O)C1=CC=C2N(CC)CSC2=C1 HQFLTUZKIRYQSP-UHFFFAOYSA-N 0.000 description 1
• XWHHYOYVRVGJJY-QMMMGPOBSA-N 4-fluoro-L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(F)C=C1 XWHHYOYVRVGJJY-QMMMGPOBSA-N 0.000 description 1
• 238000010269 ABTS assay Methods 0.000 description 1
• 206010000234 Abortion spontaneous Diseases 0.000 description 1
• 206010067484 Adverse reaction Diseases 0.000 description 1
• PBAMJJXWDQXOJA-FXQIFTODSA-N Ala-Asp-Arg Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCCN=C(N)N PBAMJJXWDQXOJA-FXQIFTODSA-N 0.000 description 1
• DVJSJDDYCYSMFR-ZKWXMUAHSA-N Ala-Ile-Gly Chemical compound [H]N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(O)=O DVJSJDDYCYSMFR-ZKWXMUAHSA-N 0.000 description 1
• 244000109331 Albuca major Species 0.000 description 1
• 102100027211 Albumin Human genes 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 108010087765 Antipain Proteins 0.000 description 1
• 241000269350 Anura Species 0.000 description 1
• FNXCAFKDGBROCU-STECZYCISA-N Arg-Ile-Tyr Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 FNXCAFKDGBROCU-STECZYCISA-N 0.000 description 1
• NGTYEHIRESTSRX-UWVGGRQHSA-N Arg-Lys-Gly Chemical compound NCCCC[C@@H](C(=O)NCC(O)=O)NC(=O)[C@@H](N)CCCN=C(N)N NGTYEHIRESTSRX-UWVGGRQHSA-N 0.000 description 1
• KSUALAGYYLQSHJ-RCWTZXSCSA-N Arg-Met-Thr Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(O)=O KSUALAGYYLQSHJ-RCWTZXSCSA-N 0.000 description 1
• QUBKBPZGMZWOKQ-SZMVWBNQSA-N Arg-Trp-Arg Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCN=C(N)N)N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O)=CNC2=C1 QUBKBPZGMZWOKQ-SZMVWBNQSA-N 0.000 description 1
• 206010003210 Arteriosclerosis Diseases 0.000 description 1
• SEKBHZJLARBNPB-GHCJXIJMSA-N Asn-Ile-Ser Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(O)=O SEKBHZJLARBNPB-GHCJXIJMSA-N 0.000 description 1
• PNHQRQTVBRDIEF-CIUDSAMLSA-N Asn-Leu-Ala Chemical compound C[C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)N PNHQRQTVBRDIEF-CIUDSAMLSA-N 0.000 description 1
• RTFWCVDISAMGEQ-SRVKXCTJSA-N Asn-Phe-Asn Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC(=O)N)N RTFWCVDISAMGEQ-SRVKXCTJSA-N 0.000 description 1
• SKQTXVZTCGSRJS-SRVKXCTJSA-N Asn-Tyr-Asp Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)O)NC(=O)[C@H](CC(=O)N)N)O SKQTXVZTCGSRJS-SRVKXCTJSA-N 0.000 description 1
• AXXCUABIFZPKPM-BQBZGAKWSA-N Asp-Arg-Gly Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O AXXCUABIFZPKPM-BQBZGAKWSA-N 0.000 description 1
• CNKAZIGBGQIHLL-GUBZILKMSA-N Asp-Arg-Met Chemical compound CSCC[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N CNKAZIGBGQIHLL-GUBZILKMSA-N 0.000 description 1
• BUVNWKQBMZLCDW-UGYAYLCHSA-N Asp-Asn-Ile Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O BUVNWKQBMZLCDW-UGYAYLCHSA-N 0.000 description 1
• RRKCPMGSRIDLNC-AVGNSLFASA-N Asp-Glu-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O RRKCPMGSRIDLNC-AVGNSLFASA-N 0.000 description 1
• PZXPWHFYZXTFBI-YUMQZZPRSA-N Asp-Gly-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H](N)CC(O)=O PZXPWHFYZXTFBI-YUMQZZPRSA-N 0.000 description 1
• DRCOAZZDQRCGGP-GHCJXIJMSA-N Asp-Ser-Ile Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O DRCOAZZDQRCGGP-GHCJXIJMSA-N 0.000 description 1
• 206010003645 Atopy Diseases 0.000 description 1
• 208000008035 Back Pain Diseases 0.000 description 1
• 241001674044 Blattodea Species 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
• UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
• 108010053835 Catalase Proteins 0.000 description 1
• 102100035882 Catalase Human genes 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 108010001857 Cell Surface Receptors Proteins 0.000 description 1
• 102000000844 Cell Surface Receptors Human genes 0.000 description 1
• 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
• 206010008796 Chromaturia Diseases 0.000 description 1
• 206010009192 Circulatory collapse Diseases 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 208000011038 Cold agglutinin disease Diseases 0.000 description 1
• 102000012422 Collagen Type I Human genes 0.000 description 1
• 108010022452 Collagen Type I Proteins 0.000 description 1
• 208000035473 Communicable disease Diseases 0.000 description 1
• 108020004635 Complementary DNA Proteins 0.000 description 1
• 206010010356 Congenital anomaly Diseases 0.000 description 1
• 241001137251 Corvidae Species 0.000 description 1
• JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
• UDPSLLFHOLGXBY-FXQIFTODSA-N Cys-Glu-Glu Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O UDPSLLFHOLGXBY-FXQIFTODSA-N 0.000 description 1
• DTFJUSWYECELTM-BPUTZDHNSA-N Cys-Pro-Trp Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CS)N)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)O DTFJUSWYECELTM-BPUTZDHNSA-N 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 102000010831 Cytoskeletal Proteins Human genes 0.000 description 1
• 108010037414 Cytoskeletal Proteins Proteins 0.000 description 1
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
• 206010066182 Delayed haemolytic transfusion reaction Diseases 0.000 description 1
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 108091006149 Electron carriers Proteins 0.000 description 1
• 208000005189 Embolism Diseases 0.000 description 1
• 108700039887 Essential Genes Proteins 0.000 description 1
• 102000008857 Ferritin Human genes 0.000 description 1
• 108050000784 Ferritin Proteins 0.000 description 1
