BR112020008552A2 - métodos e composições para tratamento de resistência a antibiótico - Google Patents

Abstract

a presente invenção refere-se a composições e métodos para reduzir o transporte de genes de resistência a antibióticos.

Description

COMPOSIÇÕES E MÉTODOS PARA TRATAMENTO DA RESISTÊNCIA A ANTIBIÓTICOS CAMPO DA INVENÇÃO

[0001] A invenção refere-se à prevenção e tratamento da resistência a antibióticos.

FUNDAMENTOS

[0002] De acordo com a Organização Mundial da Saúde (OMS), a resistência bacteriana a "[a]ntibióticos é uma das maiores ameaças à saúde, segurança alimentar e desenvolvimento global hoje" (who.int/mediacentre/factsheets/antibiotic-resistance/en). A resistência a antibióticos pode ocorrer naturalmente nas bactérias, mas é exacerbada pelo aumento do uso e uso indevido de antibióticos. Para agravar o problema, há a diversidade de mecanismos de resistência a antibióticos; uma variedade de genes díspares pode conferir resistência e bactérias não relacionadas podem transmitir horizontalmente genes de resistência a antibióticos. A OMS também declarou que “embora existam novos antibióticos em desenvolvimento, nenhum deles deve ser eficaz contra as formas mais perigosas de bactérias resistentes a antibióticos (ibid).”

[0003] Em conformidade, é imperativo que novos métodos de redução da resistência aos antibióticos sejam desenvolvidos e disponibilizados.

SUMÁRIO

[0004] A invenção refere-se à descoberta de que composições bacterianas podem ser usadas para reduzir a abundância de genes de resistência a antibióticos no microbioma gastrointestinal (GI) de um sujeito.

[0005] A invenção fornece composições que incluem uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo bactérias formadoras de esporo para uso na redução da abundância de pelo menos um gene de resistência a antibióticos no microbioma de um sujeito.

[0006] A invenção também fornece composições que incluem uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo Firmicutes derivados de um ou mais sujeitos humanos saudáveis para uso no tratamento de um sujeito em risco ou diagnosticado com um nível indesejável ou população de bactérias resistentes a medicamentos.

[0007] A invenção fornece ainda composições ROAR para uso, reduzindo a abundância de bactérias resistentes a antibióticos no microbioma de um sujeito.

[0008] A invenção fornece adicionalmente composições ROAR para uso na interrupção de um ciclo de transmissão de genes de resistência a antibióticos, por administração a pelo menos dois sujeitos com uma alta probabilidade de contato direto ou indireto, incluindo contato opcional com um fluido ou resíduo corporal.

[0009] Além disso, a invenção fornece métodos para reduzir a abundância de pelo menos um gene de resistência a antibióticos no microbioma de um sujeito, incluindo os métodos de administração de uma quantidade terapeuticamente eficaz de uma composição de microbioma que contém bactérias formadoras de esporo.

[0010] A invenção também fornece métodos de tratamento de um sujeito em risco ou diagnosticado com um nível ou população indesejável de bactérias resistentes a medicamentos, incluindo os métodos de administração de uma quantidade terapeuticamente eficaz de uma composição de microbioma contendo Firmicutes derivados de um ou mais sujeitos humanos saudáveis.

[0011] A invenção fornece ainda métodos para reduzir a abundância de bactérias resistentes a antibióticos no microbioma de um sujeito, incluindo os métodos de administração de uma quantidade terapeuticamente eficaz de uma composição ROAR.

[0012] A invenção fornece adicionalmente métodos para interromper um ciclo de transmissão de genes de resistência a antibióticos, incluindo os métodos de administração de uma composição ROAR a pelo menos dois sujeitos com uma alta probabilidade de contato direto ou indireto, incluindo o contato com um fluido ou resíduo corporal.

[0013] Várias modalidades de qualquer um dos métodos observados acima são como estabelecidas abaixo.

[0014] Em algumas modalidades, os genes de resistência a antibióticos são selecionados dentre os listados na Tabela 1.

[0015] Em algumas modalidades, a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é reduzida.

[0016] Em algumas modalidades, o medicamento ou antibiótico é de uma classe de medicamentos listados na Tabela 2.

[0017] Em algumas modalidades, os métodos incluem ainda, ou as composições para uso resultam ainda mais na redução da abundância de 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 ou mais classes de medicamentos ou genes de resistência a antibióticos.

[0018] Em algumas modalidades, a composição inclui uma ou mais espécies listadas na Tabela 3. Em algumas modalidades, as espécies listadas na Tabela 3 também não estão listadas na Tabela 4. A composição pode ser administrada por um método descrito acima ou em outra parte neste documento.

[0019] Em algumas modalidades, a composição inclui 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais espécies listadas na Tabela 3. Em algumas modalidades, as espécies listadas na Tabela 3 também não estão listadas na Tabela 4. A composição pode ser administrada por um método descrito acima ou em outra parte neste documento.

[0020] Em algumas modalidades, as espécies incluem uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade com a mesma. As espécies podem ser administradas por um método descrito acima ou em outra parte neste documento.

[0021] Em algumas modalidades, a composição não inclui uma ou mais espécies da Tabela 4. Em algumas modalidades, as espécies listadas na Tabela 4 que não estão incluídas não estão listadas na Tabela 3. A composição pode ser administrada por um método descrito acima ou em outra parte neste documento.

[0022] Em algumas modalidades, as espécies não incluem uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6, ou uma sequência com pelo menos 95% de identidade com a mesma. As espécies podem ser administradas por um método descrito acima ou em outra parte neste documento.

[0023] Em algumas modalidades, as bactérias na composição estão na forma de esporos.

[0024] Em algumas modalidades, as bactérias na composição são cultivadas.

[0025] Em algumas modalidades, a composição inclui Firmicutes e uma ou mais espécies de Bacteroides.

[0026] Em algumas modalidades, o sujeito tem uma abundância reduzida de uma, duas ou três bactérias selecionadas do grupo que consiste em bactérias resistentes a quinolona, resistentes a beta-lactâmicos e resistentes a carbapenêmicos.

[0027] Em algumas modalidades, o sujeito não respondeu ao tratamento com antibióticos.

[0028] Em algumas modalidades, o sujeito tem ou está em risco de desenvolver infecção ou doença por C. difficile, ou uma colite em que, em algumas modalidades, a colite é opcionalmente doença de Crohn ou colite ulcerativa (por exemplo, colite ulcerativa leve a moderada). Em algumas modalidades, o sujeito não tem (ou não corre o risco de desenvolver) infecção ou doença por C. difficile, ou uma colite (como a doença de Crohn ou colite ulcerativa, por exemplo, colite ulcerativa leve a moderada).

[0029] A invenção também fornece composições incluindo espécies bacterianas associadas a uma diminuição na abundância de pelo menos um gene de resistência a antibióticos em um sujeito.

[0030] Em algumas modalidades, os genes de resistência a antibióticos são selecionados dentre os listados na Tabela 1.

[0031] Em algumas modalidades, a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é diminuída.

[0032] Em algumas modalidades, o antibiótico é de uma classe listada na Tabela 2.

[0033] Em algumas modalidades, a composição inclui uma ou mais espécies listadas na Tabela 3. Em algumas modalidades, as espécies listadas na Tabela 3 também não estão listadas na Tabela 4.

[0034] Em algumas modalidades, a composição inclui 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais espécies listadas na Tabela 3. Em algumas modalidades, as espécies listadas na Tabela 3 também não estão listadas na Tabela 4.

[0035] Em algumas modalidades, as espécies incluem uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade com a mesma.

[0036] Em algumas modalidades, a composição não inclui uma ou mais espécies da Tabela 4. Em algumas modalidades, as espécies da Tabela 4 que não estão incluídas não estão listadas na Tabela 3.

[0037] Em algumas modalidades, as espécies não incluem uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6, ou uma sequência com pelo menos 95% de identidade com a mesma.

[0038] Em algumas modalidades, a composição inclui uma ou mais espécies de Firmicutes.

[0039] Em algumas modalidades, a composição inclui e uma ou mais espécies de Bacteroides.

[0040] Em algumas modalidades, as bactérias na composição estão na forma de esporos.

[0041] Em algumas modalidades, as bactérias na composição são obtidas a partir de uma fração de esporos derivada das fezes de um sujeito saudável.

[0042] Em algumas modalidades, a composição inclui uma ou mais espécies de Firmicutes e, opcionalmente, uma ou mais espécies de Bacteroides, como a única espécie bacteriana na composição.

[0043] Em algumas modalidades, as bactérias na composição são cultivadas.

[0044] A invenção fornece ainda composições incluindo bactérias para uso na diminuição da abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada.

[0045] Em algumas modalidades, as bactérias na composição são obtidas a partir de uma fração de esporos derivada das fezes de um sujeito saudável.

[0046] Em algumas modalidades, as bactérias são selecionadas por serem associadas a uma diminuição na abundância de um ou mais genes de resistência a antibióticos em um sujeito.

[0047] Em algumas modalidades, os genes de resistência a antibióticos são selecionados da Tabela 1.

[0048] Em algumas modalidades, a composição inclui pelo menos uma espécie selecionada da Tabela 3.

[0049] Em algumas modalidades, a composição não inclui uma espécie da Tabela 4.

[0050] A invenção também fornece métodos para identificar uma composição bacteriana útil para diminuir a abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada, os métodos incluindo o rastreamento da composição quanto à presença de uma ou mais espécies bacterianas da Tabela 3, em que a detecção de uma ou mais espécies da Tabela 3 na composição bacteriana indica a identificação de uma composição que pode ser usada para diminuir a abundância de pelo menos um gene de resistência a antibióticos. Em algumas modalidades, as espécies da Tabela 3 também não estão listadas na Tabela 4.

[0051] Em algumas modalidades, a triagem inclui a detecção de uma ou mais sequências de 16S rDNA, V4 e/ou V6 da Tabela 5 na composição, ou uma sequência com pelo menos 95% de identidade.

[0052] Em algumas modalidades, os métodos incluem ainda a triagem para a presença de uma ou mais espécies bacterianas da Tabela 4. Em algumas modalidades, as espécies pesquisadas na Tabela 4 também não estão listadas na Tabela 3.

[0053] Em algumas modalidades, a triagem inclui a detecção de uma ou mais sequências de 16S rDNA, V4 e/ou V6 da Tabela 6 na composição, ou uma sequência com pelo menos 95% de identidade.

[0054] A invenção também inclui métodos para rastrear um potencial doador de fezes para uso em métodos terapêuticos, incluindo os métodos de teste de uma amostra de fezes do potencial doador para a presença de uma espécie bacteriana da Tabela 3 ou Tabela 4, em que a detecção de uma ou mais espécies da Tabela 3 indica que o potencial doador pode continuar a se tornar um doador, enquanto a detecção de uma ou mais espécies da Tabela 4 indica que o potencial doador não deve se tornar um doador. Em algumas modalidades, as espécies da Tabela 3 testadas não estão listadas na Tabela 4. Em algumas modalidades, as espécies da Tabela 4 testadas não estão listadas na Tabela 3.

[0055] A invenção inclui ainda métodos para determinar se um sujeito pode se beneficiar do tratamento com uma composição ROAR, incluindo os métodos para determinar se uma amostra do sujeito inclui uma ou mais espécies de bactérias da Tabela 4, em que a detecção de uma ou mais espécies da Tabela 4 indica que o sujeito pode se beneficiar do tratamento com uma composição ROAR. Em algumas modalidades, as espécies da Tabela 3 testadas não estão listadas na Tabela 4. Em algumas modalidades, as espécies da Tabela 4 testadas não estão listadas na Tabela 3.

[0056] A invenção fornece ainda composições (por exemplo, as composições descritas acima e em outras partes deste documento), em que as bactérias nas composições demonstram a capacidade de diminuir a abundância de um ou mais genes de resistência a antibióticos em um modelo animal de resistência a antibióticos. Em algumas modalidades, o modelo animal é um camundongo tratado com um ou mais antibióticos e depois colonizado com uma ou mais bactérias que abrigam um ou mais genes de resistência a antibióticos. Em algumas modalidades, os camundongos são colonizados com bactérias resistentes à vancomicina ou bactérias resistentes à vancomicina e carbapenem.

[0057] A invenção também inclui o uso das composições aqui descritas para os fins especificados nos métodos aqui descritos, bem como o uso dessas composições para a preparação de medicamentos para esses usos.

[0058] A divulgação inteira de cada documento de patente e artigo científico referidos neste documento, e àqueles documentos de patente e artigos científicos citados por meio deste, está expressamente incorporada por referência neste documento para todos os propósitos.

[0059] Características e vantagens adicionais da invenção são mais particularmente descritas abaixo.

BREVE DESCRIÇÃO DAS FIGURAS

[0060] A Figura 1 é um gráfico que representa os resultados de uma experiência que detecta a redução de genes associados à resistência à fluoroquinolona em sujeitos humanos 7, 28 e 56 dias após a administração de uma composição de esporos comensais humanos. Branco = sujeitos que receberam placebo, cinza claro = todos os sujeitos tratados com a composição de esporos e cinza escuro = resulta do subconjunto de sujeitos com um sinal significativo de enxerto.

[0061] A Figura 2 é um gráfico que representa os resultados de uma experiência que detecta a redução de genes associados à resistência a antibióticos beta-lactâmicos em sujeitos humanos 7, 28 e 56 dias após a administração de uma composição de esporos comensais humanos. Branco = sujeitos que receberam placebo, cinza claro = todos os sujeitos tratados com a composição de esporos, cinza escuro = resulta do subconjunto de sujeitos com um sinal significativo de enxerto.

[0062] A Figura 3 é um gráfico que mostra a abundância de genes de resistência a antibióticos por ponto no tempo (eixo x), facetados por coorte (A: placebo, B: esporo preparado a partir de fezes de humanos saudáveis e triados, semanalmente, D: vancomicina, preparação de esporos semanalmente e C: vancomicina, preparação de esporos diariamente.

[0063] A Figura 4 é um gráfico que mostra que, em sujeitos com enxerto rápido e precoce com preparação de esporos no Braço D (Vancomicina, preparação semanal de esporos), os genes de resistência a antibióticos diminuíram mais rapidamente quando comparados aos sujeitos que não exibiram enxerto rápido e precoce. A Visita 4 (dia 8) ocorre imediatamente após a interrupção dos antibióticos e a Visita 4 (dia 11) é o primeiro ponto no tempo de preparação dos esporos.

DESCRIÇÃO DETALHADA

[0064] A resistência a antibióticos (referida neste documento como "AbxR") é um crescente problema de saúde pública global. A resistência a todas as classes de antibióticos tem sido relatada em todas as partes do mundo (2014, Antimicrobial Resistance, Global Report on Surveillance, Summary, OMS) e o desenvolvimento de antibióticos convencionais tem sido relativamente lento em comparação com a demanda. Por exemplo, nenhuma nova classe de antibióticos foi comercializada desde a descoberta do antibiótico lipopeptídeo daptomicina na década de 1980. Além disso, os programas de administração de antibióticos que limitam o uso de antibióticos não revertem imediatamente a tendência de aumento da resistência.

[0065] Os depositantes descobriram que o tratamento de um sujeito com uma composição compreendendo bactérias, por exemplo, bactérias formadoras de esporo derivadas de um ser humano saudável, pode reduzir a abundância de genes AbxR (coletivamente, o "resistoma intestinal") em um sujeito humano. Essas composições são referidas neste documento como redução de composições resistentes a antibióticos (composições ROAR (reduction of antibiotic resistance)).

[0066] Além disso, esse tratamento pode reduzir a abundância de genes AbxR associados à resistência a múltiplas classes de antibióticos, por exemplo, b- lactamas (incluindo carbapenêmicos), quinolonas, glicopeptídeos (por exemplo, vancomicina) e tetraciclinas. Além disso, verificou-se que os comensais não patogênicos podem abrigar genes de resistência a antibióticos, e o tratamento resulta em uma diminuição na abundância de genes de resistência a antibióticos em organismos comensais não patogênicos. Sem se comprometer com nenhuma teoria em particular, esses dados dão suporte a um método para diminuir a presença de genes de resistência a antibióticos por, pelo menos em parte, um mecanismo de diminuição da transferência horizontal de genes de resistência a antibióticos de organismos comensais não patogênicos para bactérias patogênicas. Esse mecanismo pode estar relacionado, pelo menos em parte, à diminuição da abundância de bactérias que abrigam genes de resistência a antibióticos, superando a concorrência dessas bactérias por nutrientes; diminuir a abundância de bactérias que abrigam genes de resistência a antibióticos, induzindo uma resposta no hospedeiro que limita o crescimento de possíveis patógenos que abrigam os genes AbxR; diminuir a abundância de bactérias que abrigam genes de resistência a antibióticos através da introdução de bactérias diretamente antagônicas a possíveis patógenos que abrigam genes AbxR; reduzir patógenos oportunistas e/ou diminuir o potencial de disseminação de genes de resistência a antibióticos entre organismos resistentes a antibióticos e suscetíveis. Em algumas modalidades, a diminuição na presença de genes de resistência a antibióticos ocorre reduzindo a colonização no hospedeiro de micróbios que abrigam os genes AbxR.

[0067] Em algumas modalidades, uma composição ROAR é usada para quebrar ou impedir um ciclo de transmissão de resistência a antibióticos. Nestes métodos, uma composição ROAR pode ser administrada a um sujeito que entra em um ambiente no qual existe o risco de um ciclo de resistência a antibióticos ou em um ambiente no qual a existência de um ciclo de resistência a antibióticos tenha sido identificada, por exemplo, um ambiente no qual a resistência a antibióticos foi identificada como propagação ou no qual existe o risco de propagação. Os exemplos destes ambientes incluem hospitais, unidades de terapia intensiva, asilos, centros de reabilitação, abrigos e afins. Em algumas modalidades, a dosagem em tal ambiente é crônica. Em algumas modalidades, um sujeito é tratado para prevenir ou reduzir a colonização por um ou mais genes AbxR. Em um sujeito que abriga um ou mais genes AbxR, uma composição pode ser administrada, reduzindo assim o risco de infecção por AbxR nesse sujeito e reduzindo o risco de o sujeito transmitir os genes AbxR após o tratamento da doença por C. difficile, pois esses sujeitos podem ser suscetíveis à infecção ou abrigam bactérias resistentes a antibióticos. Em algumas modalidades, uma composição é administrada a trabalhadores em ambientes nos quais há um risco particular associado à disseminação dos genes AbxR.

[0068] Em alguns ambientes, a “descontaminação seletiva” dos pacientes tem sido recomendada, por exemplo, em hospitais (particularmente unidades de terapia intensiva) e casas de repouso (por exemplo, ver Silvestri e van Saene, “Selective decontamination of the digestive tract: an update of the evidence,” HSR Proc. Intensive Care Cardiovasc. Anesth. 4:21-29, 2012; Oostdijk et al., “Selective decontamination in European intensive care patients,” Intensive Care Med. 38:533- 538, 2012). Uma composição ROAR pode ser uma alternativa útil ou complemento a essa descontaminação seletiva, adicionando ao arsenal de métodos disponíveis para diminuir a presença de genes de resistência a antibióticos nesses e em outros cenários. Composições ROAR

[0069] As composições ROAR geralmente compreendem Firmicutes. Em algumas modalidades, os Firmicutes são capazes de formar esporos (formadores de esporos). As bactérias em uma composição podem estar na forma de esporos, formas vegetativas e de esporos misturadas ou forma vegetativa. Em alguns casos, uma composição consiste em Firmicutes. Em algumas modalidades, uma composição ROAR compreende uma ou mais espécies de Bacteroidetes. Em algumas modalidades, uma composição ROAR consiste em pelo menos uma espécie de cada um de Firmicutes e Bacteroidetes. As composições que compreendem ou consistem em Firmicutes (ou Firmicutes e Bacteroidetes) como a única espécie bacteriana das composições não possuem ocorrência natural.

[0070] Como um exemplo não limitativo, uma composição ROAR pode ser preparada a partir de bactérias que são isoladas das fezes, por exemplo, fezes humanas. Em geral, as fezes são de um animal saudável (por exemplo, um humano) da mesma espécie que o animal a ser tratado. As bactérias podem ser preparadas, por exemplo, em um método usando uma quantidade de etanol adequada para matar qualquer bactéria sem forma de esporos presente nas fezes. Um exemplo de tal preparação pode ser encontrado em, por exemplo, WO

2014/121302.

[0071] Em algumas modalidades, uma composição ROAR compreende ou consiste em espécies bacterianas selecionadas associadas a uma diminuição na abundância de genes de resistência a antibióticos em um sujeito (ver, por exemplo, Tabela 3, abaixo). Essas composições são referidas neste documento como "composições Abx projetadas". O número de espécies (por exemplo, da Tabela 3) em uma composição projetada pode ser, por exemplo, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais. Em algumas modalidades, o número de espécies é pelo menos uma e menor ou igual a 50, por exemplo, menor que 45, menor que 40, menor que 35, menor que 30, menor que 25, menor que 20, menor que 15, inferior a 10 ou inferior a 5. Em algumas modalidades, as espécies selecionadas na Tabela 3 não incluem espécies que também estão listadas na Tabela 4.

[0072] As espécies individuais em uma composição ROAR projetada podem ser cultivadas separadamente e depois combinadas para criar a composição. Em algumas modalidades, uma composição ROAR é produzida cocultivando toda ou subconjuntos da composição e depois combinando os componentes que não foram cocultivados para criar a composição. Em algumas modalidades, uma composição ROAR é produzida cultivando uma fração de esporos derivada de fezes de um ser humano saudável. A cultura resultante pode ser usada como uma composição ROAR.

[0073] Em algumas modalidades, as espécies selecionadas para inclusão em uma composição ROAR estão associadas a uma diminuição na abundância de uma classe específica de genes de resistência a antibióticos, por exemplo, genes associados à resistência a quinolonas, beta-lactâmicos e/ou carbapenêmicos (ver também Tabela 2). Em exemplos específicos de, por exemplo, as composições descritas acima, espécies bacterianas em uma composição ROAR (por exemplo, composições Abx projetadas) são selecionadas na Tabela 2 e, opcionalmente, podem ser identificadas pela análise de sequências de 16S rDNA (ou fragmentos destas, por exemplo, uma fragmento compreendendo as regiões 16S rDNA V4 e/ou V6; ver também abaixo e Tabela 5 para sequências exemplificativas).

[0074] Em algumas modalidades, uma espécie útil em uma composição ROAR é uma espécie com um rDNA 16S completo com pelo menos 95% de identidade de sequência ("identidade") (por exemplo, pelo menos 96%, 97%, 98% ou 99% ou 100%) para o rDNA 16S de uma espécie de referência, por exemplo, uma espécie identificada na Tabela 3 (ver, por exemplo, Tabela 5 para obter informações sobre a sequência). Em algumas modalidades, uma espécie útil em uma composição ROAR é uma espécie com um rDNA 16S completo com pelo menos 97% de identidade de sequência ("identidade") para o rDNA 16S de uma espécie de referência, por exemplo, uma espécie na Tabela 3 (veja, por exemplo, a Tabela 5 para obter informações sobre a sequência). Em algumas modalidades, uma espécie útil possui uma sequência de 16S rDNA da região V4 e/ou V6 com pelo menos 95% de identidade (por exemplo, pelo menos 96%, 97%, 98% ou 99% ou 100%) a uma região V4 e/ou V6 da sequência de 16S rDNA de uma espécie de referência, por exemplo, uma espécie identificada na Tabela 3 (ver, por exemplo, Tabela 5 para obter informações sobre a sequência). Em algumas modalidades, uma espécie útil possui uma sequência de 16S rDNA da região V4 e/ou V6 com pelo menos 97% de identidade com uma região V4 e/ou V6 da sequência de 16S rDNA de uma espécie de referência, por exemplo, uma espécie identificada na Tabela 3 (ver, por exemplo, a Tabela 5 para obter informações sobre a sequência). Em algumas modalidades, uma espécie útil tem uma sequência genômica com pelo menos 95% de identidade (por exemplo, pelo menos 96%, 97%, 98% ou 99% ou 100%) ao DNA genômico completo de uma espécie de referência, por exemplo, uma espécie identificada na Tabela 3. Em algumas modalidades, uma espécie útil tem uma sequência genômica com pelo menos 97% de identidade com a sequência genômica completa de uma espécie de referência, por exemplo, uma espécie identificada na Tabela 3. Caso uma sequência não seja fornecida neste documento, por exemplo, uma sequência de 16S rDNA, V4 ou V6, os métodos são bem conhecidos na técnica para identificar essas sequências. A Tabela 5 fornece exemplos não limitativos de sequências de 16S rDNA completas que podem ser usadas como sequências de referência. Em geral, identidade ou porcentagem de identidade com uma espécie de referência significa identidade ou porcentagem de identidade com pelo menos uma sequência de 16S rDNA (ou fragmento; por exemplo, V4 e / ou V6) encontrada em um organismo.

[0075] Em alguns casos, cepas de espécies bacterianas úteis na invenção, por exemplo, espécies divulgadas neste documento, podem ser obtidas em um centro público de recursos biológicos, como o ATCC (atcc.org), o DSMZ (dsmz.de) ou o Riken BioResource Center (en.brc.riken.jp). As sequências de rDNA 16s úteis para identificar espécies ou outros aspectos da invenção podem ser obtidas em bancos de dados públicos, por exemplo, o site do Human Microbiome Project (HMP) ou o GenBank.

[0076] Os métodos para determinar a identidade da sequência são conhecidos na técnica e os exemplos são fornecidos abaixo.

[0077] Em algumas modalidades, espécies excluídas das composições ROAR são espécies que estão positivamente correlacionadas com a presença de uma classe específica de genes de resistência a antibióticos (ver, por exemplo, Tabela 4). Essas espécies podem ser identificadas usando métodos como os descritos acima (consulte também a Tabela 6 para obter informações correspondentes sobre a sequência).

[0078] Deve ser entendido que "consistindo em" nesses exemplos refere-se a tipos de bactérias que estão presentes em uma composição. Uma formulação bacteriana "consistindo em" espécies listadas pode, assim, conter materiais não bacterianos adicionais, como um ou mais excipientes (incluindo, por exemplo, uma ou mais cápsulas), um meio aquoso ou não aquoso (por exemplo, glicerol, polietileno glicol, manteiga de cacau, água e/ou tampão) e/ou um ou mais medicamentos prebióticos ou de moléculas pequenas. Informações sobre espécies/nomes

[0079] Os nomes e a classificação de bactérias estão sujeitos a alterações que podem não estar refletidas na literatura. Por conveniência, nomes alternativos para algumas espécies bacterianas podem ser fornecidos neste documento, mas não pretendem ser um conjunto compreensivo de nomes alternativos. Em algumas modalidades, as espécies são identificadas pela identidade de sequência de todas ou uma porção (por exemplo, regiões V4 ou V6) de uma sequência de 16S rDNA, por exemplo, pelo menos 90%, 93% 95%, 96%, 97%, 98%, 99% ou 100% de identidade. Determinação da identidade

[0080] Clados, unidades taxonômicas operacionais (OTUs), espécies e cepas são, em algumas modalidades, identificados por suas sequências de 16S rDNA. A relação de clados, OTUs, espécies e cepas podem ser determinadas pela porcentagem de identidade entre clados, OTUs, espécies ou cepas. A identidade percentual entre uma sequência de referência e consulta pode ser determinada usando métodos conhecidos na técnica. Exemplos não limitativos de métodos para tais determinações são fornecidos abaixo. Conforme usado neste documento, a relação entre duas sequências de nucleotídeos é descrita pelo parâmetro "identidade".

[0081] Em uma modalidade, o grau de identidade de sequência entre uma sequência de consulta e uma sequência de referência é determinado por (1) alinhar as duas sequências por qualquer programa de alinhamento adequado usando a matriz de pontuação padrão e a penalidade de intervalo padrão, (2) identificar o número de combinações exatas, onde uma combinação exata é onde o programa de alinhamento identificou um nucleotídeo idêntico nas duas sequências alinhadas em uma determinada posição no alinhamento e (3) dividir o número de combinações exatas com o comprimento da sequência de referência.

[0082] Em outra modalidade, o grau de identidade de sequência entre uma sequência de consulta e uma sequência de referência é determinado por (1) alinhar as duas sequências por qualquer programa de alinhamento adequado usando a matriz de pontuação padrão e a penalidade de intervalo padrão, (2) identificar o número de combinações exatas, onde uma combinação exata é onde o programa de alinhamento identificou um nucleotídeo idêntico nas duas sequências alinhadas em uma determinada posição no alinhamento e (3) dividir o número de combinações exatas com o comprimento da maior das duas sequências.

[0083] Em outra modalidade, o grau de identidade de sequência entre a sequência de consulta e a sequência de referência é determinado por (1) alinhar as duas sequências por qualquer programa de alinhamento adequado usando a matriz de pontuação padrão e a penalidade de intervalo padrão, (2) identificar o número de combinações exatas, onde uma combinação exata é onde o programa de alinhamento identificou um aminoácido ou nucleotídeo idêntico nas duas sequências alinhadas em uma determinada posição no alinhamento e (3) dividir o número de combinações exatas com o "comprimento do alinhamento", em que o comprimento do alinhamento é o comprimento de todo o alinhamento, incluindo intervalos e partes pendentes das sequências.

[0084] As comparações de identidade de sequência são realizadas,

geralmente, com o auxílio de um programa de comparação de sequência. Esses programas de computador disponíveis comercialmente ou publicamente usam algoritmos de comparação complexos para alinhar duas ou mais sequências que melhor refletem os eventos evolutivos que podem ter levado às diferenças entre duas ou mais sequências. Portanto, esses algoritmos operam com um sistema de pontuação que recompensa o alinhamento de aminoácidos idênticos ou semelhantes e penaliza a inserção de intervalos, extensões de intervalos e alinhamento de aminoácidos não semelhantes. O sistema de pontuação dos algoritmos de comparação inclui: i) atribuição de uma pontuação de penalidade cada vez que um intervalo é inserido (pontuação de penalidade de intervalo), ii) atribuição de uma pontuação de penalidade cada vez que um intervalo existente for estendido com uma posição extra (pontuação de penalidade de extensão), iii) atribuição de pontuações mais altas mediante o alinhamento de aminoácidos idênticos, e iv) atribuição de pontuações variáveis após o alinhamento de aminoácidos não idênticos.

[0085] Em geral, os valores padrão do programa de alinhamento são usados para comparações de sequência. Programas de computador adequados, úteis para determinar a identidade, incluem, por exemplo, BLAST (blast.ncbi.nlm.nih.gov).

[0086] Em uma modalidade da presente invenção, o programa de alinhamento otimiza o alinhamento das sequências completas dentre as sequências selecionadas, por exemplo, sequência de 16S rDNA completa, V4 ou V6. Por exemplo, o programa de alinhamento global é baseado no algoritmo Needleman-Wunsch (Needleman e Wunsch, J. Mol. Biol. 48: 443-453, 1970). Exemplos não limitantes de tais programas são os programas EMBOSS Needle e EMBOSS Stretcher, disponíveis em ebi.ac.uk/Tools/psa/.

[0087] Em uma modalidade, as sequências são alinhadas por um programa de alinhamento global e a identidade da sequência é calculada identificando o número de combinações exatas identificadas pelo programa dividido pelo "comprimento do alinhamento", onde o comprimento do alinhamento é o comprimento de todo o alinhamento, incluindo intervalos e partes pendentes das sequências. Em uma modalidade adicional, o programa de alinhamento global usa o algoritmo Needleman-Wunsch e a identidade da sequência é calculada identificando o número de combinações exatas identificadas pelo programa dividido pelo "comprimento do alinhamento", onde o comprimento do alinhamento é o comprimento de todo alinhamento, incluindo intervalos e partes pendentes das sequências.

[0088] Em uma outra modalidade adicional, o programa de alinhamento global é selecionado do grupo que consiste em EMBOSS Needle e em EMBOSS stretcher e a identidade da sequência é calculada pela identificação do número de combinações exatas identificadas pelo programa dividido pelo "comprimento do alinhamento", onde o comprimento de alinhamento é o comprimento de todo o alinhamento, incluindo intervalos e partes pendentes das sequências.

[0089] Uma vez que o software produz um alinhamento, é possível calcular a porcentagem (%) de similaridade e a porcentagem de identidade de sequência. Os métodos de teste de composições para a atividade AbxR ou a presença de genes AbxR

[0090] Uma composição ROAR pode ser testada quanto à capacidade de reduzir a abundância de genes de resistência a antibióticos no trato GI de um animal usando modelos in vitro e/ou in vivo conhecidos na técnica (por exemplo, ver Schjørring e Krogfelt, Int. J. Microbiol. 2011:312956, 2011; Marra, “Animal models in drug development for MRSA,” Meth. Mol. Biol. 1085:333-345, 2014). Esses modelos podem ser adaptados para uso no teste de composições ROAR candidatas. Exemplos adicionais de modelos adequados são descritos nos Exemplos. Além disso, uma composição ROAR pode ser testada quanto à capacidade de reduzir a abundância de genes AbxR em sujeitos humanos inscritos em ensaios clínicos. Sujeitos

[0091] Em algumas modalidades, um sujeito adequado para tratamento com uma composição divulgada neste documento (uma composição ROAR) é um animal, por exemplo, um mamífero como um humano, cachorro, gato, bovino, ovino, caprino, equino ou outra fazenda, doméstica, ou animal de zoológico em risco de, ou com diagnóstico de, ter um nível indesejável de micro-organismos

AbxR, por exemplo, em pelo menos uma porção do trato gastrointestinal (GI). Um nível indesejável de organismos AbxR pode ser identificado como um nível significativamente maior que o de uma população saudável, por exemplo, no contexto de tratamento de seres humanos, a população saudável documentada no banco de dados do Projeto de Microbioma Humano. Tais organismos podem ser detectados por, por exemplo, cultura de fezes ou outra amostra gastrointestinal do sujeito e usando métodos conhecidos de teste para a presença de resistência a antibióticos. Os métodos incluem, por exemplo, métodos de diluição (métodos de diluição em caldo e ágar), métodos de difusão em disco, teste E, métodos automatizados, testes específicos de mecanismos como o teste de detecção de beta-lactamase e testes cefalosporínicos cromogênicos e métodos genotípicos como Métodos de PCR e hibridação de DNA. Esses métodos também incluem a identificação e quantificação de genes associados à resistência a antibióticos por sequenciamento metagenômico da espingarda (WMS). Em algumas modalidades, um nível indesejável de organismos ou genes de AbxR pode ser identificado usando métodos moleculares que identificam a presença ou ausência de genes, cassetes de genes ou marcadores genéticos associados ao fenótipo de AbxR. Alguns exemplos de tais métodos moleculares incluem, mas não estão limitados a, sequenciamento de DNA, perfis de transcrição e métodos que utilizam uma sonda molecular.

[0092] Em algumas modalidades, um sujeito adequado para o tratamento com uma composição ROAR é ou não respondeu ao tratamento com um ou mais antibióticos e a presença de uma população microbiana resistente a antibióticos é inferida.

[0093] Em algumas modalidades, um sujeito adequado para tratamento com uma composição ROAR tem ou está em risco de desenvolver infecção ou doença por C. difficile . Em algumas modalidades, um sujeito adequado para o tratamento com uma composição ROAR tem ou está em risco de desenvolver uma colite (por exemplo, doença de Crohn ou colite ulcerativa (por exemplo, colite ulcerativa leve a moderada)). Vantagens

[0094] O uso de antibióticos convencionais, além do potencial para a existência ou desenvolvimento de resistência a antibióticos pelo microbioma de um indivíduo, pode causar efeitos colaterais graves, incluindo, por exemplo, efeitos gastrointestinais, como disbiose, crescimento excessivo de patógenos, danos ao sistema nervoso e reações alérgicas. Uma composição ROAR normalmente compreende bactérias comensais e tem efeitos colaterais limitados, por exemplo, é bem tolerada pelos sujeitos que recebem o tratamento. Uma composição ROAR pode ser administrada repetidamente ao longo do tempo, conforme necessário, e pode reduzir o risco de desenvolver resistência a antibióticos a um grande grupo de antibióticos, por exemplo, reduzindo a prevalência de genes de resistência a antibióticos em um sujeito tratado. Em geral, uma composição ROAR pode modular ciclos de transmissão nos quais bactérias transmitem genes de resistência a antibióticos. Esse recurso é útil, por exemplo, em serviços de saúde nos quais o uso das composições diminui o risco de pacientes frágeis serem expostos ou desenvolver resistência a antibióticos, tanto individualmente quanto em população de pacientes.

[0095] Em algumas modalidades, uma vantagem adicional de uma composição ROAR de que a administração da composição pode melhorar a integridade das barreiras epiteliais e mucosas, por exemplo, reduzindo a quantidade de inflamação local e reduzindo o risco de translocação e infecção por micróbios locais GI. Definições

[0096] "Aumento" de um tipo de bactéria, por exemplo, uma espécie, é um efeito do tratamento com uma composição da invenção que é caracterizada pela detecção pós-tratamento de uma abundância aumentada de uma espécie que não está presente na composição por um teste não paramétrico de abundância.

[0097] "Enxerto" de um tipo de bactéria, por exemplo, uma espécie, é um efeito do tratamento com uma composição da invenção que é caracterizada pela detecção pós-tratamento de uma espécie da composição administrada, que não é detectada no pré-tratamento do sujeito tratado. Os métodos de detecção são conhecidos na técnica. Em um exemplo, o método é a detecção por PCR de uma sequência de 16S rDNA usando parâmetros padrão para PCR.

[0098] "Unidade taxonômica operacional", "OTU" (ou plural, "OTUs") refere- se a uma folha terminal em uma árvore filogenética e é definida por uma sequência de ácido nucleico, por exemplo, todo o genoma ou uma sequência genética específica e todas as sequências que compartilham identidade de sequência com essa sequência de ácido nucleico no nível das espécies. Em algumas modalidades, a sequência genética específica é a sequência de 16S ou uma porção da sequência de 16S, como uma região variável, por exemplo, uma região V4. Em outras modalidades, todo o genoma de duas entidades é sequenciado e comparado. Em outra modalidade, as regiões selecionadas, tais como marcações de sequência multilocus (MLST), genes específicos ou conjuntos de genes podem ser comparados geneticamente. Nas modalidades de 16S, as OTUs que compartilham ≥97% de identidade nucleotídica média em toda uma 16S ou em uma região variável de uma sequência de 16S são consideradas as mesmas OTU (ver, por exemplo, Claesson et al., Nucleic Acids Res. 38: e200, 2010; Konstantinidis et al., Philos. Trans. R. Soc. Lond. B. Biol. Sci. 361: 1929-1940, 2006). Em modalidades que envolvem o genoma completo, MLSTs, genes específicos ou conjuntos de genes, as OTUs que compartilham ≥95% de identidade nucleotídica média são consideradas as mesmas OTU (ver, por exemplo, Achtman e Wagner, Nat. Rev. Microbiol. 6: 431-440, 2008). As OTUs podem ser distinguidas, em algumas modalidades, comparando sequências entre organismos. Geralmente, as sequências com menos de 95% de identidade de sequência não são consideradas parte da mesma OTU. As OTUs também podem ser caracterizadas por qualquer combinação de marcadores ou genes de nucleotídeos, particularmente genes altamente conservados (por exemplo, genes de “manutenção da casa”) ou uma combinação destes. Essa caracterização emprega, por exemplo, dados WGS ou uma sequência inteira do genoma. Conforme usado neste documento, os termos "espécie" e "OTU" são usados de forma intercambiável, a menos que de outra forma distinguidos por contexto.

