JP5642361B2 - 循環抗体の分析のための方法 - Google Patents
循環抗体の分析のための方法 Download PDFInfo
- Publication number
- JP5642361B2 JP5642361B2 JP2009157404A JP2009157404A JP5642361B2 JP 5642361 B2 JP5642361 B2 JP 5642361B2 JP 2009157404 A JP2009157404 A JP 2009157404A JP 2009157404 A JP2009157404 A JP 2009157404A JP 5642361 B2 JP5642361 B2 JP 5642361B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- zone
- substrate
- liquid sample
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 46
- 238000004458 analytical method Methods 0.000 title claims description 12
- 210000004027 cell Anatomy 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 28
- 239000000758 substrate Substances 0.000 claims description 28
- 230000014759 maintenance of location Effects 0.000 claims description 20
- 239000012530 fluid Substances 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 12
- 239000008280 blood Substances 0.000 claims description 12
- 238000001514 detection method Methods 0.000 claims description 11
- 210000003850 cellular structure Anatomy 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 4
- 208000031886 HIV Infections Diseases 0.000 claims description 3
- 208000037357 HIV infectious disease Diseases 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 241000700605 Viruses Species 0.000 claims description 3
- 210000001185 bone marrow Anatomy 0.000 claims description 3
- 230000002489 hematologic effect Effects 0.000 claims description 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 3
- 239000012678 infectious agent Substances 0.000 claims description 3
- 210000004072 lung Anatomy 0.000 claims description 3
- 210000003296 saliva Anatomy 0.000 claims description 3
- 210000004243 sweat Anatomy 0.000 claims description 3
- 210000001179 synovial fluid Anatomy 0.000 claims description 3
- 210000001138 tear Anatomy 0.000 claims description 3
- 210000002700 urine Anatomy 0.000 claims description 3
- 210000003743 erythrocyte Anatomy 0.000 description 32
- 239000012491 analyte Substances 0.000 description 6
- 108010090804 Streptavidin Proteins 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 108090001090 Lectins Proteins 0.000 description 4
- 102000004856 Lectins Human genes 0.000 description 4
- 239000002523 lectin Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 229920001213 Polysorbate 20 Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 3
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 101710186708 Agglutinin Proteins 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 102000028180 Glycophorins Human genes 0.000 description 1
- 108091005250 Glycophorins Proteins 0.000 description 1
- 101710146024 Horcolin Proteins 0.000 description 1
- 101710189395 Lectin Proteins 0.000 description 1
- 101710179758 Mannose-specific lectin Proteins 0.000 description 1
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 description 1
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 101000874347 Streptococcus agalactiae IgA FC receptor Proteins 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000000910 agglutinin Substances 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 108010014507 erythroagglutinating phytohemagglutinin Proteins 0.000 description 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 108010084553 jacalin Proteins 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 108010086662 phytohemagglutinin-M Proteins 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 244000052613 viral pathogen Species 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7829508P | 2008-07-03 | 2008-07-03 | |
| US61/078,295 | 2008-07-03 | ||
| SE0801587-7 | 2008-07-03 | ||
| SE0801587A SE532644C2 (sv) | 2008-07-03 | 2008-07-03 | Förfarande för att analysera cirkulerande antikroppar |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010014714A JP2010014714A (ja) | 2010-01-21 |
| JP5642361B2 true JP5642361B2 (ja) | 2014-12-17 |
Family
ID=41508487
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009157404A Active JP5642361B2 (ja) | 2008-07-03 | 2009-07-02 | 循環抗体の分析のための方法 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP5642361B2 (zh) |
| CN (1) | CN101672843A (zh) |
| CA (1) | CA2671142C (zh) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012268393B2 (en) * | 2011-06-09 | 2016-09-15 | Gen-Probe Incorporated | Diagnostic devices, methods and systems for detecting platelet factor 4 (PF4)/heparin antibodies |