• 238000012413 Fluorescence activated cell sorting analysis Methods 0.000 description 1
• 206010017533 Fungal infection Diseases 0.000 description 1
• SBYVDRJAXWSXQL-AVGNSLFASA-N Glu-Asn-Phe Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O SBYVDRJAXWSXQL-AVGNSLFASA-N 0.000 description 1
• FKGNJUCQKXQNRA-NRPADANISA-N Glu-Cys-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCC(O)=O FKGNJUCQKXQNRA-NRPADANISA-N 0.000 description 1
• YBTCBQBIJKGSJP-BQBZGAKWSA-N Glu-Pro Chemical compound OC(=O)CC[C@H](N)C(=O)N1CCC[C@H]1C(O)=O YBTCBQBIJKGSJP-BQBZGAKWSA-N 0.000 description 1
• DXVOKNVIKORTHQ-GUBZILKMSA-N Glu-Pro-Glu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(O)=O DXVOKNVIKORTHQ-GUBZILKMSA-N 0.000 description 1
• JYXKPJVDCAWMDG-ZPFDUUQYSA-N Glu-Pro-Ile Chemical compound CC[C@H](C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)N JYXKPJVDCAWMDG-ZPFDUUQYSA-N 0.000 description 1
• WXONSNSSBYQGNN-AVGNSLFASA-N Glu-Ser-Tyr Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O WXONSNSSBYQGNN-AVGNSLFASA-N 0.000 description 1
• MXJYXYDREQWUMS-XKBZYTNZSA-N Glu-Thr-Ser Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O MXJYXYDREQWUMS-XKBZYTNZSA-N 0.000 description 1
• QIZJOTQTCAGKPU-KWQFWETISA-N Gly-Ala-Tyr Chemical compound [NH3+]CC(=O)N[C@@H](C)C(=O)N[C@H](C([O-])=O)CC1=CC=C(O)C=C1 QIZJOTQTCAGKPU-KWQFWETISA-N 0.000 description 1
• JXYMPBCYRKWJEE-BQBZGAKWSA-N Gly-Arg-Ala Chemical compound [H]NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O JXYMPBCYRKWJEE-BQBZGAKWSA-N 0.000 description 1
• RJIVPOXLQFJRTG-LURJTMIESA-N Gly-Arg-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N RJIVPOXLQFJRTG-LURJTMIESA-N 0.000 description 1
• BIRKKBCSAIHDDF-WDSKDSINSA-N Gly-Glu-Cys Chemical compound NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(O)=O BIRKKBCSAIHDDF-WDSKDSINSA-N 0.000 description 1
• XMPXVJIDADUOQB-RCOVLWMOSA-N Gly-Gly-Ile Chemical compound CC[C@H](C)[C@@H](C([O-])=O)NC(=O)CNC(=O)C[NH3+] XMPXVJIDADUOQB-RCOVLWMOSA-N 0.000 description 1
• YKJUITHASJAGHO-HOTGVXAUSA-N Gly-Lys-Trp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)CN YKJUITHASJAGHO-HOTGVXAUSA-N 0.000 description 1
• BMWFDYIYBAFROD-WPRPVWTQSA-N Gly-Pro-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)CN BMWFDYIYBAFROD-WPRPVWTQSA-N 0.000 description 1
• LCRDMSSAKLTKBU-ZDLURKLDSA-N Gly-Ser-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)CN LCRDMSSAKLTKBU-ZDLURKLDSA-N 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• 201000005569 Gout Diseases 0.000 description 1
• 208000009329 Graft vs Host Disease Diseases 0.000 description 1
• 102000008015 Hemeproteins Human genes 0.000 description 1
• 108010089792 Hemeproteins Proteins 0.000 description 1
• 208000032759 Hemolytic-Uremic Syndrome Diseases 0.000 description 1
• 208000031220 Hemophilia Diseases 0.000 description 1
• 208000009292 Hemophilia A Diseases 0.000 description 1
• 108010017480 Hemosiderin Proteins 0.000 description 1
• 208000002972 Hepatolenticular Degeneration Diseases 0.000 description 1
• FDQYIRHBVVUTJF-ZETCQYMHSA-N His-Gly-Gly Chemical compound [O-]C(=O)CNC(=O)CNC(=O)[C@@H]([NH3+])CC1=CN=CN1 FDQYIRHBVVUTJF-ZETCQYMHSA-N 0.000 description 1
• ZUPVLBAXUUGKKN-VHSXEESVSA-N His-Gly-Pro Chemical compound C1C[C@@H](N(C1)C(=O)CNC(=O)[C@H](CC2=CN=CN2)N)C(=O)O ZUPVLBAXUUGKKN-VHSXEESVSA-N 0.000 description 1
• JIUYRPFQJJRSJB-QWRGUYRKSA-N His-His-Gly Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)NCC(O)=O)C1=CN=CN1 JIUYRPFQJJRSJB-QWRGUYRKSA-N 0.000 description 1
• 108010093488 His-His-His-His-His-His Proteins 0.000 description 1
• CKRJBQJIGOEKMC-SRVKXCTJSA-N His-Lys-Ser Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O CKRJBQJIGOEKMC-SRVKXCTJSA-N 0.000 description 1
• 102000000543 Histamine Receptors Human genes 0.000 description 1
• 108010002059 Histamine Receptors Proteins 0.000 description 1
• 101001043564 Homo sapiens Prolow-density lipoprotein receptor-related protein 1 Proteins 0.000 description 1
• YZJSUQQZGCHHNQ-UHFFFAOYSA-N Homoglutamine Chemical compound OC(=O)C(N)CCCC(N)=O YZJSUQQZGCHHNQ-UHFFFAOYSA-N 0.000 description 1
• 241000702617 Human parvovirus B19 Species 0.000 description 1
• 208000023105 Huntington disease Diseases 0.000 description 1
• 208000006031 Hydrops Fetalis Diseases 0.000 description 1
• 206010020529 Hydrops foetalis Diseases 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• 208000035150 Hypercholesterolemia Diseases 0.000 description 1
• 208000008454 Hyperhidrosis Diseases 0.000 description 1
• 206010020751 Hypersensitivity Diseases 0.000 description 1
• 208000001953 Hypotension Diseases 0.000 description 1
• 206010021143 Hypoxia Diseases 0.000 description 1
• IALVDKNUFSTICJ-GMOBBJLQSA-N Ile-Met-Asp Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)O)N IALVDKNUFSTICJ-GMOBBJLQSA-N 0.000 description 1
• XLXPYSDGMXTTNQ-DKIMLUQUSA-N Ile-Phe-Leu Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(O)=O XLXPYSDGMXTTNQ-DKIMLUQUSA-N 0.000 description 1
• SVZFKLBRCYCIIY-CYDGBPFRSA-N Ile-Pro-Arg Chemical compound CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(O)=O SVZFKLBRCYCIIY-CYDGBPFRSA-N 0.000 description 1
• JHNJNTMTZHEDLJ-NAKRPEOUSA-N Ile-Ser-Arg Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O JHNJNTMTZHEDLJ-NAKRPEOUSA-N 0.000 description 1
• CNMOKANDJMLAIF-CIQUZCHMSA-N Ile-Thr-Ala Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O CNMOKANDJMLAIF-CIQUZCHMSA-N 0.000 description 1