[0099] Uma "quantidade terapeuticamente eficaz" de uma composição descrita neste documento pode variar de acordo com fatores, tais como estado da doença, idade, sexo e peso do indivíduo e a capacidade da composição de provocar uma resposta desejada no indivíduo, por exemplo, melhoria de pelo menos um parâmetro do distúrbio ou melhoria de pelo menos um sintoma do distúrbio (e, opcionalmente, o efeito de qualquer agente adicional sendo administrado). Uma quantidade terapeuticamente eficaz também é uma na qual quaisquer efeitos tóxicos ou prejudiciais da composição são compensados pelos efeitos benéficos terapeuticamente. Uma composição, conforme descrita neste documento, é geralmente administrada em uma quantidade terapeuticamente eficaz. Formulações

[0100] As composições ROAR (por exemplo, composições Abx projetadas) descritas neste documento podem ser preparadas e administradas usando métodos conhecidos na técnica. Em geral, as composições são formuladas para administração oral, colonoscópica ou nasogástrica, embora qualquer método apropriado possa ser usado.

[0101] Uma formulação ROAR pode conter um ou mais excipientes farmacêuticos adequados para a preparação ou distribuição destas formulações. Em algumas modalidades, a formulação é uma formulação líquida. Em algumas modalidades, uma formulação compreendendo uma composição ROAR pode compreender um ou mais surfactantes, adjuvantes, tampões, antioxidantes, ajustadores de tonicidade, espessantes, modificadores de viscosidade e semelhantes.

[0102] Em algumas modalidades, o tratamento inclui a administração de uma composição ROAR em uma formulação que inclui um veículo farmaceuticamente aceitável. Em algumas modalidades, o excipiente inclui uma cápsula ou outro formato adequado para fornecer a composição ROAR como uma forma de dosagem oral. Quando um excipiente serve como diluente, pode ser um sólido, semissólido ou material líquido, o qual atua como um veículo, carreador ou meio, para o ingrediente ativo. Portanto, as formulações podem estar na forma de comprimidos, pílulas, pós, pastilhas, sachês, cachets, elixires, suspensões, emulsões, soluções, xaropes, cápsulas moles ou duras, supositórios ou pós embalados.

[0103] Alguns exemplos de excipientes adequados incluem lactose, dextrose, sacarose, sorbitol, manitol, amidos, goma acácia, fosfato de cálcio, alginatos, tragacanto, gelatina, silicato de cálcio, celulose microcristalina, polivinilpirrolidona, celulose, água, xarope, polietilenoglicol, glicerol e metilcelulose. As composições podem ser formuladas de modo a fornecer uma liberação rápida, sustentada ou retardada do ingrediente ativo após a administração ao paciente, empregando procedimentos conhecidos na técnica.

[0104] Uma composição ROAR pode ser formulada em uma forma de dosagem unitária. Em geral, uma dosagem compreende cerca de 10e2 a 10e9 unidades formadoras de colônias viáveis (ufc). Em algumas modalidades, as composições ROAR compreendem ou são compostas por bactérias ex-esporos na forma de esporos. Nesses casos, a dosagem pode ser determinada como "CFU de esporos" ou "sCFU", que quantifica o número de esporos viáveis por germinação e crescimento, geralmente em placas.

[0105] O termo "formas de dosagem unitárias" refere-se a unidades fisicamente discretas apropriadas como doses unitárias para seres humanos e/ou outros mamíferos, cada unidade contendo uma quantidade pré-determinada de material ativo calculada para produzir um início desejado, tolerabilidade e/ou efeitos terapêuticos, em associação com um excipiente farmacêutico adequado. Uma dosagem pode ser administrada em vários veículos de entrega, por exemplo, vários comprimidos ou cápsulas.

[0106] A quantidade e frequência de administração de uma composição ROAR a um paciente irá variar dependendo do que esta sendo administrado, o propósito da administração, tal como profilaxia ou terapia, o estado do paciente, a maneira de administração e semelhantes. Em aplicações terapêuticas, composições podem ser administradas a um paciente que já sofre de uma doença em quantidade suficiente para curar ou, pelo menos parcialmente, controlar um ou mais sintomas da doença e suas complicações. Doses eficazes dependerão da condição da doença ou condição a ser tratada, bem como pelo julgamento do médico atendente, dependendo de fatores tais como a gravidade da doença, a idade, peso e condição geral do paciente e semelhantes.

[0107] A dosagem pode se referir, por exemplo, ao número total de cfus de cada espécie ou linhagem individual, ou pode se referir ao número total de micro- organismos na dose. Entende-se na arte que a determinação do número de organismos em uma dosagem não é exata e pode depender do método usado para determinar o número de organismos presentes. Por exemplo, o número de esporos em uma composição pode ser determinado usando um ensaio de ácido dipicolínico. Em alguns casos, o número de organismos pode ser determinado usando um ensaio de cultura. Quando os esporos estão presentes, a capacidade de ensaios baseados em métodos de cultura pode depender da germinação eficiente dos esporos. Os métodos quantitativos baseados em ácido nucleico podem depender se os ácidos nucleicos de microrganismos não viáveis são suficientemente reduzidos ou eliminados. Doses eficazes podem ser extrapoladas a partir de curvas dose-resposta derivadas de sistemas de teste in vitro ou modelo animal. Métodos de Triagem

[0108] A invenção também fornece métodos para identificar composições bacterianas que podem ser usadas para diminuir a abundância de genes de resistência a antibióticos em sujeitos. Nesses métodos, as composições candidatas são analisadas quanto à presença de uma ou mais espécies bacterianas da Tabela

3. A detecção de uma ou mais (por exemplo, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais) dessas espécies indica que a composição pode ser útil na diminuição da abundância de genes de resistência a antibióticos. Testes adicionais podem ser feitos para realizar a triagem das composições candidatas. Por exemplo, as composições candidatas podem ainda ser analisadas quanto à presença de uma ou mais espécies da Tabela 4. Em algumas modalidades, pode ser determinado que é preferível evitar o uso de composições identificadas como incluindo uma ou mais (por exemplo, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais) espécies da Tabela 4.

[0109] Em outros métodos de rastreio da invenção, os potenciais dadores de fezes para uso em métodos terapêuticos (por exemplo, métodos terapêuticos da presente invenção) são triados quanto à sua adequação para servirem como dadores. Nesses métodos, uma amostra fecal de um potencial doador é examinada quanto à presença de uma ou mais espécies bacterianas associadas à diminuição dos genes de resistência a antibióticos (ver, por exemplo, Tabela 3; ver Tabela 5 para sequências) e/ou uma ou mais espécies bacterianas correlacionado com a presença de genes de resistência a antibióticos (ver, por exemplo, Tabela 4; ver Tabela 6 para sequências). A detecção do primeiro pode indicar que o doador potencial é adequado para continuar a servir como doador, enquanto a detecção do último pode indicar que o potencial doador não deve prosseguir, como pode ser determinado pelos versados na técnica.

[0110] Os métodos de triagem adicionais incluem aqueles usados para determinar se um sujeito pode se beneficiar do tratamento com uma composição ROAR, conforme descrito neste documento. Nestes métodos, uma amostra do sujeito (por exemplo, uma amostra fecal) é testada quanto à presença de uma ou mais espécies bacterianas correlacionadas com a presença de genes de resistência a antibióticos (ver, por exemplo, Tabelas 4 e 6). A detecção de uma ou mais dessas espécies pode indicar que o sujeito pode se beneficiar do tratamento de acordo com os métodos terapêuticos da invenção, como pode ser determinado pelos versados na técnica.

[0111] A detecção de espécies nesses métodos da invenção pode ser realizada usando métodos conhecidos na técnica (ver, por exemplo, acima e em outras partes deste documento). Por exemplo, métodos que incluem, por exemplo, qPCR, sequenciamento metagenômico da espingarda (WMS; ver, por exemplo, abaixo) e/ou análise de sequências de 16S rDNA ou uma porção destas (por exemplo, as regiões V4 e/ou V6; ver, por exemplo, Tabela 5) podem ser realizados. As sequências da Tabela 5 podem ser detectadas com relação à identificação de correlatos negativos (isto é, redução nos genes de resistência a antibióticos). As sequências da Tabela 6 podem ser detectadas com relação à identificação de correlatos positivos (isto é, aumento da abundância de genes de resistência a antibióticos).

EQUIVALENTES

[0112] Todas características técnicas podem ser combinados individualmente em todas as combinações possíveis de tais características.

[0113] A invenção pode ser incorporada de outras formas específicas sem se afastar do espírito ou das características essenciais da mesma. As modalidades precedentes devem, portanto, ser consideradas em todos os aspectos, ilustrativas ao invés de limitantes da invenção descrita neste documento.

EXEMPLOS

[0114] Os seguintes exemplos não limitantes adicionalmente ilustram as modalidades das invenções descritas neste documento. Exemplo 1: Estudos em humanos - Clostridium difficile

[0115] Os sujeitos humanos em risco de infecção recorrente por Clostridium difficile (rCDI) foram tratados com esporos enriquecidos e purificados, preparados a partir das fezes de humanos saudáveis, triados em um estudo de Fase 2 randomizado, duplo-cego e controlado por placebo (n = 89; randomizado 2: 1; 36 sites). Os esporos foram administrados por via oral em dose única (de 4 cápsulas).

A dosagem foi de 10e8 equivalentes de esporos. Os microbiomas gastrointestinais desses sujeitos, bem como os sujeitos de um estudo de dose aberta de fase 1b, foram perfilados usando todo o sequenciamento metagenômico de espingarda (WMS). As amostras de fezes foram coletadas antes do tratamento com esporos (após tratamento com antibióticos) e após o recebimento de esporos ou placebo, conforme aplicável.

[0116] O DNA foi extraído das amostras de fezes e usado para gerar dados WMS com a plataforma de sequenciamento Illumina. Os dados do WMS foram triados quanto à presença e abundância de marcadores genéticos de proteínas conhecidas por conferir resistência a antibióticos, conforme catalogadas no Comprehensive Antibiotic Resistance Database (CARD v.1.1.8) (card.mcmaster.ca). Os marcadores genéticos associados a essas proteínas foram construídos usando ShortBRED (Kaminski et al., PLoS Comput Biol 11 (12): e1004557), uma ferramenta de informática projetada para identificar proteínas de interesse com alta especificidade nos dados de WMS (Tabela 1). Para cada classe de antibióticos, a abundância de marcadores genéticos associados à resistência a essa classe foi somada para gerar valores de abundância de genes normalizados (referidos neste documento como abundância de marcadores de classe de medicamentos ou DCMA).

[0117] Para o estudo da Fase 2, a prevalência diferencial de espécies formadoras de esporos foi observada com base na análise WMS. A abundância de genes foi avaliada usando os marcadores ShortBRED (Kaminski et al., Supra) para genes associados à resistência a antibióticos identificados no ARDB (Liu e Pop, 2009, ARDB - Antibiotic Resistance Genes Database). Nuc Acids Res 37 (edição do Banco de Dados): D443-447). Os dados foram analisados quanto a um sinal significativo de enxerto, definido como sujeitos nos quais um número significativo de espécies foi identificado como sendo geneticamente semelhante às espécies identificadas na composição ROAR administrada. A análise dos dados resultou na descoberta de que, em sujeitos com um sinal significativo de enxerto para a composição, a abundância de genes associados à resistência a múltiplas classes de medicamentos, como medicamentos com quinolona (Fig. 1) e medicamentos beta-lactâmicos ou carbapenêmicos (Fig. 2) foi reduzido.

[0118] Em análises adicionais, para cada sujeito e classe de medicamentos

(dos estudos de Fase 1b e Fase 2), calculamos a fold change de log2 (log2FC) da abundância de marcadores de classe de medicamentos (DCMA) entre amostras coletadas na visita 1 semana após o recebimento do placebo ou esporos, em comparação com as amostras coletadas um dia antes do tratamento com placebo ou esporos. Comparamos sujeitos com rCDI que receberam placebo com sujeitos com rCDI que receberam esporos e nos quais foram detectados enxertos significativos. Usamos o teste não paramétrico de Mann-Whitney para determinar se o log2FC no DCMA foi significativamente maior em sujeitos com enxerto de esporos em comparação com os sujeitos que receberam placebo (Tabela 2). As taxas de descoberta falsa (FDR), a proporção esperada de hipóteses nulas incorretamente rejeitadas para um determinado valor p devido à execução de vários testes, foram calculadas usando o procedimento de Benjamini-Hochberg (p<0,1)

[0119] Os dados demonstram que uma composição ROAR pode ser usada para reduzir a abundância de genes de resistência a antibióticos em um sujeito.

[0120] Tabela 1 - Mudança na Abundância de Genes em Resposta ao Tratamento Cartão de Acesso p-valor FDR Enxertos de log2 - Símbolo do Gene Placebo de log2 ARO_3000753 1.5E-03 8.5E-02 0,91 abeM ARO_3000216 2.9E-03 8.5E-02 -1,24 acrB ARO_3000828 2.5E-03 8.5E-02 -1,38 baeR ARO_3000830 1.3E-03 8.5E-02 -1,57 cpxA ARO_3002867 2.7E-03 8.5E-02 1,35 dfrF ARO_3004039 3.7E-03 8.5E-02 -1,27 Escherichia coli emrE ARO_3002522 2.4E-04 8.5E-02 0,90 novA ARO_3000196 1.1E-03 8.5E-02 1.72 tet32 ARO_3002871 2.2E-03 8.5E-02 1,46 tet37 ARO_3000195 7.4E-04 8.5E-02 -1,28 tetB (P) ARO_3002829 3.0E-03 8.5E-02 0,70 vgaA ARO_3000499 5.1E-03 9.5E-02 -1,47 acrE ARO_3002626 6.1E-03 9.5E-02 -0,76 ANT(6)-Ia ARO_3003838 5.7E-03 9.5E-02 -1,50 gadW ARO_3002836 5.6E-03 9.5E-02 -0,50 lnuB ARO_3000263 6.7E-03 9.5E-02 -1,33 marA ARO_3000793 6.3E-03 9.5E-02 -1,40 mdtB ARO_3000794 6.7E-03 9.5E-02 -1,59 mdtC ARO_3000180 4.9E-03 9.5E-02 -0,53 tetA(P)

ARO_3000194 5.1E-03 9.5E-02 1,57 tetW ARO_3003202 5.4E-03 9.5E-02 -0,30 TLA-1 ARO_3000796 7.4E-03 1.0E-01 -1,65 mdtF ARO_3000615 8.5E-03 1.1E-01 -1,41 mefA ARO_3002818 8.3E-03 1.1E-01 -1,24 msrB ARO_3000024 9.0E-03 1.1E-01 -1,02 patA ARO_3000829 1.0E-02 1.2E-01 -1,47 baeS ARO_3000491 1.1E-02 1.2E-01 -1,11 acrD ARO_3000656 1.3E-02 1.2E-01 -1,17 acrS ARO_3000074 1.1E-02 1.2E-01 -1,10 emrB ARO_3000309 1.2E-02 1.2E-01 -1,33 emrD ARO_3000206 1.5E-02 1.2E-01 -1,15 emrK ARO_3000254 1.4E-02 1.2E-01 -1,42 emrY ARO_3000833 1.3E-02 1.2E-01 -1,20 evgS ARO_3000795 1.3E-02 1.2E-01 -1,31 mdtE ARO_3003550 1.4E-02 1.2E-01 -1,20 mdtP ARO_3003950 1.3E-02 1.2E-01 -1,48 msbA ARO_3003952 1.4E-02 1.2E-01 -1,12 yojI ARO_3003549 1.5E-02 1.3E-01 -1,14 mdtO ARO_3002630 1.8E-02 1.3E-01 -0,41 ANT (9) -Ia ARO_3002634 1.9E-02 1.3E-01 -1,04 APH(2'') -ie ARO_3001328 1.9E-02 1.3E-01 -1,02 Escherichia coli mdfA ARO_3000832 1.8E-02 1.3E-01 -1,18 evgA ARO_3000676 1.7E-02 1.3E-01 -1,08 H-NS ARO_3003206 1.8E-02 1.3E-01 -0,40 lsaE ARO_3001329 2.0E-02 1.3E-01 -1,05 mdtG ARO_3001216 1.8E-02 1.3E-01 -1,12 mdtH ARO_3003107 1.8E-02 1.3E-01 -0,20 mefB ARO_3002174 2.0E-02 1.3E-01 -1,21 MIR-9 ARO_3000237 1.9E-02 1.3E-01 -1,11 tolC ARO_3000502 2.4E-02 1.4E-01 -0,91 acrF ARO_3002986 2.4E-02 1.4E-01 -1,33 bacA ARO_3002669 2.9E-02 1.5E-01 -0,90 APH(2'')-Ig ARO_3002152 2.9E-02 1.5E-01 -1,25 DHA-21 ARO_3000516 2.9E-02 1.5E-01 -1,23 emrR ARO_3002985 3.2E-02 1.7E-01 -0,84 arnA ARO_3003057 3,4E-02 1.7E-01 -0,23 smeF ARO_3000803 3,4E-02 1.7E-01 -0,18 MexE ARO_3001304 3.5E-02 1.7E-01 -0,49 ErmS ARO_3002559 3.6E-02 1.7E-01 -1,06 AAC(6')-Ip ARO_3003017 3.7E-02 1.7E-01 -0,09 dfrA21 ARO_3002804 3.7E-02 1.7E-01 -0,37 FosA2

ARO_3002894 3.7E-02 1.7E-01 -0,06 otrC ARO_3003576 3.7E-02 1.7E-01 -0,89 PmrC ARO_3003841 3.8E-02 1.7E-01 -0,84 kdpE ARO_3003578 4.0E-02 1.8E-01 -0,87 pmrF ARO_3002597 4.4E-02 2.0E-01 -0,93 AAC(6')-Ie-APH (2'')-Ia ARO_3002635 4.4E-02 2.0E-01 -1,22 APH(2'')-IIa ARO_3000205 4.8E-02 2.1E-01 -1,14 tetX ARO_3000192 4.9E-02 2.1E-01 -0,15 tetS ARO_3004042 5.0E-02 2.1E-01 -1,14 Enterobacter cloacae acrA ARO_3003773 5.6E-02 2.3E-01 -0,04 Clostridium perfringens mprF ARO_3002859 5.6E-02 2.3E-01 0,23 dfrA14 ARO_3003548 5.5E-02 2.3E-01 -0,87 mdtN ARO_3002688 5.8E-02 2.3E-01 0,21 catS ARO_3002835 5.8E-02 2.3E-01 -0,21 lnuA ARO_3000518 6.1E-02 2.3E-01 -0,99 CRP ARO_3000792 6.2E-02 2.3E-01 -0,60 mdtA ARO_3000826 6.1E-02 2.3E-01 -0,90 sdiA ARO_3002671 6.3E-02 2.3E-01 -0,32 cat-TC ARO_3003112 6.3E-02 2.3E-01 0,11 lsaC ARO_3002670 6.9E-02 2.5E-01 0,70 cat ARO_3000508 6.9E-02 2.5E-01 -0,81 gadX ARO_3000300 7.0E-02 2.5E-01 -0,22 lsaA ARO_3003699 7.0E-02 2.5E-01 -0,25 mexQ ARO_3000191 6.8E-02 2.5E-01 -1,21 tetQ ARO_3000027 7.2E-02 2.5E-01 -0,76 emrA ARO_3000377 7.5E-02 2.6E-01 -0,25 MexA ARO_3003704 8.0E-02 2.6E-01 -0,10 mexM ARO_3003705 8.0E-02 2.6E-01 -0,24 mexN ARO_3001421 7.8E-02 2.6E-01 0,03 OXA-26 ARO_3002639 8.3E-02 2.6E-01 -0,51 APH(3'')-Ib ARO_3004072 8.5E-02 2.6E-01 -0,22 OpmB ARO_3003681 8.5E-02 2.6E-01 -0,22 TriC ARO_3002932 8.3E-02 2.6E-01 -0,30 vanSB ARO_3002831 8.4E-02 2.6E-01 -1,15 vgaC ARO_3000250 8.9E-02 2.7E-01 -0,27 ErmC ARO_3002964 8.9E-02 2.7E-01 -0,35 vanWB ARO_3003679 9.0E-02 2.7E-01 -0,13 TriA ARO_3002950 9.5E-02 2.8E-01 -0,39 vanXB ARO_3002553 9.8E-02 2.9E-01 -0,02 AAC(6')-If ARO_3001777 9.8E-02 2.9E-01 -0,04 OXA-347 ARO_3001303 1.1E-01 3.0E-01 0,07 ErmO

ARO_3000823 1.1E-01 3.0E-01 -0,98 ramA ARO_3002933 1.1E-01 3.0E-01 -0,12 vanSC ARO_3003031 1.1E-01 3.1E-01 -0,34 mexW ARO_3002679 1.1E-01 3.1E-01 -0,25 catB7 ARO_3000578 1.2E-01 3.4E-01 -0,21 CcrA beta-lactamase ARO_3002156 1.2E-01 3.4E-01 0,16 FOX-2 ARO_3000811 1.2E-01 3.4E-01 -0,04 mtrD ARO_3001299 1.2E-01 3.4E-01 0,02 tlrB conferindo resistência à tilosina ARO_3002502 1.3E-01 3.4E-01 -0,23 PDC-5 ARO_3000149 1.3E-01 3.5E-01 -0,15 fosA ARO_3000378 1.4E-01 3.6E-01 -0,29 MexB ARO_3002923 1.4E-01 3.6E-01 -0,59 vanRD ARO_3003577 1.4E-01 3.7E-01 -0,65 pmrE ARO_3003922 1.4E-01 3.7E-01 -0,99 oqxA ARO_3000806 1.5E-01 3.7E-01 -0,18 mexG ARO_3002629 1.5E-01 3.9E-01 0,74 ANT(6)-Ib ARO_3002868 1.6E-01 3.9E-01 -0,25 dfrG ARO_3000379 1.6E-01 3.9E-01 -0,14 OprM ARO_3002687 1.7E-01 4.0E-01 -0,05 catQ ARO_3002858 1.7E-01 4.0E-01 -0,03 dfrA12 ARO_3000347 1.7E-01 4.0E-01 -0,28 ErmA ARO_3000807 1.6E-01 4.0E-01 -0,26 mexH ARO_3000621 1.6E-01 4.0E-01 0,01 PC1 beta-lactamase (blaZ) ARO_3003046 1.7E-01 4.0E-01 -0,03 qacA ARO_3002965 1.6E-01 4.0E-01 -0,26 vanWG ARO_3002943 1.7E-01 4.0E-01 0,30 vanHB ARO_3000025 1.7E-01 4.0E-01 0,12 patB ARO_3004073 1.7E-01 4.0E-01 -0,20 MuxA ARO_3000368 1.8E-01 4.0E-01 -0,13 vanC ARO_3002970 1.8E-01 4.1E-01 -0,11 vanTC ARO_3003698 1.8E-01 4.1E-01 -0,21 mexP ARO_3003835 1.9E-01 4.2E-01 -0,24 cdeA ARO_3004077 1.9E-01 4.2E-01 -0,20 PmpM ARO_3003551 1.9E-01 4.3E-01 -0,19 emeA ARO_3002528 2.0E-01 4.3E-01 0,02 AAC(3)-Ia ARO_3002578 2.0E-01 4.3E-01 -0,24 AAC(6')-Ib7 ARO_3002686 2.0E-01 4.3E-01 0,15 catP ARO_3003693 2.0E-01 4.3E-01 -0,19 mexK ARO_3002452 2.0E-01 4.3E-01 -0,79 OKP-B-19 ARO_3002957 2.0E-01 4.3E-01 -0,14 vanYD ARO_3002921 2.0E-01 4.4E-01 -0,38 vanRB

ARO_3001338 2.1E-01 4.4E-01 -0,57 SHV-100 ARO_3004056 2.2E-01 4.5E-01 -0,10 ArmR ARO_3002317 2.2E-01 4.5E-01 0,00 KPC-7 ARO_3002391 2.1E-01 4.5E-01 -0,94 OXY-1-3 ARO_3000567 2.1E-01 4.5E-01 0,97 tet(40) ARO_3002185 2.2E-01 4.5E-01 -0,06 MOX-6 ARO_3002972 2.2E-01 4.5E-01 -0,11 vanTG ARO_3001796 2.3E-01 4.6E-01 -0,23 OXA-50 ARO_3002956 2.3E-01 4.6E-01 -0,40 vanYB ARO_3002999 2.3E-01 4.7E-01 0,10 CblA-1 ARO_3004036 2.3E-01 4.7E-01 0,02 tetB(60) ARO_3000316 2.5E-01 5.0E-01 0,05 mphA ARO_3003923 2.5E-01 5.0E-01 -0,89 oqxB ARO_3002930 2.5E-01 5.0E-01 0,19 vanRO ARO_3003022 2.9E-01 5.1E-01 0,01 dfrB3 ARO_3002705 2.9E-01 5.1E-01 -0,01 floR ARO_3002213 2.9E-01 5.1E-01 -0,01 IMP-22 ARO_3004041 2.9E-01 5.1E-01 -0,48 Klebsiella pneumoniae acrA ARO_3002482 2.9E-01 5.1E-01 -0,05 LRA-1 ARO_3002486 2.9E-01 5.1E-01 0,01 LRA-7 ARO_3001214 2.6E-01 5.1E-01 -0,56 mdtM ARO_3000215 2.9E-01 5.1E-01 0,00 mecR1 ARO_3001610 2.9E-01 5.1E-01 0,01 OXA-243 ARO_3001503 2.9E-01 5.1E-01 0,03 OXA-258 ARO_3001780 2.7E-01 5.1E-01 0,08 OXA-85 ARO_3003836 2.9E-01 5.1E-01 0,01 qacH ARO_3002828 2.7E-01 5.1E-01 -0,19 srmB ARO_3000573 2.9E-01 5.1E-01 0,02 tet(43) ARO_3000013 2.6E-01 5.1E-01 -0,26 vanB ARO_3003727 2.9E-01 5.1E-01 0,00 vanKI ARO_3003724 2.9E-01 5.1E-01 -0,01 vanWI ARO_3002841 2.9E-01 5.1E-01 0,01 vatB ARO_3004032 3.0E-01 5.2E-01 0,40 tetA(46) ARO_3003033 3.1E-01 5.4E-01 -0,20 mexY ARO_3004033 3.1E-01 5.4E-01 0,36 tetB(46) ARO_3003209 3.2E-01 5.5E-01 -0,60 FosA5 ARO_3002538 3.8E-01 5.5E-01 0,01 AAC(3)-IIIc ARO_3002540 3.8E-01 5.5E-01 0,00 AAC(3)-VIa ARO_3002589 3.8E-01 5.5E-01 0,04 AAC(6')-Iid ARO_3001816 3.4E-01 5.5E-01 -0,24 ACC-2 ARO_3003848 3.8E-01 5.5E-01 -0,02 ADC-2

ARO_3000780 3.8E-01 5.5E-01 0,02 adeI ARO_3002646 3.8E-01 5.5E-01 0,01 APH(3')-IIc ARO_3002660 3.8E-01 5.5E-01 -0,44 APH(6)-Id ARO_3000838 3.8E-01 5.5E-01 -0,03 arlR ARO_3000839 3.8E-01 5.5E-01 -0,02 arlS ARO_3002847 3.8E-01 5.5E-01 -0,04 arr-2 ARO_3002854 3.2E-01 5.5E-01 -0,18 dfrA1 ARO_3003013 3.8E-01 5.5E-01 -0,03 dfrA15 ARO_3002860 3.4E-01 5.5E-01 0,14 dfrA17 ARO_3003953 3.8E-01 5.5E-01 0,01 hmrM ARO_3002259 3.8E-01 5.5E-01 -0,02 IND-3 ARO_3003111 3.8E-01 5.5E-01 -0,15 lsaB ARO_3000800 3.2E-01 5.5E-01 -0,17 MexC ARO_3000808 3.5E-01 5.5E-01 -0,14 mexI ARO_3003692 3.3E-01 5.5E-01 -0,16 mexJ ARO_3003035 3.8E-01 5.5E-01 -0,01 mfpA ARO_3004074 3.3E-01 5.5E-01 -0,08 MuxB ARO_3000802 3.8E-01 5.5E-01 -0,12 OprJ ARO_3000805 3.8E-01 5.5E-01 -0,09 OprN ARO_3001710 3.4E-01 5.5E-01 0,18 OXA-211 ARO_3001398 3.8E-01 5.5E-01 0,02 OXA-3 ARO_3000822 3.6E-01 5.5E-01 0,03 pmrA ARO_3002794 3.2E-01 5.5E-01 0,01 QnrS5 ARO_3001301 3.5E-01 5.5E-01 0,05 RlmA(II) ARO_3003056 3.8E-01 5.5E-01 -0,01 smeE ARO_3002493 3.8E-01 5.5E-01 -0,01 SRT-1 ARO_3000168 3.7E-01 5.5E-01 -0,04 tet(D) ARO_3000178 3.8E-01 5.5E-01 0,01 tet(K) ARO_3000186 3.4E-01 5.5E-01 -0,22 tetM ARO_3000193 3.8E-01 5.5E-01 0,00 tetT ARO_3000005 3.4E-01 5.5E-01 -0,20 vanD ARO_3002934 3.6E-01 5.5E-01 -0,47 vanSD ARO_3002935 3.8E-01 5.5E-01 -0,03 vanSE ARO_3002953 3.8E-01 5.5E-01 -0,01 vanXM ARO_3004075 3.8E-01 5.5E-01 -0,15 MuxC ARO_3000410 3.9E-01 5.6E-01 0,20 sul1 ARO_3002598 4.0E-01 5.7E-01 -0,17 Proteína de fusão ANT(3'')-Ii-AAC(6')-IId ARO_3001396 4.1E-01 5.8E-01 -0,32 OXA-1 ARO_3000616 4.2E-01 5.9E-01 0,12 mel ARO_3004038 4.3E-01 6.0E-01 -0,20 Pseudomonas aeruginosa emrE ARO_3000498 4.4E-01 6.1E-01 -1,33 ErmF

ARO_3004054 4.4E-01 6.2E-01 -0,11 Pseudomonas aeruginosa CpxR ARO_3002982 4.6E-01 6.4E-01 -0,11 amrA ARO_3000593 4.6E-01 6.4E-01 0,19 ErmQ ARO_3000801 4.6E-01 6.4E-01 -0,18 MexD ARO_3003839 4.7E-01 6.4E-01 0,11 Mrx ARO_3003680 4.8E-01 6.6E-01 -0,25 TriB ARO_3003030 5.2E-01 7.0E-01 -0,17 mexV ARO_3000167 5.3E-01 7.1E-01 0,02 tet(C) ARO_3001307 5.3E-01 7.1E-01 -0,02 VgbA ARO_3003954 5.4E-01 7.2E-01 0,00 efmA ARO_3000804 5.4E-01 7.2E-01 0,04 MexF ARO_3000412 5.5E-01 7.3E-01 -0,25 sul2 ARO_3003583 5.5E-01 7.3E-01 -0,19 graves ARO_3002684 5.6E-01 7.3E-01 -0,03 catII ARO_3003948 5.5E-01 7.3E-01 -0,04 efrA ARO_3000230 5.6E-01 7.3E-01 0,00 ANT(2'')-Ia ARO_3002966 5.8E-01 7.5E-01 -0,15 vanXYC ARO_3000190 5.8E-01 7.5E-01 0,35 tetO ARO_3002645 5.9E-01 7.5E-01 -0,11 APH(3')-IIb ARO_3003097 5.9E-01 7.5E-01 -0,12 CfxA6 ARO_3000522 5.9E-01 7.5E-01 -0,53 ErmG ARO_3000595 5.9E-01 7.5E-01 -0,30 ErmT ARO_3002881 6.0E-01 7.5E-01 0,03 lmrC ARO_3002895 6.0E-01 7.5E-01 -0,16 SAT-1 ARO_3003070 6.0E-01 7.5E-01 -0,13 vanXD ARO_3002535 6.1E-01 7.5E-01 -0,22 AAC(3)-IIc ARO_3002539 6.1E-01 7.5E-01 -0,29 AAC(3)-IV ARO_3000174 6.1E-01 7.5E-01 0,01 tet(G) ARO_3002944 6.1E-01 7.6E-01 -0,03 vanHD ARO_3003717 6.4E-01 7.8E-01 -0,05 ESP-1 ARO_3000181 6.4E-01 7.8E-01 0,01 tet(V) ARO_3003710 6.5E-01 7.9E-01 -0,06 mexL ARO_3000165 6.5E-01 7.9E-01 -0,15 tet(A) ARO_3002931 6.5E-01 7.9E-01 -0,03 vanSA ARO_3000010 6.7E-01 8.1E-01 -0,03 vanA ARO_3002605 6.7E-01 8.1E-01 0,00 aadA5 ARO_3001933 7.1E-01 8.5E-01 -0,63 CTX-M-72 ARO_3000175 7.1E-01 8.5E-01 0,01 tet(H) ARO_3002556 7.1E-01 8.5E-01 0,05 AAC(6')-II ARO_3002680 7.2E-01 8.6E-01 -0,25 catB8 ARO_3000809 7.3E-01 8.6E-01 -0,14 opmD

ARO_3002897 7.3E-01 8.6E-01 -0,37 SAT-4 ARO_3001313 7.3E-01 8.6E-01 0,00 facT ARO_3003197 7.4E-01 8.7E-01 -0,06 aadA25 ARO_3003949 7.7E-01 9.0E-01 0,00 efrB ARO_3003682 7.7E-01 9.0E-01 -0,13 OpmH ARO_3001959 7.8E-01 9.0E-01 -0,45 CTX-M-100 ARO_3002942 7.9E-01 9.1E-01 -0,02 vanHA ARO_3003559 8.1E-01 9.3E-01 -0,29 cepA beta-lactamase ARO_3002628 8.2E-01 9.4E-01 -0,02 aad(6) ARO_3000596 8.2E-01 9.4E-01 0,02 ErmX ARO_3002949 8.2E-01 9.4E-01 -0,05 vanXA ARO_3002837 8.3E-01 9.4E-01 -0,30 lnuC ARO_3002756 8.3E-01 9.4E-01 0,21 QnrB41 ARO_3002875 8.4E-01 9.4E-01 0,04 dfrE ARO_3002647 8.5E-01 9.5E-01 0,00 APH(3')-IIIa ARO_3000179 8.5E-01 9.5E-01 -0,21 tet(L) ARO_3002069 8.6E-01 9.6E-01 -0,09 CMY-59 ARO_3002019 9.0E-01 9.8E-01 0,01 CMY-8 ARO_3003095 9.0E-01 9.8E-01 0,12 imiS ARO_3002225 9.0E-01 9.8E-01 -0,03 IMP-34 ARO_3001413 9.0E-01 9.8E-01 0,01 OXA-18 ARO_3000565 9.0E-01 9.8E-01 0,00 tet(38) ARO_3000177 8.8E-01 9.8E-01 -0,25 tet(J) ARO_3002882 9.1E-01 9.8E-01 0,07 lmrD ARO_3002363 9.1E-01 9.8E-01 0,02 PER-1 ARO_3003069 9.1E-01 9.8E-01 -0,02 vanXYG ARO_3002819 9.2E-01 9.9E-01 -0,03 msrC ARO_3003210 9.4E-01 9.9E-01 -0,27 FosA4 ARO_3000026 9.4E-01 9.9E-01 -0,01 mepA ARO_3000746 9.4E-01 9.9E-01 0,00 mepR ARO_3000815 9.4E-01 9.9E-01 0,00 mgrA ARO_3003199 1.0E+00 1.0E+00 0,02 AAC(6')-Iak ARO_3002613 9.6E-01 1.0E+00 0,01 aadA13 ARO_3002641 9.7E-01 1.0E+00 -0,07 APH(3')-Ia ARO_3002655 1.0E+00 1.0E+00 -0,24 APH(4)-Ia ARO_3003730 1.0E+00 1.0E+00 -0,06 IleS intrínseco das bifidobactérias que conferem resistência à mupirocina ARO_3001920 9.8E-01 1.0E+00 -0,09 CTX-M-59 ARO_3003955 9.9E-01 1.0E+00 -0,03 efpA ARO_3000375 9.6E-01 1.0E+00 0,07 ErmB ARO_3004085 1.0E+00 1.0E+00 -0,06 InuG

ARO_3002665 9.9E-01 1.0E+00 -0,16 npmA ARO_3003700 9.9E-01 1.0E+00 -0,18 opmE ARO_3002788 1.0E+00 1.0E+00 -0,04 QnrD1 ARO_3001388 9.6E-01 1.0E+00 -0,37 TEM-211 ARO_3000556 9.5E-01 1.0E+00 -0,01 tet44 ARO_3004035 9.7E-01 1.0E+00 -0,01 tetA(60) ARO_3002909 1.0E+00 1.0E+00 0,00 vanG ARO_3002919 9.9E-01 1.0E+00 -0,08 vanRA ARO_3002922 1.0E+00 1.0E+00 -0,06 vanRC ARO_3002955 9.5E-01 1.0E+00 0,01 vanYA ARO_3002962 1.0E+00 1.0E+00 -0,09 vanZA

[0121] Tabela 2 - O Enxerto de Esporos Está Associado a Uma Redução Significativa Nos Genes de Resistência a antibióticos Exertos altos Exemplos de de log2FC - antibióticos na Classe de Placebo de classe de Medicamento log2 p-valor FDR medicamentos Antibiótico -1,534 0,003 0,035 Novobiocina, aminocumarina Albamicina, Coumemicina, Clorobiocina Antibiótico -1,241 0,009 0,035 Canamicina, aminoglicosídeo Amicacina, Tobramicina, Dibecacina, Gentamicina, Sisomicina, Netilmicina, Neomicinas (B, C, E) Estreptomicina cefalosporina -1,428 0,014 0,035 Cefacetrill, Cefradrina, Cefroxadina, Cefaloglicina, Cefaclor, Cefalexina, Cefadroxila, Cefatrizina, Cefazedona, Cefapirina, Ceftezol, Cefazolina, Cefazaflur, Cefalotina, Cefaloridina, Cefalônio cefamicina -1,214 0,008 0,035 Cefoxitina, Cefotetano, Cefmetazol Antibiótico -1,401 0,007 0,035 Flumequina, ácido fluoroquinolona oxolínico, rosoxacina, ciprofloxacina, fleroxacina, lomefloxacina,

nadifloxacina, norfloxacina, ofloxacina, pefloxacina, rufloxacina, balofloxacin, grepafloxacina, levofloxacina, pazufloxacin, sparfloxacina, temafloxacina, clinafloxacina, gatifloxacina, moxifloxacina, sitafloxacina, prulifloxacina, besifloxacino, delafloxacin, ozenoxacina, danofloxacina, difloxacina, enrofloxacina, ibafloxacina, marbofloxacina, orbifloxacina, sarafloxacina glicilciclina -1,658 0,009 0,035 Tigerciclina Antibiótico -1,288 0,002 0,035 Eritromicina, macrolídeo Claritromicina, Roxitromicina Antibiótico -1,477 0,013 0,035 nitroimidazol Nitroimidazol Antibiótico -1,347 0,011 0,035 Tunicamicina, nucleosídeo estreptotricina penam -1,424 0,010 0,035 Benzilpenicilina Antibiótico -1,279 0,006 0,035 peptídico Antibiótico -1,139 0,012 0,035 fenicol cloranfenicol Antibiótico -1,470 0,006 0,035 rifamicina rifamicina Cloreto de -1,016 0,019 0,035 Cloreto de benzalcônio benzalcônio monobactam -1,114 0,018 0,035 Aztreonam penem -1,155 0,015 0,035 Faropenem rodamina -1,016 0,019 0,035 rodamina triclosan -1,234 0,018 0,035 antibióticos triclosan Antibiótico -1,123 0,021 0,037 lincomicina, lincosamida clindamicina, pirlimicina Antibiótico de -1,065 0,035 0,057 estreptogamina estreptograma Corante acridina -0,905 0,043 0,067 carbapenem -1,239 0,052 0,075 carbapenem Antibiótico da -0,558 0,050 0,075 tetraciclina tetraciclina fosfomicina -1,024 0,066 0,091 fosfomicina Exemplo 2: Bactérias Associadas a Alterações na Abundância de Genes de resistência a Abx

[0122] Foi realizada análise computacional para determinar se a presença de espécies bacterianas específicas é preditiva de uma diminuição na abundância de genes de resistência a antibióticos. As espécies identificadas nessas análises podem ser usadas em composições Abx projetadas. Para identificar espécies microbianas que estão associadas a uma redução de genes de resistência antimicrobiana, calculamos a correlação de Spearman entre abundância de espécies e o DCMA de classes de medicamentos, mostrando uma redução significativa em sujeitos nos quais o enxerto de esporos foi observado em relação ao placebo. Os p-valores foram ajustados para levar em consideração o teste de múltiplas hipóteses usando o procedimento de Benjamini-Hochberg (p <0,1), conforme descrito acima. O conjunto de espécies associadas à redução significativa de pelo menos um medicamento de genes de resistência a antibióticos está resumido na Tabela 3. Definimos ainda o conjunto de espécies correlacionadas positivamente com abundâncias elevadas de pelo menos uma classe de genes de resistência a antibióticos, resumidas na Tabela 4. As espécies de doses em todas as tabelas são espécies bacterianas identificadas em lotes de doses administrados aos sujeitos. As sequências 16S de comprimento total das espécies descritas neste documento são fornecidas nas Tabelas 5 (correlatos negativos) e 6 (correlatos positivos). Em algumas modalidades, as bactérias são de um gênero listado abaixo. Os versados na técnica podem usar métodos padrão para identificar os gêneros.

[0123] Tabela 3 - Espécies Correlacionadas Significativamente com a Redução de Pelo Menos uma Classe de Genes de Resistência a antibióticos Número de classes de Formadores Espécies Identifi Número medicamentos com redução de esporos de Dose cador s significativa (S/N) (S/N) de represe sequên ntativos cia de exempl acesso ificativ de a genoma Espécie (NCBI) Anaerofustis_stercorihomi 21 S S 96, 97 GCF_00 nis 0154825 Anaerostipes_caccae 20 S N 62-66 GCF_00 0154305 Anaerostipes_hadrus 23 S S 223 GCF_00 0332875 Anaerostipes_sp. 24 S S 24 GCA_90 0066985 Anaerostipes_não 21 N N classificado

Anaerotruncus_colihomini 24 S S 89-92 GCF_00 s 0154565 Anaerotruncus_não 22 N N classificado Bacteroides_fragilis 18 N N 184- GCF_00 191 0273095 Bacteroides_uniformis 6 N N 192- GCF_00 198 0273275 Bacteroides_vulgatus 16 N N 199- GCF_00 204 0273295 Blautia_faecis (a) 22 S S 9 GCA_90 0066145 Blautia_faecis (b) 24 S S 22 GCA_90 0066945 Blautia_hydrogenotrophic 22 S S 101 GCF_00 a 0157975 Blautia_producta 21 S S 281 GCF_00 0373885 Blautia_sp. 22 S S 268, 269 Blautia_sp_CAG_257 22 S S 261 Blautia_wexlerae 24 S S 104- GCF_00 110, 0159975 255 Clostridiaceae_bacterium 21 S S 222 GCF_00 _JC118 0313565 Clostridiales_bacterium_1 23 S S 98 GCF_00 _7_47FAA 0155435 Clostridium_aldenense 21 S S 278 Clostridium_asparagiform 22 S S 103 GCF_00 e 0158075 Clostridium_bartlettii 24 S S 80-85 GCF_00 0154445 Clostridium_bolteae 23 S S 73 GCF_00 0154365 Clostridium_clostridioform 21 S S 231- GCF_00 e 233 0371525 Clostridium_hathewayi 24 S S 229, GCF_00 230 0371445 Clostridium_lavalense 20 S S 280 Clostridium_leptum 22 S S 71, 72 GCF_00 0154345 Clostridium_nexile 24 S N 282 GCF_00 0156035 Clostridium_ramosum 21 S S 86 GCF_00 0154485 Clostridium_sp. 21 S S 21 GCA_90 0066915 Clostridium_sp. 22 S S 18 GCA_90 0066805 Clostridium_sp. 22 S S 6 GCA_90 0066055 Clostridium_sp. 22 S S 12 GCA_90 0066535 Clostridium_sp. 23 S S 11 GCA_90 0066365 Clostridium_sp. 24 S S 8 GCA_90 0066135 Clostridium_sp. 24 S S Clostridium_sp. 23 S S 17 GCA_90 0066795 Clostridium_sp. 22 S S 15, 16 GCA_90 0066785 Clostridium_sp. 23 S S 10 GCA_90 0066155 Clostridium_scindens 21 S S 87, 88 GCF_00 0154505 Clostridium_sp_CAG_91 23 S S 266 Clostridium_sp_KLE_175 22 S N 247 GCF_00 5 0466465 Clostridium_symbiosum 23 S S 248 GCF_00 0466485

Coprobacillus_unclassifie 21 N N d Coprococcus_catus 22 S S 143 GCF_00 0210555 Coprococcus_comes 21 S S 99 GCF_00 0155875 Dialister_invisus 21 N N 111- GCF_00 113 0160055 Dorea_formicigenerans 22 S S 114- GCF_00 119 0169235 Dorea_longicatena 21 S S 60, 61 GCF_00 0154065 Eggerthella_lenta 22 N N 39-41 GCF_00 0024265 Eggerthella_não 20 N N classificado Emergencia_timonensis 22 S S 14 GCA_90 0066695 Erysipelotrichaceae_bact 21 N N 164- GCF_00 erium_21_3 168 0242195 Erysipelotrichaceae_bact 21 N N 160- GCF_00 erium_6_1_45 163 0242175 Eubacterium_contortum 23 S S 272- 275 Eubacterium_eligens 22 S S 43-47 GCF_00 0146185 Eubacterium_hallii 22 S S 120 GCF_00 0173975 Eubacterium_ramulus 22 S S 249 GCF_00 0469345 Eubacterium_rectale 23 S S 34-38 GCF_00 0020605 Eubacterium_sp. 21 S S Eubacterium_sp_3_1_31 20 S S 205- GCF_00 209, 0273585 262 Eubacterium_ventriosum 23 S S 48 GCF_00 0153885 Faecalibacterium_prausni 24 S S 74-79 GCF_00 tzii 0154385 Flavonifractor_plautii 23 S S 158 GCF_00 0239295 Flavonifractor_sp. (a) 21 S S 19 GCA_90 0066825 Flavonifractor_sp. (b) 23 S S 13 GCA_90 0066645 Fusicatenibacter_sacchar 23 S S 4 GCA_00 ivorans 1405555 Gemmiger_formicilis_ (a) 24 S S 256 Gemmiger_formicilis_ (b) 24 S S 263 Holdemania_filiformis 24 S S 102 GCF_00 0157995 Holdemania_unclassified 24 N N Intestinimonas_butyricipr 23 S S 264 oducens Intestinimonas_massilien 22 N N 20 GCA_90 sis 0066895 Lachnospira_pectinoschiz 24 S S 5 GCA_00 a 1405835 Lachnospira_pectinoschiz 19 S S 270 a Lachnospiraceae_bacteri 23 S S 150 GCF_00 um_1_1_57FAA 0218445 Lachnospiraceae_bacteri 21 S S 145 GCF_00 um_1_4_56FAA 0218385 Lachnospiraceae_bacteri 23 S S 151 GCF_00 um_2_1_58FAA 0218465 Lachnospiraceae_bacteri 22 S S 139 GCF_00 um_3_1_46FAA 0209405 Lachnospiraceae_bacteri 22 S S 146- GCF_00 um_3_1_57FAA_CT1 148 0218405 Lachnospiraceae_bacteri 18 S N 137 GCF_00 um_4_1_37FAA 0191805 Lachnospiraceae_bacteri 22 S S 149 GCF_00 um_5_1_57FAA 0218425 Lachnospiraceae_bacteri 24 S S 134 GCF_00 um_5_1_63FAA 0185525 Lachnospiraceae_bacteri 23 S S 159 GCF_00 um_7_1_58FAA 0242155 Lachnospiraceae_bacteri 21 S S 135 GCF_00 um_8_1_57FAA 0185545 Lachnospiraceae_bacteri 24 S S 141 GCF_00 um_9_1_43BFAA 0209445 Lactonifactor_longoviform 23 S S 271 is Oscillibacter_não 23 N N classificado Oscillospiraceae_bacteriu 23 N N 265 m_VE202_24 Parabacteroides_não 18 N N classificado Prevotella_buccae 22 N N 133 GCF_00 0184945 Roseburia_faecis 23 S S 259 Roseburia_hominis 21 S S 152- GCF_00 155 0225345 Roseburia_intestinalis 23 S S 100 GCF_00 0156535 Roseburia_inulinivorans 24 S S 283 GCF_00 0174195 Ruminococcus_bicirculan 23 S S 25, 26 GCA_90 s 0067025 Ruminococcus_bromii 22 S S 142 GCF_00 0209875 Ruminococcus_gnavus 23 S S 250- GCF_00 254, 0507805 277 Ruminococcus_obeum_ 23 S S 49-53 GCF_00 (a) 0153905 Ruminococcus_obeum_ 19 S S 267 (b) Ruminococcus_sp. 22 S S 7, 258 GCA_90 0066095 Ruminococcus_torques 24 S S 54-59 GCF_00 0153925 Streptococcus_parasang 21 N N 170- GCF_00 uinis 173 0262145 Streptococcus_salivarius 21 N N 210- GCF_00 216 0286295 Subdoligranulum_não 23 N N classificado Sutterella_wadsworthensi 9 N N 243- GCF_00 s 246 0411515 Bacteroides_thetaiotaomi 1 N N 239- GCF_00 cron 242 0403155 Haemophilus_parainfluen 7 N N 169 GCF_00 zae 0261285 Parabacteroides_distason 2 N N 217- GCF_00 is 221 0307435 Akkermansia_muciniphila 17 N N 31-33 GCF_00 0020225 Bacteroides_dorei 11 N N 174- GCF_00 183 0273055 Butyrivibrio_sp. 15 N N 260 Clostridium_citroniae 20 S S 157 GCF_00 0233455 Clostridium_difficile 8 S N 1-3 GCA_00 0451045 Clostridium_disporicum 9 S S 23 GCA_90 0066955 Clostridium_innocuum 4 S S 224- GCF_00 228 0371425 Clostridium_spiroforme 11 S S 93-95 GCF_00 0154805

Dorea_não classificado 13 N N Eisenbergiella_massiliens 11 S S 257 is Eisenbergiella_tayi_sp. 14 S S 276 Erysipelotrichaceae_bact 20 N N 156 GCF_00 erium_2_2_44A 0225685 Eubacterium_siraeum 14 S S 67-70 GCF_00 0154325 Lachnospiraceae_bacteri 11 S N 140 GCF_00 um_6_1_63FAA 0209425 Ruminococcaceae_bacter 19 S S 121 ium_D16 Ruminococcus_gnavus 7 S S 250- GCF_00 254, 0507805 277 Ruminococcus_sp. 12 S S 7, 258 GCF_00 0507805 Streptococcus_australis 4 N N 136 GCF_00 0186465 Streptococcus_gordonii 3 N N 27-30 GCF_00 0017005 Streptococcus_infantis 5 N N 284- GCF_00 286 0215385 , GCF_00 0187465 , GCF_00 0223335 , GCF_00 0223255 , GCF_00 0260755 Streptococcus_sanguinis 5 N N 138 GCF_00 0192205 Dysgonomonas_mossii 6 N N 144 GCF_00 0213575 Streptococcus_thermophil 1 N N 128- GCF_00 us 132 0182875 Peptostreptococcaceae_s 10 N N em nome_não classificado Turicibacter_não 6 N N classificado Burkholderiales_bacteriu 3 N N 42 GCF_00 m_1_1_47 0144975 Clostridium_sp_CL_6 4 S N 287 Desulfovibrio_desulfurica 1 N N GCF_00 ns 0384815 , GCF_00 0022125 , GCF_00 0420465 , GCF_00 0189295 Lactobacillus_fermentum 1 N N 234- GCF_00 238 0397165 Streptococcus_vestibulari 1 N N 122- GCF_00 s 127 0180075

[0124] Tabela 4 - Espécies Correlacionadas Significativamente Positivamente com Abundâncias Elevadas de Pelo Menos uma Classe de Genes de Resistência a antibióticos Número de Formador Espécie Identificador Números Espécie classes de es de s de de sequência representativo medicament esporos Dose exemplificati s de acesso de os (S/N) (S/N) va genoma associados (NCBI) ao aumento da abundância de espécies 367 GCF_0003763 Campylobacter_curvus 20 N N 25 361, 362 GCF_0003124 Citrobacter_freundii 22 N N 65 Citrobacter_não classificado 22 N N GCF_0003848 15, GCF_0000221 25, GCF_0004204 65, GCF_0001892 Desulfovibrio_desulfuricans 6 N N 95 387 GCF_0004676 Enterobacter_cloacae 22 N N 55 GCF_0003935 15, GCF_0003940 95, GCF_0003936 15, GCF_0001574 95, GCF_0003906 25, GCF_0003909 25, GCF_0001480 05, GCF_0001480 65, GCF_0003940 75, GCF_0003934 95, GCF_0003914 65, GCF_0003926 75, GCF_0003963 65, GCF_0001574 75, GCF_0003966 65, GCF_0001482 45, GCF_0003931 55, GCF_0001481 65, GCF_0003911 65, GCF_0001575 15, GCF_0003960 85, GCF_0003952 85, GCF_0004790 65, GCF_0003930 95, GCF_0003932 55, GCF_0003910 Enterococcus faecalis 21 N N 65,

GCF_0003949 55, GCF_0004150 65, GCF_0003949 75, GCF_0004150 85, GCF_0003954 05, GCF_0001725 75, GCF_0003905 25, GCF_0003931 15, GCF_0003947 75, GCF_0003934 75, GCF_0003907 05, GCF_0002052 05, GCF_0003951 35, GCF_0003928 15, GCF_0003203 05, GCF_0003962 05, GCF_0003906 65, GCF_0003906 85, GCF_0003917 25, GCF_0001638 15, GCF_0003916 05, GCF_0003914 45, GCF_0003914 25, GCF_0003961 85, GCF_0001484 45, GCF_0001481 25, GCF_0003966 05, GCF_0003960 45, GCF_0002915 65, GCF_0003943 15, GCF_0003950 35, GCF_0001474 55, GCF_0003913 45, GCF_0003965 25, GCF_0003927 55 388-394 GCF_0004748 Escherichia_coli 24 N N 25 Escherichia_não classificado 23 N N Fusobacterium_nucleatum 15 N N 403 GCF_0004791

330 GCF_0002529 Klebsiella_oxytoca 22 N N 15 395-402 GCF_0004748 Klebsiella_pneumoniae 22 N N 65 Klebsiella_não classificado 21 N N 317 GCF_0001838 Lactobacillus_animalis 22 N N 25 378, 379, 381- GCF_0004098 385 35, GCF_0004185 Lactobacillus_casei_paracasei 22 N N 15 386 GCF_0004630 Lactobacillus_plantarum 22 N N 75 328, 329 GCF_0002357 Lactobacillus_rhamnosus 24 N N 85 303 GCF_0001593 Lactobacillus_salivarius 9 N N 95 363, 364 GCF_0003489 Lactococcus_lactis 15 N N 65 310 GCF_0001657 Megasphaera_micronuciformis 22 N N 35 Megasphaera_não classificado 11 N N 355 GCF_0002864 Morganella_morganii 24 N N 35 Pantoea_não classificado 24 N N 299 GCF_0001463 Pediococcus_acidilactici 19 N N 25 301, 302 GCF_0001558 Proteus_penneri 17 N N 35 288-291, 332 GCF_0000143 65, GCF_0002578 Streptococcus_mitis_oralis_pneumoniae 3 N N 65 312-316 GCF_0001828 Streptococcus_thermophilus 5 N N 75 311 GCF_0001797 Veillonella_atypica 19 N N 55 304-306 GCF_0001600 Veillonella_dispar 18 N N 15 322 GCF_0002150 Veillonella_parvula 13 N N 25 300 GCF_0001467 Bifidobacterium_dentium 1 N N 75 Butyrivibrio_sp. 1 N N 404 287 ID de taxonomia Clostridium_sp_CL_6 1 S N NCBI 1499683 380 GCF_0004149 Enterococcus_faecium 18 N N 65 326 GCF_0002256 Erysipelotrichaceae_bacterium_2_2_44A 1 N N 85 368-372 GCF_0003971 Lactobacillus_fermentum 2 N N 65 377 GCF_0004063 Lactobacillus_gasseri 1 N N 45 292-298 GCF_0000699 Proteus_mirabilis 8 N N 65 307-309 GCF_0001646 Rothia_dentocariosa 5 N N 95 Proteus_não classificado 5 N N Veillonella_não classificado 14 N N 365, 366 GCF_0003745 Alistipes_onderdonkii 1 N N 05 333-336 GCF_0002731 Bacteroides_ovatus 5 N N 95 344-349 GCF_0002732 Bacteroides_vulgatus 4 N N 95 Bilophila_não classificado 3 N N 318-321 GCF_0001857 Bilophila_wadsworthia 3 N N 05 Parabacteroides_distasonis 6 N N 356-360 GCF_0003074

Parabacteroides_não classificado 3 N N Alistipes_não classificado 2 N N 327 GCF_0002312 Rothia_mucilaginosa 1 N N 35 373-376 GCF_0004031 Bacteroides_thetaiotaomicron 1 N N 55 337-343 GCF_0002732 Bacteroides_uniformis 2 N N 75 Eggerthella_não classificado 1 N N 350-354 GCF_0002735 Eubacterium_sp_3_1_31 2 S S 85 Lachnospiraceae_bacterium_3_1_57FA 323-325 GCF_0002184 A_CT1 1 S S 05 Ruminococcus_obeum 1 S S 405 Turicibacter_não classificado 1 N N 331 GCF_0002554 Clostridium_perfringens 1 S S 75

[0125] Tabela 5 - Sequências Completas de 16S rDNA das Espécies (Correlatos Negativos) Nome da Espécie Identificador Sequência de 16S rDNA de Sequência Clostridium_difficil SEQ ID NO: 1 ttatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgcttctttttcca e ccggagcttgctccaccggaaaaagaggagtggcgaacgggtgagtaacacgtgggtaacctgcccatcag aaggggataacacttggaaacaggtgctaataccgtataacaatcgaaaccgcatggttttgatttgaaaggcg ctttcgggtgtcgctgatggatggacccgcggtgcattagctagttggtgaggtaacggctcaccaaggccacga tgcatagccgacctgagagggtgatcggccacattgggactgagacacggcccaaactcctacgggaggcag cagtagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaaactctgttgttagagaagaacaaggatgagagtaactgttcatcccttgacggtatctaaccagaaagcc acggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggatttattgggcgtaaagc gagcgcaggcggtttcttaagtctgatgtgaaagcccccggctcaaccggggagggtcattggaaactgggag acttgagtgcagaagaggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagt ggcgaaggcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagatacc ctggtagtccacgccgtaaacgatgagtgctaagtgttggagggtttccgcccttca Clostridium_difficil SEQ ID NO:2 ttatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgcttctttttcca e ccggagcttgctccaccggaaaaagaggagtggcgaacgggtgagtaacacgtgggtaacctgcccatcag aaggggataacacttggaaacaggtgctaataccgtataacaatcgaaaccgcatggttttgatttgaaaggcg ctttcgggtgtcgctgatggatggacccgcggtgcattagctagttggtgaggtaacggctcaccaaggccacga tgcatagccgacctgagagggtgatcggccacattgggactgagacacggcccaaactcctacgggaggcag cagtagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaaactctgttgttagagaagaacaaggatgagagtaactgttcatcccttgacggtatctaaccagaaagcc acggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggatttattgggcgtaaagc gagcgcaggcggtttcttaagtctgatgtgaaagcccccggctcaaccggggagggtcattggaaactgggag acttgagtgcagaagaggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagt ggcgaaggcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagatacc ctggtagtccacgccgtaaacgatgagtgctaagtgttggagggtttccgcccttca Clostridium_difficil SEQ ID NO: 3 ttatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgcttctttttcca e ccggagcttgctccaccggaaaaagaggagtggcgaacgggtgagtaacacgtgggtaacctgcccatcag aaggggataacacttggaaacaggtgctaataccgtataacaatcgaaaccgcatggttttgatttgaaaggcg ctttcgggtgtcgctgatggatggacccgcggtgcattagctagttggtgaggtaacggctcaccaaggccacga tgcatagccgacctgagagggtgatcggccacattgggactgagacacggcccaaactcctacgggaggcag cagtagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaaactctgttgttagagaagaacaaggatgagagtaactgttcatcccttgacggtatctaaccagaaagcc acggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggatttattgggcgtaaagc gagcgcaggcggtttcttaagtctgatgtgaaagcccccggctcaaccggggagggtcattggaaactgggag acttgagtgcagaagaggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagt ggcgaaggcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagatacc ctggtagtccacgccgtaaacgatgagtgctaagtgttggagggtttccgcccttca Fusicatenibacter_ SEQ ID NO: 4 tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcagtta saccharivorans agttgatttcttcggattgattcttgactgactgagcggcggacgggtgagtaacgcgtgggtgacctgccccatac cgggggataacagctggaaacggctgctaataccgcataagcgcacagagctgcatggctcggtgtgaaaaa ctccggtggtatgggatgggcccgcgtctgattaggcagttggcggggtaacggcccaccaaaccgacgatca gtagccggcctgagagggcgaccggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatg taaagctctatcagcagggaagataatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcaaggcaagtc tgatgtgaaaacccagggcttaaccctgggactgcattggaaactgtctggctcgagtgccggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttactggacggt aactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatgctaggtgttggggagcaaagctcttcggtgccgccgcaaacgcattaagcattccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttaccaggtcttgacatcccgatgaccggcccgtaacggggctttctcttcggagcattgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttat cctcagtagccagcaggtaaagctgggcactctgtggagactgccagggataacctggaggaaggtggggat gacgtcaaatcatcatgccccttatgatctgggctacacacgtgctacaatggcgtaaacaaagggaggcaaa gccgcgaggtggagcaaatcccaaaaataacgtctcagttcggactgcagtctgcaactcgactgcacgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagttggtaacgcccgaagtcagtgacccaaccttttaggagggagctgccgaaggcgggactgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospira_pecti SEQ ID NO: 5 ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttaa noschiza gacagattacttcggtttgaagtcttttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggatagcagctggaaacggctggtaataccgcataagcgcacagtaccacatggtacagtgtgaaaa actccggtggtatgagatggacccgcgtctgattagcttgttggcggggtaacggcccaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagca gtggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtagttcgctatgta aagctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgc ggtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccaggcaagtcaga agtgaaagcccggggctcaaccccgggactgcttttgaaactgcagggctagagtgcaggaggggcaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggactgta actgacactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatactaggtgtcggggcacataagtgctccggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttaccaagtcttgacatcctcttgaccggtcagtaatgtgaccttttcttcggaacaagagt gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttat ccttagtagccagcagttcggctgggcactctagggagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgagagc gtgagcttaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagtcggaaatgcccgaagtcggtgacctaacgtaagaaggagccgccgaaggcaggtctgataactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: 6 tccggtggtatgagatggacccgcgtctgattagctagttggtgaggtaacggcccaccaaggcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagt gggggatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgacgcaagtctga agtgaaatacccgggctcaacctgggaactgctttggaaactgtgttgctagagtgctggagaggtaagcggaa ttcctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttactggacagtaac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgttggtgagcaaagctcatcggtgccgccgcaaacgcaataagtattccacctggggagtacgttcg caagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaac gcgaagaaccttaccaaatcttgacatccctctgaaaagcctttaatcgggctcctccttcgggacagaggtgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattgtc agtagccagcaggtaaagctgggcactctgatgagactgccagggataacctggaggaaggtggggatgac gtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagagaagcgagcctgc gagggggagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcggaaatgcccgaagccagtgacccaagcgaaagcagggagctgtcgaaggcaggtctgataactggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_sp SEQ ID NO: 7 tacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactta . agtttgattcttcggatgaagacttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatac agggggataacagttagaaatggctgctaataccgcataagaccacagcaccgcatggtgcaggggtaaaaa ctccggtggtatgagatggacccgcgtctgattagctggttggtggggtaacggcctaccaaggcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaa acttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtatggcaagtctgat gtgaaaggccagggctcaaccctgggactgcattggaaactgtcgaactagagtgtcggagaggcaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggacgatga ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga ctactaggtgtcgggtagcagagctattcggtgccgcagccaacgcaataagtagtccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatctccctgaccggcaagtaatgttgcctttccttcgggacagggatgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttt agtagccagcggtacggccgggcactctagagagactgccagggataacctggaggaaggtggggatgacg tcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcgagcctg cgagggtaagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: 8 tttagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttat ggagattcttcggatgatccatttgtgactgagcggcggacgggtgagtaacgcgtgagtaacctgcctcataca ggggaataacagttagaaatgactgctaatgccgcataagcgcacagggccacatggcctggtgtgaaaaact ccggtggtatgagatggactcgcgtctgattagctagttggtgaggtaacggcccaccaaggcgacgatcagta gccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctttgcaagtctgacg tgaaaatccggggctcaaccccggaactgcgttggaaactgtgaggcttgagtgccggagaggtaagcggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggcaact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgatgaat actaggtgttgggggacaaagtccttcggtgccgccgcaaacgcattaagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcgattcgccgggactgtaatgagtcctttcccttcggggacgaagaaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttc agtagccagcaagtgaagttgggcactctggagagactgccagggacaacctggaggaaggtggggatgac gtcaaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcagccctgt gaaggtgagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcggtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggcgggactggtaactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_faecis (b) SEQ ID NO: 9 ctccggtggtataagatggacccgcgttggattagctagttggcagggcagcggcctaccaaggcgacgatcca tagccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgta aacttctatcagcagggaagataatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcgagcgttatccggatttactgggtgtaaagggagcgtagacggcgtatcaagtctgat gtgaaaggcaggggcttaacccctggactgcattggaaactggtatgcttgagtgccggaggggtaagcggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtctgggagcacagctcttaggtgccgccgcaaacgcattaagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaaatcttgacatccctctgacagagtatgtaatgtacttttccttcgggacaggggagacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatccttagt agccagcaagtaatgttgggcactctgaggagactgccagggataacctggaggaaggcggggatgacgtca aatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaacctgtgag ggtgggcaaatctcaaaaataacgtcccagttcggactgcagtctgcaactcgactgcacgaagctggaatcgc tagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggga gtcagtaacgcccgaagtcagtgacctaaccgtaaggaaggagctgccgaaggcgggacggatgactgggg tgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: taaagagtttgatcctggctcaggacgaacgctgtcggcgcgcctaacacatgcaagtcgaacgaagttgctttg 10 aatgaattcttcggaaggaatttgattcaacttagtggcggacgggtgagtaacgcgtgagtaacctgcctttcag agggggataacgtctggaaacggacgctaataccgcataacatattggtttcgcatggagctgatatcaaagga gcaatccgctgaaagatggactcgcgtccaattagctagttggtgaggtaacggcccaccaaggcgacgattg gtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgagtgagggaagaaggttttcggattgt aaacctctgtccttggtgaagataatgacggtaaccaaggaggaagctacggctaactacgtgccagcagccg cggtaatacgtaggtagcgagcgttgtccggaattactgggtgtaaagggagcgtaggcgggattgcaagttga atgttaaatctatgggctcaacccatagccgcgttcaaaactgcagttcttgagtgaagtagaggcaggcggaatt cctagtgtagcggtgaaatgcgtaaatattaggaggaacaccagtggcgaaggcggcctgctgggctttaactg acgctgaggctcgaaagcgtgggtagcaaacaggattagataccctggtagtccacgctgtaaacgatgattac taggtgtggggggactgaccccttccgtgccggagttaacacaataagtaatccacctggggagtacgaccgca aggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagcaacgcg aagaaccttaccaggtcttgacatccggtgcatagcctagagataggtgaagcccttcggggcaccgagacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttacgtttagt tgctacgcaagagcactctagacggactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatc atgccccttatgacctgggctacacacgtactacaatggctattaacagagggaagcaagatggtgacatggag caaacccctaaaaatagtctcagttcggattgcaggctgcaacccgcctgcatgaagccggaattgctagtaatc gcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagttggcaa cacccgaagccgatagtctaaccgcaagggggacgtcgtcgaaggtggggttgatgattggggtgaagtcgta acaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacggaatttacatg 11 aagcctagcgattgtaaatttagtggcggacgggtgagtaacgcgtgggtaacctgccttgtactgggggacaac agttggaaacgactgctaataccgcataagcgcacagcttcgcatgaagcagtgtgaaaaactccggtggtac aagatggacccgcgtctgattagctggttggtgaggtaacggcccaccaaggcgacgatcagtagccggcctg agagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtggggaatatt gcacaatgggggaaaccctgatgcagcaacgccgcgtgagtgaagaagtatttcggtatgtaaagctctatcag caggaaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggtaatacgta gggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttttgcaagtctgaagtgaaagccc ggggcttaaccccgggactgctttggaaactgtaggactagagtgcaggagaggtaagtggaattcctagtgta gcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaactgacgttgag gctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtt ggtgggtacgacccatcggtgccgcagcaaacgcaataagtaatccacctggggagtacgttcgcaagaatg aaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaa ccttacctggtcttgacatccctatgaataacgggcaatgccgttagtacttcggtacataggagacaggtggtgc atggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtagccagc agtaagatgggcactctagagagactgccggggataacccggaggaaggtggggatgacgtcaaatcatcat gccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagagaagcgaagtcgtgaggcagag cgaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatc gcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcggaaa tgcccgaagtcggtgacctaaccgaaaggaaggagccgccgaaggcaggtctgataactggggtgaagtcgt aacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaggtattttgat 12 tgaagttttcggatggatttcaagataccgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacggttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagctagttggtggggtaacggcccaccaaggcgacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg gggatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaagc tctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgacgcaagtctgaag tgaaatacccgggctcaacctgggaactgctttggaaactgtgttgctagagtgctggagaggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttactggacagtaactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaata ctaggtgttggtgagcaaagctcatcggtgccgccgcaaacgcaataagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaaatcttgacatccctctgaaannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnncctccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgtt gggttaagtcccgcaacgagcgcaacccctattgtcagtagccagcaggtaaagctgggcactctgatgagact gccagggataacctggaggaaggtggggatgacgtcaaatcatcatgccccttatgatttgggctacacacgtg ctacaatggcgtaaacaaagagaagcgagcctgcgagggggagcaaatctcaaaaataacgtctcagttcgg attgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcagatcagaatgctgcggtgaatacgtt cccgggtcttgtacacaccgcccgtcacaccatgggagtcggaaatgcccgaagccagtgacccaagcgaaa gcagggagctgtcgaaggcaggtctgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcg gctggatcacctccttt Flavonifractor_sp.

SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggagtgctcat 13 gacagaggattcgtccaatggagtgagttacttagtggcggacgggtgagtaacgcgtgagtaacctgccttgg agtggggaataacaggtggaaacatctgctaataccgcatgatgcagttgggtcgcatggctctgactgccaaa gatttatcgctctgagatggactcgcgtctgattagctggttggcggggtaacggcccaccaaggcgacgatcag tagccggactgagaggttggccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgta aacttcttttctcagggacgaagcaagtgacggtacctgaggaataagccacggctaactacgtgccagcagcc gcggtaatacgtaggtggcgagcgttatccggatttactgggtgtaaagggcgtgtaggcgggactgcaagtca gatgtgaaaaccatgggctcaacctgtggcctgcatttgaaactgtagttcttgagtactggagaggcagacgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggtctgctggacagca actgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgat ggatactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagtatcccacctggggagtacg atcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccagggcttgacatcccggtgaccggtgtagagatacaccttcttcttcggaagcgcc ggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccct tattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacgacgtc aaatcatcatgccccttatgtcctgggccacacacgtactacaatggtggtcaacagagggaagcaagaccgc gaggtggagcaaacccctaaaagccatcccagttcggattgcaggctgcaactcgcctgtatgaagttggaatc gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatga gagtcgggaacacccgaagtccgtagcctaaccgcaaggggggcgcggccgaaggtgggttcgataattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Emergencia_timo SEQ ID NO: attaagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgagaagccat nensis 14 tgaccgatacttcggtaaagggatatggcggaaagcggcggacgggtgagtaacgcgtaggcaacctgcccc ttacagagggatagccattggaaacgatgattaagacctcataacgcctccctcccacatgagggggaggcca aagattcatcggtaagggatgggcctgcgtctgattagcttgttggcggggtaacggcccaccaaggcgacgat cagtagccgacctgagagggtgatcggccacattggaactgagacacggtccaaactcctacgggaggcagc agtggggaatattgcacaatgggcggaagcctgatgcagcaacgccgcgtgagggatgaaggccttcgggtc gtaaacctctgtccttggggaagaaacaaatgacggtacccatggaggaagccccggctaactacgtgccagc agccgcggtaatacgtagggggcgagcgttatccggaattattgggcgtaaagagtgcgtaggtggttacctaa gcgcagggtctaaggcaatggctcaaccattgttcgccctgcgaactgggctacttgagtgcaggagaggaaa gcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggac tgttactgacactgaggcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaac gatgagcactaggtgtcggggccgcaaggcttcggtgccgcagttaacgcattaagtgctccgcctggggagta cgcacgcaagtgtgaaactcaaaggaattgacggggacccgcacaagcagcggagcatgtggtttaattcga agcaacgcgaagaaccttaccaggacttgacatccccctgacagatccttaaccggatccttcttcggacaggg gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gccattagttgccatcattcagttgggcactctaatgggactgccggggacaactcggaggaaggtggggatga cgtcaaatcatcatgccccttatgttctgggctacacacgtgctacaatggccggtacagcaggaagcgatcccg cgagggggagcaaatcccaaaaaccggtcccagttcggactgcaggctgcaacccgcctgcacgaagccgg agttgctagtaatcgtggatcagaatgccacggtgaatgcgttcccgggtcttgtacacaccgcccgtcacaccat ggaagttgggggtgcccgaagccggcagggagatatgctgtctaaggcaaaaccaatgactggggtgaagtc gtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaggtaaatga 15 gatgaagttttcggatggattcttatttaccgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacgattggaaacgattgctaataccgcataagcgcacagtaccacatggtacagtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagctagttggtgaggtaacggcccaccaaggcaacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg gggatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaagc tctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgatgcaagtctgaagt gaaatacccgggctcaacctgggaactgctttggaaactgtatggctagagtgctggagaggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttactggacagtaactg acgttcaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaata ctaggtgtcgggggacaaagtctttcggtgccgccgcaaacgcaataagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaaatcttgacatccctctgaaaagcctttaatcgggctcctccttcgggacagaggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattgtcag tagccagcaggtaaagctgggcactctgatgagactgccagggataacctggaggaaggtggggatgacgtc aaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagagaggcgaagctgtga ggcagagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgc tagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggga gtcggaaatgcccgaagccagtgacccaagcgaaagcagggagctgtcgaaggcaggtctgataactgggg tgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: nccggatttactgggtgtaaagggtgcgtaggcggaactgcaagtcagtggtgaaatctgagggctcaaccctc 16 aaactgccattgaaactgtggttcttgagtgaagtagaggtaggcggaattcccggtgtagcggtggaatgcgta gagatcgggaggaacaccagtggcgaaggcggcctactgggctttaactgacgctgaggcacgaaagcatg ggtagcaaacaggattagataccctggtagtccatgccgtaaacgatgattactaggtgtggggggtctgacccc ctccgtgccggagttaacacaataagtaatccacctggggagtacggccgcaaggttgaaactcaaaggaatt gacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggtcttga catccaactaacgaggtagagatacgtcaggtgcccttcggggaaagttgagacaggtggtgcatggttgtcgtc agctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtgattagttgctacgcaagagcact ctaatcagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccctttatgacctggg ctacacacgtactacaatggccgtaaacagagagaggcgacaccgcgaggtgaagcgaaaccctaaaaac ggtctcagttcggattgtaggctgcaacccgcctacatgaagttggaattgctagtaatcgcggatcagcatgccg cggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagccggtaatacccgaagtcagtag tctaaccgcaaggggggcgctgccgaaggtaggattggcgactggggtgaagtcgtaacaaggtagccgtatc ggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: acggcccagactcctacgggaggcagcagtggggaatattgcgcaatgggggaaaccctgacgcagcaacg 17 ccgcgtgattgaagaaggccttcgggttgtaaagatctttaattagggacgaaataaatgacggtacctgaagaa taagctccggctaactacgtgccagcagccgcggtaatacgtagggagcaagcgttatccggatttactgggtgt aaagggcgcgcaggcgggccggtaagttggaagtgaaatctatgggcttaacccataaactgctttcaaaactg ctggtcttgagtgatggagaggcaggcggaattccgtgtgtagcggtgaaatgcgtagatatacggaggaacac cagtggcgaaggcggcctgctggacattaactgacgctgaggcgcgaaagcgtggggagcaaacaggatta gataccctggtagtccacgccgtaaacgatggatactaggtgtgggaggtattgaccccttccgtgccgcagttaa cacaataagtatcccacctggggagtacggccgcaaggttgaaactcaaaggaattgacgggggcccgcaca agcagtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgaccgncttt tcttcggaacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaac gagcgcaacccttacggttagttgatacgcaagatcactctagccggactgccgttgacaaaacggaggaagg tggggacgacgtcaaatcatcatgccccttatgacctgggctacacacgtactacaatggcagtcatacagagg gaagcaaaaccgcgaggtggagcaaatccctaaaagctgtcccagttcagattgcaggctgcaacccgcctg catgaagtcggaattgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgc ccgtcacaccatgagagccgtcaatacccgaagtccgtagcctaac Clostridium_sp.

