JP5677721B2 - Ｔｒｐｖ発現レベルの制御 - Google Patents

Ｔｒｐｖ発現レベルの制御 Download PDF

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Publication number
JP5677721B2
JP5677721B2 JP2008536136A JP2008536136A JP5677721B2 JP 5677721 B2 JP5677721 B2 JP 5677721B2 JP 2008536136 A JP2008536136 A JP 2008536136A JP 2008536136 A JP2008536136 A JP 2008536136A JP 5677721 B2 JP5677721 B2 JP 5677721B2
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Prior art keywords
sina
trpv1
sirna
seq
nucleotides
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Japanese (ja)
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JP2009512673A5 (enExample
JP2009512673A (ja
Inventor
マリア・デル・カルメン・アコスタ・ボフ
フアナ・ガジャー・マルティネス
アンジェラ・セスト・ジャゲ
マリア・コンセプシオン・ヒメネス・ゴメス
カルロス・ベルモンテ・マルティネス
アナ・イサベル・ヒメネス・アントン
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シレンティス・エセ・ア・ウ
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Control Of El Displays (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transmitters (AREA)
  • Amplitude Modulation (AREA)
  • Amplifiers (AREA)
  • Details Of Television Scanning (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
JP2008536136A 2005-10-20 2006-10-20 Ｔｒｐｖ発現レベルの制御 Active JP5677721B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0521351.7A GB0521351D0 (en) 2005-10-20 2005-10-20 Modulation of TRPV expression levels
GB0521351.7 2005-10-20
PCT/GB2006/050342 WO2007045930A2 (en) 2005-10-20 2006-10-20 Modulation of trpv expression levels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013007528A Division JP2013074902A (ja) 2005-10-20 2013-01-18 Ｔｒｐｖ発現レベルの制御

Publications (3)

Publication Number Publication Date
JP2009512673A JP2009512673A (ja) 2009-03-26
JP2009512673A5 JP2009512673A5 (enExample) 2012-08-09
JP5677721B2 true JP5677721B2 (ja) 2015-02-25

Family

ID=35458356

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008536136A Active JP5677721B2 (ja) 2005-10-20 2006-10-20 Ｔｒｐｖ発現レベルの制御
JP2013007528A Pending JP2013074902A (ja) 2005-10-20 2013-01-18 Ｔｒｐｖ発現レベルの制御

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013007528A Pending JP2013074902A (ja) 2005-10-20 2013-01-18 Ｔｒｐｖ発現レベルの制御

Country Status (15)

Country Link
US (1) US8354385B2 (enExample)
EP (1) EP1937281B1 (enExample)
JP (2) JP5677721B2 (enExample)
AT (1) ATE493994T1 (enExample)
AU (1) AU2006305657B2 (enExample)
CA (1) CA2626181C (enExample)
CY (1) CY1111384T1 (enExample)
DE (1) DE602006019458D1 (enExample)
DK (1) DK1937281T3 (enExample)
ES (1) ES2358538T3 (enExample)
GB (1) GB0521351D0 (enExample)
PL (1) PL1937281T3 (enExample)
PT (1) PT1937281E (enExample)
SI (1) SI1937281T1 (enExample)
WO (1) WO2007045930A2 (enExample)

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EP2865759B1 (en) * 2012-06-20 2017-05-17 NapaJen Pharma, Inc. Nucleic acid complex and nucleic acid-polysaccharide complex
GB201215857D0 (en) 2012-09-05 2012-10-24 Sylentis Sau siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
KR101681229B1 (ko) 2013-07-24 2016-11-30 고려대학교 산학협력단 TRPV4 활성 억제제로서의 vorinostat의 용도
GB202219829D0 (en) 2022-12-29 2023-02-15 Ivy Farm Tech Limited Genetically manipulated cells
WO2025215354A1 (en) 2024-04-08 2025-10-16 Ivy Farm Technologies Limited Method of culturing an animal cell

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Also Published As

Publication number Publication date
DE602006019458D1 (de) 2011-02-17
ATE493994T1 (de) 2011-01-15
JP2009512673A (ja) 2009-03-26
WO2007045930A2 (en) 2007-04-26
ES2358538T3 (es) 2011-05-11
CA2626181C (en) 2014-03-18
US20100286230A1 (en) 2010-11-11
GB0521351D0 (en) 2005-11-30
DK1937281T3 (da) 2011-05-02
PT1937281E (pt) 2011-03-29
CA2626181A1 (en) 2007-04-26
PL1937281T3 (pl) 2011-06-30
AU2006305657A1 (en) 2007-04-26
WO2007045930A3 (en) 2007-07-12
HK1120741A1 (en) 2009-04-09
EP1937281B1 (en) 2011-01-05
CY1111384T1 (el) 2015-08-05
US8354385B2 (en) 2013-01-15
SI1937281T1 (sl) 2011-09-30
JP2013074902A (ja) 2013-04-25
EP1937281A2 (en) 2008-07-02
AU2006305657B2 (en) 2011-10-20

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