• JJQQGCMKLOEGAV-OSUNSFLBSA-N Ile-Thr-Met Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)O)N JJQQGCMKLOEGAV-OSUNSFLBSA-N 0.000 description 1
• PRTZQMBYUZFSFA-XEGUGMAKSA-N Ile-Tyr-Gly Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCC(=O)O)N PRTZQMBYUZFSFA-XEGUGMAKSA-N 0.000 description 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
• 102100034343 Integrase Human genes 0.000 description 1
• 208000032984 Intraoperative Complications Diseases 0.000 description 1
• 208000016286 Iron metabolism disease Diseases 0.000 description 1
• SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 1
• SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 1
• HXEACLLIILLPRG-YFKPBYRVSA-N L-pipecolic acid Chemical compound [O-]C(=O)[C@@H]1CCCC[NH2+]1 HXEACLLIILLPRG-YFKPBYRVSA-N 0.000 description 1
• DZLNHFMRPBPULJ-VKHMYHEASA-N L-thioproline Chemical compound OC(=O)[C@@H]1CSCN1 DZLNHFMRPBPULJ-VKHMYHEASA-N 0.000 description 1
• KKJQZEWNZXRJFG-UHFFFAOYSA-N L-trans-4-Methyl-2-pyrrolidinecarboxylic acid Chemical compound CC1CNC(C(O)=O)C1 KKJQZEWNZXRJFG-UHFFFAOYSA-N 0.000 description 1
• 241000272168 Laridae Species 0.000 description 1
• HASRFYOMVPJRPU-SRVKXCTJSA-N Leu-Arg-Glu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(O)=O HASRFYOMVPJRPU-SRVKXCTJSA-N 0.000 description 1
• OMHLATXVNQSALM-FQUUOJAGSA-N Leu-Ile-Pro Chemical compound CC[C@H](C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@H](CC(C)C)N OMHLATXVNQSALM-FQUUOJAGSA-N 0.000 description 1
• KPYAOIVPJKPIOU-KKUMJFAQSA-N Leu-Lys-Lys Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O KPYAOIVPJKPIOU-KKUMJFAQSA-N 0.000 description 1
• GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 description 1
• 102000013519 Lipocalin-2 Human genes 0.000 description 1
• 108010051335 Lipocalin-2 Proteins 0.000 description 1
• 102000004895 Lipoproteins Human genes 0.000 description 1
• 108090001030 Lipoproteins Proteins 0.000 description 1
• HAUUXTXKJNVIFY-ONGXEEELSA-N Lys-Gly-Val Chemical compound [H]N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O HAUUXTXKJNVIFY-ONGXEEELSA-N 0.000 description 1
• CBNMHRCLYBJIIZ-XUXIUFHCSA-N Lys-Ile-Met Chemical compound CC[C@H](C)[C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CCCCN)N CBNMHRCLYBJIIZ-XUXIUFHCSA-N 0.000 description 1
• VUTWYNQUSJWBHO-BZSNNMDCSA-N Lys-Leu-Tyr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O VUTWYNQUSJWBHO-BZSNNMDCSA-N 0.000 description 1
• ATNKHRAIZCMCCN-BZSNNMDCSA-N Lys-Lys-Phe Chemical compound C1=CC=C(C=C1)C[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)N ATNKHRAIZCMCCN-BZSNNMDCSA-N 0.000 description 1
• LNMKRJJLEFASGA-BZSNNMDCSA-N Lys-Phe-Leu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(O)=O LNMKRJJLEFASGA-BZSNNMDCSA-N 0.000 description 1
• GIKFNMZSGYAPEJ-HJGDQZAQSA-N Lys-Thr-Asp Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O GIKFNMZSGYAPEJ-HJGDQZAQSA-N 0.000 description 1
• NROQVSYLPRLJIP-PMVMPFDFSA-N Lys-Trp-Tyr Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O NROQVSYLPRLJIP-PMVMPFDFSA-N 0.000 description 1
• 101710085938 Matrix protein Proteins 0.000 description 1
• 101710127721 Membrane protein Proteins 0.000 description 1
• RXWPLVRJQNWXRQ-IHRRRGAJSA-N Met-His-His Chemical compound C([C@H](NC(=O)[C@@H](N)CCSC)C(=O)N[C@@H](CC=1N=CNC=1)C(O)=O)C1=CNC=N1 RXWPLVRJQNWXRQ-IHRRRGAJSA-N 0.000 description 1
• GWADARYJIJDYRC-XGEHTFHBSA-N Met-Thr-Ser Chemical compound CSCC[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O GWADARYJIJDYRC-XGEHTFHBSA-N 0.000 description 1
• 241000699666 Mus <mouse, genus> Species 0.000 description 1
• 206010028470 Mycoplasma infections Diseases 0.000 description 1
• 208000031888 Mycoses Diseases 0.000 description 1
• 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
• 102100032965 Myomesin-2 Human genes 0.000 description 1
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 1
• 108010079364 N-glycylalanine Proteins 0.000 description 1
• 102000004722 NADPH Oxidases Human genes 0.000 description 1
• 108010002998 NADPH Oxidases Proteins 0.000 description 1
• 206010028813 Nausea Diseases 0.000 description 1
• 208000012902 Nervous system disease Diseases 0.000 description 1
• 101100068676 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) gln-1 gene Proteins 0.000 description 1
• 108091005461 Nucleic proteins Proteins 0.000 description 1
• 102000012404 Orosomucoid Human genes 0.000 description 1
• 108010061952 Orosomucoid Proteins 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 238000012408 PCR amplification Methods 0.000 description 1
• 238000010222 PCR analysis Methods 0.000 description 1
• 108700020962 Peroxidase Proteins 0.000 description 1
• 102000003992 Peroxidases Human genes 0.000 description 1
• CMHTUJQZQXFNTQ-OEAJRASXSA-N Phe-Leu-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)N)O CMHTUJQZQXFNTQ-OEAJRASXSA-N 0.000 description 1
• KNYPNEYICHHLQL-ACRUOGEOSA-N Phe-Leu-Tyr Chemical compound C([C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(O)=O)C1=CC=CC=C1 KNYPNEYICHHLQL-ACRUOGEOSA-N 0.000 description 1
• WEDZFLRYSIDIRX-IHRRRGAJSA-N Phe-Ser-Arg Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC1=CC=CC=C1 WEDZFLRYSIDIRX-IHRRRGAJSA-N 0.000 description 1
• OLZVAVSJEUAOHI-UNQGMJICSA-N Phe-Thr-Met Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCSC)C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)N)O OLZVAVSJEUAOHI-UNQGMJICSA-N 0.000 description 1
• 241000224016 Plasmodium Species 0.000 description 1
• 229920001213 Polysorbate 20 Polymers 0.000 description 1
