CA2626181C - Modulation of trpv expression levels - Google Patents
Modulation of trpv expression levels Download PDFInfo
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- CA2626181C CA2626181C CA2626181A CA2626181A CA2626181C CA 2626181 C CA2626181 C CA 2626181C CA 2626181 A CA2626181 A CA 2626181A CA 2626181 A CA2626181 A CA 2626181A CA 2626181 C CA2626181 C CA 2626181C
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- trpv1
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- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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Landscapes
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| TW200927192A (en) * | 2007-11-19 | 2009-07-01 | Alcon Res Ltd | Use of TRPV1 receptor antagonists for treating dry eye and ocular pain |
| EP2390327A1 (en) * | 2010-05-27 | 2011-11-30 | Sylentis S.A. | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| EP2865759B1 (en) * | 2012-06-20 | 2017-05-17 | NapaJen Pharma, Inc. | Nucleic acid complex and nucleic acid-polysaccharide complex |
| GB201215857D0 (en) | 2012-09-05 | 2012-10-24 | Sylentis Sau | siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions |
| KR101681229B1 (ko) | 2013-07-24 | 2016-11-30 | 고려대학교 산학협력단 | TRPV4 활성 억제제로서의 vorinostat의 용도 |
| GB202219829D0 (en) | 2022-12-29 | 2023-02-15 | Ivy Farm Tech Limited | Genetically manipulated cells |
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| US4652586A (en) | 1980-11-07 | 1987-03-24 | The General Hospital Corporation | Selective beta-2 adrenergic antagonists for the treatment of glaucoma |
| US4617299A (en) | 1983-12-19 | 1986-10-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
| US5242943A (en) | 1984-03-28 | 1993-09-07 | William J. Louis | 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them |
| US4812448A (en) | 1984-10-22 | 1989-03-14 | Knepper Paul A | Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension |
| US4757089A (en) | 1985-06-14 | 1988-07-12 | Massachusetts Eye And Ear Infirmary | Increasing aqueous humor outflow |
| US5075323A (en) | 1988-08-24 | 1991-12-24 | Aktiebolaget Hassle | Compounds including omeprazole in the treatment of glaucoma |
| US5260059A (en) | 1989-04-14 | 1993-11-09 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor |
| US6372249B1 (en) | 1991-12-16 | 2002-04-16 | Baylor College Of Medicine | Senscent cell-derived inhibitors of DNA synthesis |
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| US5545626A (en) | 1994-01-19 | 1996-08-13 | The Trustees Of Columbia University In The City Of New York | Method of treating glaucoma with oligonucleotides |
| US5585401A (en) | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| US20020055536A1 (en) | 1996-09-26 | 2002-05-09 | Dewitte Robert S. | System and method for structure-based drug design that includes accurate prediction of binding free energy |
| US6489307B1 (en) | 1998-09-14 | 2002-12-03 | University Of Florida | Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use |
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| US6365576B1 (en) | 1999-06-24 | 2002-04-02 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method for inhibiting herpes infection |
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| US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
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| WO2005117938A2 (en) | 2004-04-13 | 2005-12-15 | Regents Of The University Of Minnesota | Methods of treating ocular conditions |
| EP1768954A4 (en) | 2004-06-24 | 2008-05-28 | Incyte Corp | 2-METHYLPROPANAMIDES AND THEIR USE AS PHARMACEUTICALS |
| EP2990410A1 (en) | 2004-08-10 | 2016-03-02 | Alnylam Pharmaceuticals Inc. | Chemically modified oligonucleotides |
| WO2006021817A2 (en) | 2004-08-23 | 2006-03-02 | Sylentis S.A.U. | Treatment of eye disorders characterized by an elevated introacular pressure by sirnas |
| TW200639253A (en) | 2005-02-01 | 2006-11-16 | Alcon Inc | RNAi-mediated inhibition of ocular targets |
| BRPI0609206A2 (pt) | 2005-03-11 | 2010-03-02 | Alcon Inc | inibiÇço mediada por rnai de proteÍna relacionada frizzled-1 para tratamento de glaucoma |
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2005
- 2005-10-20 GB GBGB0521351.7A patent/GB0521351D0/en not_active Ceased
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2006
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- 2006-10-20 US US12/090,426 patent/US8354385B2/en active Active
- 2006-10-20 PL PL06794999T patent/PL1937281T3/pl unknown
- 2006-10-20 ES ES06794999T patent/ES2358538T3/es active Active
- 2006-10-20 AU AU2006305657A patent/AU2006305657B2/en active Active
- 2006-10-20 JP JP2008536136A patent/JP5677721B2/ja active Active
- 2006-10-20 CA CA2626181A patent/CA2626181C/en active Active
- 2006-10-20 DE DE602006019458T patent/DE602006019458D1/de active Active
- 2006-10-20 SI SI200630965T patent/SI1937281T1/sl unknown
- 2006-10-20 DK DK06794999.0T patent/DK1937281T3/da active
- 2006-10-20 EP EP06794999A patent/EP1937281B1/en active Active
- 2006-10-20 PT PT06794999T patent/PT1937281E/pt unknown
- 2006-10-20 WO PCT/GB2006/050342 patent/WO2007045930A2/en not_active Ceased
-
2011
- 2011-04-05 CY CY20111100350T patent/CY1111384T1/el unknown
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| DE602006019458D1 (de) | 2011-02-17 |
| ATE493994T1 (de) | 2011-01-15 |
| JP2009512673A (ja) | 2009-03-26 |
| WO2007045930A2 (en) | 2007-04-26 |
| ES2358538T3 (es) | 2011-05-11 |
| US20100286230A1 (en) | 2010-11-11 |
| GB0521351D0 (en) | 2005-11-30 |
| DK1937281T3 (da) | 2011-05-02 |
| PT1937281E (pt) | 2011-03-29 |
| CA2626181A1 (en) | 2007-04-26 |
| PL1937281T3 (pl) | 2011-06-30 |
| AU2006305657A1 (en) | 2007-04-26 |
| WO2007045930A3 (en) | 2007-07-12 |
| HK1120741A1 (en) | 2009-04-09 |
| EP1937281B1 (en) | 2011-01-05 |
| CY1111384T1 (el) | 2015-08-05 |
| US8354385B2 (en) | 2013-01-15 |
| JP5677721B2 (ja) | 2015-02-25 |
| SI1937281T1 (sl) | 2011-09-30 |
| JP2013074902A (ja) | 2013-04-25 |
| EP1937281A2 (en) | 2008-07-02 |
| AU2006305657B2 (en) | 2011-10-20 |
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