SEQ ID NO:18 tttagagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacggggttattttg gaaatctcttcggagatggaattcttaacctagtggcggacgggtgagtaacgcgtgagcaatctgcctttaggag ggggataacagtcggaaacggctgctaataccgcataatacgtttgggaggcatctcttgaacgtcaaagatttta tcgcctttagatgagctcgcgtctgattagctggttggcggggtaacggcccaccaaggcgacgatcagtagccg gactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggga atattgcgcaatgggggaaaccctgacgcagcaacgccgcgtgattgaagaaggccttcgggttgtaaagatct ttaatcagggacgaaaaatgacggtacctgaagaataagctccggctaactacgtgccagcagccgcggtaat acgtagggagcaagcgttatccggatttactgggtgtaaagggcgcgcaggcgggccggcaagttgggagtg aaatcccggggcttaaccccggaactgctttcaaaactgctggtcttgagtgatggagaggcaggcggaattcc gtgtgtagcggtgaaatgcgtagatatacggaggaacaccagtggcgaaggcggcctgctggacattaactga cgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatggata ctaggtgtgggaggtattgaccccttccgtgccgcagttaacacaataagtatcccacctggggagtacggccgc aaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagcaacgc gaagaaccttaccaggtcttgacatcccgatgaccggcgtagagatacgccctctcttcggagcatcggtgaca ggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttacggtta gttgatacgcaagatcactctagccggactgccgttgacaaaacggaggaaggtggggacgacgtcaaatcat catgccccttatgacctgggctacacacgtactacaatggcagtcatacagagggaagcaataccgcgaggtg gagcaaatccctaaaagctgtcccagttcagattgcaggctgcaacccgcctgcatgaagtcggaattgctagta atcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccgt caatacccgaagtccgtagcctaaccgcaaggggggcgcggccgaaggtaggggtggtaattagggtgaagt cgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Flavonifractor_sp.

SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggagtgccca 19 tgacagaggattcgtccaatggattgggttacttagtggcggacgggtgagtaacgcgtgaggaacctgcctcgg agtggggaataacacaacgaaagctgtgctaataccgcatgatacagttgggtcgcatgactctgactgtcaaa gatttatcgctctgagatggcctcgcgtctgattagctagttggtggggtaacggcccaccaaggcgacgatcagt agccggactgagaggttgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgta aacttcttttctcagggacgaagcaagtgacggtacctgaggaataagccacggctaactacgtgccagcagcc gcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagggcgtgtaggcgggatcgcaagtca gatgtgaaaactggaggctcaacctccagcctgcatttgaaactgtggttcttgagtactggagaggcagacgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggtctgctggacagca actgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgat ggatactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagtatcccacctggggagtacg atcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccagggcttgacatcccgaggcccggcctagagataggcctttctcttcggagacctc ggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccc ctattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacgacgt caaatcatcatgccccttatgtcctgggccacacacgtactacaatggtggttaacagagggaggcaagaccgt gaggtggagcaaatccctaaaagccatcccagttcggattgcaggctgcaacccgcctgcatgaagttggaatc gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatga gagtcgggaacacccgaagtccgtagcctaacagcaatgggggcgcggccgaaggtgggttcgataattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Intestinimonas_m SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggaacgcca assiliensis 20 aggaaagagttttcggacaatggaattggctgtttagtggcggacgggtgagtaacgcgtgagtaacctgccttg gagtggggaataacacagtgaaaactgtgctaataccgcatgacatattggtgtcgcatggcactgatatcaaa gatttatcgctctgagatggactcgcgtctgattagatagttggcggggtaacggcccaccaagtcgacgatcagt agccggactgagaggttggccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgta aacttcttttaacagggacgaagtaagtgacggtacctgttgaataagccacggctaactacgtgccagcagcc gcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagggcgtgtaggcgggactgcaagtca gatgtgaaaactatgggctcaacccatagcctgcatttgaaactgtagttcttgagtgtcggagaggcaatcggaa ttccgtgtgtagcggtgaaatgcgtagatatacggaggaacaccagtggcgaaggcggattgctggacgataa ctgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg gatactaggtgtggggggtctgaccccctccgtgccgcagctaacgcaataagtatcccacctggggagtacga tcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaagca acgcgaagaaccttaccagggcttgacatcctactaacgaaccagagatggattaggtgcccttcggggaaag tagagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacc cttattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacgacg tcaaatcatcatgccccttatgtcctgggccacacacgtactacaatggcggttaacagagggaggcaaagccg cgaggcagagcaaacccctaaaagccgtcccagttcggattgcaggctgaaacccgcctgtatgaagtcgga atcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccat gagagtcgggaacacccgaagtccgtagcctaactgcaaagggggcgcggccgaaggtgggttcgataattg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO:21 atggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgcttcacttcg gtgaagagtggcgaacgggtgagtaatacataagtaacctggcatctacagggggataactgatggaaacgtc agctaagaccgcataggtgtagagatcgcatgaactctatatgaaaagtgctacgggactggtagatgatggac ttatggcgcattagctggttggtagggtaacggcctaccaaggcgacgatgcgtagccgacctgagagggtgac cggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaattttcggcaatgggg gaaaccctgaccgagcaacgccgcgtgaaggaagaagtaattcgttatgtaaacttctgtcatagaggaagaa cggtggatatagggaatgatatccaagtgacggtactctataagaaagccacggctaactacgtgccagcagc cgcggtaatacgtaggtggcgagcgttatccggaattattgggcgtaaagagggagcaggcggcactaagggt ctgtggtgaaagatcgaagcttaacttcggtaagccatggaaaccgtagagctagagtgtgtgagaggatcgtg gaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagtggcgaaggcgacgatctggcgca taactgacgctcagtcccgaaagcgtggggagcaaataggattagataccctagtagtccacgccgtaaacga tgagtactaagtgttgggtgtcaaagctcagtgctgcagttaacgcaataagtactccgcctgagtagtacgttcgc aagaatgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaggtcttgacatcgatctaaaggctccagagatggagagatagctatagagaagacagg tggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctgttgccagtt gccagcattaagttggggactctggcgagactgccggtgacaagccggaggaaggcggggatgacgtcaaat catcatgccccttatgacctgggctacacacgtgctacaatggacagagcagagggaagcgaagccgcgagg tggagcgaaacccataaaactgttctcagttcggactgcagtctgcaactcgactgcacgaagatggaatcgcta gtaatcgcgaatcagcatgtcgcggtgaatacgttctcgggccttgtacacaccgcccgtcacaccatgagagtc ggtaacacccgaagccggtggcctaaccgcaaggaaggagctgtctaaggtgggactgatgattggggtgaa gtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Blautia_faecis (b) SEQ ID NO:22 tattgagagtttgatcctggctcaggacgaacgctggcggcatgcctaacacatgcaagtcgagcgagttgatct cttcggagtgaagctagcggcggacgggtgagtaacacgtgggcaacctgcctcatagaggggaatagcctc ccgaaagggagattaataccgcataagattgtagcttcgcatgaagnagcaattaaaggagcaatccgctatg agatgggcccgcggcgcattagctagttggtgaggtaacggctcaccaaggcgacgatgcgtagccgacctga gagggtgatcggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgc acaatgggggaaaccctgatgcagcaatgccgcgtgagtgatgacggccttcgggttgtaaagctctgtcttcgg ggacgataatgacggtacccgaggaggaagccacggctaactacgtgccagcagccgcggtaatacgtagg tggcaagcgttgtccggatttactgggcgtaaagggagcgtaggcggatttttaagtgagatgtgaaatacccgg gcttaacttgggtgctgcatttcaaactggaagtctagagtgcaggagaggagaagggaattcctagtgtagcgg tgaaatgcgtagagattaggaagaacaccagtggcgaaggcgcttctctggactgtaactgacgctgaggctcg aaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgtaggg gttgtcatgacctctgtgccgccgctaacgcattaagtattccgcctggggagtacggtcgcaagattaaaactca aaggaattgacgggggcccgcacaagcagcggagcatgtggtttaattcgaagcaacgcgaagaaccttacc tagacttgacatctcctgcattacccttaatcggggaagtcgcttcggcgacaggaagacaggtggtgcatggttg tcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattgttagttgctaccatttagtt gagcactctagcgagactgcccgggttaaccgggaggaaggtggggatgacgtcaaatcatcatgccccttat gtctagggctacacacgtgctacaatggcaagtacaaagagaagcaagaccgcgaggtggagcaaaactca aaaacttgtctcagttcggattgtaggctgaaactcgcctacatgaagctggagttgctagtaatcgcgaatcagc atgtcgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagttggcaatacccaaagt gcgtgatctaactcgtaagagaggaagcgccctaaggtagggtcagcgattggggtgaagtcgtaacaaggta gccgtaggagaacctgcggctggatcacctccttt

Clostridium_dispo SEQ ID NO:23 agtgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaacacatgcaagtcgagcgagtgaatct ricum ccttcgggagtgaagctagcggcggacgggtgagtaacacgtgggcaacctgcctcatagaggggaatagcc ttccgaaaggaagattaataccgcataagattgtagcttcgcatgaagtagcaattaaaggagcaatccgctatg agatgggcccgcggcgcattagctagttggtgaggtaacggctcaccaaggcgacgatgcgtagccgacctga gagggtgatcggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgc acaatgggggaaaccctgatgcagcaacgccgcgtgagtgatgacggccttcgggttgtaaagctctgtcttca gggacgataatgacggtacctgaggaggaagccacggctaactacgtgccagcagccgcggtaatacgtag gtggcgagcgttgtccggatttactgggcgtaaagggagcgtaggcggacttttaagtgagatgtgaaatacccg ggctcaacttgggtgctgcatttcaaactggaagtctagagtgcaggagaggagaatggaattcctagtgtagcg gtgaaatgcgtagagattaggaagaacaccagtggcgaaggcgattctctggactgtaactgacgctgaggctc gaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgtagg ggttgtcatgacctctgtgccgccgctaacgcattaagtattccgcctggggagtacggtcgcaagattaaaactc aaaggaattgacgggggcccgcacaagcagcggagcatgtggtttaattcgaagcaacgcgaagaaccttac ctagacttgacatctcctgcattacccttaatcggggaagttccttcgggaacaggaagacaggtggtgcatggtt gtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattgttagttgctaccatttagt tgagcactctagcgagactgcccgggttaaccgggaggaaggtggggatgacgtcaaatcatcatgccccttat gtctagggctacacacgtgctacaatggcaagtacaaagagaagcaagaccgcgaggtggagcaaaactca aaaacttgtctcagttcggattgtaggctgaaactcgcctacatgaagctggagttgctagtaatcgcgaatcagc atgtcgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagttggcaatacccaaagt gcgtgatctgactcgcaagagaggaagcgccctaaggtagggtcagcgattggggtgaagtcgtaacaaggt agccgtaggagaacctgcggctggatcacctccttt Anaerostipes_sp.

SEQ ID NO:24 atgagagttcgatcctggctcaggataaacgctggcggcgtgcttaacacatgcaagtcgaacgaagtttttctttc gggaggaacttagtggcggacgggtgagtaacgcgtgggtaacctgccctgtacagggggacaacagctgga aacggctgctaataccgcataagcccttagcactgcatggtgcatagggaaaaggagcaatccggtacaggat ggacccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcagtagccgatctgagagg atgtacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcacaa tggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaagctctatcagcaggga agaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggtaatacgtatggtgc aagcgttatccggatttactgggtgtaaagggagcgtaggtggcaaggcaagccagaagtgaaaacccgggg ctcaaccgcgggattgcttttggaactgtcatgctagagtgcaggaggggtgagcggaattcctagtgtagcggtg aaatgcgtagatattaggaggaacaccggaggcgaaggcggctcactggactgtaactgacactgaggctcg aaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgatgaatactagatgtcgggt agcaaagctactcggtgtcgtcgcaaacgcaataagtattccacctggggagtacgttcgcaagaatgaaactc aaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttac ctgctcttgacatcccattcgatagagggtaatgcctctagcccttcgggggaatggagacaggtggtgcatggtt gtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattgtcagtagccagcaggt gaagctgggcactctgatgagactgccggggataacccggaggaaggtggggatgacgtcaaatcatcatgc cccttatgagcagggctacacacgtgctacaatggcgtaaacagagggaagcgaaggagtgatccggagca aatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgc agatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcggtaatgc ccgaagtcagtgactcaaccgaaaggagagagctgccgaaggcaggactggtaactggggtgaagtcgtaa caaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_bi SEQ ID NO: tttagagagtttgatcctggctcaggacgaacgctggcggcgtgcctaacacatgcaagtcgaacggagcttga circulans 25 ggggcttgcccttcaagcttagtggcggacgggtgagtaacgcgtgagtaacctgcctctcagagggggataac gttctgaaaaggacgctaataccgcatgacatcccggggccgcatggccctgggatcaaaggagcaatccgct gagagatggactcgcgtccgattagctagttggtgagataaaggcccaccaaggcgacgatcggtagccgga ctgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggat attgcacaatggagggaactctgatgcagcaacgccgcgtgagggaagaaggtcttcggattgtaaacctttgtc ctcagggaagataatgacggtacctgaggaggaagctccggctaactacgtgccagcagccgcggtaatacg tagggagcaagcgttgtccggatttactgggtgtaaagggtgcgtaggcggaactgcaagtcagtggtgaaatct gagggctcaaccctcaaactgccattgaaactgtggttcttgagtgaagtagaggtaggcggaattcccggtgta gcggtggaatgcgtagagatcgggaggaacaccagtggcgaaggcggcctactgggctttaactgacgctga ggcacgaaagcatgggtagcaaacaggattagataccctggtagtccatgccgtaaacgatgattactaggtgt ggggggtctgaccccctccgtgccggagttaacacaataagtaatccacctggggagtacggccgcaaggttg aaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaa ccttaccaggtcttgacatccaactaacgaggtagagatacgtcaggtgcccttcggggaaagttgagacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtgattagttg ctacgcaagagcactctaatcagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatg ccctttatgacctgggctacacacgtactacaatggccgtaaacagagagaggcgacaccgcgaggtgaagc gaaaccctaaaaacggtctcagttcggattgtaggctgcaacccgcctacatgaagttggaattgctagtaatcg cggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagccggtaat acccgaagtcagtagtctaaccgcaaggggggcgctgccgaaggtaggattggcgactggggtgaagtcgta acaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_bi SEQ ID NO: attaagagtttgatcctggctcaggacgaacgctggcggcacgcttaacacatgcaagtcgaacgagagaaga circulans 26 gaagcttgcttttctgatctagtggcggacgggtgagtaacacgtgagcaatctgcctttcagagggggataccga ttggaaacgatcgttaataccgcataacataattgaaccgcatgatttgattatcaaagatttatcgctgaaagatg agctcgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatcagtagccggactgagaggttg atcggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcacaatgg aggaaactctgatgcagcgatgccgcgtgagggaagaaggttttaggattgtaaacctctgtcttcagggacga aaaaaaagacggtacctgaggaggaagctccggctaactacgtgccagcagccgcggtaatacgtagggag cgagcgttgtccggaattactgggtgtaaagggagcgtaggcgggatcgcaagtcagatgtgaaaactatggg cttaacccataaactgcatttgaaactgtggttcttgagtgaagtagaggtaagcggaattcctagtgtagcggtga aatgcgtagatattaggaggaacatcagtggcgaaggcggcttactgggctttaactgacgctgaggctcgaaa gcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggggggact gaccccttccgtgccgcagcaaacgcaataagtaatccacctggggagtacgaccgcaaggttgaaactcaa aggaattgacgggggcccgcacaagcagtggagtatgtggattaattcgaagcaacgcgaagaaccttacca ggtcttgacatcgtatgcatagctcagagatgagtgaaatctcttcggagacatatagacaggtggtgcatggttgt cgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttactgttagttgctacgcaagag cactctagcaggactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccccttatgacc tgggcctcacacgtactacaatggctgtcaacagagggatgcaaagccgcgaggtggagcgaacccctaaaa gcagtcttagttcggattgtaggctgcaacccgcctacatgaagtcggaattgctagtaatcgcagatcagcatgc tgcggtgaatacgttcccgggccttgtacacaccgcccgtcacgccatgggagtcggtaacacccgaagcctgt agtctaaccgcaaggaggacgcagtcgaaggtgggattgatgactggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctccttt Streptococcus_go SEQ ID NO:27 aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgcacagtttat rdonii accgtagcttgctacaccatagactgtgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgg gggataactattggaaacgatagctaataccgcataatattaattattgcatgataattgattgaaagatgcaactg catcactaccagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagc cgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagg gaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagct ctgttgtaagagaagaacgggtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggct aactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgc aggcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgca gaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagc ggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtcc acgccgtaaacgatgagtgctaggtgttaggccctttccggggcttagtgccgcagctaacgcattaagcactcc gcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatg tggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgcccgctctagagatagagttttac ttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacga gcgcaacccttattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaag gtggggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagt cgcaagtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatga agtcggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgt cacaccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggata gatgattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_go SEQ ID NO:28 aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgcacagtttat rdonii accgtagcttgctacaccatagactgtgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgg gggataactattggaaacgatagctaataccgcataatattaattattgcatgataattgattgaaagatgcaactg catcactaccagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagc cgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagg gaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagct ctgttgtaagagaagaacgggtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggct aactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgc aggcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgca gaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagc ggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtcc acgccgtaaacgatgagtgctaggtgttaggccctttccggggcttagtgccgcagctaacgcattaagcactcc gcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatg tggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgcccgctctagagatagagttttac ttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacga gcgcaacccttattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaag gtggggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagt cgcaagtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatga agtcggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgt cacaccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggata gatgattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_go SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgcacagtttat rdonii 29 accgtagcttgctacaccatagactgtgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgg gggataactattggaaacgatagctaataccgcataatattaattattgcatgataattgattgaaagatgcaactg catcactaccagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagc cgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagg gaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagct ctgttgtaagagaagaacgggtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggct aactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgc aggcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgca gaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagc ggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtcc acgccgtaaacgatgagtgctaggtgttaggccctttccggggcttagtgccgcagctaacgcattaagcactcc gcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatg tggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgcccgctctagagatagagttttac ttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacga gcgcaacccttattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaag gtggggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagt cgcaagtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatga agtcggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgt cacaccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggata gatgattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt

Streptococcus_go SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgcacagtttat rdonii 30 accgtagcttgctacaccataaactgtgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgg gggataactattggaaacgatagctaataccgcataatattgattattgcatgataattgattgaaagatgctattgc atcactaccagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagcc gacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtaggg aatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctc tgttgtaagagaagaacgggtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggcta actacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgca ggcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcag aaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcg gctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtcca cgccgtaaacgatgagtgctaggtgttaggccctttccggggcttagtgccgcagctaacgcattaagcactccg cctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgt ggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgcccgctctagagatagagttttact tcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgag cgcaacccttattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcg caagtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaag tcggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtca caccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagat gattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Akkermansia_muc SEQ ID NO: atggagagtttgattctggctcagaacgaacgctggcggcgtggataagacatgcaagtcgaacgagagaatt iniphila 31 gctagcttgctaataattctctagtggcgcacgggtgagtaacacgtgagtaacctgcccccgagagcgggata gccctgggaaactgggattaataccgcatagtatcgaaagattaaagcagcaatgcgcttggggatgggctcgc ggcctattagttagttggtgaggtaacggctcaccaaggcgatgacgggtagccggtctgagaggatgtccggc cacactggaactgagacacggtccagacacctacgggtggcagcagtcgagaatcattcacaatgggggaa accctgatggtgcgacgccgcgtgggggaatgaaggtcttcggattgtaaacccctgtcatgtgggagcaaatta aaaagatagtaccacaagaggaagagacggctaactctgtgccagcagccgcggtaatacagaggtctcaa gcgttgttcggaatcactgggcgtaaagcgtgcgtaggctgtttcgtaagtcgtgtgtgaaaggcgcgggctcaac ccgcggacggcacatgatactgcgagactagagtaatggagggggaaccggaattctcggtgtagcagtgaa atgcgtagatatcgagaggaacactcgtggcgaaggcgggttcctggacattaactgacgctgaggcacgaag gccaggggagcgaaagggattagatacccctgtagtcctggcagtaaacggtgcacgcttggtgtgcggggaa tcgaccccctgcgtgccggagctaacgcgttaagcgtgccgcctggggagtacggtcgcaagattaaaactca aagaaattgacggggacccgcacaagcggtggagtatgtggcttaattcgatgcaacgcgaagaaccttacct gggcttgacatgtaatgaacaacatgtgaaagcatgcgactcttcggaggcgttacacaggtgctgcatggccgt cgtcagctcgtgtcgtgagatgtttggttaagtccagcaacgagcgcaacccctgttgccagttaccagcacgtga aggtggggactctggcgagactgcccagatcaactgggaggaaggtggggacgacgtcaggtcagtatggcc cttatgcccagggctgcacacgtactacaatgcccagtacagagggggccgaagccgcgaggcggaggaaa tcctaaaaactgggcccagttcggactgtaggctgcaacccgcctacacgaagccggaatcgctagtaatggc gcatcagctacggcgccgtgaatacgttcccgggtcttgtacacaccgcccgtcacatcatggaagccggtcgc acccgaagtatctgaagccaaccgcaaggaggcagggtcctaaggtgagactggtaactgggatgaagtcgt aacaaggtagccgtaggggaacctgcggctggatcacctccttt Akkermansia_muc SEQ ID NO: atggagagtttgattctggctcagaacgaacgctggcggcgtggataagacatgcaagtcgaacgagagaatt iniphila 32 gctagcttgctaataattctctagtggcgcacgggtgagtaacacgtgagtaacctgcccccgagagcgggata gccctgggaaactgggattaataccgcatagtatcgaaagattaaagcagcaatgcgcttggggatgggctcgc ggcctattagttagttggtgaggtaacggctcaccaaggcgatgacgggtagccggtctgagaggatgtccggc cacactggaactgagacacggtccagacacctacgggtggcagcagtcgagaatcattcacaatgggggaa accctgatggtgcgacgccgcgtgggggaatgaaggtcttcggattgtaaacccctgtcatgtgggagcaaatta aaaagatagtaccacaagaggaagagacggctaactctgtgccagcagccgcggtaatacagaggtctcaa gcgttgttcggaatcactgggcgtaaagcgtgcgtaggctgtttcgtaagtcgtgtgtgaaaggcgcgggctcaac ccgcggacggcacatgatactgcgagactagagtaatggagggggaaccggaattctcggtgtagcagtgaa atgcgtagatatcgagaggaacactcgtggcgaaggcgggttcctggacattaactgacgctgaggcacgaag gccaggggagcgaaagggattagatacccctgtagtcctggcagtaaacggtgcacgcttggtgtgcggggaa tcgaccccctgcgtgccggagctaacgcgttaagcgtgccgcctggggagtacggtcgcaagattaaaactca aagaaattgacggggacccgcacaagcggtggagtatgtggcttaattcgatgcaacgcgaagaaccttacct gggcttgacatgtaatgaacaacatgtgaaagcatgcgactcttcggaggcgttacacaggtgctgcatggccgt cgtcagctcgtgtcgtgagatgtttggttaagtccagcaacgagcgcaacccctgttgccagttaccagcacgtga aggtggggactctggcgagactgcccagatcaactgggaggaaggtggggacgacgtcaggtcagtatggcc cttatgcccagggctgcacacgtactacaatgcccagtacagagggggccgaagccgcgaggcggaggaaa tcctaaaaactgggcccagttcggactgtaggctgcaacccgcctacacgaagccggaatcgctagtaatggc gcatcagctacggcgccgtgaatacgttcccgggtcttgtacacaccgcccgtcacatcatggaagccggtcgc acccgaagtatctgaagccaaccgcaaggaggcagggtcctaaggtgagactggtaactgggatgaagtcgt aacaaggtagccgtaggggaacctgcggctggatcacctccttt Akkermansia_muc SEQ ID NO: atggagagtttgattctggctcagaacgaacgctggcggcgtggataagacatgcaagtcgaacgagagaatt iniphila 33 gctagcttgctaataattctctagtggcgcacgggtgagtaacacgtgagtaacctgcccccgagagcgggata gccctgggaaactgggattaataccgcatagtatcgaaagattaaagcagcaatgcgcttggggatgggctcgc ggcctattagttagttggtgaggtaacggctcaccaaggcgatgacgggtagccggtctgagaggatgtccggc cacactggaactgagacacggtccagacacctacgggtggcagcagtcgagaatcattcacaatgggggaa accctgatggtgcgacgccgcgtgggggaatgaaggtcttcggattgtaaacccctgtcatgtgggagcaaatta aaaagatagtaccacaagaggaagagacggctaactctgtgccagcagccgcggtaatacagaggtctcaa gcgttgttcggaatcactgggcgtaaagcgtgcgtaggctgtttcgtaagtcgtgtgtgaaaggcgcgggctcaac ccgcggacggcacatgatactgcgagactagagtaatggagggggaaccggaattctcggtgtagcagtgaa atgcgtagatatcgagaggaacactcgtggcgaaggcgggttcctggacattaactgacgctgaggcacgaag gccaggggagcgaaagggattagatacccctgtagtcctggcagtaaacggtgcacgcttggtgtgcggggaa tcgaccccctgcgtgccggagctaacgcgttaagcgtgccgcctggggagtacggtcgcaagattaaaactca aagaaattgacggggacccgcacaagcggtggagtatgtggcttaattcgatgcaacgcgaagaaccttacct gggcttgacatgtaatgaacaacatgtgaaagcatgcgactcttcggaggcgttacacaggtgctgcatggccgt cgtcagctcgtgtcgtgagatgtttggttaagtccagcaacgagcgcaacccctgttgccagttaccagcacgtga aggtggggactctggcgagactgcccagatcaactgggaggaaggtggggacgacgtcaggtcagtatggcc cttatgcccagggctgcacacgtactacaatgcccagtacagagggggccgaagccgcgaggcggaggaaa tcctaaaaactgggcccagttcggactgtaggctgcaacccgcctacacgaagccggaatcgctagtaatggc gcatcagctacggcgccgtgaatacgttcccgggtcttgtacacaccgcccgtcacatcatggaagccggtcgc acccgaagtatctgaagccaaccgcaaggaggcagggtcctaaggtgagactggtaactgggatgaagtcgt aacaaggtagccgtaggggaacctgcggctggatcacctccttt Eubacterium_rect SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt ale 34 tgatttccttcgggactgattattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtacag ggggataacagttggaaacggctgctaataccgcataagcgcacggcatcgcatgatgcagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatccatag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagataatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggt aatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtctgatgtg aaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactg acgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttgggaagcattgcttctcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaagtcttgacatccttctgaccggtacttaaccgtaccttctcttcggagcaggagtgacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtag ccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaaagctgtgaagc cgagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaatcgcta gtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtt gggaatgcccgaagccagtgacctaaccgaaaggaaggagctgtcgaaggcaggctcgataactggggtga agtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_rect SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt ale 35 tgatttccttcgggactgattattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtacag ggggataacagttggaaacggctgctaataccgcataagcgcacagcatcgcatgatgcagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatccatag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagataatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggt aatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtctgatgtg aaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactg acgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttgggaagcattgcttctcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaagtcttgacatccttctgaccggtacttaaccgtaccttctcttcggagcaggagtgacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtag ccagcggtccggccgggcactctagagagactgccagggataacctggaggaaggcggggatgacgtcaa atcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaaagctgtgaag ccgagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaatcgct agtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt tgggaatgcccgaagccagtgacctaaccgaaaggaaggagctgtcgaaggcaggctcgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_rect SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt ale 36 tgatttccttcgggactgattattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtacag ggggataacagttggaaacggctgctaataccgcataagcgcacggcatcgcatgatgcagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatccatag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagataatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggt aatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtctgatgtg aaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactg acgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccgcgccgtaaacgatgaat actaggtgttgggaagcattgcttctcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaagtcttgacatccttctgaccggtacttaaccgtaccttctcttcggagcaggagtgacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtag ccagcggtttggccgggcactctagagagactgccagggataacctggaggaaggcggggatgacgtcaaat catcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaaagctgtgaagcc gagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagt aatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttgg gaatgcccgaagccagtgacctaaccgaaaggaaggagctgtcgaaggcaggctcgataactggggtgaag tcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt

Eubacterium_rect SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt ale 37 tgatttccttcgggactgattattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtacag ggggataacagttggaaacggctgctaataccgcataagcgcacggcatcgcatgatgcagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatccatag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagataatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggt aatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtctgatgtg aaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactg acgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttgggaagcattgcttctcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaagtcttgacatccttctgaccggtacttaaccgtaccttctcttcggagcaggagtgacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtag ccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaaagctgtgaagc cgagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaatcgcta gtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtt gggaatgcccgaagccagtgacctaaccgaaaggaaggagctgtcgaaggcaggctcgataactggggtga agtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_rect SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt ale 38 tgatttccttcgggactgattattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtacag ggggataacagttggaaacggctgctaataccgcataagcgcacagcatcgcatgatgcagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatccatag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagataatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgcggt aatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtctgatgtg aaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactg acgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgatgaata ctaggtgttgggaagcattgcttctcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaa gaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcg aagaaccttaccaagtcttgacatccttctgaccggtacttaaccgtaccttctcttcggagcaggagtgacaggtg gtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagtagc cagcggtctggccgggcactctagagagactgccagggataacctggaggaaggcggggatgacgtcaaat catcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaagctgtgaagcc gagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagt aatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttgg gaatgcccgaagccagtgacctaaccgaaaggaaggagctgtcgaaggcaggctcgataactggggtgaag tcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eggerthella_lenta SEQ ID NO: acggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgatgaaacc 39 gccctcgggcggacatgaagtggcgaacgggtgagtaacacgtgaccaacctgccccttgctccgggacaac cttgggaaaccgaggctaataccggatactcctcgcccccctcctggggggcccgggaaagcccagacggca agggatggggtcgcggcccattaggtagtaggcggggtaacggcccacctagcccgcgatgggtagccgggt tgagagaccgaccggccacattgggactgagatacggcccagactcctacgggaggcagcagtggggaattt tgcgcaatgggggaaaccctgacgcagcaacgccgcgtgcgggacgacggccttcgggttgtaaaccgctttc agcagggaagaaattcgacggtacctgcagaagaagctccggctaactacgtgccagcagccgcggtaatac gtagggagcgagcgttatccggattcattgggcgtaaagagcgcgtaggcggcctctcaagcgggatctctaat ccgagggctcaacccccggccggatcccgaactgggaggctcgagttcggtagaggcaggcggaattcccg gtgtagcggtggaatgcgcagatatcgggaagaacaccgatggcgaaggcagcctgctgggccgcaactga cgctgaggcgcgaaagctaggggagcgaacaggattagataccctggtagtcctagccgtaaacgatggata ctaggtgtggggggctccgccctccgtgccgcagccaacgcattaagtatcccgcctggggagtacggccgca aggctaaaactcaaaggaattgacgggggcccgcacaagcagcggagcatgtggcttaattcgaagcaacg cgaagaaccttaccagggcttgacatggacgtgaagccggggaaacccggtggccgagaggagcgtccgca ggtggtgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctgcccc atgttgccagcattaggttggggactcatgggggactgccggcgtcaagccggaggaaggtggggacgacgtc aagtcatcatgccctttatgccctgggctgcacacgtgctacaatggccggtacaacgggctgcgagaccgcga ggtcgagcgaatccctcaaagccggccccagttcggatcggaggctgcaacccgcctccgtgaagtcggagtt gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccaccc gagtcgtctgcacccgaagccgccggccgaacccgcaaggggcggaggcgtcgaaggtgtggagggtaag gggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Eggerthella_lenta SEQ ID NO: acggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgatgaaacc 40 gccctcgggcggacatgaagtggcgaacgggtgagtaacacgtgaccaacctgccccttgctccgggacaac cttgggaaaccgaggctaataccggatactcctcgcccccctcctggggggcccgggaaagcccagacggca agggatggggtcgcggcccattaggtagtaggcggggtaacggcccacctagcccgcgatgggtagccgggt tgagagaccgaccggccacattgggactgagatacggcccagactcctacgggaggcagcagtggggaattt tgcgcaatgggggaaaccctgacgcagcaacgccgcgtgcgggacgacggccttcgggttgtaaaccgctttc agcagggaagaaattcgacggtacctgcagaagaagctccggctaactacgtgccagcagccgcggtaatac gtagggagcgagcgttatccggattcattgggcgtaaagagcgcgtaggcggcctctcaagcgggatctctaat ccgagggctcaacccccggccggatcccgaactgggaggctcgagttcggtagaggcaggcggaattcccg gtgtagcggtggaatgcgcagatatcgggaagaacaccgatggcgaaggcagcctgctgggccgcaactga cgctgaggcgcgaaagctaggggagcgaacaggattagataccctggtagtcctagccgtaaacgatggata ctaggtgtggggggctccgccctccgtgccgcagccaacgcattaagtatcccgcctggggagtacggccgca aggctaaaactcaaaggaattgacgggggcccgcacaagcagcggagcatgtggcttaattcgaagcaacg cgaagaaccttaccagggcttgacatggacgtgaagccggggaaacccggtggccgagaggagcgtccgca ggtggtgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctgcccc atgttgccagcattaggttggggactcatgggggactgccggcgtcaagccggaggaaggtggggacgacgtc aagtcatcatgccctttatgccctgggctgcacacgtgctacaatggccggtacaacgggctgcgagaccgcga ggtcgagcgaatccctcaaagccggccccagttcggatcggaggctgcaacccgcctccgtgaagtcggagtt gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccaccc gagtcgtctgcacccgaagccgccggccgaacccgcaaggggcggaggcgtcgaaggtgtggagggtaag gggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Eggerthella_lenta SEQ ID NO: acggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgatgaaacc 41 gccctcgggcggacatgaagtggcgaacgggtgagtaacacgtgaccaacctgccccttgctccgggacaac cttgggaaaccgaggctaataccggatactcctcgcccccctcctggggggcccgggaaagcccagacggca agggatggggtcgcggcccattaggtagtaggcggggtaacggcccacctagcccgcgatgggtagccgggt tgagagaccgaccggccacattgggactgagatacggcccagactcctacgggaggcagcagtggggaattt tgcgcaatgggggaaaccctgacgcagcaacgccgcgtgcgggacgacggccttcgggttgtaaaccgctttc agcagggaagaaattcgacggtacctgcagaagaagctccggctaactacgtgccagcagccgcggtaatac gtagggagcgagcgttatccggattcattgggcgtaaagagcgcgtaggcggcctctcaagcgggatctctaat ccgagggctcaacccccggccggatcccgaactgggaggctcgagttcggtagaggcaggcggaattcccg gtgtagcggtggaatgcgcagatatcgggaagaacaccgatggcgaaggcagcctgctgggccgcaactga cgctgaggcgcgaaagctaggggagcgaacaggattagataccctggtagtcctagccgtaaacgatggata ctaggtgtggggggctccgccctccgtgccgcagccaacgcattaagtatcccgcctggggagtacggccgca aggctaaaactcaaaggaattgacgggggcccgcacaagcagcggagcatgtggcttaattcgaagcaacg cgaagaaccttaccagggcttgacatggacgtgaagccggggaaacccggtggccgagaggagcgtccgca ggtggtgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctgcccc atgttgccagcattaggttggggactcatgggggactgccggcgtcaagccggaggaaggtggggacgacgtc aagtcatcatgccctttatgccctgggctgcacacgtgctacaatggccggtacaacgggctgcgagaccgcga ggtcgagcgaatccctcaaagccggccccagttcggatcggaggctgcaacccgcctccgtgaagtcggagtt gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccaccc gagtcgtctgcacccgaagccgccggccgaacccgcaaggggcggaggcgtcgaaggtgtggagggtaag gggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Burkholderiales_b SEQ ID NO: atagagtttgatcctggctcagattgaacgctggcggaacgctttacacatgcaagtcgaacggtaacgcggga acterium_1_1_47 42 gaagcttgcttctcccggcgacgagtggcgaacgggtgagtaatacatcggaacgtgtccgctcgtgggggac aaccagccgaaaggttggctaataccgcatgagttctacggaagaaagagggggacccgcaagggcctctc gcgagcggagcggccgatgactgattagccggttggtgaggtaacggctcaccaaagcaacgatcagtagct ggtctgagaggacgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaattttggacaatgggcgcaagcctgatccagctattccgcgtgtgggatgaaggccctcgggttgtaaaccac ttttgtagagaacgaaaagacaccttcgaataaagggtgttgctgacggtactctaagaataagcaccggctaac tacgtgccagcagccgcggtaatacgtagggtgcgagcgttaatcggaattactgggcgtaaagggtgcgcag gcggttgagtaagacagatgtgaaatccccgagcttaactcgggaatggcatatgtgactgctcgactagagtgt gtcagagggaggtggaattccacgtgtagcagtgaaatgcgtagatatgtggaagaacaccgatggcgaagg cagcctcctgggacataactgacgctcaggcacgaaagcgtggggagcaaacaggattagataccctggtag tccacgccctaaacgatgttaactagttgttgggaagtaaaattctcagtaacgcagccaacgcgagaagttaac cgcctgggaagtacggtcgcaagactaaaactcaaaggaattgacggggacccgcacaagcggtggatgat gtggattaattcgatgcaacgcgaaaaaccttacctacccttgacatgtcaggaagctcttgtaatgagagtgtgc ccgcaagggagcctgaacacaggtgctgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgc aacgagcgcaacccttgtcactagttgctacgaaagggcactctagtgagactgccggtgacaaaccggagga aggtggggatgacgtcaagtcctcatggcccttatgggtagggcttcacacgtcatacaatggtcggaacagag ggcagcgaagtcgtgagacggagccaatcccagaaaaccgatcgtagtccggattgcagtctgcaactcgact gcatgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggtcttgtacacaccg cccgtcaaacaatgggagtggtgtttaccagaagtcgttagcctaaccgcaaggagggcggcgaccacggtg agcaccgtgactaatgttaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Eubacterium_elig SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttag ens 43 aacagattacttcggtttgaagttctttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgtac tgggggatagcagctggaaacggctggtaataccgcataagcgcacaatgttgcatgacatggtgtgaaaaac tccggtggtataagatggacccgcgtctgattagctagttggtgagataacagcccaccaaggcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgtaaa gctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcgg taatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccatgcaagtcagaagt gaaaatccggggctcaaccccggaactgcttttgaaactgtaaggctggagtgcaggaggggtgagtggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctcactggactgtaactg acactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcggggcccataagggcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcctcttgaccggtcagtaatgtggcctttccttcgggacaagagagac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctt agtagccagcagtaagatgggcactctagggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgaagtcgtg aggccaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcgaaaatgcccgaagtcggtgacctaacgtaagaaggagccgccgaaggcaggtttgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt

Eubacterium_elig SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttag ens 44 aacagattatttcggtatgaagttctttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgta ctgggggatagcagctggaaacggctggtaataccgcataagcgcacaatgttgcatgacatggtgtgaaaaa ctccggtggtataagatggacccgcgtctgattagctagttggtgagataacagcccaccaaggcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgtaa agctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcg gtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccatgcaagtcagaag tgaaaatccggggctcaaccccggaactgcttttgaaactgtaaggctggagtgcaggaggggtgagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctcactggactgtaactg acactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcggggcccaaaagggcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaaccttaccaagtcttgacatcccactgaccggacagtaatgtgtcctttccttcgggacagtggtga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcct tagtagccagcagtaagatgggcactctagggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgaagtcgtg aggccaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcgaaaatgcccgaagtcggtgacctaacgtaagaaggagccgccgaaggcaggtttgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_elig SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttag ens 45 aacagattatttcggtatgaagttctttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgta ctgggggatagcagctggaaacggctggtaataccgcataagcgcacaatgttgcatgacatagtgtgaaaaa ctccggtggtataagatggacccgcgtctgattagctagttggtgagataacagcccaccaaggcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgtaa agctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcg gtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccatgcaagtcagaag tgaaaatccggggcttaaccccggaactgcttttgaaactgtaaggctggagtgcaggaggggtgagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctcactggactgtaactg acactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcggggcccataagggcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcccactgaccggacagtaatgtgtcctttccttcgggacagtggtgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctt agtagccagcagtaagatgggcactctagggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgaagtcgtg aggccaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcgaaaatgcccgaagtcggtgacctaacgaaagaaggagccgccgaaggcaggtttgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_elig SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttag ens 46 aacagattatttcggtatgaagttctttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgta ctgggggatagcagctggaaacggctggtaataccgcataagcgcacaatgttgcatgacatggtgtgaaaaa ctccggtggtataagatggacccgcgtctgattagctagttggtgagataacagcccaccaaggcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgtaa agctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcg gtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccatgcaagtcagaag tgaaaatccggggctcaaccccggaactgcttttgaaactgtgaggctggagtgcaggaggggtgagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctcactggactgtaactg acactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcggggcccataagggcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcccactgaccggacagtaatgtgtcctttccttcgggacagtggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcct tagtagccagcagtaagatgggcactctagggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcaaagtcgtg aggccaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcgaaaatgcccgaagtcggtgacctaacgcaagaaggagccgccgaaggcaggtttgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_elig SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttgc ens 47 gacagattttttcggaatgaagttgcttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgta ctgggggatagcagctggaaacggctggtaataccgcataagcgcacaatgttgcatgacatggtgtgaaaaa ctccggtggtataagatggacccgcgtctgattagctagttggtgagataacagcccaccaaggcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgtaa agctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcg gtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggccatgcaagtcagaag tgaaaatccggggctcaaccccggaactgcttttgaaactgtaaggctggagtgcaggaggggtgagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctcactggactgtaactg acactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcggggcccataagggcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcccactgaccggacagtaatgtgtcctttccttcgggacagtggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcct tagtagccagcagtaagatgggcactctagggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgaagtcgtg aggccaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcgaaaatgcccgaagtcggtgacctaacgtaagaaggagccgccgaaggcaggtttgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_vent SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaatacatgcaagtcgaacgaagcacctt riosum 48 ggacagaatccttcgggaggaagaccattgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcc ttgtacagggggataacagttggaaacgactgctaataccgcataagcgcacagtaccgcatggtacggtgtga aaaactccggtggtacaagatggacccgcgtctgattagctggttggtgaggtaacggcccaccaaggcgacg atcagtagccgacttgagagagtgatcggccacattgggactgagacacggcccaaactcctacgggaggca gcagtagggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatttcggt atgtaaacttctatcagcaaggaagaaaatgacggtacttgactaagaagccccggctaaatacgtgccagca gccgcggtaatacgtatggggcaagcgttatccggatttactgggtgtaaagggagcgtaggcggcatggcaa gtcagaagtgaaagcctggggctcaaccccggaattgcttttgaaactgtcaggctagagtgtcggaggggtaa gcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccggtggcgaaggcggcttactgga cgattactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaa cgatgaatactaggtgtcgggggacaatagttcctcggtgccgaagcaaacgcattaagtattccacctgggga gtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcg aagcaacgcgaagaaccttacctgctcttgacatcccactgacaggtcagtaatgtgaccctttcttcggaacagt ggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccc ttgtctttagtagccagcagtacggctgggcactctagagagactgccagggataacctggaggaaggcgggg atgacgtcaaatcatcatgccccttacgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcg accccgtgagggtaagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagttggatatgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtggagccgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_ob SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaactttt eum 49 cattgaagcttcggcagatttggtctgtttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacag ggggataacaaccagaaatggttgctaataccgcataagcgcacaggaccgcatggtccggtgtgaaaaact ccggtggtataagatggacccgcgttggattagctagttggcagggtaacggcctaccaaggcgacgatccata gccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaa acttctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggactggcaagtctgat gtgaaaggcgggggctcaacccctggactgcattggaaactgttagtcttgagtgccggagaggtaagcggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttggggagcaaagctcttcggtgccgccgcaaacgcattaagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatccctctgaccgttccttaaccggaactttccttcgggacagaggagaca ggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcccc agtagccagcggttcggccgggcactctgaggagactgccagggataacctggaggaaggcggggatgacg tcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagcctgcg aaggtaagcaaatcccaaaaataacgtcccagttcggactgcagtctgcaactcgactgcacgaagctggaat cgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagtcagtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_ob SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaactttt eum 50 cattgaagcttcggcagatttggtctgtttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacag ggggataacaaccagaaatggttgctaataccgcataagcgcacaggaccgcatggtctagtgtgaaaaactc cggtggtataagatggacccgcgttggattagctagttggcagggtaacggcctaccaaggcgacgatccatag ccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaac ttctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggactggcaagtctgatgt gaaaggcgggggctcaacccctggactgcattggaaactgttagtcttgagtgccggagaggtaagcggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaata ctaggtgttggggagcaaagctcttcggtgccgccgcaaacgcattaagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgc gaagaaccttaccaagtcttgacatccctctgaccgttccttaaccggaactttccttcgggacaggggagacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcccca gtagccagcagtccggctgggcactctgaggagactgccagggataacctggaggaaggcggggatgacgt caaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagcctgcg aaggtaagcaaatcccaaaaataacgtcccagttcggactgcagtctgcaactcgactgcacgaagctggaat cgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagtcagtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt

Ruminococcus_ob SEQ ID NO: gacacggcccagactcctacgggaggcagcagtggggaatattgtacaatgggggaaaccctgatgcagcg eum 51 acgccgcgtgaaggaagaagtatctcggtatgtaaacttctatcagcagggaagatagtgacggtacctgacta agaagccccggctaactacgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggt gtaaagggagcgtagacggactggcaagtctgatgtgaaaggcgggggctcaacccctggactgcattggaa actgttagtcttgagtgccggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaa caccagtggcgaaggcggcttactggacggtaactgacgttgaggctcgaaagcgtggggagcaaacaggat tagataccctggtagtccacgccgtaaacgatgaatactaggtgttggggagcaaagctcttcggtgccgccgca aacgcattaagtattccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcac aagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccctctgaccgact cttaaccgagtctttccttcgggacaggggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccctatccccagtagccagcagtccggctgggcactctgaggagactgc cagggataacctggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttgggctacacacgtgct acaatggcgtaaacaaagggaagcaagcctgcgaaggtaagcaaatccccaaaaataacgatcccagttcg gactgctgtctgcaactcgactgcacgaagctggaattcgctagtaatcgcggatcaaatgccgcggtgaatacg ttcccgggatctgtacacacccgcccgtccatccttgggagtctgtacccccgatttagtggacctacc Ruminococcus_ob SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaactttt eum 52 cattgaagcttcggcagatttggtctgtttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacag ggggataacaaccagaaatggttgctaataccgcataagcgcacaggaccgcatggtccggtgtgaaaaact ccggtggtataagatggacccgcgttggattagctagttggcagggtaacggcctaccaaggcgacgatccata gccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaa acttctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggactggcaagtctgat gtgaaaggcgggggctcaacccctggactgcattggaaactgttagtcttgagtgccggagaggtaagcggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttggggagcaaagctcttcggtgccgccgcaaacgcattaagtattccacctggggagtacgttcgc aagaatgaaactcaaaggatttgacgggggacccgcacagcggtggagcatgtggtttattcgagcacggcga agaaccttaccaagtctgacatcccct Ruminococcus_ob SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaaccttt eum 53 tattgaagcttcggcagatttagctggtttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacag ggggataacaaccagaaatggttgctaataccgcataagcgcacaggaccgcatggtccggtgtgaaaaact ccggtggtataagatggacccgcgttggattagctagttggcagggtaacggcctaccaaggcgacgatccata gccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaa acttctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggactggcaagtctgat gtgaaaggcgggggctcaacccctggactgcattggaaactgttagtcttgagtgccggagaggtaagcggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaagcggcttactggacggtaact gacgttgaggctcgaaagcgtggggagcaaacaggattagatacctggtagtccacgccgtaaacgatgaata ctagtgttgggggagcaaagctcttcgtgccgccgcaaacgcattagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgaccggcacccacaaacgcgtgagtcagggtgttaa Ruminococcus_to SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 54 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtggccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactgggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_to SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 55 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtccccgcaacgagcgcaaccccta tctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_to SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 56 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtgggagcatgtggtttaattcgaag caacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcgggcagcgga gacaggtggtgcatggttgtcgtcagct Ruminococcus_to SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 57 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtggccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactgggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_to SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 58 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctggttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctgggggagtac gttcgcaagaatgaaactcaaaggaattgacgggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcg gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcacgagcgcaaccctat ctttagtagcagcggccaggccgggcactctaaaagagactgccggggataatcccgggaggaaggtgggg at Ruminococcus_to SEQ ID NO: tacgagagtttgatcctggctcaggatgaacgcgggcggcgtgcctaacacatgcaagtcgagcgaagcacttt rques 59 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtggccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_longicaten SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgctta a 60 agtttgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcatac agggggataacagttagaaatgactgctaataccgcataagaccacggtaccgcatggtacagtggtaaaaac tccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaac ttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcacggcaagccagat gtgaaagcccggggctcaaccccgggactgcatttggaactgctgagctagagtgtcggagaggcaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggacgatga ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga ctgctaggtgtcgggtggcaaagccattcggtgccgcagctaacgcaataagcagtccacctggggagtacgtt cgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagtttttcttcggaacatcggtgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttc agtagccagcaggttaagctgggcactctggagagactgccagggataacctggaggaaggtggggatgac gtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagagaagcgaactc gcgagggtaagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaa tcgctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_longicaten SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgcttt a 61 ggaaagattcttcggatgatttcctttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggataacagttagaaatgactgctaataccgcataagaccacggtaccgcatggtacagtggtaaaaa ctccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaa cttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcacggcaagccag atgtgaaagcccggggctcaaccccgggactgcatttggaactgctgagctagagtgtcggagaggcaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaagcggcttgctggacgatga ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga ctgctaggtgtcgggtgg Anaerostipes_cac SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttagg cae 62 attgaagttttcggatggatttcctatatgactgagtggcggacgggtgagtaacgcgtggggaacctgccctatac agggggataacagctggaaacggctgctaataccgcataagcgcacagaatcgcatgattcagtgtgaaaag ccctggcagtataggatggtcccgcgtctgattagctggttggtgaggtaacggctcaccaaggcgacgatcagt agccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaacagacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggcatggtaagtca gaagtgaaagcccggggcttaaccccgggactgcttttgaaactgtcatgctggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt cactgacactgatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgtcggggccgtagaggcttcggtgccgcagcaaacgcagtaagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttacctggtcttgacatcccaatgaccgaaccttaaccggttttttctttcgagacattggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatct ttagtagccagcattacggatgggcactctagagagactgccagggataacctggaggaaggtggggacgac gtcaaatcatcatgccccttatggccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaagtc gtgaggcgaagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgtgaatcagaatgtcacggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerostipes_cac SEQ ID NO:63 ctagcggtgaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtcactgacactga cae tgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtg tcggggccgtagaggcttcggtgccgcagcaaacgcagtaagtattccacctggggagtacgttcgcaagaat gaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaaga accttacctggtcttgacatcccaatgagcgaaccttaaccggttttttctttcgagacattggagacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatctttagtagccagca tttaaggtgggcactctagagagactgccagggataacctggaggaaggtggggacgacgtcaaatcatcatg ccccttatggccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaagtcgtgaggcgaagc aaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcg tgaatcagaatgtcacggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcagtaacg cccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataactggggtgaagtcgta acaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerostipes_cac SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttagg cae 64 attgaagttttcggatggatttcctatatgactgagtggcggacgggtgagtaacgcgtggggaacctgccctatac agggggataacagctggaaacggctgctaataccgcataagcgcacagaatcgcatgattcagtgtgaaaag ccctggcagtataggatggtcccgcgtctgattagctggttggtgaggtaacggctcaccaaggcgacgatcagt agccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaacagacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggcatggtaagtca gaagtgaaagcccggggcttaaccccgggactgcttttgaaactgtcatgctggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt cactgacactgatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgtcggggccgtagaggcttcggtgccgcagcaaacgcagtaagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttacctggtcttgacatcccaatgaccgaaccttaaccggttttttctttcgagacattggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatct ttagtagccagcatttaaggtgggcactctagagagactgccagggataacctggaggaaggtggggacgac gtcaaatcatcatgccccttatggccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaagtc gtgaggcgaagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgtgaatcagaatgtcacggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagtaacgcccgaagtcagtgacccaaccgcaan Anaerostipes_cac SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttagg cae 65 attgaagttttcggatggatttcctatatgactgagtggcggacgggtgagtaacgcgtggggaacctgccctatac agggggataacagctggaaacggctgctaataccgcataagcgcacagaatcgcatgattcagtgtgaaaag ccctggcagtataggatggtcccgcgtctgattagctggttggtgaggtaacggctcaccaaggcgacgatcagt agccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaacagacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggcatggtaagtca gaagtgaaagcccggggcttaaccccgggactgcttttgaaactgtcatgctggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt cactgacactgatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgtcggggccgtagaggcttcggtgccgcagcaaacgcagtaagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttacctggtcttgacatcccaatgaccgaaccttaaccggttttttctttcgagacattggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatct ttagtagccagcatttaaggtgggcactctagagagactgccagggataacctggaggaaggtggggacgac gtcaaatcatcatgccccttatggccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaagtc gtgaggcgaagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgtgaatcagaatgtcacggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerostipes_cac SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttagg cae 66 attgaagttttcggatggatttcctatatgactgagtggcggacgggtgagtaacgcgtggggaacctgccctatac aggggggataacagctggaaacggctgctaataccgcataagcgcacagaatcgcatgattcagtgtgaaaa gccctggcagtataggatggtcccgcgtctgattagctggttggtgaggtaacggctcaccaaggcgacgatca gtagccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgta aagctctatcagcagggaagaaaacagacggtacctgactaagaagccccggctaactacgtgccagcagc cgcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggcatggtaagtc agaagtgaaagcccggggcttaaccccgggactgcttttgaaactgtcatgctggagtgcaggagaggtaagc ggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactg tcactgacactgatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcggggccgtagaggcttcggtgccgcagcaaacgcagtaagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatcccaatgagcgaaccttaaccggttttttctttcgagacattgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcatttaaggtgggcactctagagagactgccagggataacctggaggaaggtggggacga cgtcaaatcatcatgccccttatggccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaagt cgtgaggcgaagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgg aatcgctagtaatcgtgaatcagaatgtcacggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataac tggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_sira SEQ ID NO:67 caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggtgaagag eum gagcttgctcctcggatcagtggcggacgggtgagtaacacgtgagcaacctggctctaagagggggacaac agttggaaacgactgctaataccgcataacgtatcgggatggcatcttcctgataccaaagattttatcgcttagag atgggctcgcgtctgattagatagttggcggggtaacggcccaccaagtcgacgatcagtagccggactgaga ggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggatattggac aatgggggcaaccctgatccagcgacgccgcgtgagggaagaaggttttcggattgtaaacctctgttgacgga gaaaaaaatgatggtatccgtttagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtgg caagcgttgtccggaattactgggtgtaaagggagtgtaggcgggatatcaagtcagaagtgaaaattacgggc tcaactcgtaacctgcttttgaaactgacattcttgagtgaagtagaggcaagcggaattcctagtgtagcggtgaa atgcgtagatattaggaggaacaccagtggcgaaggcggcttgctgggcttttactgacgctgaggctcgaaag cgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggggggattg accccttccgtgccggagtaaacacaataagtaatccacctggggagtacgaccgcaaggttgaaactcaaag gaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggt cttgacatcgagtgaccgcctaagagattaggctttcccttcggggacacaaagacaggtggtgcatggttgtcgt cagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcattagttgctacgcaagagcac tctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccctttatgacctggg ctacacacgtactacaatggcgtttaacaaagagaagcaaagccgcgaggcagagcaaatctccaaaaaac gtctcagttcggattgtaggctgcaactcgcctacatgaagtcggaattgctagtaatcgtaggtcagcatactacg gtgaatacgttcccgggccttgtacacaccgcccgtcaaaccatgagagttggcaacacccgaagtcggtagtc taaccgcaaggaggacgccgccgaaggtggggttgatgattagggttaagtcgtaacaaggtagccgtatcgg aaggtgcggctggatcacctccttt Eubacterium_sira SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggtgaagag eum 68 gagcttgctcctcggaacagtggcggacgggtgagtaacacgtgagcaacctggctctaagagggggacaac agttggaaacgactgctaataccgcataacgtatcgggatggcatcttcctgataccaaagattttatcgcttagag atgggctcgcgtctgattagatagttggcggggtaacggcccaccaagtcgacgatcagtagccggactgaga ggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggatattggac aatgggggcaaccctgatccagcgacgccgcgtgagggaagaaggttttcggattgtaaacctctgttgacgga gaaaaaaatgatggtatccgtttagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtgg caagcgttgtccggaattactgggtgtaaagggagtgtaggcgggatatcaagtcagaagtgaaaattacgggc tcaactcgtaacctgcttttgaaactgacattcttgagtgaagtagaggcaagcggaattcctagtgtagcggtgaa atgcgtagatattaggaggaacaccagtggcgaaggcggcttgctgggcttttactgacgctgaggctcgaaag cgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggggggattg accccttccgtgccggagtaaacacaataagtaatccacctggggagtacgaccgcaaggttgaaactcaaag gaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggt cttgacatcgagtgaccgcctaagagattaggctttcccttcggggacacaaagacaggtggtgcatggttgtcgt cagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcattagttgctacgcaagagcac tctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccctttatgacctggg ctacacacgtactacaatggcgtttaacaaagagaagcaaagccgcgaggcagagcaaatctccaaaaaac gtctcagttcggattgtaggctgcaactcgcctacatgaagtcggaattgctagtaatcgtaggtcagcatactacg gtgaatacgttcccgggccttgtacacaccgcccgtcaaaccatgagagttggcaacacccgaagtcggtagtc taaccgcaaggaggacgccgccgaaggtggggttgatgattagggttaagtcgtaacaaggtagccgtatcgg aaggtgcggctggatcacctccttt Eubacterium_sira SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggtgaagag eum 69 gagcttgctcctcggatcagtggcggacgggtgagtaacacgtgagcaacctggctctaagagggggacaac agttggaaacgactgctaataccgcatgatgtatcgggatggcatcttcctgataccaaagattttatcgcttagag atgggctcgcgtctgattagatagttggcggggtaacggcccaccaagtcgacgatcagtagccggactgaga ggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggatattggac aatgggggcaaccctgatccagcgacgccgcgtgagggaagaaggttttcggattgtaaacctctgttgacgga gaaaaaaatgatggtatccgtttagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtgg caagcgttgtccggaattactgggtgtaaagggagtgtaggcgggatatcaagtcagaagtgaaaattacgggc tcaactcgtaacctgcttttgaaactgacattcttgagtgaagtagaggcaagcggaattcctagtgtagcggtgaa atgcgtagatattaggaggaacaccagtggcgaaggcggcttgctgggcttttactgacgctgaggctcgaaag cgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggggggattg accccttccgtgccggagtaaacacaataagtaatccacctggggagtacgaccgcaaggttgaaactcaaag gaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggt cttgacatcgagtgaccgcctaagagattaggctttcccttcggggacacaaagacaggtggtgcatggttgtcgt cagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcattagttgctacgcaagagcac tctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccctttatgacctggg ctacacacgtactacaatggcgtttaacaaagagaagcaaagccgcgaggcagagcaaatctccaaaaaac gtctcagttcggattgtaggctgcaactcgcctacatgaagtcggaattgctagtaatcgtaggtcagcatactacg gtgaatacgttcccgggccttgtacacaccgcccgtcaaaccatgagagttggcaacacccgaagtcggtagtc taaccgcaaggaggacgccgccgaaggtggggttgatgattagggttaagtcgtaacaaggtagccgtatcgg aaggtgcggctggatcacctccttt Eubacterium_sira SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggtgaagag eum 70 gagcttgctcctcggatcagtggcggacgggtgagtaacacgtgagcaacctggctctaagagggggacaac agttggaaacgactgctaataccgcataacgtatcgggatggcatcttcctgataccaaagattttatcgcttagag atgggctcgcgtctgattagatagttggcggggtaacggcccaccaagtcgacgatcagtagccggactgaga ggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggatattggac aatgggggcaaccctgatccagcgacgccgcgtgagggaagaaggttttcggattgtaaacctctgttgacgga gaaaaaaatgatggtatccgtttagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtgg caagcgttgtccggaattactgggtgtaaagggagtgtaggcgggatatcaagtcagaagtgaaaattacgggc tcaactcgtaacctgcttttgaaactgacattcttgagtgaagtagaggcaagcggaattcctagtgtagcggtgaa atgcgtagatattaggaggaacaccagtggcgaaggcggcttgctgggcttttactgacgctgaggctcgaaag cgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggggggattg accccttccgtgccggagtaaacacaataagtaatccacctggggagtacgaccgcaaggttgaaactcaaag gaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggt cttgacatcgagtgaccgcctaagagattaggccttcccttcggggacacaaagacaggtggtgcatggttgtcg tcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcattagttgctacgcaagagca ctctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccctttatgacctgg gctacacacgtactacaatggcgtttaacaaagagaagcaaagccgcgaggcagagcaaatctccaaaaaa cgtctcagttcggattgtaggctgcaactcgcctacatgaagtcggaattgctagtaatcgtaggtcagcatactac ggtgaatacgttcccgggccttgtacacaccgcccgtcaaaccatgagagttggcaacacccgaagtcggtagt ctaaccgcaaggaggacgccgccgaaggtggggttgatgattagggttaagtcgtaacaaggtagccgtatcg gaaggtgcggctggatcacctccttt

Clostridium_leptu SEQ ID NO: tttagagagtttgatcctggctcaggacgaacgctggcggcgtgcctaacacatgcaagtcgaacggagttaaat m 71 tcgacacccgagtatccggccgggaggcggggtgctgggggttggatttaacttagtggcggacgggtgagtaa cgcgtgagtaacctgcctttcagagggggataacgttctgaaaagaacgctaataccgcataacatcaatttatc gcatgataggttgatcaaaggagcaatccgctggaagatggactcgcgtccgattagccagttggcggggtaac ggcccaccaaagcgacgatcggtagccggactgagaggttgaacggccacattgggactgagacacggccc agactcctacgggaggcagcagtgggggatattgcacaatgggggaaaccctgatgcagcaacgccgcgtg agggaagaaggttttcggattgtaaacctctgttcttagtgacgataatgacggtagctaaggagaaagctccgg ctaactacgtgccagcagccgcggtaatacgtagggagcgagcgttgtccggatttactgggtgtaaagggtgc gtaggcggcgaggcaagtcaggcgtgaaatctatgggcttaacccataaactgcgcttgaaactgtcttgcttga gtgaagtagaggtaggcggaattcccggtgtagcggtgaaatgcgtagagatcgggaggaacaccagtggcg aaggcggcctactgggctttaactgacgctgaagcacgaaagcatgggtagcaaacaggattagataccctgg tagtccatgccgtaaacgatgattactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagta atccacctggggagtacggccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggag tatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccgtctaacgaagcagagatgcatta ggtgcccttcggggaaaggcgagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaacccttgtttctagttgctacgcaagagcactctagagagactgccgttgacaaaacgga ggaaggtggggacgacgtcaaatcatcatgccccttatgacctgggccacacacgtactacaatggctgtaaac agagggaagcaaagccgcgaggtggagcaaaaccctaaaagcagtcccagttcggatcgcaggctgcaac ccgcctgcgtgaagtcggaattgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtac acaccgcccgtcacaccatgggagccggtaatacccgaagccagtagttcaaccgcaaggagagcgctgtcg aaggtaggattggcgactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_leptu SEQ ID NO: tttagagagtttgatcctggctcaggacgaacgctggcggcgtgcctaacacatgcaagtcgaacggagttaaat m 72 tcgacacccgagtatccggccgggaggcggggtgctgggggttggatttaacttagtggcggacgggtgagtaa cgcgtgagtaacctgcctttcagagggggataacgttctgaaaagaacgctaataccgcataacatcaatttatc gcatgataggttgatcaaaggagcaatccgctggaagatggactcgcgtccgattagccagttggcggggtaac ggcccaccaaagcgacgatcggtagccggactgagaggttgaacggccacattgggactgagacacggccc agactcctacgggaggcagcagtgggggatattgcacaatgggggaaaccctgatgcagcaacgccgcgtg agggaagaaggttttcggattgtaaacctctgttcttagtgacgataatgacggtagctaaggagaaagctccgg ctaactacgtgccagcagccgcggtaatacgtagggagcgagcgttgtccggatttactgggtgtaaagggtgc gtaggcggcgaggcaagtcaggcgtgaaatctatgggcttaacccataaactgcgcttgaaactgtcttgcttga gtgaagtagaggtaggcggaattcccggtgtagcggtgaaatgcgtagagatcgggaggaacaccagtggcg aaggcggcctactgggctttaactgacgctgaagcacgaaagcatgggtagcaaacaggattagataccctgg tagtccatgccgtaaacgatgattactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagta atccacctggggagtacggccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggag tatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccgtctaacgaagcagagatgcatta ggtgcccttcggggaaaggcgagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaacccttgtttctagttgctacgcaagagcactctagagagactgccgttgacaaaacgga ggaaggtggggacgacgtcaaatcatcatgccccttatgacctgggccacacacgtactacaatggctgtaaac agagggaagcaaagccgcgaggtggagcaaaaccctaaaagcagtcccagttcggatcgcaggctgcaac ccgcctgcgtgaagtcggaattgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtac acaccgcccgtcacaccatgggagccggtaatacccgaagccagtagttcaaccgcaaggagagcgctgtcg aaggtaggattggcgactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_bolte SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcaattga ae 73 aggaagttttcggatggaattcgattgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacact gggggataacagttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacagtgtgaaaaact ccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgaagcaagtctg aagtgaaaacccagggctcaaccctgggactgctttggaaactgttttgctagagtgtcggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcagtaagcattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcctcttgaccggcgtgtaacggcgccttcccttcggggcaagagag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcc ttagtagccagcaggtaaagctgggcactctagggagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagaca gtgatgtggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagcaacgcccgaagtcagtgacccaactcgcaagagagggagctgccgaaggcggggcaggt aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 74 agagagcttgctttcttgagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagagggggac aacagttggaaacgactgctaataccgcataagcccacggctcggcatcgagcagagggaaaaggagcaat ccgctttgagatggcctcgcgtccgattagctggttggtgaggtaacggcccaccaaggcgacgatcggtagcc ggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggg aatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaactc ctgttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggtaa aacgtaggtcacaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagacaagttggaagt gaaatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattcccg gtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactgac gctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacactgtaaacgatgattactag gtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaagg ttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaag aaccttaccaagtcttgacatcccttgacgatgctggaaacagtatttctcttcggagcaaggagacaggtggtgc atggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttactac gcaagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccc tttatgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaaaa ctcagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcgca gatcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccgggggga cccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgtaa caaggtagccgtaggagaacctgcggctggatcacctccttt Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 75 aggaggtttactttctcaagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagagggggac aacagttggaaacgactgctaataccgcataagcccacgacccggcatcgggtagagggaaaaggagcaat ccgctttgagatggcctcgcgtccgattagctagttggtgaggtaatggcccaccaaggcgacgatcggtagccg gactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggga atattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaactcct gttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggtaaaa cgtaggtcacaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagacaagttggaagtga aatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattcccggt gtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactgacg ctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacactgtaaacgatgattactagg tgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaaggtt gaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaaga accttaccaagtcttgacatcctgcgacgcacatagaaatatgtgtttccttcgggacgcagagacaggtggtgca tggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttactacgc aagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgcccttt atgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaaaact cagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcgcag atcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggggggac ccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgtaac aaggtagccgtaggagaacctgcggctggatcacctccttt Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 76 agagagcttgctttctcaagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagaggggga caacagttggaaacgactgctaataccgcataagcccacgacccggcatcgggtagagggaaaaggagca atccgctttgagatggcctcgcgtccgattagctagttggtgaggtaacggcccaccaaggcgacgatcggtagc cggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaact cctgttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggta aaacgtaggtcacaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagacaagttggaag tgaaatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattccc ggtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactga cgctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacaccgtaaacgatgattact aggtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaa ggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcga agaaccttaccaagtcttgacatcccttgacgatgctggaaacagtatttctcttcggagcaaggagacaggtggt gcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttact acgcaagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgc cctttatgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaa aactcagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcg cagatcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggggg gacccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgt aacaaggtagccgtaggagaacctgcggctggatcacctccttt Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 77 agagagcttgctttctcaagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagaggggga caacagttggaaacgactgctaataccgcataagcccacgacccggcatcgggtagagggaaaaggagca atccgctttgagatggcctcgcgtccgattagctggttggtgaggtaacggcccaccaaggcgacgatcggtagc cggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaact cctgttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggta aaacgtaggtcacaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagacaagttggaag tgaaatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattccc ggtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactga cgctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacaccgtaaacgatgattact aggtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaa ggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcga agaaccttaccaagtcttgacatcctgcgacgcacatagaaatatgtgtttccttcgggacgcagagacaggtgg tgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttact acgcaagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgc cctttatgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaa aactcagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcg cagatcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggggg gacccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgt aacaaggtagccgtaggagaacctgcggctggatcacctccttt

Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 78 agagagcttgctttctcaagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagaggggga caacagttggaaacgactgctaataccgcataagcccacgacccggcatcgggtagagggaaaaggagca atccgctttgagatggcctcgcgtccgattagctagttggtgaggtaacggcccaccaaggcgacgatcggtagc cggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaact cctgttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggta aaacgtaggtcacaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagacaagttggaag tgaaatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattccc ggtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactga cgctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacactgtaaacgatgattacta ggtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaag gttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaa gaaccttaccaagtcttgacatcctgcgacgcacatagaaatatgtgtttccttcgggacgcagagacaggtggt gcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttact acgcaagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgc cctttatgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaa aactcagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcg cagatcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggggg gacccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgt aacaaggtagccgtaggagaacctgcggctggatcacctccttt Faecalibacterium_ SEQ ID NO: tataaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacgagcgag prausnitzii 79 agagagcttgctttctcaagcgagtggcgaacgggtgagtaacgcgtgaggaacctgcctcaaagaggggga caacagttggaaacgactgctaataccgcataagcccacgacccggcatcgggtagagggaaaaggagca atccgctttgagatggcctcgcgtccgattagctagttggtgaggtaatggcccaccaaggcgacgatcggtagc cggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggtcttcggattgtaaact cctgttgttgaggaagataatgacggtactcaacaaggaagtgacggctaactacgtgccagcagccgcggta aaacgtaggtcacaagcgttgtccggaattattgggtgtaaagggagcgcaggcgggaagacaagttggaagt gaaatccatgggctcaacccatgaactgctttcaaaactgtttttcttgagtagtgcagaggtaggcggaattcccg gtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggcctactgggcaccaactgac gctgaggctcgaaagtgtgggtagcaaacaggattagataccctggtagtccacactgtaaacgatgattactag gtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtacgaccgcaagg ttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgacgcaacgcgaag aaccttaccaagtcttgacatcctgcgacgcacatagaaatatgtgtttccttcgggacgcagagacaggtggtgc atggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatggtcagttactac gcaagaggactctggccagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccc tttatgacttgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcgaggtggagcaaaa ctcagaaacaacgtcccagttcggactgcaggctgcaactcgcctgcacgaagtcggaattgctagtaatcgca gatcagcatgctgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccgggggga cccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggggtgaagtcgtaa caaggtagccgtaggagaacctgcggctggatcacctccttt Clostridium_bartle SEQ ID NO: atttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgattctcttcg ttii 80 gagaagagcggcggacgggtgagtaacgcgtgggtaacctgccctgtacacacggataacataccgaaagg tatgctaatacgggataacataagaaattcgcatgtttttcttatcaaagctccggcggtacaggatggacccgcgt ctgattagctagttggtgaggtaacggctcaccaaggcgacgatcagtagccgacctgagagggtgatcggcc acattggaactgagacacggtccaaactcctacgggaggcagcagtggggaatattgcacaatgggcgaaag cctgatgcagcaacgccgcgtgagcgatgaaggccttcgggtcgtaaagctctgtcctcaaggaagataatgac ggtacttgaggaggaagccccggctaactacgtgccagcagccgcggtaatacgtagggggctagcgttatcc ggatttactgggcgtaaagggtgcgtaggcggtcttttaagtcaggagtgaaaggctacggctcaaccgtagtaa gctcttgaaactggaggacttgagtgcaggagaggagagtggaattcctagtgtagcggtgaaatgcgtagatat taggaggaacaccagtagcgaaggcggctctctggactgtaactgacgctgaggcacgaaagcgtggggag caaacaggattagataccctggtagtccacgccgtaaacgatgagtactaggtgtcgggggttacccccctcggt gccgcagctaacgcattaagtactccgcctggggagtacgctcgcaagagtgaaactcaaaggaattgacgg ggacccgcacaagtagcggagcatgtggtttaattcgaagcaacgcgaagaaccttacctaagcttgacatcctt ttgaccgatgcctaatcgcatctttcccttcggggacagaagtgacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccttgcctttagttgccatcattaagttgggcactctagagg gactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgccccttatgcttagggctacaca cgtgctacaatgggtggtacagagggcagcgaagtcgtgaggccaagctaatcccttaaagccattctcagttc ggattgtaggctgaaactcgcctacatgaagctggagttactagtaatcgcagatcagaatgctgcggtgaatgc gttcccgggtcttgtacacaccgcccgtcacaccatgggagttgggggcgcccgaagccggctagctaacctttt ggaagcggtcgtcgaaggtgaaaccaataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcg gctggatcacctccttt Clostridium_bartle SEQ ID NO:81 atttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgattctctttgg ttii agaagagcggcggacgggtgagtaacgcgtgggtaacctgccctgtacacacggataacataccgaaaggt atgctaatacgggataacataagaaattcgcatgtttttcttatcaaagctccggcggtacaggatggacccgcgt ctgattagctagttggtgaggtaacggctcaccaaggcgacgatcagtagccgacctgagagggtgatcggcc acattggaactgagacacggtccaaactcctacgggaggcagcagtggggaatattgcacaatgggcgaaag cctgatgcagcaacgccgcgtgagcgatgaaggccttcgggtcgtaaagctctgtcctcaaggaagataatgac ggtacttgaggaggaagccccggctaactacgtgccagcagccgcggtaatacgtagggggctagcgttatcc ggatttactgggcgtaaagggtgcgtaggcggtcttttaagtcaggagtgaaaggctacggctcaaccgtagtaa gctcttgaaactgggggacttgagtgcaggagaggagagtggaattcctagtgtagcggtgaaatgcgtagatat taggaggaacaccagtagcgaaggcggctctctggactgtaactgacgctgaggcacgaaagcgtggggag caaacaggattagataccctggtagtccacgccgtaaacgatgagtactagctgtcggaggttacccccttcggt ggcgcagctaacgcattaagtactccgcctggggagtacgctcgcaagagtgaaactcaaaggaattgacgg ggacccgcacaagtagcggagcatgtggtttaattcgaagcaacgcgaagaaccttacctaagcttgacatcctt ttgaccgatgcctaatcgcatctttcccttcggggacagaagtgacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccttgcctttagttgccatcattaagttgggcactctagagg gactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgccccttatgcttagggctacaca cgtgctacaatgggtggtacagagggcagcgaagtcgtgaggccaagctaatcccttaaagccattctcagttc ggattgtaggctgaaactcgcctacatgaagctggagttactagtaatcgcagatcagaatgctgcggtgaatgc gttcccgggtcttgtacacaccgcccgtcacaccatgggagttgggggcgcccgaagccggctagctaacctttt ggaagcggtcgtcgaaggtgaaaccaataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcg gctggatcacctccttt Clostridium_bartle SEQ ID NO: gaggcagcagtggggaatattgcacaatgggcgaaagcctgatgcagcaacgccgcgtgagcgatgaaggc ttii 82 cttcgggtcgtaaagctctgtcctcaaggaagataatgacggtacttgaggaggaagccccggctaactacgtg ccagcagccgcggtaatacgtagggggctagcgttatccggatttactgggcgtaaagggtgcgtaggcggtctt ttaagtcaggagtgaaaggctacggctcaaccgtagtaagctcttgaaactggaggacttgagtgcaggagag gagagtggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtagcgaaggcggctctct ggactgtaactgacgctgaggcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccg taaacgatgagtactagctgtcggaggttacccccttcggtggcgcagctaacgcattaagtactccgcctgggg agtacgctcgcaagagtgaaactcaaaggaattgacggggacccgcacaagtagcggagcatgtggtttaatt cgaagcaacgcgaagaaccttacctaagcttgacatccttttgaccgatgcctaatcgcatctttcccttcggggac agaagtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaa cccttgcctttagttgccatcattaagttgggcactctagagggactgccagggataacctggaggaaggtgggg atgacgtcaaatcatcatgccccttatgcttagggctacacacgtgctacaatgggtggtacagagggcagcga agtcgtgaggccaagctaatcccttaaagccattctcagttcggattgtaggctgaaactcgcctacatgaagctg gagttactagtaatcgcagatcagaatgctgcggtgaatgcgttcccgggtcttgtacacaccgcccgtcacacc atgggagttgggggcgcccgaagccggctagctaaccttttggaagcggtcgtcgaaggtgaaaccaataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_bartle SEQ ID NO: atttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgatcttcttcg ttii 83 gaagagagcggcggacgggtgagtaacgcgtgggtaacctgccctgtacacacggataacataccgaaagg tatgctaatacgggataacataagaaattcgcatgtttttcttatcaaagctccggcggtacaggatggacccgcgt ctgattagctagttggtgaggtaacggctcaccaaggcgacgatcagtagccgacctgagagggtgatcggcc acattggaactgagacacggtccaaactcctacgggaggcagcagtggggaatattgcacaatgggcgaaag cctgatgcagcaacgccgcgtgagcgatgaaggccttcgggtcgtaaagctctgtcctcaaggaagataatgac ggtacttgaggaggaagccccggctaactacgtgccagcagccgcggtaatacgtagggggctagcgttatcc ggatttactgggcgtaaagggtgcgtaggcggtcttttaagtcaggagtgaaaggctacggctcaaccgtagtaa gctcttgaaactggaggacttgagtgcaggagaggagagtggaattcctagtgtagcggtgaaatgcgtagatat taggaggaacaccagtagcgaaggcggctctctggactgtaactgacgctgaggcacgaaagcgtggggag caaacaggattagataccctggtagtccacgccgtaaacgatgagtactagctgtcggaggttacccccttcggt ggcgcagctaacgcattaagtactccgcctggggagtacgctcgcaagagtgaaactcaaaggaattgacgg ggacccgcacaagtagcggagcatgtggtttaattcgaagcaacgcgaagaaccttacctaagcttgacatcctt ttgaccgatgcctaatcgcatctttcccttcggggacagaagtgacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccttgcctttagttgccatcattaagttgggcactctagagg gactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgccccttatgcttagggctacaca cgtgctacaatgggtggtacagagggcagcgaagtcgtgaggccaagctaatcccttaaagccattctcagttc ggattgtaggctgaaactcgcctacatgaagctggagttactagtaatcgcagatcagaatgctgcggtgaatgc gttcccgggtcttgtacacaccgcccgtcacaccatgggagttgggggcgcccgaagccggctagctaacctttt ggaagcggtcgtcgaaggtgaaaccaataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcg gctggatcacctccttt Clostridium_bartle SEQ ID NO: atgcagtcgagcgatcttcttcggagagagcggcggacgggggagtaacgcgtgggtaacctgccctgtacac ttii 84 acggattacataccgaaaggtatgctaatacgggataacataagaaattcgcatgtttttcttatcaaagctccggc ggtacaggatggacccgcgtctgattagctagttggtgaggtaacggctcaccaaggcgacgatcagtagccg acctgagagggtgatcggccacattggaactgagacacggtccaaactcctacgggaggcagcagtgggga atattgcacaatgggcgaaagcctgatgcagcaacgccgcgtgagcgatgaaggccttcgggtcgtaaagctc tgtcctcaaggaagataatgacggtacttgaggaggaagccccggctaactacgtgccagcagccgcggtaat acgtagggggctagcgttatccggatttactgggcgtaaagggtgcgtaggcggtcttttaagtcaggagtgaaa ggctacggctcaaccgtagtaagctcttgaaactggaggacttgagtgcaggagaggagagtggaattcctagt gtagcggtgaaatgcgtagatattaggaggaacaccagtagcgaaggcggctctctggactgtaactgacgctg aggcacgaaagcgtggggagcaaacaggattaaataccctggtattccacgccgtaaacgatgagtactagct gtcggaggttaccccctttcggtggcgcagctaacgcataaatactcgcctggggagtacgctcgctagagtgaa attaacagaattgactggatcctgcccaattagcggaacatgtgcttgactcgtaccaacggaaaaaccttagca ttcctgcttccttgacgtg Clostridium_bartle SEQ ID NO: atttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgattctcttcg ttii 85 gagaagagcggcggacgggtgagtaacgcgtgggtaacctgccctgtacacacggataacataccgaaagg tatgctaatacgggataacataagaaattcgcatgtttttcttatcaaagctccggcggtacaggatggacccgcgt ctgattagctagttggtgaggtaacggctcaccaaggcgacgatcagtagccgacctgagagggtgatcggcc acattggaactgagacacggtccaaactcctacgggaggcagcagtggggaatattgcacaatgggcgaaag cctgatgcagcaacgccgcgtgagcgatgaaggccttcgggtcgtaaagctctgtcctcaaggaagataatgac ggtacttgaggaggaagccccggctaactacgtgccagcagccgcggtaatacgtagggggctagcgttatcc ggatttactgggcgtaaagggtgcgtaggcggtcttttaagtcaggagtgaaaggctacggctcaaccgtagtaa gctcttgaaactggaggacttgagtgcaggagaggagagtggaattcctagtgtagcggtgaaatgcgtagatat taggaggaacaccagtagcgaaggcggctctctggactgtaactgacgctgaggcacgaaagcgtggggag caaacaggattagataccctggtagtccacgccgtaaacgatgagtactagctgtcggaggttacccccttcggt ggcgcagctaacgcattaagtactccgcctggggagtacgctcgcaagagtgaaactcaaaggaattgacgg ggacccgcacaagtagcggagcatgtggtttaattcgaagcaacgcgaagaaccttacctaagcttgacatcctt ttgaccgatgcctaatcgcatctttcccttcggggacagaagtgacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccttgcctttagttgccatcattaagttgggcactctagagg gactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgccccttatgcttagggctacaca cgtgctacaatgggtggtacagagggcagcgaagtcgtgaggccaagctaatcccttaaagccattctcagttc ggattgtaggctgaaactcgcctacatgaagctggagttactagtaatcgcagatcagaatgctgcggtgaatgc gttcccgggtcttgtacacaccgcccgtcacaccatgggagttgggggcgcccgaagccggctagctaacctttt ggaagcggtcgtcgaaggtgaaaccaataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcg gctggatcacctccttt Clostridium_ramo SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgcgagcactt sum 86 gtgctcgagtggcgaacgggtgagtaatacataagtaacctgccctagacagggggataactattggaaacga tagctaagaccgcataggtacggacactgcatggtgaccgtattaaaagtgcctcaaagcactggtagaggatg gacttatggcgcattagctggttggcggggtaacggcccaccaaggcgacgatgcgtagccgacctgagagg gtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaattttcggcaa tgggggaaaccctgaccgagcaacgccgcgtgaaggaagaaggttttcggattgtaaacttctgttataaagga agaacggcggctacaggaaatggtagccgagtgacggtactttattagaaagccacggctaactacgtgccag cagccgcggtaatacgtaggtggcaagcgttatccggaattattgggcgtaaagagggagcaggcggcagca agggtctgtggtgaaagcctgaagcttaacttcagtaagccatagaaaccaggcagctagagtgcaggagag gatcgtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagtggcgaaggcgacgatct ggcctgcaactgacgctcagtcccgaaagcgtggggagcaaataggattagataccctagtagtccacgccgt aaacgatgagtactaagtgttggatgtcaaagttcagtgctgcagttaacgcaataagtactccgcctgagtagta cgttcgcaagaatgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttaccaggtcttgacatactcataaaggctccagagatggagagatagctatatgagat acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatc gttagttaccatcattaagttggggactctagcgagactgccagtgacaagctggaggaaggcggggatgacgt caaatcatcatgccccttatgacctgggctacacacgtgctacaatggatggtgcagagggaagcgaagccgc gaggtgaagcaaaacccataaaaccattctcagttcggattgtagtctgcaactcgactacatgaagttggaatc gctagtaatcgcgaatcagcatgtcgcggtgaatacgttctcgggccttgtacacaccgcccgtcacaccacgag agttgataacacccgaagccggtggcctaaccgcaaggaaggagctgtctaaggtgggattgatgattggggt gaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_scind SEQ ID NO: cagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcga ens 87 tgcaagccagatgtgaaagcccggggctcaaccccgggactgcatttggaactgcgtggctggagtgtcggag aggcaggcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcc tgctggacgatgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacg ccgtaaacgatgactactaggtgtcgggtggcaaggccattcggtgccgcagcaaacgcaataagtagtccac ctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtgg tttaattcgaagcaacgcgaagaaccttacctgatcttgacatcccgatgccaaagcgcgtaacgcgctctttcttc ggaacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagc gcaacccctatcttcagtagccagcattttggatgggcactctggagagactgccagggagaacctggaggaa ggtggggatgacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaag ggaggcgaacccgcgagggtgggcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgact acatgaagctggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccg cccgtcacaccatgggagtcagtaacgcccgaagccggtgacccaacccgtaagggagggagccgtcgaa ggtgggaccgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_scind SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcgcct ens 88 ggccccgacttcttcggaacgaggagccttgcgactgagtggcggacgggtgagtaacgcgtgggcaacctgc cttgcactgggggataacagccagaaatggctgctaataccgcataagaccgaagcgccgcatggcgcggcg gccaaagccccggcggtgcaagatgggcccgcgtctgattaggtagttggcggggtaacggcccaccaagcc gacgatcagtagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacggg aggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatt tcggtatgtaaacttctatcagcagggaagaagatgacggtacctgactaagaagccccggctaactacgtgcc agcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgat gcaagccagatgtgaaagcccggggctcaaccccgggactgcatttggaactgcgtggctggagtgtcggag aggcaggcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcc tgctggacgatgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacg ccgtaaacgatgactactaggtgtcgggtggcaaggccattcggtgccgcagcaaacgcaataagtagtccac ctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtgg tttaattcgaagcaacgcgaagaaccttacctgatcttgacatcccgatgccaaagcgcgtaacgcgctctttcttc ggaacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagc gcaacccctatcttcagtagccagcattttggatgggcactctggagagactgccagggagaacctggaggaa ggtggggatgacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaag ggaggcgaacccgcgagggtgggcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgact acatgaagttggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccg cccgtcacaccatgggagtcagtaacgcccgaagccggtgacccaacccgtaagggagggagccgtcgaa ggtgggaccgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerotruncus_co SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggagcttacg lihominis 89 ttttgaagttttcggatggatgaatgtaagcttagtggcggacgggtgagtaacacgtgagcaacctgcctttcaga gggggataacagccggaaacggctgctaataccgcatgatgttgcgggggcacatgcccctgcaaccaaagg agcaatccgctgaaagatgggctcgcgtccgattagccagttggcggggtaacggcccaccaaagcgacgat cggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcag cagtgggggatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagggaagacggtcttcggatt gtaaacctctgtctttggggaagaaaatgacggtacccaaagaggaagctccggctaactacgtgccagcagc cgcggtaatacgtagggagcaagcgttgtccggaattactgggtgtaaagggagcgtaggcgggatggcaagt agaatgttaaatccatcggctcaaccggtggctgcgttctaaactgccgttcttgagtgaagtagaggcaggcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctgggcttta actgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gattactaggtgtggggggactgaccccttccgtgccgcagttaacacaataagtaatccacctggggagtacg gccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccaggtcttgacatcggatgcatagcctagagataggtgaagcccttcggggcatcca gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatt attagttgctacgcaagagcactctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaa tcatcatgccccttatgacctgggctacacacgtactacaatggcactaaaacagagggcggcgacaccgcga ggtgaagcgaatcccgaaaaagtgtctcagttcagattgcaggctgcaacccgcctgcatgaagtcggaattgc tagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatggga gtcggtaacacccgaagccagtagcctaaccgcaaggggggcgctgtcgaaggtgggattgatgactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerotruncus_co SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggagcttacg lihominis 90 ttttgaagttttcggatggacgaatgtaagcttagtggcggacgggtgagtaacacgtgagcaacctgcctttcag agggggataacagccggaaacggctgctaataccgcatgatgttgcgggggcacatgcccctgcaaccaaag gagcaatccgctgaaagatgggctcgcgtccgattagccagttggcggggtaacggcccaccaaagcgacga tcggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcag cagtgggggatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagggaagacggtcttcggatt gtaaacctctgtctttggggaagaaaatgacggtacccaaagaggaagctccggctaactacgtgccagcagc cgcggtaatacgtagggagcaagcgttgtccggaattactgggtgtaaagggagcgtaggcgggatggcaagt agaatgttaaatccatcggctcaaccggtggctgcgttctaaactgccgttcttgagtgaagtagaggcaggcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctgggcttta actgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gattactaggtgtggggggactgaccccttccgtgccgcagttaacacaataagtaatccacctggggagtacg gccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccaggtcttgacatcggatgcatagcctagagataggtgaagcccttcggggcatcca gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatt attagttgctacgcaagagcactctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaa tcatcatgccccttatgacctgggctacacacgtactacaatggcactaaaacagagggcggcgacaccgcga ggtgaagcgaatcccgaaaaagtgtctcagttcagattgcaggctgcaacccgcctgcatgaagtcggaattgc tagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatggga gtcggtaacacccgaagccagtagcctaaccgcaaggggggcgctgtcgaaggtgggattgatgactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Anaerotruncus_co SEQ ID NO: tcaaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggagcttac lihominis 91 gttttgaagttttcggatggatgaatgtaagcttagtggcggacgggtgagtaacacgtgagcaacctgcctttcag agggggataacagccggaaacggctgctaataccgcatgatgttgcgggggcacatgcccctgcaaccaaag gagcaatccgctgaaagatgggctcgcgtccgattagccagttggcggggtaacggcccaccaaagcgacga tcggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcag cagtgggggatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagggaagacggtcttcggatt gtaaacctctgtctttggggaagaaaatgacggtacccaaagaggaagctccggctaactacgtgccagcagc cgcggtaatacgtagggagcaagcgttgtccggaattactgggtgtaaagggagcgtaggcgggatggcaagt agaatgttaaatccatcggctcaaccggtggctgcgttctaaactgccgttcttgagtgaagtagaggcaggcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctgggcttta actgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaacgatg attactaggtgtggggggactgaccccttccgtgccgcagttaacacataagtaatccacctggggagtacggcc gcaggtgaactcaaggattgacggggcccgcacagcagtgagtatgtggtttatcgagcacgcgagactacag tctgacatcgatgcatagctagagatagtgagccctcgggcatccagacaggtgggtgcatgggtgtcg Anaerotruncus_co SEQ ID NO: caaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggagcttacg lihominis 92 ttttgaagttttcggatggatgaatgtaagcttagtggcggacgggtgagtaacacgtgagcaacctgcctttcaga gggggataacagccggaaacggctgctaataccgcatgatgttgcgggggcacatgcccctgcaaccaaagg agcaatccgctgaaagatgggctcgcgtccgattagccagttggcggggtaacggcccaccaaagcgacgat cggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggcag cagtgggggatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagggaagacggtcttcggatt gtaaacctctgtctttggggaagaaaatgacggtacccaaagaggaagctccggctaactacgtgccagcagc cgcggtaatacgtagggagcaagcgttgtccggaattactgggtgtaaagggagcgtaggcgggatggcaagt agaatgttaaatccatcggctcaaccggtggctgcgttctaaactgccgttcttgagtgaagtagaggcaggcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctgggcttta actgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gattactaggtgtggggggactgaccccttccgtgccgcagttaacacaataagtaatccacctggggagtacg gccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccaggtcttgacatcggatgcatagcctagagataggtgaagcccttcggggcatcca gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatt attagttgctacgcaagagcactctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaa tcatcatgccccttatgacctgggctacacacgtactacaatggcactaaaacagagggcggcgacaccgcga ggtgaagcgaatcccgaaaaagtgtctcagttcagattgcaggctgcaacccgcctgcatgaagtcggaattgc tagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatggga gtcggtaacacccgaagccagtagcctaaccgcaaggggggcgctgtcgaaggtgggattgatgactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_spirof SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgcgagcagc orme 93 aatgctcgagtggcgaacgggtgagtaatacataagtaacctgccctagacagggggataactgctggaaacg gcagctaagaccgcataggtatggacactgcatggtgaccatattaaaagtgccaaggcactggtagaggatg gacttatggcgcattagctggttggtgaggtaacagctcaccaaggcgacgatgcgtagccgacctgagagggt gaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaattttcggcaatg gggggaaccctgaccgagcaacgccgcgtgaaggaagaaggaattcgttctgtaaacttctgttataaaggaa gaacggcggatatagggaatgatatccgagtgacggtactttatgagaaagccacggctaactacgtgccagc agccgcggtaatacgtaggtggcgagcgttatccggaattattgggcgtaaagagggagcaggcggcggcag aggtctgtggtgaaagactgaagcttaacttcagtaagccatagaaaccgggctgctagagtgcaggagagga tcgtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagtggcgaaggcgacggtctgg cctgtaactgacgctcattcccgaaagcgtggggagcaaataggattagataccctagtagtccacgccgtaaa cgatgagtactaagtgttgggagtcaaatttcagtgctgcagttaacgcaataagtactccgcctgagtagtacgtt cgcaagaatgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaggtcttgacatccggataaagacctcagagatgaggggatagatatatccgagac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtcgct agttaccatcattaagttggggactctagcgagactgccagtgacaagctggaggaaggcggggatgacgtca aatcatcatgccccttatgacctggctacacacgtgctacaatgatggagcagagggaagcgaagccgcgagt gagcaaacccataaaccattctcagtcggattgtagtctgcactcgactacatga Clostridium_spirof SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgcgagcagc orme 94 aatgctcgagtggcgaacgggtgagtaatacataagtaacctgccctagacagggggataactgctggaaacg gcagctaagaccgcataggtatggacactgcatggtgaccatattaaaagtgccaaggcactggtagaggatg gacttatggcgcattagctggttggtgaggtaacggctcaccaaggcgacgatgcgtagccgacctgagagggt gaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaattttcggcaatg gggggaaccctgaccgagcaacgccgcgtgaaggaagaaggaattcgttctgtaaacttctgttataaaggaa gaacggcggatatagggaatgatatccgagtgacggtactttatgagaaagccacggctaactacgtgccagc agccgcggtaatacgtaggtggcgagcgttatccggaattattgggcgtaaagagggagcaggcggcggcag aggtctatggtgaaagactgaagcttaacttcagtaagccatagaaaccgggctgctagagtgcaggagagga tcgtgaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagtggcgaaggcgacggtctgcct gtaactgacgctcattcccgaaagcgtggggagcaaataggattagataccctagtagtccacgccgtaacgat gagtactaagtgtgggagtcaaatttcagtgctgcagttaacgcaataagtacctccgccttgaatagtacgttcgc aaga Clostridium_spirof SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgcgagcagc orme 95 aatgctcgagtggcgaacgggtgagtaatacataagtaacccgccctagacagggggataactgctggaaac ggcagctaagaccgcataggtatggacactgcatggtgaccatattaaaagtgccaaggcactggtagaggat ggacttatggcgcattagctggttggtgaggtaacggctcaccaaggcgacgatgcgtagccgacctgagagg gtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaattttcggcaa tggggggaaccctgaccgagcaacgccgcgtgaaggaagaaggaattcgttctgtaaacttctgttataaagga agaacggcggatatagggaatgatatccgagtgacggtactttatgagaaagccacggctaactacgtgccag cagccgcggtaatacgtaggtggcgagcgttatccggaattattgggcgtaaagagggagcaggcggcggca gaggtctatggtgaaagactgaagcttaacttcagtaagccatagaaaccgggctgctagagtgcaggagagg atcgtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccagtggcgaaggcgacggtctg gcctgtaactgacgctcattcccgaaagcgtggggagcaaataggattagataccctagtagtccacgccgtaa acgatgagtactaagtgttgggagtcaaatttcagtgctgcagttaacgcaataagtactccgcctgagtagtacgt tcgcaagaatgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaggtcttgacatccggataaagacctcagagatgaggggatagatatatccgagac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtcgct agttaccatcattaagttggggactctagcgagactgccagtgacaagctggaggaaggcggggatgacgtca aatcatcatgccccttatgacctgcgctacacacgtgctacaatgtatggagcagagggaagcgaagccgcga ggtgaagcaaacccataaaccattctcagttcggattgtagtctgcaactcgactacatgagtgtatcgctagtatc gcgatcagcatgtcgcgtgaatacgttctcggccttgtacacaccccgcccgtcaacaccattg Anaerofustis_ster SEQ ID NO: ttttgagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgagaaacttat corihominis 96 aaatgatccttcgggtgaatctataagcggacagtggcgaacgggtgagtaacgcgtaggtaaccaacctcatg cagggggatagcccagggaaacttggattaaacccgcataagaccacagcaccgcatggtgcaggggtaaa aactccggtggcatgagacggacctgcgtcttattaggtagttggtgaggtaacggctcaccaagccaacgatg agtagccgacctgagagggtgatcggccacattgggactgagacacggcccagactcctacgggaggcagc agtggggaatattgcgcaatgggggaaaccctgacgcagcaacgccgcgtgagcgatgaaggttttcggatcg taaagctctgtctttggggaagataatgacggtacccaaggaggaagctccggctaactacgtgccagcagcc gcggtaatacgtagggagcaagcgttgtccggattcactgggcgtaaagagcacgtaggcggttaattaagtca ggtgtgaaagttttcggctcaaccggaaaagtgcacttgaaactggataacttgagtatcggagaggtaagcgg aattcctagtgtagcggtgaaatgcgtagagattaggaagaacaccggtggcgaaggcggcttactggacgat aactgacgctgaggtgcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgttggggtaactcagtgccgcagttaacacattaagtattccgcctggggagtacgctcgcaag agtgaaactcaaaggaattgacgggggcccgcacaagcagcggagcatgtggtttaattcgaagcaacgcga agaaccttaccaggtcttgacatcccttgaccgcctaagagattaggctttccttcgggacaaggagacaggtggt gcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgtttagttacta acattcagttgaggactctagacagactgcccttgaaagagggaggaaggtggggacgacgtcaaatcatcat gccccttacgacctgggctacacacgtgctacaatggtctgtacagagggttgcgaagcagtgatgctaagctaa tctcaaaaagcagatctcagttcggattgcaggctgcaactcgcctgcatgaagtcggagttgctagtaatcgcg aatcagaatgtcgcggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccacgagagttggtaacac ccgaagccagtgagctaaccattaggaggcagctgtcgaaggtgggatcagtaattggggtgaagtcgtaaca aggtagccgtatcggaaggtgcggctggatcacctccttt Anaerofustis_ster SEQ ID NO: ttttgagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgagaaacttat corihominis 97 aaatgatccttcgggtgaatctataagcggacagtggcgaacgggtgagtaacgcgtaggtaaccaacctcatg cagggggatagcccagggaaacttggattaaacccgcataagaccacagcaccgcatggtgcaggggtaaa aactccggtggcatgagacggacctgcgtcttattaggtagttggtgaggtaacggctcaccaagccaacgatg agtagccgacctgagagggtgatcggccacattgggactgagacacggcccagactcctacgggaggcagc agtggggaatattgcgcaatgggggaaaccctgacgcagcaacgccgcgtgagcgatgaaggttttcggatcg taaagctctgtctttggggaagataatgacggtacccaaggaggaagctccggctaactacgtgccagcagcc gcggtaatacgtagggagcaagcgttgtccggattcactgggcgtaaagagcacgtaggcggttaattaagtca ggtgtgaaagttttcggctcaaccggaaaagtgcacttgaaactggataacttgagtatcggagaggtaagcgg aattcctagtgtagcggtgaaatgcgtagagattaggaagaacaccggtggcgaaggcggcttactggacgat aactgacgctgaggtgcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgttggggtaactcagtgccgcagttaacacattaagtattccgcctggggagtacgctcgcaag agtgaaactcaaaggaattgacgggggcccgcacaagcagcggagcatgtggtttaattcgaagcaacgcga agaaccttaccaggtcttgacatcccttgaccgcctaagagattaggctttccttcgggacaaggagacaggtggt gcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgtttagttacta acattcagttgaggactctagacagactgcccttgaaagagggaggaaggtggggacgacgtcaaatcatcat gccccttacgacctgggctacacacgtgctacaatggtctgtacagagggttgcgaagcagtgatgctaagctaa tctcaaaaagcagatctcagttcggattgcaggctgcaactcgcctgcatgaagtcggagttgctagtaatcgcg aatcagaatgtcgcggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccacgagagttggtaacac ccgaagccagtgagctaaccattaggaggcagctgtcgaaggtgggatcagtaattggggtgaagtcgtaaca aggtagccgtatcggaaggtgcggctggatcacctccttt Clostridiales_bact SEQ ID NO: tttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcatcttat erium_1_7_47FA 98 aggaagttttcggatggaatatgggatgactgagtggcggacgggtgagtaacgcgtggataacctgcctcaca A ctgggggataacagttagaaatggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaa cccaggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatctcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgatgcaagtct gaagtgaaagcccggggctcaaccccgggactgctttggaaactgtgtggctggagtgcaggagaggtaagtg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt aactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatgctaggtgtcggggggcaaagcccctcggtgccgccgctaacgcaataagcattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaagtcttgacatccccctgaccggacagtaacgtgtcccttccttcgggacaggg gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt atccttagtagccagcatttcgggtgggcactctagggagactgccagggataacctggaggaaggtggggatg acgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaccctg cgaaggtgagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgga atcgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagcaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggcggggcaggtaa ctggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Coprococcus_co SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcacttt mes 99 aacctgattcttcggatgaaggtttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatac agggggataacagttagaaatgactgctaataccgcataagaccacagagccgcatggctcggtgggaaaaa ctccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccaacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgtaagtctgaag tgaaagcccggggctcaaccccgggactgctttggaaactatgcagctagagtgtcggagaggtaagtggaatt cccagtgtagcggtgaaatgcgtagatattgggaggaacaccagtggcgaaggcggcttactggacgatgact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgact actaggtgtcggggagcaaagctcttcggtgccgcagcaaacgcaataagtagtccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatcccggtgaccggcgtgtaatgacgccttttcttcggaacaccggtgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttc agtagccagcaattcggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcgagcctgc gagggtaagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Roseburia_intesti SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttatt nalis 100 tgatttcttcggaatgaagattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacagttggaaacgactgctaataccgcataagcgcacagggtcgcatgacctggtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagccagttggtggggtaacggcctaccaaagcgacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtgg ggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaag ctctatcagcagggaagaagaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtacggcaagtctgat gtgaaagcccggggctcaaccccggtactgcattggaaactgtcggactagagtgtcggaggggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgattact gacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtcggggagtattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccggtgacagaacatgtaatgtgttttctcttcggagcatcggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttggg Blautia_hydrogen SEQ ID NO: cagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcgatag otrophica 101 agaacggagatttcggttgaagttttctattgactgagtggcggacgggtgagtaacgcgtgggtaacctgcccta tacagggggataacagttagaaatgactgctaataccgcataagcgcacagcttcgcatgaagcggtgtgaaa aactgaggtggtataggatggacccgcgttggattagctagttggtgaggtaacggcccaccaaggcgacgatc catagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtat gtaaacttctatcagcagggaagaaagtgacggtacctgactaagaagccccggctaattacgtgccagcagc cgcggtaatacgtaaggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtttggcaagtct gatgtgaaaggcatgggctcaacctgtggactgcattggaaactgtcagacttgagtgccggagaggcaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctggacgg taactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgat gaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaaatcttgacatccctctgaccgggaagtaatgttcccttttcttcggaacagagga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatt cttagtagccagcaggtagagctgggcactctagggagactgccagggataacctggaggaaggtggggatg acgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaagg ggtgacctggagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggactgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Holdemania_filifor SEQ ID NO: acctaggcgatgatacgtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactc mis 102 ctacgggaggcagcagtagggaattttcggcaatgggcgaaagcctgaccgagcaacgccgcgtgagtgaa gaaggccttcgggttgtaaagctctgttgtgaaggaagaacggctcatacagggaatggtatgggagtgacggt actttaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcgagcgttatccgga attattgggcgtaaagggtgcgcaggcggtttgttaagtttaaggtgaaagcgtggggcttaaccccatatagcctt agaaactgacagactagagtacaggagagggcaatggaattccatgtgtagcggtaaaatgcgtagatatatg gaggaacaccagtggcgaaggcggttgcctggcctgtaactgacgctcatgcacgaaagcgtggggagcaa ataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggggaaactcagtgctgcagtt aacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgca caagcggtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggtcttgacatcccctgcaaagac atagagatatgttggaggttatcagggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggtt aagtcccgcaacgagcgcaacccttgtctttagttgctaacattaagttgaggactctagagagactgccggtgac aaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtactacaatg gcggatacaacgagaagcaagacagtgatgtggagcaaaactcagaaagtccgtctcagttcggattgaagtc tgcaacccgacttcatgaagccggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttctcgggc cttgtacacaccgcccgtcaaaccatgagagttggcaatacccgaagccggtggcctaacctcgcaagagga gggagccgtcgaaggtagggctgatgattggggttaagtcgtaacaaggtatccctacgggaacgtggggatg gatcacctccttt Clostridium_aspar SEQ ID NO: tttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcattttag agiforme 103 atgaagttttcggatggattctgagatgactgagtggcggacgggtgagtaacacgtggataacctgcctcacact gggggacaacagttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaact ccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagataatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagtctga agtgaaaacccagggctcaaccctgggactgctttggaaactgtcaagctagagtgcaggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga gtgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcaataagcactccacctggggagtacgtt cgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatccccctgaccggcgtgtaacggcgcctttccttcgggacagggga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttat ccttagtagccagcattaagatgggcactctagggagactgccagggacaacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaccctg cgaaggtgagcaaatctcaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagcaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggcggggcaggtaa ctggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaattacttt 104 attgaaacttcggtcgatttaatttaattctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctagttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcgggtggcagagccattcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccgcctgactgatccttaaccggatctttccttcgggacaggcgagacaggtg gtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagtag ccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaat catcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatgg agcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagt aatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggggagtc agtaacgcccgaagtcagtgacctaaccgaaagggaggagctgccgaaggcgggaccgatgactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt

Blautia_wexlerae SEQ ID NO: cagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaattacttt 105 attgaaacttcggtcgatttaatttaattctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctagttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcggggagcatggctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccgcctgaccgatccttaaccggatctttccttcgggacaggcgagacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagta gccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatg gagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgcta gtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt cagtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: cagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaattacttt 106 attgaaacttcggtcgatttaatttaattctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctggttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcgggtagcatagctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaaga atgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaa gaaccttaccaagtcttgacatccctctgaccgaaacttaatcggatctttccttcgggacagacgagacaggtgg tgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagtagc cagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaatc atcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatgga gcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagta atcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcag taacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactggggtgaag tcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaatattt 107 cattgagacttcggtggatttgatctatttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctggttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcggggagcatggctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccgcctgaccgatccttaaccggatctttccttcgggacaggcgagacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagta gccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatg gagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaa Blautia_wexlerae.