| CN103248611B (zh) * | 2012-02-07 | 2017-05-24 | 华为终端有限公司 | 媒体播放处理与控制方法、装置及系统 |
| CN112048401B (zh) * | 2020-08-28 | 2022-05-17 | 上海符贝基因科技有限公司 | 一种微流控芯片清洗剂及其方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5759774A (en) * | 1988-05-18 | 1998-06-02 | Cobe Laboratories, Inc. | Method of detecting circulating antibody types using dried or lyophilized cells |
| JP3005303B2 (ja) * | 1991-01-31 | 2000-01-31 | 湧永製薬株式会社 | 測定装置 |
| JP3581360B2 (ja) * | 2002-12-10 | 2004-10-27 | 株式会社生理科学研究所 | 抗体または抗原を用いた病態解析チップおよびその利用法 |
| SE0400662D0 (sv) * | 2004-03-24 | 2004-03-24 | Aamic Ab | Assay device and method |
| SE527036C2 (sv) * | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
| JP4797619B2 (ja) * | 2005-12-22 | 2011-10-19 | 東レ株式会社 | 分析チップおよび被検物質の分析方法 |
| CN101506657B (zh) * | 2006-06-20 | 2013-11-06 | 阿米克公司 | 实验设备 |
-
2009
- 2009-07-02 JP JP2009157404A patent/JP5642361B2/ja active Active
- 2009-07-02 CA CA2671142A patent/CA2671142C/en active Active
- 2009-07-03 CN CN200910163972A patent/CN101672843A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2671142C (en) | 2016-12-06 |
| CA2671142A1 (en) | 2010-01-03 |
| JP2010014714A (ja) | 2010-01-21 |
| CN101672843A (zh) | 2010-03-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2141497B1 (en) | Method for the analysis of circulating antibodies | |
| AU2020233741B2 (en) | Method and device for combined detection of viral and bacterial infections | |
| JP5068641B2 (ja) | アッセイ装置及び方法 | |
| JP5479417B2 (ja) | 制御流れアッセイ装置及び方法 | |
| US20110008776A1 (en) | Integrated separation and detection cartridge using magnetic particles with bimodal size distribution | |
| CN105308458A (zh) | 用于进行过敏症和自身免疫性疾病的诊断测定的自动化免疫分析系统 | |
| US20100047766A1 (en) | Analyte manipulation and detection | |
| WO2006137933A2 (en) | Microbubbles for affinity separation | |
| US20100233675A1 (en) | Analyte manipulation and detection | |
| Songjaroen et al. | Simultaneous forward and reverse ABO blood group typing using a paper-based device and barcode-like interpretation | |
| JP5642361B2 (ja) | 循環抗体の分析のための方法 | |
| EP2796880B1 (en) | Platelet allo-antigen typing and platelet antibody tests | |
| JP2007170840A (ja) | 分析装置 | |
| US11422128B2 (en) | Immunoassay employing sulfated polysaccharide | |
| JP2001221799A (ja) | 判定部を複数有する被検物質の測定器具及び測定方法 | |
| WO2017009926A1 (ja) | 特異的結合物質の固定化方法 | |
| US9285361B2 (en) | Method for the analysis of circulating antibodies | |
| JP2002196001A (ja) | 被検物質の測定器具及び測定方法 | |
| JP4806645B2 (ja) | 免疫学的検査用担体及び該担体を用いた検査方法 | |
| WO2005069002A1 (en) | Rapid test for antibodies against hiv in urine | |
| JPH09229936A (ja) | 磁性粒子を用いる被検物質の測定方法並びに該方法に使用する担体及び測定器具 | |
| JP4521946B2 (ja) | 検体測定方法 | |
| JPH06148188A (ja) | 免疫学的再検査方法 | |
| JPH10227794A (ja) | 粒子を使用する被検物質の測定方法 | |
| JP2003107091A (ja) | 生物学的検査のための分離体および検査方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20100803 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20111207 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120508 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20121024 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20121030 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130130 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130204 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130228 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130305 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130326 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20130917 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140116 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140425 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A712 Effective date: 20140425 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140520 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20140523 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20141007 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20141029 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5642361 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R371 | Transfer withdrawn |
Free format text: JAPANESE INTERMEDIATE CODE: R371 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |