JP5675340B2 - 新規阻害剤 - Google Patents
新規阻害剤 Download PDFInfo
- Publication number
- JP5675340B2 JP5675340B2 JP2010503510A JP2010503510A JP5675340B2 JP 5675340 B2 JP5675340 B2 JP 5675340B2 JP 2010503510 A JP2010503510 A JP 2010503510A JP 2010503510 A JP2010503510 A JP 2010503510A JP 5675340 B2 JP5675340 B2 JP 5675340B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- alkyl
- inhibitor
- imidazol
- nitrovinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000003112 inhibitor Substances 0.000 title claims description 165
- 150000001875 compounds Chemical class 0.000 claims description 144
- -1 cyano, hydroxyl Chemical group 0.000 claims description 137
- 125000000217 alkyl group Chemical group 0.000 claims description 87
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 55
- 239000003814 drug Substances 0.000 claims description 54
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 33
- 125000003118 aryl group Chemical group 0.000 claims description 31
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 31
- 125000000623 heterocyclic group Chemical group 0.000 claims description 26
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- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 17
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 17
- 125000003545 alkoxy group Chemical group 0.000 claims description 17
- 238000006243 chemical reaction Methods 0.000 claims description 17
- 229910052736 halogen Inorganic materials 0.000 claims description 17
- 150000002367 halogens Chemical class 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 108010081484 glutaminyl-peptide cyclotransferase Proteins 0.000 claims description 15
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- 229940079593 drug Drugs 0.000 claims description 14
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- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 11
- 239000012453 solvate Substances 0.000 claims description 11
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- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 7
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- 238000004519 manufacturing process Methods 0.000 claims description 7
- 125000004001 thioalkyl group Chemical group 0.000 claims description 7
- MSYGAHOHLUJIKV-UHFFFAOYSA-N 3,5-dimethyl-1-(3-nitrophenyl)-1h-pyrazole-4-carboxylic acid ethyl ester Chemical compound CC1=C(C(=O)OCC)C(C)=NN1C1=CC=CC([N+]([O-])=O)=C1 MSYGAHOHLUJIKV-UHFFFAOYSA-N 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 6
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- LZCDAPDGXCYOEH-UHFFFAOYSA-N adapalene Chemical compound C1=C(C(O)=O)C=CC2=CC(C3=CC=C(C(=C3)C34CC5CC(CC(C5)C3)C4)OC)=CC=C21 LZCDAPDGXCYOEH-UHFFFAOYSA-N 0.000 claims description 6
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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| US9925282B2 (en) | 2009-01-29 | 2018-03-27 | The General Hospital Corporation | Cromolyn derivatives and related methods of imaging and treatment |
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| EP1713780B1 (en) * | 2004-02-05 | 2012-01-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
| BRPI0718507A2 (pt) * | 2006-09-21 | 2013-11-12 | Probiodrug Ag | Genes relacionados à glutaminil ciclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| WO2008055950A1 (en) * | 2006-11-09 | 2008-05-15 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| WO2008065141A1 (en) * | 2006-11-30 | 2008-06-05 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| US20080200567A1 (en) * | 2007-01-19 | 2008-08-21 | Probiodrug Ag | In vivo screening models for treatment of alzheimer's disease and other qpct-related disorders |
| DK2118101T3 (da) * | 2007-03-09 | 2013-01-02 | Probiodrug Ag | IMIDAZO (1,5-A)-PYRIDinderivater som glutaminylcyclaseinhibitorer |
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2008
- 2008-04-18 WO PCT/EP2008/054710 patent/WO2008128981A1/en not_active Ceased
- 2008-04-18 ES ES08736360.2T patent/ES2468551T3/es active Active
- 2008-04-18 JP JP2010503510A patent/JP5675340B2/ja not_active Expired - Fee Related
- 2008-04-18 DK DK08736360.2T patent/DK2142513T3/da active
- 2008-04-18 US US12/105,730 patent/US8772508B2/en active Active
- 2008-04-18 EP EP08736360.2A patent/EP2142513B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2468551T3 (es) | 2014-06-16 |
| EP2142513B1 (en) | 2014-03-12 |
| US20080292582A1 (en) | 2008-11-27 |
| WO2008128981A1 (en) | 2008-10-30 |
| DK2142513T3 (da) | 2014-06-10 |
| JP2010524893A (ja) | 2010-07-22 |
| US8772508B2 (en) | 2014-07-08 |
| EP2142513A1 (en) | 2010-01-13 |
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