JP5620392B2 - クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物 - Google Patents

クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物 Download PDF

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JP5620392B2
JP5620392B2 JP2011534525A JP2011534525A JP5620392B2 JP 5620392 B2 JP5620392 B2 JP 5620392B2 JP 2011534525 A JP2011534525 A JP 2011534525A JP 2011534525 A JP2011534525 A JP 2011534525A JP 5620392 B2 JP5620392 B2 JP 5620392B2
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difficile
acid
spores
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JP2012507521A (ja
JP2012507521A5 (https=
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ソーグ，ジョーゼフ
エル ソーネンシャイン，アブラハム
エル ソーネンシャイン，アブラハム
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Tufts University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
JP2011534525A 2008-11-03 2009-11-02 クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物 Expired - Fee Related JP5620392B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11074708P 2008-11-03 2008-11-03
US61/110,747 2008-11-03
US12283508P 2008-12-16 2008-12-16
US61/122,835 2008-12-16
US15013609P 2009-02-05 2009-02-05
US61/150,136 2009-02-05
PCT/US2009/005929 WO2010062369A2 (en) 2008-11-03 2009-11-02 Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth

Publications (3)

Publication Number Publication Date
JP2012507521A JP2012507521A (ja) 2012-03-29
JP2012507521A5 JP2012507521A5 (https=) 2012-12-13
JP5620392B2 true JP5620392B2 (ja) 2014-11-05

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JP2011534525A Expired - Fee Related JP5620392B2 (ja) 2008-11-03 2009-11-02 クロストリジウム・ディフィシレ胞子の発芽および伸長を阻害するための方法および組成物

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US (2) US9340569B2 (https=)
EP (1) EP2367839A4 (https=)
JP (1) JP5620392B2 (https=)
AU (1) AU2009320350B2 (https=)
CA (1) CA2779413A1 (https=)
WO (1) WO2010062369A2 (https=)

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US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
CA3212215A1 (en) 2012-11-23 2014-05-30 Seres Therapeutics, Inc. Synergistic bacterial compositions and methods of production and use thereof
US8906668B2 (en) 2012-11-23 2014-12-09 Seres Health, Inc. Synergistic bacterial compositions and methods of production and use thereof
HK1218560A1 (zh) 2013-02-04 2017-02-24 Seres Therapeutics, Inc. 组成与方法
CA2899925A1 (en) * 2013-02-04 2014-08-07 Seres Therapeutics, Inc. Compositions and methods for inhibition of pathogenic bacterial growth
EP2967077A4 (en) 2013-03-15 2016-09-14 Seres Therapeutics Inc NETWORK-BASED MICROBIAL COMPOSITIONS AND METHOD
WO2015076788A1 (en) 2013-11-19 2015-05-28 The Texas A&M University System Muricholic acid-based compounds as inhibitors of clostridium difficile spore germination
EP3074027B1 (en) 2013-11-25 2024-12-18 Seres Therapeutics, Inc. Synergistic bacterial compositions and methods of production and use thereof
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
PT3146065T (pt) * 2014-05-19 2025-01-14 Memorial Sloan Kettering Cancer Center Métodos e composições para reduzir a infecção por clostridium difficile
US10610552B2 (en) * 2016-04-05 2020-04-07 Nch Corporation Nutrient rich germinant composition and spore incubation method
GB201421071D0 (en) * 2014-11-27 2015-01-14 Univ Aston Compound for treating clostridium difficile
WO2016127102A2 (en) 2015-02-06 2016-08-11 Ernesto Abel-Santos Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
CN115252650A (zh) 2015-11-03 2022-11-01 布里格姆及妇女医院股份有限公司 用于治疗和/或预防食物变态反应的治疗性微生物群
EP3668527A1 (en) 2017-08-14 2020-06-24 Seres Therapeutics, Inc. Compositions and methods for treating cholestatic disease
KR102323783B1 (ko) * 2017-09-22 2021-11-09 주식회사 고바이오랩 클로스트리디움 디피실레(Clostridium difficile) 성장 억제효과를 갖는 클로스트리디움 신덴스 균주
JP2021501185A (ja) 2017-10-30 2021-01-14 セレス セラピューティクス インコーポレイテッド 抗生物質耐性を処置するための組成物及び方法
AR115921A1 (es) 2018-08-10 2021-03-10 Phenex Pharmaceuticals Ag Ácido isolitocólico o ácido isoalolitocólico y derivados deuterados de los mismos para prevenir y tratar enfermedades asociadas a clostridium difficile
EP3836947A4 (en) 2018-08-17 2022-04-20 Universidad Andres Bello METHOD AND PHARMACOLOGICAL COMPOSITION FOR THE PREVENTION OF RECURRING INFECTIONS CAUSED BY CLOSTRIDIUM DIFFICILE
WO2020260558A1 (en) 2019-06-27 2020-12-30 Phenex Pharmaceuticals Ag 3-modified iso-/isoallo-lithocholic acid derivatives or their homo-analogs for preventing and treating clostridioides difficile-associated diseases
WO2021023100A1 (zh) * 2019-08-06 2021-02-11 杜心赟 脱氧胆酸类化合物、药物组合物及其用途
WO2021145458A1 (ja) * 2020-01-16 2021-07-22 学校法人慶應義塾 胆汁酸を生成するための組成物
WO2021163212A1 (en) 2020-02-10 2021-08-19 Native Microbials, Inc. Microbial compositions and methods of use for canine enteropathy and dysbiosis
EP4398890A4 (en) 2021-09-09 2025-07-30 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve C. Difficile Spore Germination Inhibitors
WO2023079335A1 (en) 2021-11-03 2023-05-11 Universidad Andrés Bello Composition based on nystatin and vancomycin nanoparticles for the treatment of clostridioides difficile infection and prevention of recurrence
US20250002450A1 (en) 2021-12-10 2025-01-02 Universidade Do Porto Cationic steroid compounds, method of obtaining thereof, formulations comprising thereof and their uses
CN120905091A (zh) * 2025-09-30 2025-11-07 北京常友生物科技有限公司 大肠埃希氏菌yc49及其协同拟杆菌在抑制艰难梭菌中的应用

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JPS62175497A (ja) 1986-01-28 1987-08-01 Wakunaga Pharmaceut Co Ltd 胆汁酸誘導体およびその製造法
JPH0749438B2 (ja) * 1990-10-31 1995-05-31 東京田辺製薬株式会社 タウリン抱合型胆汁酸の精製方法
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US20080254010A1 (en) * 2007-03-12 2008-10-16 Joseph Myron Sasser Controlling Clostridium difficile-Associated Disease in the Gastrointestinal Tract

Also Published As

Publication number Publication date
US9340569B2 (en) 2016-05-17
JP2012507521A (ja) 2012-03-29
AU2009320350B2 (en) 2015-09-24
CA2779413A1 (en) 2010-06-03
AU2009320350A1 (en) 2010-06-03
US20170056419A1 (en) 2017-03-02
WO2010062369A3 (en) 2010-10-14
WO2010062369A2 (en) 2010-06-03
EP2367839A4 (en) 2012-07-04
US20110280847A1 (en) 2011-11-17
EP2367839A2 (en) 2011-09-28

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