• 208000004880 Polyuria Diseases 0.000 description 1
• 208000035965 Postoperative Complications Diseases 0.000 description 1
• 206010036600 Premature labour Diseases 0.000 description 1
• CJZTUKSFZUSNCC-FXQIFTODSA-N Pro-Asp-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1 CJZTUKSFZUSNCC-FXQIFTODSA-N 0.000 description 1
• VYWNORHENYEQDW-YUMQZZPRSA-N Pro-Gly-Glu Chemical compound OC(=O)CC[C@@H](C(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1 VYWNORHENYEQDW-YUMQZZPRSA-N 0.000 description 1
• VZKBJNBZMZHKRC-XUXIUFHCSA-N Pro-Ile-Leu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O VZKBJNBZMZHKRC-XUXIUFHCSA-N 0.000 description 1
• CHYAYDLYYIJCKY-OSUNSFLBSA-N Pro-Thr-Ile Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O CHYAYDLYYIJCKY-OSUNSFLBSA-N 0.000 description 1
• AIOWVDNPESPXRB-YTWAJWBKSA-N Pro-Thr-Pro Chemical compound C[C@H]([C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@@H]2CCCN2)O AIOWVDNPESPXRB-YTWAJWBKSA-N 0.000 description 1
• ZMLRZBWCXPQADC-TUAOUCFPSA-N Pro-Val-Pro Chemical compound CC(C)[C@@H](C(=O)N1CCC[C@@H]1C(=O)O)NC(=O)[C@@H]2CCCN2 ZMLRZBWCXPQADC-TUAOUCFPSA-N 0.000 description 1
• 102100027378 Prothrombin Human genes 0.000 description 1
• 108010094028 Prothrombin Proteins 0.000 description 1
• 238000002123 RNA extraction Methods 0.000 description 1
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
• 230000010757 Reduction Activity Effects 0.000 description 1
• 206010063837 Reperfusion injury Diseases 0.000 description 1
• 206010038687 Respiratory distress Diseases 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 108010077895 Sarcosine Proteins 0.000 description 1
• 229940125377 Selective β-Amyloid-Lowering Agent Drugs 0.000 description 1
• VQBLHWSPVYYZTB-DCAQKATOSA-N Ser-Arg-His Chemical compound C1=C(NC=N1)C[C@@H](C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)N VQBLHWSPVYYZTB-DCAQKATOSA-N 0.000 description 1
• LWMQRHDTXHQQOV-MXAVVETBSA-N Ser-Ile-Phe Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O LWMQRHDTXHQQOV-MXAVVETBSA-N 0.000 description 1
• LPSKHZWBQONOQJ-XIRDDKMYSA-N Ser-Lys-Trp Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)N LPSKHZWBQONOQJ-XIRDDKMYSA-N 0.000 description 1
• NADLKBTYNKUJEP-KATARQTJSA-N Ser-Thr-Leu Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O NADLKBTYNKUJEP-KATARQTJSA-N 0.000 description 1
• HAYADTTXNZFUDM-IHRRRGAJSA-N Ser-Tyr-Val Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(O)=O HAYADTTXNZFUDM-IHRRRGAJSA-N 0.000 description 1
• 241000607768 Shigella Species 0.000 description 1
• 206010049771 Shock haemorrhagic Diseases 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• 206010072170 Skin wound Diseases 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
• 208000002847 Surgical Wound Diseases 0.000 description 1
• 206010043391 Thalassaemia beta Diseases 0.000 description 1
• VOGXLRKCWFLJBY-HSHDSVGOSA-N Thr-Arg-Trp Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)N)O VOGXLRKCWFLJBY-HSHDSVGOSA-N 0.000 description 1
• JVTHIXKSVYEWNI-JRQIVUDYSA-N Thr-Asn-Tyr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O JVTHIXKSVYEWNI-JRQIVUDYSA-N 0.000 description 1
• JEDIEMIJYSRUBB-FOHZUACHSA-N Thr-Asp-Gly Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O JEDIEMIJYSRUBB-FOHZUACHSA-N 0.000 description 1
• XDARBNMYXKUFOJ-GSSVUCPTSA-N Thr-Asp-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O XDARBNMYXKUFOJ-GSSVUCPTSA-N 0.000 description 1
• KWQBJOUOSNJDRR-XAVMHZPKSA-N Thr-Cys-Pro Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CS)C(=O)N1CCC[C@@H]1C(=O)O)N)O KWQBJOUOSNJDRR-XAVMHZPKSA-N 0.000 description 1
• MGJLBZFUXUGMML-VOAKCMCISA-N Thr-Lys-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N)O MGJLBZFUXUGMML-VOAKCMCISA-N 0.000 description 1
• UJQVSMNQMQHVRY-KZVJFYERSA-N Thr-Met-Ala Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(O)=O UJQVSMNQMQHVRY-KZVJFYERSA-N 0.000 description 1
• MCDVZTRGHNXTGK-HJGDQZAQSA-N Thr-Met-Glu Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(O)=O MCDVZTRGHNXTGK-HJGDQZAQSA-N 0.000 description 1
• MROIJTGJGIDEEJ-RCWTZXSCSA-N Thr-Pro-Pro Chemical compound C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(O)=O)CCC1 MROIJTGJGIDEEJ-RCWTZXSCSA-N 0.000 description 1
• SGAOHNPSEPVAFP-ZDLURKLDSA-N Thr-Ser-Gly Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)NCC(O)=O SGAOHNPSEPVAFP-ZDLURKLDSA-N 0.000 description 1
• RVMNUBQWPVOUKH-HEIBUPTGSA-N Thr-Ser-Thr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O RVMNUBQWPVOUKH-HEIBUPTGSA-N 0.000 description 1
• MNYNCKZAEIAONY-XGEHTFHBSA-N Thr-Val-Ser Chemical compound C[C@@H](O)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(O)=O MNYNCKZAEIAONY-XGEHTFHBSA-N 0.000 description 1
• 208000024799 Thyroid disease Diseases 0.000 description 1
• 108020004566 Transfer RNA Proteins 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• 239000007983 Tris buffer Substances 0.000 description 1
• LAIUAVGWZYTBKN-VHWLVUOQSA-N Trp-Asn-Ile Chemical compound CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(O)=O LAIUAVGWZYTBKN-VHWLVUOQSA-N 0.000 description 1
• RRVUOLRWIZXBRQ-IHPCNDPISA-N Trp-Leu-Lys Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)N RRVUOLRWIZXBRQ-IHPCNDPISA-N 0.000 description 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
• 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
• NSOMQRHZMJMZIE-GVARAGBVSA-N Tyr-Ala-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 NSOMQRHZMJMZIE-GVARAGBVSA-N 0.000 description 1
