JP5624894B2 - アゼチジン誘導体 - Google Patents

アゼチジン誘導体 Download PDF

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Publication number
JP5624894B2
JP5624894B2 JP2010549188A JP2010549188A JP5624894B2 JP 5624894 B2 JP5624894 B2 JP 5624894B2 JP 2010549188 A JP2010549188 A JP 2010549188A JP 2010549188 A JP2010549188 A JP 2010549188A JP 5624894 B2 JP5624894 B2 JP 5624894B2
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JP
Japan
Prior art keywords
phenyl
yloxy
azetidine
carboxylic acid
pyridin
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Application number
JP2010549188A
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English (en)
Japanese (ja)
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JP2011513374A (ja
JP2011513374A5 (enExample
Inventor
ラフリー，スティーブン
ウォールズ，スティーブン
ハート，テレンス
パーソンズ，レイチェル
ブラフ，ポール
グラハム，クリストファー
マシアス，アルバ
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Vernalis R&D Ltd
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Vernalis R&D Ltd
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Publication date
Priority claimed from GBGB0804006.5A external-priority patent/GB0804006D0/en
Priority claimed from GBGB0821694.7A external-priority patent/GB0821694D0/en
Application filed by Vernalis R&D Ltd filed Critical Vernalis R&D Ltd
Publication of JP2011513374A publication Critical patent/JP2011513374A/ja
Publication of JP2011513374A5 publication Critical patent/JP2011513374A5/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Virology (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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JP2010549188A 2008-03-04 2009-02-27 アゼチジン誘導体 Active JP5624894B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0804006.5A GB0804006D0 (en) 2008-03-04 2008-03-04 Azetidine derivatives
GB0804006.5 2008-04-05
GBGB0821694.7A GB0821694D0 (en) 2008-11-27 2008-11-27 Azetidine derivatives
GB0821694.7 2008-11-27
PCT/GB2009/000568 WO2009109743A1 (en) 2008-03-04 2009-02-27 Azetidine derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014198461A Division JP5986163B2 (ja) 2008-03-04 2014-09-29 アゼチジン誘導体

Publications (3)

Publication Number Publication Date
JP2011513374A JP2011513374A (ja) 2011-04-28
JP2011513374A5 JP2011513374A5 (enExample) 2012-03-29
JP5624894B2 true JP5624894B2 (ja) 2014-11-12

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JP2010549188A Active JP5624894B2 (ja) 2008-03-04 2009-02-27 アゼチジン誘導体
JP2014198461A Active JP5986163B2 (ja) 2008-03-04 2014-09-29 アゼチジン誘導体

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US (6) US8450346B2 (enExample)
EP (1) EP2265578B1 (enExample)
JP (2) JP5624894B2 (enExample)
CN (1) CN102015635B (enExample)
AU (1) AU2009220974B2 (enExample)
BR (1) BRPI0909782B8 (enExample)
CA (1) CA2717750C (enExample)
DK (1) DK2265578T3 (enExample)
EA (1) EA017842B1 (enExample)
ES (1) ES2550367T3 (enExample)
HU (1) HUE025411T2 (enExample)
IL (1) IL207768A (enExample)
MX (1) MX2010009658A (enExample)
NZ (1) NZ587532A (enExample)
PL (1) PL2265578T3 (enExample)
PT (1) PT2265578E (enExample)
WO (1) WO2009109743A1 (enExample)
ZA (1) ZA201006270B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102015635B (zh) 2008-03-04 2013-05-08 弗奈利斯（R&D）有限公司 氮杂环丁烷衍生物
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
WO2011123719A2 (en) 2010-03-31 2011-10-06 Ironwood Pharmaceuticals, Inc. Use of faah inhibitors for treating abdominal, visceral and pelvic pain
KR101273566B1 (ko) 2011-09-05 2013-06-11 한국과학기술연구원 신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물
JP6232384B2 (ja) * 2012-01-06 2017-11-15 ノバルティス アーゲー 複素環式化合物およびその使用方法
US10570146B2 (en) * 2014-07-25 2020-02-25 Northeastern University Urea/carbamates FAAH MAGL or dual FAAH/MAGL inhibitors and uses thereof
JOP20190072A1 (ar) * 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
JP7282028B2 (ja) * 2017-06-02 2023-05-26 富士フイルム富山化学株式会社 脳萎縮予防または治療剤
RU2728717C1 (ru) * 2017-06-02 2020-07-30 ФУДЖИФИЛМ Тояма Кемикал Ко., Лтд. Средство для профилактики или лечения спиноцеребеллярной атаксии
US11541033B2 (en) 2017-06-02 2023-01-03 Fujifilm Toyama Chemical Co., Ltd. Agent for preventing or treating Alzheimer's disease
CN110691594A (zh) * 2017-06-02 2020-01-14 富士胶片富山化学株式会社 Tau蛋白病预防或治疗剂
KR20200003102A (ko) 2017-06-02 2020-01-08 후지필름 도야마 케미컬 가부시키가이샤 아밀로이드 β 단백질량 감소제
JP7227914B2 (ja) 2017-10-30 2023-02-22 富士フイルム富山化学株式会社 エモパミル結合タンパク質結合剤およびその利用
US20240180905A1 (en) * 2020-07-21 2024-06-06 Neuritek Ltd. Uses of fatty acid amide hydrolase inhibitors in treatment of trauma related psychiatric disorders
CN112374984A (zh) * 2020-11-06 2021-02-19 苏州求索生物科技有限公司 一种2-溴-4-羟基苯甲醚的制备工艺
US11141404B1 (en) 2020-11-18 2021-10-12 Anebulo Pharmaceuticals, Inc. Formulations and methods for treating acute cannabinoid overdose
US11795146B2 (en) 2021-10-11 2023-10-24 Anebulo Pharmaceuticals, Inc. Crystalline forms of a cannabinoid receptor type 1 (CB1) modulator and methods of use and preparation thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5183902A (en) 1985-02-28 1993-02-02 A. H. Robins Company, Incorporated Method of treating muscular tension, muscle spasticity and anxiety with 3-aryloxy and 3-arylthioazetidinecarboxamides
IN162808B (enExample) * 1985-02-28 1988-07-09 Robins Co Inc A H
US6335445B1 (en) * 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
GB9801501D0 (en) * 1998-01-23 1998-03-18 Cerebrus Ltd Chemical compounds - II
FR2866884B1 (fr) * 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
CN102015635B (zh) * 2008-03-04 2013-05-08 弗奈利斯（R&D）有限公司 氮杂环丁烷衍生物

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