• AYHSJESDFKREAR-KKUMJFAQSA-N Tyr-Asn-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 AYHSJESDFKREAR-KKUMJFAQSA-N 0.000 description 1
• SLCSPPCQWUHPPO-JYJNAYRXSA-N Tyr-Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 SLCSPPCQWUHPPO-JYJNAYRXSA-N 0.000 description 1
• WVGKPKDWYQXWLU-BZSNNMDCSA-N Tyr-His-Lys Chemical compound C1=CC(=CC=C1C[C@@H](C(=O)N[C@@H](CC2=CN=CN2)C(=O)N[C@@H](CCCCN)C(=O)O)N)O WVGKPKDWYQXWLU-BZSNNMDCSA-N 0.000 description 1
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
• 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
• KOPBYUSPXBQIHD-NRPADANISA-N Val-Cys-Glu Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N KOPBYUSPXBQIHD-NRPADANISA-N 0.000 description 1
• ZIGZPYJXIWLQFC-QTKMDUPCSA-N Val-His-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)[C@H](C(C)C)N)O ZIGZPYJXIWLQFC-QTKMDUPCSA-N 0.000 description 1
• SJRUJQFQVLMZFW-WPRPVWTQSA-N Val-Pro-Gly Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O SJRUJQFQVLMZFW-WPRPVWTQSA-N 0.000 description 1
• SSKKGOWRPNIVDW-AVGNSLFASA-N Val-Val-His Chemical compound CC(C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N SSKKGOWRPNIVDW-AVGNSLFASA-N 0.000 description 1
• 208000035868 Vascular inflammations Diseases 0.000 description 1
• 206010047139 Vasoconstriction Diseases 0.000 description 1
• 229930003268 Vitamin C Natural products 0.000 description 1
• 229930003316 Vitamin D Natural products 0.000 description 1
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
• 208000018839 Wilson disease Diseases 0.000 description 1
• 102000005773 Xanthine dehydrogenase Human genes 0.000 description 1
• 108010091383 Xanthine dehydrogenase Proteins 0.000 description 1
• 102100033220 Xanthine oxidase Human genes 0.000 description 1
• 241000269370 Xenopus <genus> Species 0.000 description 1
• 241000269368 Xenopus laevis Species 0.000 description 1
• XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
• 210000000683 abdominal cavity Anatomy 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000011149 active material Substances 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 230000006838 adverse reaction Effects 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 108010087924 alanylproline Proteins 0.000 description 1
• 208000026935 allergic disease Diseases 0.000 description 1
• 230000007815 allergy Effects 0.000 description 1
• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 description 1
• 230000000689 aminoacylating effect Effects 0.000 description 1
• 210000004381 amniotic fluid Anatomy 0.000 description 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• 230000002587 anti-hemolytic effect Effects 0.000 description 1
• 230000002924 anti-infective effect Effects 0.000 description 1
• 229940124599 anti-inflammatory drug Drugs 0.000 description 1
• 230000002141 anti-parasite Effects 0.000 description 1
• 230000000840 anti-viral effect Effects 0.000 description 1
• 230000005875 antibody response Effects 0.000 description 1
• 230000010100 anticoagulation Effects 0.000 description 1
• 239000002246 antineoplastic agent Substances 0.000 description 1
• SDNYTAYICBFYFH-TUFLPTIASA-N antipain Chemical compound NC(N)=NCCC[C@@H](C=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 SDNYTAYICBFYFH-TUFLPTIASA-N 0.000 description 1
• 108010091092 arginyl-glycyl-proline Proteins 0.000 description 1
• 208000011775 arteriosclerosis disease Diseases 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 108010038633 aspartylglutamate Proteins 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 230000003143 atherosclerotic effect Effects 0.000 description 1
• 208000010668 atopic eczema Diseases 0.000 description 1
• 230000001363 autoimmune Effects 0.000 description 1
• 230000006470 autoimmune attack Effects 0.000 description 1
• 230000005784 autoimmunity Effects 0.000 description 1
• 230000001580 bacterial effect Effects 0.000 description 1
• 210000002469 basement membrane Anatomy 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 230000000975 bioactive effect Effects 0.000 description 1
• 239000013060 biological fluid Substances 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000008512 biological response Effects 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 239000000090 biomarker Substances 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 230000008499 blood brain barrier function Effects 0.000 description 1
• 230000036772 blood pressure Effects 0.000 description 1
• 210000001218 blood-brain barrier Anatomy 0.000 description 1
• 210000001124 body fluid Anatomy 0.000 description 1
• 239000010839 body fluid Substances 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 230000003139 buffering effect Effects 0.000 description 1
• 239000006227 byproduct Substances 0.000 description 1
• 238000010805 cDNA synthesis kit Methods 0.000 description 1
• 238000004422 calculation algorithm Methods 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 230000004856 capillary permeability Effects 0.000 description 1
• 125000000837 carbohydrate group Chemical group 0.000 description 1
• 229910052799 carbon Inorganic materials 0.000 description 1
• 229910002091 carbon monoxide Inorganic materials 0.000 description 1
• 230000006315 carbonylation Effects 0.000 description 1
• 238000005810 carbonylation reaction Methods 0.000 description 1
• 230000000747 cardiac effect Effects 0.000 description 1
• 210000000845 cartilage Anatomy 0.000 description 1
• 238000006555 catalytic reaction Methods 0.000 description 1
• 230000001364 causal effect Effects 0.000 description 1
• 230000025084 cell cycle arrest Effects 0.000 description 1
• 230000022534 cell killing Effects 0.000 description 1
• 230000006037 cell lysis Effects 0.000 description 1
• 239000013553 cell monolayer Substances 0.000 description 1
• 230000003833 cell viability Effects 0.000 description 1
• 210000004671 cell-free system Anatomy 0.000 description 1
• 108091092356 cellular DNA Proteins 0.000 description 1
• 230000010001 cellular homeostasis Effects 0.000 description 1
• 230000030570 cellular localization Effects 0.000 description 1
• 230000033077 cellular process Effects 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 239000002738 chelating agent Substances 0.000 description 1
• 238000002655 chelation therapy Methods 0.000 description 1
• 238000002512 chemotherapy Methods 0.000 description 1
• XFIOKOXROGCUQX-UHFFFAOYSA-N chloroform;guanidine;phenol Chemical compound NC(N)=N.ClC(Cl)Cl.OC1=CC=CC=C1 XFIOKOXROGCUQX-UHFFFAOYSA-N 0.000 description 1
• 208000037976 chronic inflammation Diseases 0.000 description 1
• 230000006020 chronic inflammation Effects 0.000 description 1
• 230000012085 chronic inflammatory response Effects 0.000 description 1
• 239000011248 coating agent Substances 0.000 description 1
• 238000000576 coating method Methods 0.000 description 1
• 230000037319 collagen production Effects 0.000 description 1
• 238000007398 colorimetric assay Methods 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 239000002299 complementary DNA Substances 0.000 description 1
• 230000009918 complex formation Effects 0.000 description 1
• 230000003750 conditioning effect Effects 0.000 description 1
• 210000002808 connective tissue Anatomy 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 230000010485 coping Effects 0.000 description 1
• 229910001431 copper ion Inorganic materials 0.000 description 1
• 210000004351 coronary vessel Anatomy 0.000 description 1
• 230000002594 corticospinal effect Effects 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 229940127089 cytotoxic agent Drugs 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 210000003785 decidua Anatomy 0.000 description 1
• 230000002950 deficient Effects 0.000 description 1
• 210000004443 dendritic cell Anatomy 0.000 description 1
• 238000000432 density-gradient centrifugation Methods 0.000 description 1
• 230000001687 destabilization Effects 0.000 description 1
• 229910001882 dioxygen Inorganic materials 0.000 description 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
• 238000007599 discharging Methods 0.000 description 1
• 231100000676 disease causative agent Toxicity 0.000 description 1
• 208000016097 disease of metabolism Diseases 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• 230000035619 diuresis Effects 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 210000003027 ear inner Anatomy 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 230000002357 endometrial effect Effects 0.000 description 1
• 210000002889 endothelial cell Anatomy 0.000 description 1
• 210000003038 endothelium Anatomy 0.000 description 1
• 238000005516 engineering process Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 238000003912 environmental pollution Methods 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 210000000267 erythroid cell Anatomy 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• 210000003013 erythroid precursor cell Anatomy 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• 238000011156 evaluation Methods 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 210000005002 female reproductive tract Anatomy 0.000 description 1
• 208000001031 fetal erythroblastosis Diseases 0.000 description 1
• 239000000835 fiber Substances 0.000 description 1
• 210000002950 fibroblast Anatomy 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• 229930003935 flavonoid Natural products 0.000 description 1
• 150000002215 flavonoids Chemical class 0.000 description 1
• 235000017173 flavonoids Nutrition 0.000 description 1
• 238000001215 fluorescent labelling Methods 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 230000002496 gastric effect Effects 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 238000001502 gel electrophoresis Methods 0.000 description 1
• 238000002523 gelfiltration Methods 0.000 description 1
• 238000003500 gene array Methods 0.000 description 1
• 102000034356 gene-regulatory proteins Human genes 0.000 description 1
• 108091006104 gene-regulatory proteins Proteins 0.000 description 1
• 108060003196 globin Proteins 0.000 description 1
• 102000018146 globin Human genes 0.000 description 1
• 230000024924 glomerular filtration Effects 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 235000013922 glutamic acid Nutrition 0.000 description 1
• 239000004220 glutamic acid Substances 0.000 description 1
• 108010055341 glutamyl-glutamic acid Proteins 0.000 description 1
• LXJXRIRHZLFYRP-UHFFFAOYSA-N glyceraldehyde 3-phosphate Chemical compound O=CC(O)COP(O)(O)=O LXJXRIRHZLFYRP-UHFFFAOYSA-N 0.000 description 1
• VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 1
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Natural products NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 description 1
• 108010001064 glycyl-glycyl-glycyl-glycine Proteins 0.000 description 1
• 108010015792 glycyllysine Proteins 0.000 description 1
• 108010077515 glycylproline Proteins 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 208000024908 graft versus host disease Diseases 0.000 description 1
• 230000009554 growth spurt Effects 0.000 description 1
• 230000005802 health problem Effects 0.000 description 1
• 230000036074 healthy skin Effects 0.000 description 1
• 108010036302 hemoglobin AS Proteins 0.000 description 1
• 108010028295 histidylhistidine Proteins 0.000 description 1
• 239000005556 hormone Substances 0.000 description 1
• 229940088597 hormone Drugs 0.000 description 1
• 210000005260 human cell Anatomy 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• MWFRVMDVLYIXJF-BYPYZUCNSA-N hydroxyethylcysteine Chemical compound OC(=O)[C@@H](N)CSCCO MWFRVMDVLYIXJF-BYPYZUCNSA-N 0.000 description 1
• TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
• 230000033444 hydroxylation Effects 0.000 description 1
• 238000005805 hydroxylation reaction Methods 0.000 description 1
• 230000036543 hypotension Effects 0.000 description 1
• 230000007954 hypoxia Effects 0.000 description 1
• 101150026046 iga gene Proteins 0.000 description 1
• 230000002519 immonomodulatory effect Effects 0.000 description 1
• 230000008105 immune reaction Effects 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 210000000987 immune system Anatomy 0.000 description 1
• 230000002163 immunogen Effects 0.000 description 1
• 238000010874 in vitro model Methods 0.000 description 1
• 239000000411 inducer Substances 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 230000009027 insemination Effects 0.000 description 1
• 238000003780 insertion Methods 0.000 description 1
• 230000037431 insertion Effects 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 230000000745 ion overload Effects 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 239000002085 irritant Substances 0.000 description 1
• 231100000021 irritant Toxicity 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• 230000000302 ischemic effect Effects 0.000 description 1
• 210000004153 islets of langerhan Anatomy 0.000 description 1
• HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
• 239000010410 layer Substances 0.000 description 1
• GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
• 108010052968 leupeptin Proteins 0.000 description 1
• 230000001795 light effect Effects 0.000 description 1
• 238000012417 linear regression Methods 0.000 description 1
• 235000019136 lipoic acid Nutrition 0.000 description 1
• 231100000516 lung damage Toxicity 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 150000002669 lysines Chemical class 0.000 description 1
• 230000002934 lysing effect Effects 0.000 description 1
• 108010054155 lysyllysine Proteins 0.000 description 1
• 108010038320 lysylphenylalanine Proteins 0.000 description 1
• 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
• 230000036244 malformation Effects 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 238000004949 mass spectrometry Methods 0.000 description 1
• 230000008590 mechanical hemolysis Effects 0.000 description 1
• 210000002901 mesenchymal stem cell Anatomy 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• 108010056582 methionylglutamic acid Proteins 0.000 description 1
• 238000000520 microinjection Methods 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 208000015994 miscarriage Diseases 0.000 description 1
• 210000003470 mitochondria Anatomy 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
• 201000006417 multiple sclerosis Diseases 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 208000010125 myocardial infarction Diseases 0.000 description 1
• 208000031225 myocardial ischemia Diseases 0.000 description 1
• 239000002105 nanoparticle Substances 0.000 description 1
• 230000008693 nausea Effects 0.000 description 1
• 230000001338 necrotic effect Effects 0.000 description 1
• 230000004770 neurodegeneration Effects 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 230000000926 neurological effect Effects 0.000 description 1
• BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
• 230000009871 nonspecific binding Effects 0.000 description 1
• 235000003715 nutritional status Nutrition 0.000 description 1
• 229920002113 octoxynol Polymers 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• 210000004248 oligodendroglia Anatomy 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 210000000287 oocyte Anatomy 0.000 description 1
• 238000011369 optimal treatment Methods 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 210000003101 oviduct Anatomy 0.000 description 1
• 108010071584 oxidized low density lipoprotein Proteins 0.000 description 1
• 239000003002 pH adjusting agent Substances 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 230000001314 paroxysmal effect Effects 0.000 description 1
• 230000008775 paternal effect Effects 0.000 description 1
• 230000007310 pathophysiology Effects 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 239000008188 pellet Substances 0.000 description 1
• 229950000964 pepstatin Drugs 0.000 description 1
• 108010091212 pepstatin Proteins 0.000 description 1
• FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
• 210000003200 peritoneal cavity Anatomy 0.000 description 1
• 210000004303 peritoneum Anatomy 0.000 description 1
• 230000002085 persistent effect Effects 0.000 description 1
• 238000002205 phenol-chloroform extraction Methods 0.000 description 1
• 108010051242 phenylalanylserine Proteins 0.000 description 1
• 230000019612 pigmentation Effects 0.000 description 1
• 230000028742 placenta development Effects 0.000 description 1
• 210000005059 placental tissue Anatomy 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 239000011505 plaster Substances 0.000 description 1
• 231100000614 poison Toxicity 0.000 description 1
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1
• RWPGFSMJFRPDDP-UHFFFAOYSA-L potassium metabisulfite Chemical compound [K+].[K+].[O-]S(=O)S([O-])(=O)=O RWPGFSMJFRPDDP-UHFFFAOYSA-L 0.000 description 1
• 229940124606 potential therapeutic agent Drugs 0.000 description 1
• 239000000843 powder Substances 0.000 description 1
• 239000002244 precipitate Substances 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 230000003449 preventive effect Effects 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 230000000750 progressive effect Effects 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 108010077112 prolyl-proline Proteins 0.000 description 1
• 108010004914 prolylarginine Proteins 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 230000002633 protecting effect Effects 0.000 description 1
• 239000011814 protection agent Substances 0.000 description 1
• 201000001474 proteinuria Diseases 0.000 description 1
• 230000006337 proteolytic cleavage Effects 0.000 description 1
• 229940039716 prothrombin Drugs 0.000 description 1
• 238000011002 quantification Methods 0.000 description 1
• 235000008001 rakum palm Nutrition 0.000 description 1
• 239000011535 reaction buffer Substances 0.000 description 1
• 230000007115 recruitment Effects 0.000 description 1
• 238000006479 redox reaction Methods 0.000 description 1
• 230000001172 regenerating effect Effects 0.000 description 1
• 238000000611 regression analysis Methods 0.000 description 1
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
• 230000003716 rejuvenation Effects 0.000 description 1
• 230000011506 response to oxidative stress Effects 0.000 description 1
• 230000003938 response to stress Effects 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• 239000012487 rinsing solution Substances 0.000 description 1
• 239000012266 salt solution Substances 0.000 description 1
• 238000012216 screening Methods 0.000 description 1
• 229940076279 serotonin Drugs 0.000 description 1
• 239000002453 shampoo Substances 0.000 description 1
• 206010040560 shock Diseases 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 239000000779 smoke Substances 0.000 description 1
• 239000000344 soap Substances 0.000 description 1
• 210000000952 spleen Anatomy 0.000 description 1
• 208000000995 spontaneous abortion Diseases 0.000 description 1
• 230000007480 spreading Effects 0.000 description 1
• 238000003892 spreading Methods 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 230000037072 sun protection Effects 0.000 description 1
• 239000013589 supplement Substances 0.000 description 1
• 230000009469 supplementation Effects 0.000 description 1
• 230000008093 supporting effect Effects 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 230000035900 sweating Effects 0.000 description 1
• 238000002636 symptomatic treatment Methods 0.000 description 1
• 208000011580 syndromic disease Diseases 0.000 description 1
• 230000002194 synthesizing effect Effects 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• NPDBDJFLKKQMCM-UHFFFAOYSA-N tert-butylglycine Chemical compound CC(C)(C)C(N)C(O)=O NPDBDJFLKKQMCM-UHFFFAOYSA-N 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 229960002663 thioctic acid Drugs 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 239000003440 toxic substance Substances 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 231100000765 toxin Toxicity 0.000 description 1
• 108700012359 toxins Proteins 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 239000012096 transfection reagent Substances 0.000 description 1
• 239000012581 transferrin Substances 0.000 description 1
• 230000032258 transport Effects 0.000 description 1
• 210000002993 trophoblast Anatomy 0.000 description 1
• 108010080629 tryptophan-leucine Proteins 0.000 description 1
• 108010044292 tryptophyltyrosine Proteins 0.000 description 1
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 238000002604 ultrasonography Methods 0.000 description 1
• 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
• 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
• 230000008346 uterine blood flow Effects 0.000 description 1
• 230000008347 uteroplacental blood flow Effects 0.000 description 1
• 210000004291 uterus Anatomy 0.000 description 1
• 230000002227 vasoactive effect Effects 0.000 description 1
• 230000025033 vasoconstriction Effects 0.000 description 1
• 239000005526 vasoconstrictor agent Substances 0.000 description 1
• 235000015112 vegetable and seed oil Nutrition 0.000 description 1
• 239000008158 vegetable oil Substances 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 238000011179 visual inspection Methods 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 235000019166 vitamin D Nutrition 0.000 description 1
• 239000011710 vitamin D Substances 0.000 description 1
• 150000003710 vitamin D derivatives Chemical class 0.000 description 1
• 229940046009 vitamin E Drugs 0.000 description 1
• 229940046008 vitamin d Drugs 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 239000011787 zinc oxide Substances 0.000 description 1