SEQ ID NO: cagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaattacttt 108 attgaaacttcggtcgatttaatttaattctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctagttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcggggagcatggctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccgcctgaccgatccttaaccggatctttccttcgggacaggcgagacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagta gccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatg gagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgcta gtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt cagtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaattacttt 109 attgaaacttcggtcgatttaatttaattctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagcttgttggtgaggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcggggagcatggctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccctctgaccggaacttaatcgttcctttccttcgggacagaggagacaggtg gtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagtag ccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaat catcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatgg agcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagt aatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtca gtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactggggtgaa gtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaatattt 110 cattgagacttcggtggatttgatctatttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctggttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcgggtggcagagccattcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccctctgaccggaacttaatcgttcctttccttcgggacagaggagacaggtg gtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagtag ccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaat catcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatgg agcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagt aatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtca gtaacgcccgaagtcagtgacctaactgcaaagaaggagctgccgaaggcgggaccgatgactggggtgaa gtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dialister_invisus SEQ ID NO: atggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaaaagacg 111 gaaagagcttgctcttttcagaattgagtggcaaacgggtgagtaacacgtaaacaacctgccttcaggatgggg acaacagacggaaacgactgctaataccgaataagttccaagagccgcatggcccatggaagaaaaggtgg cctctacctgtaagctatcgcctgaagaggggtttgcgtctgattagctggttggaggggtaacggcccaccaag gcgacgatcagtagccggtctgagaggatgaacggccacactggaactgagacacggtccagactcctacgg gaggcagcagtggggaatcttccgcaatgggcgaaagcctgacggagcaacgccgcgtgagtgatgacggc cttcgggttgtaaaactctgtgatccgggacgaaaaggcagagtgcgaagaacaaactgcattgacggtaccg gaaaagcaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggaatt attgggcgtaaagcgcgcgcaggcggcttcccaagtccctcttaaaagtgcggggcttaaccccgtgatgggaa ggaaactgggaagctggagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcgtagagattag gaagaacaccggtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagcgtggggagca aacaggattagataccctggtagtccacgccgtaaacgatggatactaggtgtaggaggtatcgacccctcctgt gccggagttaacgcaataagtatcccgcctgggaagtacgatcgcaagattaaaactcaaaggaattgacggg gcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggtcttgacattgatcg cgatctgcagaaatgcggagttcttcttcggaagacgagaaaacaggtggtgcacggctgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctatcatttgttaccagcacgtaaaggtggggactca aatgagaccgccgcggacaacgcggaggaaggcggggacgacgtcaagtcatcatgccccttatgacctgg gctacacacgtactacaatgggtgtcaacaaagagaagcgaacccgcgaggaagagcaaacctcaaaaac acacccccagttcagatcgcaggctgcaacccgcctgcgtgaagtaggaatcgctagtaatcgcgggtcagca taccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacactatgagagtcagaaacacccgaagc cggtgaggtaaccgcaaggagccagccgtcgaaggcggagctgatgattggagtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Dialister_invisus SEQ ID NO: atggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaaaagagg 112 gaaagagcttgctctttccggaattgagtggcaaacgggtgagtaacacgtaaacaacctgccttcaggatggg gacaacagacggaaacgactgctaataccgaataagttccaagagccgcatggcccatggaagaaaaggtg gcctctacctgtaagctatcgcctgaagaggggtttgcgtctgattagctggttggaggggtaacggcccaccaa ggcgacgatcagtagccggtctgagaggatgaacggccacactggaactgagacacggtccagactcctacg ggaggcagcagtggggaatcttccgcaatgggcgaaagcctgacggagcaacgccgcgtgagtgatgacgg ccttcgggttgtaaaactctgtgatccgggacgaaaaggcagagtgcgaagaacaaactgcattgacggtacc ggaaaagcaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggaat tattgggcgtaaagcgcgcgcaggcggcttcccaagtccctcttaaaagtgcggggcttaaccccgtgatggga aggaaactgggaagctggagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcgtagagatta ggaagaacaccggtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagcgtggggagc aaacaggattagataccctggtagtccacgccgtaaacgatggatactaggtgtaggaggtatcgacccctcct gtgccggagttaacgcaataagtatcccgcctgggaagtacgatcgcaagattaaaactcaaaggaattgacg ggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggtcttgacattg atcgcgatctgcagaaatgcggagttcttcttcggaagacgagaaaacaggtggtgcacggctgtcgtcagctc gtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcatttgttaccagcacgtaaaggtgggg actcaaatgagaccgccgcggacaacgcggaggaaggcggggacgacgtcaagtcatcatgccccttatga cctgggctacacacgtactacaatgggtgtcaacaaagagaagcgaacccgcgaggaagagcaaacctcaa aaacacacccccagttcagatcgcaggctgcaacccgcctgcgtgaagtaggaatcgctagtaatcgcgggtc agcataccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacactatgagagtcagaaacacccg aagccggtgaggtaaccgcaaggagccagccgtcgaaggcggagctgatgattggagtgaagtcgtaacaa ggtagccgtatcggaaggtgcggctggatcacctccttt Dialister_invisus SEQ ID NO: atggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaaaagacg 113 gaaagagcttgctcttttcagaattgagtggcaaacgggtgagtaacacgtaaacaacctgccttcaggatgggg acaacagacggaaacgactgctaatgccgaataagttccaagagccgcatggcccatggaagaaaaggtgg cctctacctgtaagctatcgcctgaagaggggtttgcgtctgattagctggttggaggggtaacggcccaccaag gcgacgatcagtagccggtctgagaggatgaacggccacactggaactgagacacggtccagactcctacgg gaggcagcagtggggaatcttccgcaatgggcgaaagcctgacggagcaacgccgcgtgagtgatgacggc cttcgggttgtaaaactctgtgatccgggacgaaaaggcagagtgcgaagaacaaactgcattgacggtaccg gaaaagcaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggaatt attgggcgtaaagcgcgcgcaggcggcttcccaagtccctcttaaaagtgcggggcttaaccccgtgatgggaa ggaaactgggaagctggagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcgtagagattag gaagaacaccggtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagcgtggggagca aacaggattagataccctggtagtccacgccgtaaacgatggatactaggtgtaggaggtatcgacccctcctgt gccggagttaacgcaataagtatcccgcctgggaagtacgatcgcaagattaaaactcaaaggaattgacggg ggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaaccttaccaggtcttgacattgatc gcgatctgcagaaatgcggagttcttcttcggaagacgagaaaacaggtggtgcacggctgtcgtcagctcgtgt cgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcatttgttaccagcacgtaaaggtggggactc aaatgagaccgccgcggacaacgcggaggaaggcggggacgacgtcaagtcatcatgccccttatgacctg ggctacacacgtactacaatgggtgtcaacaaagagaagcgaacccgcgaggaagagcaaacctcaaaaa cacacccccagttcagatcgcaggctgcaacccgcctgcgtgaagtaggaatcgctagtaatcgcgggtcagc ataccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacactatgagagtcagaaacacccgaag ccggtgaggtaaccgcaaggagccagccgtcgaaggcggagctgatgattggagtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: acgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacata erans 114 agttcgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggataacagctagaaatggctgctaataccgcataagaccacagtactgcatggtacagtggtaaaaa ctccggtggtatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaa acttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctga agtgaaaggcatgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgac tgctaggtgtcgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagtttttcttcggaacatcggtgaca ggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttca gtagccagcattaaggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtc aaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaggcagagccgc gaggccgagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: acgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttaa erans 115 gtttgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcataca gggggataacagttagaaatggctgctaataccgcataagaccacagtactgcatggtacagtggtaaaaactc cggtggtatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaact tctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctgaagt gaaaggcatgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgactg ctaggtgtcgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagcttttcttcggaacatcggtgacagg tggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttcagta gccagcattaaggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtcaa atcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcagagccgcga ggccgagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgc tagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggag tcagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: acgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttaa erans 116 gtttgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcataca gggggataacagttagaaatggctgctaataccgcataagaccacagtactgcatggtacagtggtaaaaactc cggtggtatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaact tctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctgaagt gaaaggcatgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgactg ctaggtgtcgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagtttttcttcggaacatcggtgacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatattcagta gccagcatttaggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtcaaa tcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaggcagagccgcgag gccgagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgct agtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt cagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: acgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttaa erans 117 gtttgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcataca gggggataacagttagaaatggctgctaataccgcataagaccacagtactgcatggtacagtggtaaaaactc cggtggtatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagtag ccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaact tctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggt aatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctgaagt gaaaggcatgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaattc ctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgactg ctaggtgtcgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagcttttcttcggaacatcggtgacagg tggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttcagta gccagcatttaggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtcaaa tcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaggcagagccgcgag gccgagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgct agtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt cagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: tatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagtagccgacc erans 118 tgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaata ttgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaaacttctatca gcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggtaatacgt agggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctgaagtgaaagg catgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaattcctagtgta gcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgactgacgttgag gctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgactgctaggtgt cgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttcgcaagaatg aaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaa ccttacctgatcttgacatcccgatgaccgcttcgtaatggaagtttttcttcggaacatcggtgacaggtggtgcatg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttcagtagccagcatt taggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgcc ccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaggcagagccgcgaggccgagcaa atctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgca gatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcagtaacgc ccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactggggtgaagtcgtaa caaggtagccgtatcggaaggtgcggctggatcacctccttt Dorea_formicigen SEQ ID NO: acgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacata erans 119 agttcgattcttcggatgaagacttttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggataacagctagaaatggctgctaataccgcataagaccacagtactgcatggtacagtggtaaaaa ctccggtggtatgagatggacccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgtaa acttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggctgtgcaagtctga agtgaaaggcatgggctcaacctgtggactgctttggaaactgtgcagctagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgac tgctaggtgtcgggtagcaaagctattcggtgccgcagctaacgcaataagcagtccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgatcttgacatcccgatgaccgcttcgtaatggaagcttttcttcggaacatcggtgaca ggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttca gtagccagcatttaggatgggcactctggagagactgccagggataacctggaggaaggtggggatgacgtc aaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcagagccgc gaggccgagcaaatctcaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatc gctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcagtaacgcccgaagtcagtgacccaaccgaaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_hallii SEQ ID NO: ctgagtggcggacgggtgagtaacgcgtgggtaacctgccctgtacagggggataacagctggaaacggctg 120 ctaataccgcataagcgcacgaggagacatctccttgtgtgaaaaactccggtggtacaggatgggcccgcgtc tgattagctggttggcagggtaacggcctaccaaggcaacgatcagtagccggtctgagaggatgaacggcca cattggaactgagacacggtccaaactcctacgggaggcagcagtggggaatattgcacaatgggggaaacc ctgatgcagcaacgccgcgtgagtgaagaagtatttcggtatgtaaagctctatcagcagggaagataatgacg gtacctgactaagaagctccggctaaatacgtgccagcagccgcggtaatacgtatggagcaagcgttatccgg atttactgggtgtaaagggtgcgtaggtggcagtgcaagtcagatgtgaaaggccggggctcaaccccggagct gcatttgaaactgctcggctagagtacaggagaggcaggcggaattcctagtgtagcggtgaaatgcgtagata ttaggaggaacaccagtggcgaaggcggcctgctggactgttactgacactgaggcacgaaagcgtggggag caaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgtcggggccgtataggcttcg gtgccgccgctaacgcagtaagtattccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacg gggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcc ttctgaccgcaccttaatcggtgctttccttcgggacagaagagacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccctatcttcagtagccagcaggtaaggctgggcactctg gagagactgccagggataacctggaggaaggtggggacgacgtcaaatcatcatgccccttatgatctgggcg acacacgtgctacaatggcggtcacagagtgaggcgaacccgcgagggggagcaaaccacaaaaaggcc gtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgctagtaatcgcgaatcagaatgtcg cggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcggaaatgcccgaagccagtg acccaaccttttggagggagctgtcgaaggtggagccggtaactggggtgaagtcgtaacaaggtagccgtatc ggaaggtgcggctggatcacctccttt Ruminococcaceae SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggagtgccttt _bacterium_D16 121 gaaagaggattcgtccaattgataaggttacttagtggcggacgggtgagtaacgcgtgaggaacctgccttgg agtggggaataacacagtgaaaattgtgctaataccgcataatgcagttgggccgcatggctctgactgccaaa gatttatcgctctgagatggcctcgcgtctgattagctagttggtggggtaacggcccaccaaggcgacgatcagt agccggactgagaggttggccggccacattgggactgagacacggcccagactcctacgggaggcagcagt ggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgta aacttcttttcttagggacgaagcaagtgacggtacctaaggaataagccacggctaactacgtgccagcagcc gcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagggcgtgtaggcgggattgcaagtcag atgtgaaaaccacgggctcaacctgtggcctgcatttgaaactgtagttcttgagtactggagaggcagacggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggtctgctggacagcaac tgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgatgg atactaggtgtggggggtctgaccccttccgtgccgcagttaacacaataagtatcccacctggggagtacgatc gcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaagcaac gcgaagaaccttaccagggcttgacatcccgaggcccggtctagagatagacctttctcttcggagacctcggtg acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatt gttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacgacgtcaa atcatcatgccccttatgtcctgggccacacacgtactacaatggtggttaacagagggaggcaataccgcgag gtggagcaaacccctaaaagccatcccagttcggattgcaggctgcaacccgcctgcatgaagttggaatcgct agtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tcgggaacacccgaagtccgtagcctaaccgcaaggggggcgcggccgaaggtgggttcgataattggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 122 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac attggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtaggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaaccgagaaagggacggctaacta cgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtgggagcgaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggg agtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaatt cgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtac atcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggat gacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcg gtgacggcaagctaatctcttaaagaccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgga atcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacca cgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 123 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 124 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgtcg taaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctggg gagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaat tcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagtaagttacttcggtac atcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccgtaataaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcgg tgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatc gctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacg agagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtggggtagatgattggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 125 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatggtgacacatgtcattatttgaaaggggcaattgctccactac aagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggtt tgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagggg agagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctctg gtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgta aacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggga gtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattc gaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtacat cggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacc cctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcgg tgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatc gctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacg agagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 126 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_ve SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag stibularis 127 aggagcttgctcttcttgaatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_th SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ermophilus 128 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggg ttgataagtctgaagttaaaggctggggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaaggg gagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctct ggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttggatcctttccgggattcagtgccgaagctaacgcattaagcactccgcctggg gagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaat tcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtac atcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggat gacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcg gtgacggcgagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaat cgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggacagatgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctgggtcacctcctt Streptococcus_th SEQ ID NO: atgaaagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagaga ermophilus 129 ggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataact attggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggtt tgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagggg agagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctcact ggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggg agtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaatt cgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtac atcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggat gacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcg gtgacggcgagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaat cgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggacagatgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_th SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ermophilus 130 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggtt tgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagggg agagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctctg gtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgta aacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggga gtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattc gaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtacat cggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacc cctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcgg tgacggcgagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatc gctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacg agagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggacagatgattggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_th SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ermophilus 131 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggg ttgataagtctgaagttaaaggctggggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaaggg gagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctct ggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggg agtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaatt cgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtac atcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggat gacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcg gtgacggcgagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaat cgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggacagatgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggtcacctcctt Streptococcus_th SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ermophilus 132 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatagccgacctga gagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttcg gcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgtaa gtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactacgt gccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcggg ttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaaggg gagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctct ggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgggg agtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaatt cgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggtac atcggtgacaggtgggcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaac ccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggggat gacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgagtcg gtgacggcgagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcggaat cgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggacagatgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctgggtcacctcctt Prevotella_buccae SEQ ID NO: cgtatccaaccttcccgcgaccaagggataacctgccgaaaggcagactaataccttatgtcctcctttgaaggc 133 atctgacgaggagcaaagatccgtcggtcacggatggggatgcgtccgattagcttgttggcggggcaacggc ccaccaaggcttcgatcggtaggggttctgagaggaaggccccccacactggaactgagacacggtccagac tcctacgggaggcagcagtgaggaatattggtcaatgggcggaagcctgaaccagccaagtagcgtgcagga tgacggccctacgggttgtaaactgcttttatgcggggataaagttgcccacgcgtgggtttttgcaggtaccgcat gaataaggaccggctaattccgtgccagcagccgcggtaatacggaaggtccgggcgttatccggatttattgg gtttaaagggagcgcaggccgccgtgcaagcgtgccgtgaaaagcagcggcccaaccgctgccctgcggcg cgaactgcttggcttgagtgcgccggaagcgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaa gaaccccgattgcgaaggcagcccgctgtggcgccactgacgctgaggctcgaaggtgcgggtatcgaacag gattagataccctggtagtccgcacggtaaacgatggatacccgctgtccggcccgtacggtctgggcggccaa gcgaaagcgttaagtatcccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcc cgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaggaga atgattcagagatgatgaagtccctcgggactcctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggt gtcggctcaagtgccataacgagcgcaacccctctccgcagttgccatcgggtcatgccgggcactctgcggac actgccgccgcaaggtgcgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggccaca cacgtgttacaatggccggcacagagggctgtccgcatgcaagtgcgggcgaatccccaaatccggtcccagt tcggactggggtctgcaacccgaccccacgaagctggattcgctagtaatcgcgcatcagccatggcgcggtg aatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtgcctgaagtccgtgaccgc gagggtcggcctagggcaaaaccggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggc tggaacacctccttt Lachnospiraceae_ SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaaacaccttat bacterium_5_1_6 134 ttgattttcttcggaactgaagatttggtgattgagtggcggacgggtgagtaacgcgtgggtaacctgccctgtac 3FAA agggggataacagtcagaaatgactgctaataccgcataagaccacagcaccgcatggtgcaggggtaaaa actccggtggtacaggatggacccgcgtctgattagctggttggtgaggtaacggctcaccaaggcgacgatca gtagccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatctcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggtatggcaagtca gaagtgaaaacccagggcttaactctgggactgcttttgaaactgtcagactggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacatcagtggcgaaggcggcttactggactga aactgacactgaggcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcggggccgtagaggcttcggtgccgcagccaacgcagtaagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatccttctgaccggtccttaaccggacctttccttcgggacaggag agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atctttagtagccagcatataaggtgggcactctagagagactgccagggataacctggaggaaggtggggac gacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacagagggaagcagc ctcgtgagagtgagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt bacterium_8_1_5 135 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat 7FAA acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_au SEQ ID NO: aatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaaggaa stralis 136 ggagcttgctctttctggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgggggataact attggaaacgatagctaataccgcataacagtagatgttgcatgatatctgcttgaaaggggcaattgctccacta ccagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttatccggatttattgggcgtaaagcgagcgcaggcg gttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttgggtcctttccgggactcagtgccgtagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgatcgctctagagatagagttttccttcggga cagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgcaa gtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagtcg gaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac cacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagatgatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcacttg bacterium_4_1_3 137 aatggaattcttcggaaggaagctcaagtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctca 7FAA tacagggggataacagttagaaatgactgctaataccgcataagcacacgtgatcgcatgatcgagtgtgaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtggggtaacggcccaccaaggcgacgatc agtagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgt aaacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcagtgcaagtct gaagtgaaagcccggggctcaaccccgggactgctttggaaactgtgcagctagagtgtcggagaggcaagc ggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgactactaggtgtcggggagcaaagctcttcggtgccgcagccaacgcaataagtagtccacctggggagt acgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcga agcaacgcgaagaaccttacctgctcttgacatccctctgaccggcaagtaatgttgcctttccttcgggacagag gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccc tatcttcagtagccagcggtaaggccgggcactctggagagactgccagggataacctggaggaaggtgggg atgacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagca gagtcgtgaggccgagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaag ctggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcac accatgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccg ataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_sa SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag nguinis 138 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcgggggataa ctattggaaacgatagctaataccgcatgatattaattatcgcatgataattaattgaaagatgcaattgcatcacta ccagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatggggggaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agagaagaacgggtgtgagagtggaaagttcacactgtgacggtatcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gttagataagtctgaagttaaaggctgtggcttaaccatagtatgctttggaaactgtttaacttgagtgcagaaggg gagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctctct ggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgt aaacgatgagtgctaggtgttaggccctttccggggcttagtgccgcagctaacgcattaagcactccgcctggg gagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaat tcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgaccgctctagagatagagttttccttcgggac agaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaa cccctattgttagttgccatcattgagttgggcactctagcgagactgccggtaataaaccggaggaaggtgggg atgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgcaag ccggtgacggcaagctaatctctgaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagtcg gaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac cacgagagtttgtaacacccgaagtcggtgaggtaaccgtaaggagccagccgcctaaggtgggatagatgat tggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt bacterium_3_1_4 139 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat 6FAA acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttat bacterium_6_1_6 140 cattgactcttcggaagatttgatatttgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcatac 3FAA aggggaataacagttagaaatggctgctaatgccgcataagcgcacaggaccgcatggtctggtgtgaaaaac tgaggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatcagta gccggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaa acttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggaagagcaagtctg atgtgaaaggctggggcttaaccccaggactgcattggaaactgtttttctagagtgccggagaggtaagcgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atactaggtgtcggggtgcaaagcagttcggtgccgcagcaaacgcaataagtattccacctggggagtacgtt cgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatctgcctgaccgttccttaaccggagctttccttcgggacaggcaag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatc cttagtagccagcagtccggctgggcactctagggagactgccggggataacccggaggaaggcggggacg acgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaagc ggtgacgcttagcaaatctcaaaaataacgtcccagttcggactgcagtctgcaactcgactgcacgaagctgg aatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacca tgggagtcagtaacgcccgaagtcagtgacccaaccttatggagggagctgccgaaggcgggaccgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcacttg bacterium_9_1_4 141 aatggaattcttcggaaggaagctcaagtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctca 3BFAA tacagggggataacagttagaaatgactgctaataccgcataagcacacgtgatcgcatgatcgagtgtgaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtggggtaatggcccaccaaggcgacgatc agtagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgt aaacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcagtgcaagtct gaagtgaaagcccggggctcaaccccgggactgctttggaaactgtgcagctagagtgtcggagaggcaagc ggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgactactaggtgtcggggagcaaagctcttcggtgccgcagccaacgcaataagtagtccacctggggagt acgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcga agcaacgcgaagaaccttacctgctcttgacatccctctgaccgctctttaatcggagctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atcttcagtagccagcggtaaggccgggcactctggagagactgccagggataacctggaggaaggtgggga tgacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcag agtcgtgaggccgagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagct ggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacac catgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_br SEQ ID NO: atatcaaagattttatcgcttgaagatggactcgcgtccgattagttagttggtgaggtaacggctcaccaagaccg omii 142 cgatcggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggagg cagcagtgggggatattgcgcaatgggggcaaccctgacgcagcaacgccgcgtgaaggatgaaggttttcg gattgtaaacttcttttattaaggacgaaacttgacggtacttaatgaataagctccggctaactacgtgccagcag ccgcggtaatacgtagggagcaagcgttgtccggatttactgggtgtaaagggtgcgtaggcggctttgcaagtc agatgtgaaatctatgggctcaacccataaactgcatttgaaactgtagagcttgagtgaagtagaggcaggcg gaattccccgtgtagcggtgaaatgcgtagagatggggaggaacaccagtggcgaaggcggcctgctgggctt taactgacgctgaggcacgaaagcgtgggtagcaaacaggattagataccctggtagtccacgctgtaaacga tgattactaggtgtggggggtctgaccccttccgtgccggagttaacacaataagtaatccacctggggagtacg gccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagc aacgcgaagaaccttaccaggtcttgacatccaactaacgaagtagagatacattaggtgcccttcggggaaa gttgagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacc cttgctattagttgctacgcaagagcactctaataggactgccgttgacaaaacggaggaaggtggggacgacg tcaaatcatcatgccccttatgacctgggctacacacgtactacaatggatgttaacagagggaagcaagacag cgatgtggagcaaacccctaaaaacattctcagttcagattgcaggctgcaacccgcctgcatgaagatggaatt gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgg gagccggtaatacccgaagtcagtagtccaacctcgtgaggacgctgccgaaggtaggattggcgactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Coprococcus_cat SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggacgatgaag us 143 agcttgcttttcaaagttagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacagggggatagcagc tggaaacggctgataaaaccgcataagcgcacagcatcgcatgatgcagtgtgaaaaactccggtggtatgag atggacccgcgtctgattagctggttggtgaggtaacggcccaccaaggcgacgatcagtagccggcctgaga gggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtggggaatattgcac aatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaacttctatcagcag ggaagataatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggtaatacgtaggg ggcaagcgttatccggatttactgggtgtaaagggagcgtaggcggcggagcaagtcagaagtgaaagcccg gggctcaaccccgggacggcttttgaaactgccctgcttgatttcaggagaggtaagcggaattcctagtgtagc ggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgacaatgacgctgagg ctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgtc gggggctcataagagctttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgcaagaat gaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaaga accttaccaggccttgacatcccnnn Dysgonomonas_ SEQ ID NO: agaagagtttgatcctggctcaggatgaacgctagcgataggcctaacacatgcaagtcgaggggcagcatag mossii 144 agtagcaatactttgatggcgaccggcgcacgggtgagtaacacgtatgcaacctacctacatcaggggaata acccggagaaattcggactaataccgcataatacagggatgccgcatggcaatatttgttaaagatttatcggatg tagatgggcatgcgttccattagctggttggtaaggtaacggcttaccaaggcaacgatggataggggaactga gaggtttgtcccccacactggaactgagacacggaccagactcctacgggaggcagcagtgaggaatattggt caatggacgagagtctgaaccagccaaatcgcgtgaaggaagactgccctacgggttgtaaacttcttttgtaca ggaataaaagacattacgtgtagtgtattgcatgtactgtacgaataagcatcggctaactccgtgccagcagcc gcggtaatacggaggatgcgagcgttatccggatttattgggtttaaagggtgcgcaggcgggattttaagtcagc ggtgaaattttcaggctcaacctgaacactgccgttgaaactgggattcttgagtatggatgaagtaggcggaatt cgttgtgtagcggtgacatgcttagatataacgaggaactccgattgcgtaggcagcttactaagccataactgac gctcaagcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgccgtaaacgatgattact agttgtttgcgatataccgtaagtgactaagcgaaagcgataagtaatccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttgaaatgtacctgaccgtccttgaaaggggacttctagcaatagcaggtatgtaggtgctg catggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccacattattagttacta acaggttaagctgaggactctaataagactgccgtcgtaagatgcgaggaaggtgtggatgacgtcaaatcag cacggcccttacgtccggggcgacacacgtgttacaatgggaggtacaaagggctgctacctggtgacaggat gctaatccccaaagcctctcccagttcggatcggagtctgcaactcgactccgtgaagctggattcgctagtaatc gcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccggg ggtatctgaagtgcgtaaccgtaaggagcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggta gccgtaccggaaggtgcggctggaacacctcctt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcacttt bacterium_1_4_5 145 accggatttcttcgggatgaaagttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcata 6FAA cagggggataacagttagaaatgactgctaataccgcataagaccacaggattgcatgatccggtggtaaaaa ctccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggagaggcaagtctgat gtgaaaacccggggctcaaccccgggactgcattggaaactgtttttctagagtgtcggagaggtaagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgact gctaggtgtcgggaggcaaagcctttcggtgccgcagcaaacgcaataagcagtccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgcccttgacatccggctgaccggcgagtaatgtcgcctttccttcgggacagccgaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttt agtagccagcatttcggatgggcactctagagagactgccagggataacctggaggaaggtggggatgacgtc aaatcatcatgccccttatgggcagggctacacacgtgctacaatggcgtaaacaaagggaggcaagcctgcg agggtgagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcg ctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggga gttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttacacg bacterium_3_1_5 146 gaggaagttttcggatggaatcggtataacttagtggcggacgggtgagtaacgcgtgggaaacctgccctgta 7FAA_CT1 ccgggggataacacttagaaataggtgctaataccgcataagcgcacggaaccgcatggttccgtgtgaaaaa ctccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcag tagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcag tggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagccag atgtgaaaacccagggctcaaccttgggattgcatttggaactgccaggctggagtgcaggagaggtaagcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgatg attgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttaccaagtcttgacatccccctgaatatcttgtaaaaaagagatgccttcgggacagggg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctta ttcttagtagccagcaggtaaggctgggcactctaaggagactgccggggataacccggaggaaggcgggga tgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgag acagtgatgtggagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagttggaaatgcccgaagtctgtgacctaaccgaaagggaggagcagccgaaggcaggtctgataac tggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttatatcg bacterium_3_1_5 147 aggaagttttcggatggaatcagtataacttagtggcggacgggtgagtaacgcgtgggaaacctgccctgtacc 7FAA_CT1 gggggataacacttagaaataggtgctaataccgcataagcgcacagcttcacatgaagcagtgtgaaaaact ccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcagta gccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagccaga tgtgaaaacccagggctcaaccttgggattgcatttggaactgtcaggctggagtgcaggagaggtaagcgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgatga ttgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatccacctggggagtacgtt cgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatccccctgactctcctgtaaaagagtgaggccttcgggacattggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattc ttagtagccagcaggtaaagctgggcactctaaggagactgccggggataacccggaggaaggcggggatg acgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagac agtgatgtggagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagttggaaatgcccgaagtctgtgacctaaccgaaagggaggagcagccgaaggcaggtctgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttacaca bacterium_3_1_5 148 gaggaagttttcggatggaatcggtataacttagtggcggacgggtgagtaacgcgtgggaaacctgccctgta 7FAA_CT1 ccgggggataacacttagaaataggtgctaataccgcataagcgcacggattcacatgaagcagtgtgaaaaa ctccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcag tagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcag tggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagccag atgtgaaaacccagggctcaaccttgggattgcatttggaactgtcaggctggagtgcaggagaggtaagcgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgatg attgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttaccaagtcttgacatcccaatgacgcacctgtaaagaggtgttcccttcggggcattgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatt cttagtagccagcaggtaaagctgggcactctaaggagactgccggggataacccggaggaaggcggggat gacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaga cagtgatgtggagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgg aatcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagttggaaatgcccgaagtctgtgacctaaccgaaagggaggagcagccgaaggcaggtctgataactg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcgcct bacterium_5_1_5 149 ggccccgacttcttcggaacgaggagccttgcgactgagtggcggacgggtgagtaacgcgtgggcaacctgc 7FAA cttgcactgggggataacagccagaaatggctgctaataccgcataagaccgaagcgccgcatggcgcggcg gccaaagccccggcggtgcaagatgggcccgcgtctgattaggtagttggcggggtaacggcccaccaagcc gacgatcagtagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacggg aggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatt tcggtatgtaaacttctatcagcagggaagaagatgacggtacctgactaagaagccccggctaactacgtgcc agcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgat gcaagccagatgtgaaagcccggggctcaaccccgggactgcatttggaactgcgtggctggagtgtcggag aggcaggcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcc tgctggacgatgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacg ccgtaaacgatgactactaggtgtcgggtggcaaggccattcggtgccgcagcaaacgcaataagtagtccac ctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtgg tttaattcgaagcaacgcgaagaaccttacctgatcttgacatcccgatgccaaagcgcgtaacgcgctctttcttc ggaacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagc gcaacccctatcttcagtagccagcattatggatgggcactctggagagactgccagggagaacctggaggaa ggtggggatgacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaag ggaggcgaacccgcgagggtgggcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgact acatgaagctggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccg cccgtcacaccatgggagtcagtaacgcccgaagccggtgacccaacccgtaagggagggagccgtcgaa ggtgggaccgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgagcgaagcacttt bacterium_1_1_5 150 gcttagattcttcggatgaagaggattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat 7FAA acagggggataacagttagaaatgactgctaataccgcataagaccacagcaccgcatggtgcgggggtaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagc cgcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgtagacggatgggcaagtct gatgtgaaaacccggggctcaaccccgggactgcattggaaactgttcatctagagtgctggagaggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacagta actgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg actactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtagtccacctggggagtacg ttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagc aacgcgaagaaccttacctgctcttgacatcccgctgaccggacggtaatgcgtccttcccttcggggcagcgga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcggccaggccgggcactctagagagactgccggggataacccggaggaaggtggggat gacgtcaaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaagcga gaccgcgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagc tggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggcgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacctt bacterium_2_1_5 151 gacggatttcttcggattgaagccttggtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat 8FAA acagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaa aactccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatc agtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcc agatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggaaag cggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatccctctgaccgctctttaatcggagctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atctttagtagccagcattttcggatgggcactctagagagactgccagggataacctggaggaaggtggggat gacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcgag cccgcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagct ggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacac catgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgat aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Roseburia_homini SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttaa s 152 ttgatttcttcggaatgaagtttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacagttggaaacgactgctaataccgcataagcgcacaggattgcatgatccagtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaa gctctatcagcagggaagaagaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtacggcaagtctgat gtgaaatcccggggctcaaccccggtactgcattggaaactgtcggactagagtgtcggaggggtaagtggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgattact gacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtcggggagcattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccactgacaaagtatgtaatgtactttctcttcggagcagtggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattcttagt agccagcggttcggccgggcactctagggagactgccagggataacctggaggaaggtggggatgacgtca aatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaatcccgcgag ggggagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaactcgactacacgaagctggaatcgc tagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggag ttggtaatgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcaggactgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Roseburia_homini SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttaa s 153 ttgatttcttcggaatgaagtttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacagttggaaacgactgctaataccgcataagcgcacaggattgcatgatccagtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaa gctctatcagcagggaagaagaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtacggcaagtctgat gtgaaatcccggggctcaaccccggtactgcattggaaactgtcggactagagtgtcggaggggtaagtggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgattact gacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtcggggagcattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccactgacagagtatgtaatgtactttctcttcggagcagtggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattcttagt agccagcggttcggccgggcactctagggagactgccagggataacctggaggaaggtggggatgacgtca aatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaatcccgcgag ggggagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaactcgactacacgaagctggaatcgc tagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggag ttggtaatgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcaggactgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Roseburia_homini SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttaa s 154 ttgatttcttcggaatgaagtttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacagttggaaacgactgctaataccgcataagcgcacaggattgcatgatccagtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaa gctctatcagcagggaagaagaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtacggcaagtctgat gtgaaatcccggggctcaaccccggtactgcattggaaactgtcggactagagtgtcggaggggtaagtggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgattact gacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtcggggagcattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccactgacagagtatgtaatgtactttctcttcggagcagtggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattcttagt agccagcggttcggccgggcactctagggagactgccagggataacctggaggaaggtggggatgacgtca aatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaatcccgcgag ggggagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaactcgactacacgaagctggaatcgc tagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggag ttggtaatgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcaggactgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Roseburia_homini SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactttaa s 155 ttgatttcttcggaatgaagtttttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatacag ggggataacagttggaaacgactgctaataccgcataagcgcacaggattgcatgatccggtgtgaaaaactc cggtggtatgagatggacccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaaa gctctatcagcagggaagaagaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagccgc ggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtacggcaagtctgat gtgaaatcccggggctcaaccccggtactgcattggaaactgtcggactagagtgtcggaggggtaagtggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgattact gacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaa tactaggtgtcggggagcattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccactgacagagtatgtaatgtactttctcttcggagcagtggtgacag gtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctattcttagt agccagcggttcggccgggcactctagggagactgccagggataacctggaggaaggtggggatgacgtca aatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcaatcccgcgag ggggagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaactcgactacacgaagctggaatcgc tagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggag ttggtaatgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcaggactgataactggggtg aagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagcttcag e_bacterium_2_2 156 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat _44A aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggata attatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_citroni SEQ ID NO: tttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcaatca ae 157 gaatgaaattttcggatggatttctggttgactgagtggcggacgggtgagtaacgcgtggataacctgcctcaca ctgggggataacagttagaaatggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaa ctccggtggtgtgagatggatccgcgtctgattagttagttggcggggtaacggcccaccaagacagcgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgaagcaagtctg aagtgaaaacccagggctcaaccctgggactgctttggaaactgttttgctagagtgtcggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcaataagcattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatccccctgaccggtcagtaaagtgacctttccttcgggacaggggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcc ttagtagccagcaggtaaagctgggcactctagggagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaccctg cgaaggcaagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgg aatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacca tgggagtcagcaacgcccgaannnnn Flavonifractor_pla SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggggtgctcat utii 158 gacggaggattcgtccaatggattgagttacctagtggcggacgggtgagtaacgcgtgaggaacctgccttgg agaggggaataacactccgaaaggagtgctaataccgcatgaagcagttgggtcgcatggctctgactgccaa agatttatcgctctgagatggcctcgcgtctgattagctagtaggcggggtaacggcccacctaggcgacgatca gtagccggactgagaggttgaccggccacattgggactgagacacggcccagactcctacgggaggcagca gtggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgt aaacttcttttgtcggggacgaaacaaatgacggtacccgacgaataagccacggctaactacgtgccagcag ccgcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagggcgtgtaggcgggattgcaagtc agatgtgaaaactgggggctcaacctccagcctgcatttgaaactgtagttcttgagtgctggagaggcaatcgg aattccgtgtgtagcggtgaaatgcgtagatatacggaggaacaccagtggcgaaggcggattgctggacagt aactgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atggatactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagtatcccacctggggagtac gatcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaag caacgcgaagaaccttaccagggcttgacatcccactaacgaggcagagatgcgttaggtgcccttcggggaa agtggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaa cccttattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacga cgtcaaatcatcatgccccttatgtcctgggccacacacgtactacaatggtggttaacagagggaggcaatacc gcgaggtggagcaaatccctaaaagccatcccagttcggattgcaggctgaaacccgcctgtatgaagttgga atcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccat gagagtcgggaacacccgaagtccgtagcctaaccgcaaggagggcgcggccgaaggtgggttcgataatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_ SEQ ID NO: tattgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggggtgctcat bacterium_7_1_5 159 gacggaggattcgtccaacggattgagttacctagtggcggacgggtgagtaacgcgtgaggaacctgccttgg 8FAA agaggggaataacactccgaaaggagtgctaataccgcatgatgcagttgggtcgcatggctctgactgccaa agatttatcgctctgagatggcctcgcgtctgattagctagtaggcggggtaacggcccacctaggcgacgatca gtagccggactgagaggttgaccggccacattgggactgagacacggcccagactcctacgggaggcagca gtggggaatattgggcaatgggcgcaagcctgacccagcaacgccgcgtgaaggaagaaggctttcgggttgt aaacttcttttgtcggggacgaaacaaatgacggtacccgacgaataagccacggctaactacgtgccagcag ccgcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagggcgtgtaggcgggattgcaagtc agatgtgaaaactgggggctcaacctccagcctgcatttgaaactgtagttcttgagtgctggagaggcaatcgg aattccgtgtgtagcggtgaaatgcgtagatatacggaggaacaccagtggcgaaggcggattgctggacagt aactgacgctgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atggatactaggtgtggggggtctgaccccctccgtgccgcagttaacacaataagtatcccacctggggagtac gatcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaag caacgcgaagaaccttaccagggcttgacatcccactaacgaagcagagatgcattaggtgcccttcggggaa agtggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaa cccttattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacga cgtcaaatcatcatgccccttatgtcctgggccacacacgtactacaatggtggttaacagagggaggcaatacc gcgaggtggagcaaatccctaaaagccatcccagttcggattgcaggctgaaacccgcctgtatgaagttgga atcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccat gagagtcgggaacacccgaagtccgtagcctaaccgcaaggagggcgcggccgaaggtgggttcgataatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_6_1 160 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat _45 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn nnnnnnnnnnnnnnnnnnnnnnnnnnnngaggtaacggctcaccaaggcgatgatgcgtagccggcctg agagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagggaattttc gtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaaagctctgttgta agtgaagaacggatcatagaggaaatgctatgggagtgacggtagcttaccagaaagccacggctaactacg tgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgtaggtggc gtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctggagtgcagaaga gggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaaggcggtcgc ctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctagtagtccacgcc gtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgcctggggagtat gcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgaag caacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggataattatggatcac acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtc gcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggtggggatgac gtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagcagcgacaca gtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatc gctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatggg agtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggaccgatgactgggg ttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_6_1 161 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat _45 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgtccatcaag gcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggctcaccaaggcgatgatgcgtag ccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtag ggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaaagc tctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccacggct aactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgt aggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctggagtg cagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaag gcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctagtagt ccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgcttgg ggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaa ttcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggataattat ggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaa cccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggtgg ggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagcag cgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatgaag tcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaa accatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggaccgat gactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_6_1 162 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat _45 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggatcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggata attatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_6_1 163 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat _45 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggatcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggata attatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_21_ 164 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat 3 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggatgcaaatgttctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_21_ 165 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat 3 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacat Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_21_ 166 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat 3 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggatgcaaatgttctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_21_ 167 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat 3 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggatgcaaatgttctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Erysipelotrichacea SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtttcgag e_bacterium_21_ 168 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat 3 aactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggatgcaaatgttctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcggccacaaagagc agcgacacagtgatgtgaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Haemophilus_par SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcttaacacatgcaagtcgaacggtaacataaa ainfluenzae 169 gaagcttgcttctttgatgacgagtggcggacgggtgagtaatgcttgggaatctagcttatggagggggataact acgggaaactgtagctaataccgcgtagaatcgggagatgaaagtgtgggaccttcgggccacatgccatagg atgagcccaagtgggattaggtagttggtgaggtaaaggctcaccaagccgacgatctctagctggtctgagag gatgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcgc aatgggggcaaccctgacgcagccatgccgcgtgaatgaagaaggccttcgggttgtaaagttctttcggtagc gaggaaggcatttagtttaataaactggatgattgacgttaactacagaagaagcaccggctaactccgtgccag cagccgcggtaatacggagggtgcgagcgttaatcggaataactgggcgtaaagggcacgcaggcggtgact taagtgaggtgtgaaagccccgggcttaacctgggaattgcatttcatactgggtcgctagagtactttagggagg ggtagaattccacgtgtagcggtgaaatgcgtagagatgtggaggaataccgaaggcgaaggcagccccttg ggaatgtactgacgctcatgtgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaa acgatgtcgatttgggggttgagctttaagtttggcgcccgtagctaacgtgataaatcgaccgcctggggagtac ggccgcaaggttaaaactcaaatgaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgatgc aacgcgaagaaccttacctactcttgacatccagagaacattccagagatggattggtgccttcgggaactctga gacaggtgctgcatggctgtcgtcagctcgtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatc ctttgttgccagcgatttggtcgggaactcaaaggagactgccggtgataaaccggaggaaggtggggatgac gtcaagtcatcatggcccttacgagtagggctacacacgtgctacaatggcgtatacagagggaagcgagagt gcgagctggagcgaatctcacaaagtacgtctaagtccggattggagtctgcaactcgactccatgaagtcgga atcgctagtaatcgcaaatcagaatgttgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccat gggagtgggttgtaccagaagtagatagcttaaccttcgggggggcgtttaccacggtatgattcatgactggggt gaagtcgtaacaaggtaaccgtaggggaacctgcggttggatcacctcctt Streptococcus_pa SEQ ID NO: taatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagctt rasanguinis 170 ggtgcttgcaccgagcggaggagttgcgaacgggtgagtaacgcgtaggtaacctgcctcttagcgggggata actattggaaacgatagctaataccgcataaaagtcgacattgcatgatgttgacttgaaaggtgcaactgcatca ctaagagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccgac ctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaat cttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgtt gtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtaacttaccagaaagggacggctaac tacgtgccagcagccgcggtaatacgtaggtcccgagcgttatccggatttattgggcgtaaagcgagcgcagg cggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcagaa ggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggct ctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgc cgtaaacgatgagtgctaggtgttgggtcctttccgggactcagtgccgcagctaacgcattaagcactccgcctg gggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttt aattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgaccgctctagagatagagctttccttcgg gacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccctattgttagttgccatcatttagttgggcactctagcgagactgccggtaataaaccggaggaaggtgg ggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgcg agtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagtc ggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcaca ccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagatga ttggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_pa SEQ ID NO: taatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagctt rasanguinis 171 ggtgcttgcaccgagcggaggagttgcgaacgggtgagtaacgcgtaggtaacctgcctcttagcgggggata actattggaaacgatagctaataccgcataaaagtcgacattgcatgatgttgacttgaaaggtgcaaatgcatc actgagagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccga cctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaa tcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgt tgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtaacttaccagaaagggacggctaa ctacgtgccagcagccgcggtaatacgtaggtcccgagcgttatccggatttattgggcgtaaagcgagcgcag gcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcaga aggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcgg ctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccac gccgtaaacgatgagtgctaggtgttggtcctttccgggactcagtgccgcagctaacgcattaagcactccgcct ggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtt taattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgaccgctctagagatagagctttccttcg ggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagc gcaacccctattgttagttgccatcatttagttgggcactctagcgagactgccggtaataaaccggaggaaggtg gggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgc gagtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagt cggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcac accacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagatg attggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_pa SEQ ID NO: taatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagctt rasanguinis 172 ggtgcttgcaccgagcggaggagttgcgaacgggtgagtaacgcgtaggtaacctgcctcttagcgggggata actattggaaacgatagctaataccgcataaaagtcgacattgcatgatgttgacttgaaaggtgcaactgcatca ctaagagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccgac ctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaat cttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgtt gtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtaacttaccagaaagggacggctaac tacgtgccagcagccgcggtaatacgtaggtcccgagcgttatccggatttattgggcgtaaagcgagcgcagg cggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcagaa ggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggct ctctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgc cgtaaacgatgagtgctaggtgttgggtcctttccgggactcagtgccgcagctaacgcattaagcactccgcctg gggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttt aattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgaccgctctagagatagagctttccttcgg gacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccctattgttagttgccatcatttagttgggcactctagcgagactgccggtaataaaccggaggaaggtgg ggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgcg agtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagtc ggaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcaca ccacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagatga ttggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_pa SEQ ID NO: aatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagcttg rasanguinis 173 gtgcttgcaccgagcggatgagttgcgaacgggtgagtaacgcgtaggtaacctacctcttagcgggggataac tattggaaacgatagctaataccgcataaaagtcggcattgcatgatgttgacttgaaaggtgcaaatgcatcact gagagatggacctgcgttgtattagctagttggtgaggtaacggctcaccaaggcgacgatacatagccgacct gagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatct tcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgt aagagaagaacgagtgtgagagtggaaagttcacactgtgacggtaacttaccagaaagggacggctaacta cgtgccagcagccgcggtaatacgtaggtcccgagcgttatccggatttattgggcgtaaagcgagcgcaggcg gttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaactgtttaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttgggtcctttccgggactcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatccctctgaccgctctagagatagagctttccttcggg acagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccctattgttagttgccatcatttagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggctggtacaacgagtcgcga gtcggtgacggcaagctaatctcttaaagccagtctcagttcggattgtaggctgcaactcgcctacatgaagtcg gaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac cacgagagtttgtaacacccgaagtcggtgaggtaaccttttaggagccagccgcctaaggtgggatagatgatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 174 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 175 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 176 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 177 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 178 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 179 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 180 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 181 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 182 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_dorei SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg 183 tcttagcttgctaaggctgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttggcc agccttctgaaaggaagattaatccaggatgggatcatgagttcacatgtccgcatgattaaaggtattttccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcaacgatggataggggttctg agaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattg gtcaatgggcgatggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataa aggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagcc gcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagtt gtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatgtcttgagtgcagttgaggcaggcggaattc gtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactga cattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactc gctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacgg tgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgagg aaccttacccgggcttaaattgcactcgaatgatccggaaacggttcagctagcaatagcgagtgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttacta acaggtgatgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcag cacggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccctaaaacccctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaat cgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggatcgccctagggtaaaactggtgactggggctaagtcgtaacaag gtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 184 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatagcataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggctcaccaagccttcgatggataggggttctgagagg aaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaat gggcgttagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataagaat aaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggtaat acggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaaag tttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtgta gcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactgatg ctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgc gatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaactc aaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacc cgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggttgt cgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaacaggtcat gctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccct tacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatccc aaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcag ccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctga agtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtacc ggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: aaaggatggggatgcgttccattaggttgttggtgaggtaacggctcaccaagccttcgatggataggggttctga s 185 gaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattgg tcaatgggcgctagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatata agaataaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgc ggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgt gaaagtttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgt ggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgaca ctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgc tgtttgcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtga aactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaac cttacccgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcat ggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaaca ggttatgctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcac ggcccttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgct aatcccaaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcg catcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggt acctgaagtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagc cgtaccggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 186 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatagtataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atgggcgttagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataaga ataaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggta atacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaa agtttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtg tagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactga tgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgttt gcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaac tcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacctta cccgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaacaggtc atgctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatcc caaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctg aagtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt

Bacteroides_fragili SEQ ID NO: gcatggtttcattattaaaggattccggtaaaggatggggatgcgttccattaggttgttggtgaggtaacggctcac s 187 caagccttcgatggataggggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctac gggaggcagcagtgaggaatattggtcaatgggcgctagcctgaaccagccaagtagcgtgaaggatgaag gctctatgggtcgtaaacttcttttatataagaataaagtgcagtatgtatactgttttgtatgtattatatgaataaggat cggctaactccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaaggga gcgtaggtggactggtaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgtcagtcttga gtacagtagaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaa ggcagctcactggactgcaactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagt ccacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattcca cctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatg tggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagtggaatgatgtggaaacatgtcagtg agcaatcaccgctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacg agcgcaacccttatctttagttactaacaggttatgctgaggactctggagagactgccgtcgtaagatgtgagga aggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatggggggtacaga aggcagctagcgggtgaccgtatgctaatcccaaaagcctctctcagttcggatcgaagtctgcaacccgacttc gtgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccg cccgtcaagccatgggagccgggggtacctgaagtacgtaaccgcaaggatcgtcctagggtaaaactggtg actggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 188 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatagtataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggctcaccaagccttcgatggataggggttctgagagg aaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaat gggcgctagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataagaat aaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggtaat acggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaaag tttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtgta gcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactgatg ctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgc gatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaactc aaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacc cgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggttgt cgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagttactaacaggttatg ctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccctt acgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatccca aaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcagc cacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaa gtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccg gaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 189 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatggcataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atgggcgctagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataaga ataaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggta atacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaa agtttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtg tagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactga tgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgttt gcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaac tcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacctta cccgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaacaggtc atgctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatcc caaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctg aagtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 190 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatggcataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggctcaccaagccttcgatggataggggttctgagagg aaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaat gggcgctagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataagaat aaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggtaat acggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaaag tttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtgta gcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactgatg ctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgc gatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaactc aaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacc cgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggttgt cgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaacaggtcat gctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccct tacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatccc aaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcag ccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctga agtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtacc ggaaggtgcggctggaacacctcctt Bacteroides_fragili SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcatcagga s 191 agaaagcttgctttctttgctggcgaccggcgcacgggtgagtaacacgtatccaacctgccctttactcggggat agcctttcgaaagaaagattaatacccgatggcataatgattccgcatggtttcattattaaaggattccggtaaag gatggggatgcgttccattaggttgttggtgaggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atgggcgctagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgtaaacttcttttatataaga ataaagtgcagtatgtatactgttttgtatgtattatatgaataaggatcggctaactccgtgccagcagccgcggta atacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggactggtaagtcagttgtgaa agtttgcggctcaaccgtaaaattgcagttgatactgtcagtcttgagtacagtagaggtgggcggaattcgtggtg tagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactga tgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgttt gcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaac tcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacctta cccgggcttaaattgcagtggaatgatgtggaaacatgtcagtgagcaatcaccgctgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcttcagttactaacaggtc atgctgaggactctggagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctagcgggtgaccgtatgctaatcc caaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctg aagtacgtaaccgcaaggatcgtcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_unifo SEQ ID NO: actgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaatggacgagagtctgaacc rmis 192 agccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacgggaataaagtgaggcacgtgtg cctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccgagc gttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtgaaagtttgcggctcaaccgt aaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtggtgtagcggtgaaatgctta gatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgctgatgctcgaaagtgtgggta tcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcg gccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattgacggg ggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaa ctgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtga ggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcga gactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacac acgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttc ggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaat acgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaag gagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgga acacctcctt Bacteroides_unifo SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatga rmis 193 acttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactcgggga tagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtggaactattaaagaatttcggtcatc gatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacggga ataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtg aaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtg gtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgct gatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctg tttgcgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaa actcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacct tacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggtt atgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcc cgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctg aagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_unifo SEQ ID NO: actgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaatggacgagagtctgaacc rmis 194 agccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacgggaataaagtgaggcacgtgtg cctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccgagc gttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtgaaagtttgcggctcaaccgt aaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtggtgtagcggtgaaatgctta gatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgctgatgctcgaaagtgtgggta tcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcg gccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattgacggg ggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaa ctgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtga ggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcga gactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacac acgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttc ggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaat acgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaag gagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgga acacctcctt Bacteroides_unifo SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatga rmis 195 acttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactcgggga tagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatttcggtcatc gatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacggga ataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtg aaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtg gtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgct gatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctg tttgcgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaa actcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacct tacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggtt atgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcc cgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctg aagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_unifo SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatga rmis 196 acttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactcgggga tagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtggaactattaaagaatttcggtcatc gatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacggga ataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtg aaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtg gtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgct gatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctg tttgcgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaa actcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacct tacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggtt atgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcc cgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctg aagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_unifo SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatga rmis 197 acttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactcgggga tagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatttcggtcatc gatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacggga ataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtg aaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtg gtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgct gatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctg tttgcgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaa actcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacct tacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggtt atgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcc cgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctg aagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_unifo SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatga rmis 198 acttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactcgggga tagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatttcggtcatc gatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggataggggttctgagag gaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtca atggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacggga ataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtg aaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtg gtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgct gatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctg tttgcgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaa actcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacct tacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttaccatcaggtt atgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcc cttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgacgtgatgctaatcc cgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgctagtaatcgcgcatca gccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctg aagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtac cggaaggtgcggctggaacacctcctt Bacteroides_vulga SEQ ID NO: tttgcatgtactttatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccgagcgtta tus 199 tccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaaaatt gcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatca cgaagaactccgattgcgaaggcagcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatcaaa caggattagataccctggtagtccacacggtaaacgatgaatactcgctgtttgcgatatacggcaagcggcca agcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcc cgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagatga attacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggt gtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaacaggttctgctgaggactctgacaagact gccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgt gttacaatggggggtacagagggccgctaccacgcgagtggatgccaatcccaaaaacctctctcagttcgga ctggagtctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatac gttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcgagg agcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgga acacctccttt Bacteroides_vulga SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg tus 200 tcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttgga cagccttctgaaaggaagattaatacaagatggcatcatgagttcacatgttcacatgattaaaggtattccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggataggggttctga gaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattgg tcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataaa ggaataaagtcgggtatggatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccg cggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgt gaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgt ggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgaca ttgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgc tgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtg aaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaa ccttacccgggcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcat ggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaaca ggttctgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacg gcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggatgcca atcccaaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaatcgcg catcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggt acctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtag ccgtaccggaaggtgcggctggaacacctcctt Bacteroides_vulga SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg tus 201 tcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttgga cagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtattccggta ggcgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggataggggttctga gaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattgg tcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataaa ggaataaagtcgggtatgtatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccg cggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgt gaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgt ggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgaca ttgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgc tgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtg aaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaa ccttacccgggcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcat ggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaaca ggttctgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacg gcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggatgcca atcccaaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaatcgcg catcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggt acctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtag ccgtaccggaaggtgcggctggaacacctcctt Bacteroides_vulga SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg tus 202 tcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttgga cagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtattccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggataggggttctga gaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattgg tcaatgggcgcaggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataaa ggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccg cggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgt gaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgt ggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgaca ttgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgc tgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtg aaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaa ccttacccgggcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcat ggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaaca ggttccgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcac ggcccttacgtccggggctacacacgtgttacaatggggggtacagagggtcgctaccacgcgagtggatgcc aatccccaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaatcgc gcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggg gtacctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgtaacaaggta gccgtaccggaaggtgcggctggaacacctcctt Bacteroides_vulga SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatgg tus 203 tcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactcttgga cagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtattccggta gacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggataggggttctga gaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattgg tcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttataaa ggaataaagtcgggtatggatacccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccg cggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgt gaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgt ggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgaca ttgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgc tgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtg aaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaa ccttacccgggcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcat ggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaaca ggttctgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacg gcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggatgcca atcccaaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaatcgcg catcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggt acctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtag ccgtaccggaaggtgcggctggaacacctcctt Bacteroides_vulga SEQ ID NO: ccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccgagc tus 204 gttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaa aattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagat atcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatc aaacaggattagataccctggtagtccacacggtaaacgatgaatactcgctgtttgcgatatacagcaagcgg ccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggg gcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcaga tgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtga ggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaacaggttctgctgaggactctgacaa gactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacac acgtgttacaatggggggtacagagggccgctaccacgcgagtggatgccaatccccaaaacctctctcagttc ggactggagtctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaa tacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcga ggagcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctg gaacacctccttt Eubacterium_sp_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag 3_1_31 205 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgcccgggat aactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcaccttcgggtg tgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatgatgcgtagcc gacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagg gaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtcttcggatcgtaaagca ctgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttaccagaaagccacggcta actacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgta ggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttggaaactgtcgagctagagtgc agaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaagg cggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggagcaaataggattagataccctagtagtc cacgccgtaaacgatgagaactaagtgttggagagattcagtgctgcagttaacgcaataagttctccgcctggg gagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaatt cgaagcaacgcgaagaaccttaccaggccttgacatggatataaatgttctagagatagaaagatagctatata tcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gtcttctgttaccagcattaggttggggactcaggagagactgccggtgacaaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgcctacaaagagcagcgacac cgcgaggtggagcgaatctcataaagggcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcgga atcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccat gggagttggtaatacccgaagccggtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactg gggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag 3_1_31 206 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgcccgggat aactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcaccttcgggtg tgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatgatgcgtagcc gacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagg gaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtcttcggatcgtaaagca ctgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttaccagaaagccacggcta actacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgta ggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttggaaactgtcgagctagagtgc agaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaagg cggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggagcaaataggattagataccctagtagtc cacgccgtaaacgatgagaactaagtgttggagagattcagtgctgcagttaacgcaataagttctccgcctggg gagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaatt cgaagcaacgcgaagaaccttaccaggccttgacatggatataaatgttctagagatagaaagatagctatata tcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gtcttctgttaccagcattaggttggggactcaggagagactgccggtgacaaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgcctacaaagagcagcgacac cgcgaggtggagcgaatctcataaagggcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcgga atcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccat gggagttggtaatacccgaagccggtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactg gggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag 3_1_31 207 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgcccgggat aactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcaccttcgggtg tgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatgatgcgtagcc gacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagg gaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtcttcggatcgtaaagca ctgttgtaagtgaagaatgccatatagaggaaatgctatgtgggtgacggtagcttaccagaaagccacggcta actacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgta ggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttggaaactgtcgagctagagtgc agaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaagg cggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggagcaaataggattagataccctagtagtc cacgccgtaaacgatgagaactaagtgttggagagattcagtgctgcagttaacgcaataagttctccgcctggg gagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaatt cgaagcaacgcgaagaaccttaccaggccttgacatggatataaatgttctagagatagaaagatagctatata tcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gtcttctgttaccagcattaggttggggactcaggagagactgccggtgacaaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgcctacaaagagcagcgacac cgcgaggtgaagcgaatctcataaagggcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcgga atcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccat gggagttggtaatacccgaagccggtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactg gggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag 3_1_31 208 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgcccgggat aactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcaccttcgggtg tgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatgatgcgtagcc gacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagg gaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtcttcggatcgtaaagca ctgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttaccagaaagccacggcta actacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgta ggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttggaaactgtcgagctagagtgc agaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaagg cggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggagcaaataggattagataccctagtagtc cacgccgtaaacgatgagaactaagtgttggagagattcagtgctgcagttaacgcaataagttctccgcctggg gagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaatt cgaagcaacgcgaagaaccttaccaggccttgacatggatataaatgttctagagatagaaagatagctatata tcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gtcttctgttaccagcattaagttggggactcaggagagactgccggtgacaaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgcctacaaagagcagcgacac cgcgaggtggagcgaatctcataaagggcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcgga atcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccat gggagttggtaatacccgaagccggtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactg gggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag 3_1_31 209 gaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgcccgggat aactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcaccttcgggtg tgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatgatgcgtagcc gacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagg gaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtcttcggatcgtaaagca ctgttgtaagtgaagaatgccatatagaggaaatgctatgtgggtgacggtagcttaccagaaagccacggcta actacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtgcgta ggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttggaaactgtcgagctagagtgc agaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaagg cggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggagcaaataggattagataccctagtagtc cacgccgtaaacgatgagaactaagtgttggagagattcagtgctgcagttaacgcaataagttctccgcctggg gagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaatt cgaagcaacgcgaagaaccttaccaggccttgacatggatataaatgttctagagatagaaagatagctatata tcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt gtcttctgttaccagcattaggttggggactcaggagagactgccggtgacaaaccggaggaaggtggggatg acgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgcctacaaagagcagcgacac cgcgaggtggagcgaatctcataaagggcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcgga atcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccat gggagttggtaatacccgaagccggtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactg gggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 210 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 211 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgaatgactcatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 212 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgaatgactcatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgaccttcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag ivarius 213 agaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggat aactattggaaacgatagctaataccgcataacaatgaatgactcatgtcatttatttgaaaggggcaattgctcca ctacaagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgac ctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaat cttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgt tgtaagtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaac tacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcagg cggtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaa ggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggct ctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgc cgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctg gggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttt aattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcgg tacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtgg ggatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcga gtcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcg gaatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac cacgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 214 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgaatgactcatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 215 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgaatgactcatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Streptococcus_sal SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaagag ivarius 216 aggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcgggggataac tattggaaacgatagctaataccgcataacaatgggtgacacatgtcatttatttgaaaggggcaattgctccacta caagatggacctgcgttgtattagctagtaggtgaggtaacggctcacctaggcgacgatacatagccgacctg agagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagtagggaatcttc ggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgtaaagctctgttgta agtcaagaacgagtgtgagagtggaaagttcacactgtgacggtagcttaccagaaagggacggctaactac gtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgtaaagcgagcgcaggcg gtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgtcaaacttgagtgcagaagg ggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaacaccggtggcgaaagcggctct ctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacaggattagataccctggtagtccacgcc gtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgcagctaacgcattaagcactccgcctgg ggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggttta attcgaagcaacgcgaagaaccttaccaggtcttgacatcccgatgctatttctagagatagaaagttacttcggt acatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgca acccctattgttagttgccatcattcagttgggcactctagcgagactgccggtaataaaccggaggaaggtggg gatgacgtcaaatcatcatgccccttatgacctgggctacacacgtgctacaatggttggtacaacgagttgcgag tcggtgacggcaagctaatctcttaaagccaatctcagttcggattgtaggctgcaactcgcctacatgaagtcgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc acgagagtttgtaacacccgaagtcggtgaggtaaccttttggagccagccgcctaaggtgggatagatgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctcctt Parabacteroides_ SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcaca distasonis 217 ggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggggata acccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagattcatcgct gatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatggataggggttct gagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagcagtgaggaatatt ggtcaatgggcgtaagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatcgtaaacctcttttata agggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggctaactccgtgccagcagc cgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgtaggcggccttttaagtcagc ggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttgagtatgtttgaggcaggcggaat gcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcgaaggcagcctgccaagccatgact gacgctgatgcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgcagtaaacgatgatc actagctgtttgcgatacagtgtaagcggcacagcgaaagcgttaagtgatccacctggggagtacgccggca acggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcg aggaaccttacccgggtttgaacgcattcggaccgaggtggaaacaccttttctagcaatagccgtttgcgaggt gctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgccactagtt actaacaggtaaagctgaggactctggtgggactgccagcgtaagctgcgaggaaggcggggatgacgtcaa atcagcacggcccttacatccggggcgacacacgtgttacaatggcgtggacaaagggaggccacctggcga cagggagcgaatccccaaaccacgtctcagttcggatcggagtctgcaacccgactccgtgaagctggattcgc tagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatggg agccgggggtacctgaagtccgtaaccgcgaggatcggcctagggtaaaactggtgactggggctaagtcgta acaaggtagccgtaccggaaggtgcggctggaacacctccttt Parabacteroides_ SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcaca distasonis 218 ggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttgcctatcagagggggata acccggcgaaagtcggactaataccgcatgaagcaggggccccgcatggggatatttgctaaagattcatcgct gatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatggataggggttct gagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagcagtgaggaatatt ggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatcgtaaacctcttttat aagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggctaactccgtgccagcag ccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgtaggcggccttttaagtcag cggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttgagtatgtttgaggcaggcggaa tgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcgaaggcagcctgccaagccatgac tgacgctgatgcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgcagtaaacgatgat cactagctgtttgcgatacagtgtaagcggcacagcgaaagcgttaagtgatccacctggggagtacgccggc aacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgc gaggaaccttacccgggtttgaacgcattcggaccgaggtggaaacaccttttctagcaatagccgtttgcgagg tgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgccactagt tactaacaggtaaagctgaggactctggtgggactgccagcgtaagctgcgaggaaggcggggatgacgtca aatcagcacggcccttacatccggggcgacacacgtgttacaatggcgtggacaaagggatgccacctggcg acagggagcgaatccccaaaccacgtctcagttcggatcggagtctgcaacccgactccgtgaagctggattc gctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatg ggagccgggggtacctgaagtccgtaaccgaaaggatcggcctagggtaaaactggtgactggggctaagtc gtaacaaggtagccgtaccggaaggtgcggctggaacacctccttt Parabacteroides_ SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcaca distasonis 219 ggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggggata acccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagattcatcgct gatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatggataggggttct gagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagcagtgaggaatatt ggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatcgtaaacctcttttat aagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggctaactccgtgccagcag ccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgtaggcggccttttaagtcag cggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttgagtatgtttgaggcaggcggaa tgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcgaaggcagcctgccaagccatgac tgacgctgatgcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgcagtaaacgatgat cactagctgtttgcgatacagtgtaagcggcacagcgaaagcgttaagtgatccacctggggagtacgccggc aacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgc gaggaaccttacccgggtttgaacgcattcggaccgaggtggaaacaccttttctagcaatagccgtttgcgagg tgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgccactagt tactaacaggtgatgctgaggactctggtgggactgccagcgtaagctgcgaggaaggcggggatgacgtcaa atcagcacggcccttacatccggggcgacacacgtgttacaatggcgtggacaaagggaagccacctggcga cagggagcgaatccccaaaccacgtctcagttcggatcggagtctgcaacccgactccgtgaagctggattcgc tagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatggg agccgggggtacctgaagtccgtaaccgaaaggatcggcctagggtaaaactggtgactggggctaagtcgta acaaggtagccgtaccggaaggtgcggctggaacacctccttt Parabacteroides_ SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcggg distasonis 220 ggtagcaatacccgccggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggggata acccggcgaaagtcggactaataccgcatgaagcaggggccccgcatggggatatttgctaaagattcatcgct gatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatggataggggttct gagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagcagtgaggaatatt ggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatcgtaaacctcttttat aagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggctaactccgtgccagcag ccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgtaggcggccttttaagtcag cggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttgagtatgtttgaggcaggcggaa tgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcgaaggcagcctgccaagccatgac tgacgctgatgcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgcagtaaacgatgat cactagctgtttgcgatacagtgtaagcggcacagcgaaagcgttaagtgatccacctggggagtacgccggc aacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgc gaggaaccttacccgggtttgaacgcattcggaccgaggtggaaacaccttttctagcaatagccgtttgcgagg tgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgccactagt tactaacaggtaatgctgaggactctggtgggactgccagcgtaagctgcgaggaaggcggggatgacgtcaa atcagcacggcccttacatccggggcgacacacgtgttacaatggcgtggacaaagggaggccacctggcga cagggagcgaatccccaaaccacgtctcagttcggatcggagtctgcaacccgactccgtgaagctggattcgc tagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatggg agccgggggtacctgaagtccgtaaccgcgaggatcggcctagggtaaaactggtgactggggctaagtcgta acaaggtagccgtaccggaaggtgcggctggaacacctccttt Parabacteroides_ SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcaca distasonis 221 ggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggggata acccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagattcatcgct gatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatggataggggttct gagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagcagtgaggaatatt ggtcaatgggcgtaagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatcgtaaacctcttttata agggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggctaactccgtgccagcagc cgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgtaggcggccttttaagtcagc ggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttgagtatgtttgaggcaggcggaat gcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcgaaggcagcctgccaagccatgact gacgctgatgcacgaaagcgtggggatcaaacaggattagataccctggtagtccacgcagtaaacgatgatc actagctgtttgcgatacagtgtaagcggcacagcgaaagcgttaagtgatccacctggggagtacgccggca acggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcg aggaaccttacccgggtttgaacgcattcggaccgaggtggaaacaccttttctagcaatagccgtttgcgaggt gctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgccactagtt actaacaggtaaagctgaggactctggtgggactgccagcgtaagctgcgaggaaggcggggatgacgtcaa atcagcacggcccttacatccggggcgacacacgtgttacaatggcgtggacaaagggaagccacctggcga cagggagcgaatccccaaaccacgtctcagttcggatcggagtctgcaacccgactccgtgaagctggattcgc tagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatggg agccgggggtacctgaagtccgtaaccgcgaggatcggcctagggtaaaactggtgactggggctaagtcgta acaaggtagccgtaccggaaggtgcggctggaacacctccttt Clostridiaceae_ba SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtgaaga cterium_JC118 222 tagcttgctattggaacttagtggcgaacgggtgagtaacacgtagataacctgcctgtatgaccgggataacagt tggaaacgactgctaataccggataggcagagaggaggcatctcttctctgttaaagttgggacacaacgcaaa cagatggatctgcggtgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcatagccggcctga gagggcgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagtagggaattttc ggcaatgggggaaaccctgaccgagcaatgccgcgtgagtgaagacggccttcgggttgtaaagctctgttgta agggaagaacggcatagagagggaatgctctatgagtgacggtaccttaccagaaagccacggctaactacg tgccagcagccgcggtaatacgtaggtggcaagcgttatccggaattattgggcgtaaagggtgcgtaggcggc gagataagtctgaggtaaaagcccgtggctcaaccacggtaagccttggaaactgtctggctggagtgcagga gaggacaatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcgaaggcggtt gtctggcctgtaactgacgctgaagcacgaaagcgtggggagcaaataggattagataccctagtagtccacg ccgtaaacgatgagaactaagtgttggggaaactcagtgctgcagttaacgcaataagttctccgcctggggagt atgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgac gcaacgcgaagaaccttaccaggccttgacatggtatcaaaggccctagagatagggagatagttatggtaca cacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtt tctagttaccaacagtaagatggggactctagagagactgccggtgacaaaccggaggaaggtggggatgac gtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgtctacaaagagcagcgagcagg tgactgtgagcgaatctcataaaggacgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatc gctagtaatcgcggatcagcatgccgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgg gagttgataatacccgaagccggtggcctaaccatttatggagggagccgtcgaaggtaggatcgatgactggg gttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Anaerostipes_had SEQ ID NO: acctaccctgtacagggggataacagtcagaaatgactgctaataccgcataagaccacagcaccgcatggtg rus 223 caggggtaaaaactccggtggtacaggatggacccgcgtctgattagctggttggtgaggtaacggctcaccaa ggcgacgatcagtagccggcttgagagagtgaacggccacattgggactgagacacggcccaaactcctacg ggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagt atctcggtatgtaaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgt gccagcagccgcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggtggt atggcaagtcagaagtgaaaacccagggcttaactctgggactgcttttgaaactgtcagactggagtgcagga gaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacatcagtggcgaaggcggctt actggactgaaactgacactgaggcacgaaagcgtggggagcaaacaggattagataccctggtagtccacg ccgtaaacgatgaatactaggtgtcggggccgtagaggcttcggtgccgcagccaacgcagtaagtattccacc tggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggt ttaattcgaagcaacgcgaagaaccttacctggtcttgacatccttctgaccggtccttaaccggacctttccttcgg gacaggagagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccctatctttagtagccagca Clostridium_innoc SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagactcta uum 224 ggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccggga taactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggata attatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_innoc SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttcag uum 225 gaagcttgcttccaaaaagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat aactgctggaaacggtagctaaaaccggataggtatacggagcgcatgctctgtatattaaagcgcccatcaag gcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgta gccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagta gggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaaa gctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccacg gctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtg cgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgga gtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcga aggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctagt agtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgcc tggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtt taattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_innoc SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttcag uum 226 gaagcttgcttccaaaaagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat aactgctggaaacggtagctaaaaccggataggtatacggagcgcatgctctgtatattaaagcgcccttcaag gcgtgaacatggatggacctgcgacgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgta gccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagta gggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaaa gctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccacg gctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtg cgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgga gtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcga aggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctagt agtccacgccgtaaacgatgagaactaagtgttggagaaattcagtgctgcagttaacgcaataagttctccgcc tggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtt taattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_innoc SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttcag uum 227 gaagcttgcttccaaaaagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat aactgctggaaacggtagctaaaaccggataggtatacggagcgcatgctcagtatattaaagcgcccatcaa ggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgt agccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt agggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaa agctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccac ggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggt gcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgg agtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcg aaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctag tagtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgc ctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtgg tttaattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggata attatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_innoc SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtctttag uum 228 gaagcttgcttccaaaaagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccgggat aactgctggaaacggtagctaaaaccggataggtatacggagcgcatgctctgtatattaaagcgcccatcaag gcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcgatgatgcgta gccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagta gggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaaggtcttcggatcgtaaa gctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagcttaccagaaagccacg gctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcattgggcgtaaagggtg cgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaagctatggaaactggtatgctgga gtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatatggaggaacaccagtggcga aggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggggagcaaataggattagataccctagt agtccacgccgtaaacgatgagaactaagtgttggaggaattcagtgctgcagttaacgcaataagttctccgcc tggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtt taattcgaagcaacgcgaagaaccttaccaggccttgacatggaaacaaataccctagagatagggggataat tatggatcacacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgc aacccttgtcgcatgttaccagcatcaagttggggactcatgcgagactgccggtgacaaaccggaggaaggt ggggatgacgtcaaatcatcatgccccttatggcctgggctacacacgtactacaatggcgaccacaaagagc agcgacttggtgacaagaagcgaatctcataaaggtcgtctcagttcggattgaagtctgcaactcgacttcatga agtcggaatcgctagtaatcgcagatcagcatgctgcggtgaatacgttctcgggccttgtacacaccgcccgtc aaaccatgggagtcagtaatacccgaagccggtggcataaccgtaaggagtgagccgtcgaaggtaggacc gatgactggggttaagtcgtaacaaggtatccctacgggaacgtggggatggatcacctccttt Clostridium_hathe SEQ ID NO: atgagagttcgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcggtttc wayi 229 aatgaagttttcggatggaattgaaattgacttagcggcggacgggtgagtaacgcgtgggtaacctgccttaca ctgggggataacagttagaaatgactgctaataccgcataagcgcacagggccgcatggtctggtgtgaaaaa ctccggtggtgtaagatggacccgcgtctgattaggtagttggtggggtaacggcccaccaagccgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcag tggggaatattggacaatgggcgaaagcctgatccagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttaagcaagtctga agtgaaagcccggggctcaaccccggtactgctttggaaactgtttgacttgagtgcaggagaggtaagtggaat tcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgtcgggggacaacgtccttcggtgccgccgctaacgcaataagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaagtcttgacatcccattgaaaacactttaaccggtgtccctcttcggagcaatggagaca ggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcctta gtagccagcacatgatggtgggcactctggggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaaaggagc gatctggagcaaaccccaaaaataacgtctcagttcggattgcaggctgcaactcgcctgcatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcgggactgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_hathe SEQ ID NO: atgagagttcgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcggtttc wayi 230 aatgaagttttcggatggatttgaaattgacttagcggcggacgggtgagtaacgcgtgggtaacctgccttacac tgggggataacagttagaaatgactgctaataccgcataagcgcacagggccgcatggtctggtgtgaaaaact ccggtggtgtaagatggacccgcgtctgattaggtagttggtggggtaacggcccaccaagccgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattggacaatgggcgaaagcctgatccagcgacgccgcgtgagtgaagaagtatttcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttaagcaagtctgaa gtgaaagcccggggctcaaccccggtactgctttggaaactgtttgacttgagtgcaggagaggtaagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaactg acgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaata ctaggtgtcgggggacaaagtccttcggtgccgccgctaacgcaataagtattccacctggggagtacgttcgca agaatgaaactcaaaggaattgacggggacccgcacaagcgg Clostridium_clostri SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcaattaa dioforme 231 aggaagttttcggacggaatttgattgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacact gggggataacagttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaact ccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgaagcaagtctg aagtgaaaacccagggctcaaccctgggactgctttggaaactgttttgctagagtgtcggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcagtaagcattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatccttttgaccggcgtgtaacggcgccttcccttcggggcaagagaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcctt agtagccagcaggtagagctgggcactctagggagactgccagggataacctggaggaaggcggggatgac gtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagacag tgatgtggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaa tcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagcaacgcccgaagtcagtgacccaactcgcaagagagggagctgccgaaggcggggcaggta actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_clostri SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcaattaa dioforme 232 aggaagttttcggatggaatttgattgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacact gggggataacagttagaaatgactgctaataccgcataagcgcacagtgccgcatggtacggtgtgaaaaact ccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgaagcaagtctg aagtgaaaacccagggctcaaccctgggactgctttggaaactgttttgctagagtgtcggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcagtaagcattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcctcttgaccggcgtgtaacggcgccttcccttcggggcaagagag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcc ttagtagccagcaggtagagctgggcactctagggagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagaca gtgatgtggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagcaacgcccgaagtcagtgacccaactcgcaagagagggagctgccgaaggcggggcaggt aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_clostri SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcaattaa dioforme 233 aggaagttttcggatggaatttgattgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacact gggggataacagttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaact ccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgaagcaagtctg aagtgaaaacccagggctcaaccctgggactgctttggaaactgttttgctagagtgtcggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga atgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcagtaagcattccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttaccaagtcttgacatcctcttggccggcgtgtaacggcgccttcccttcggggcaagagag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcc ttagtagccagcaggtagagctgggcactctagggagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagaca gtgatgtggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagcaacgcccgaagtcagtgacccaactcgcaagagagggagctgccgaaggcggggcaggt aactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lactobacillus_fer SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggcccg mentum 234 attgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtaggtaacc tgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatgaacaacg cttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaacggcctacca aggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggcccatactcctacg ggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgcgtgagtgaagaagg gtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatacgttgacggtatttaacca gaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttattgggc gtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaaccggagaagtgcatcggaaact ggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtggaatgcgtagatatatggaagaac accagtggcgaaggcggctacctggtctgcaactgacgctgagactcgaaagcatgggtagcgaacaggatt agataccctggtagtccatgccgtaaacgatgagtgctaggtgttggagggtttccgcccttcagtgccggagcta acgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcac aagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttaccaggtcttgacatcttgcgccaacccta gagatagggcgtttccttcgggaacgcaatgacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccttgttactagttgccagcattaagttgggcactctagtgagactgccggt gacaaaccggaggaaggtggggacgacgtcagatcatcatgccccttatgacctgggctacacacgtgctaca atggacggtacaacgagtcgcgaactcgcgagggcaagcaaatctcttaaaaccgttctcagttcggactgcag gctgcaactcgcctgcacgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgg gccttgtacacaccgcccgtcacaccatgagagtttgtaacacccaaagtcggtggggtaaccttttaggagcca gccgcctaaggtgggacagatgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatc acctccttt Lactobacillus_fer SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggccca mentum 235 attgattgacggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtaggtaac ctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatgaacaac gcttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaacggcctacc aaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggcccatactcctac gggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgcgtgagtgaagaag ggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatacgttgacggtatttaacc agaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttattggg cgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaaccggagaagtgcatcggaaac tggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtggaatgcgtagatatatggaagaac accagtggcgaaggcggctacctggtctgcaactgacgctgagactcgaaagcatgggtagcgaacaggatt agataccctggtagtccatgccgtaaacgatgagtgctaggtgttggagggtttccgcccttcagtgccggagcta acgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcac aagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttaccaggtcttgacatcttgcgccaacccta gagatagggcgtttccttcgggaacgcaatgacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccttgttactagttgccagcattaagttgggcactctagtgagactgccggt gacaaaccggaggaaggtggggacgacgtcagatcatcatgccccttatgacctgggctacacacgtgctaca atggacggtacaacgagtcgcgaactcgcgagggcaagcaaatctcttaaaaccgttctcagttcggactgcag gctgcaactcgcctgcacgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgg gccttgtacacaccgcccgtcacaccatgagagtttgtaacacccaaagtcggtggggtaaccttttaggagcca gccgcctaaggtgggacagatgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatc acctccttt Lactobacillus_fer SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggccca mentum 236 attgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtaggtaacc tgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatgaacaacg cttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaacggcctacca aggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggcccatactcctacg ggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgcgtgagtgaagaagg gtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatacgttgacggtatttaacca gaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttattgggc gtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaaccggagaagtgcatcggaaact ggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtggaatgcgtagatatatggaagaac accagtggcgaaggcggctacctggtctgcaactgacgctgagactcgaaagcatgggtagcgaacaggatt agataccctggtagtccatgccgtaaacgatgagtgctaggtgttggagggtttccgcccttcagtgccggagcta acgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcac aagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttaccaggtcttgacatcttgcgccaacccta gagatagggcgtttccttcgggaacgcaatgacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccttgttactagttgccagcattaagttgggcactctagtgagactgccggt gacaaaccggaggaaggtggggacgacgtcagatcatcatgccccttatgacctgggctacacacgtgctaca atggacggtacaacgagtcgcgaactcgcgagggcaagcaaatctcttaaaaccgttctcagttcggactgcag gctgcaactcgcctgcacgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgg gccttgtacacaccgcccgtcacaccatgagagtttgtaacacccaaagtcggtggggtaaccttttaggagcca gccgcctaaggtgggacagatgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatc acctccttt Lactobacillus_fer SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggtcca mentum 237 attgattgacggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtaggtaac ctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatgaacaac gtttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaatggcctacca aggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggcccatactcctacg ggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgcgtgagtgaagaagg gtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatacgttgacggtatttaacca gaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttattgggc gtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaaccggagaagtgcatcggaaact ggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtggaatgcgtagatatatggaagaac accagtggcgaaggcggctacctggtctgcaactgacgctgagactcgaaagcatgggtagcgaacaggatt agataccctggtagtccatgccgtaaacgatgagtgctaggtgttggagggtttccgcccttcagtgccggagcta acgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcac aagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttaccaggtcttgacatcttgcgccaacccta gagatagggcgtttccttcgggaacgcaatgacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccttgttactagttgccagcattaagttgggcactctagtgagactgccggt gacaaaccggaggaaggtggggacgacgtcagatcatcatgccccttatgacctgggctacacacgtgctaca atggacggtacaacgagtcgcaaactcgcgagggcaagcaaatctcttaaaaccgttctcagttcggactgcag gctgcaactcgcctgcacgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgg gccttgtacacaccgcccgtcacaccatgagagtttgtaacacccaaagtcggtggggtaaccttttaggagcca gccgcctaaggtgggacagatgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatc acctcctt Lactobacillus_fer SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggccca mentum 238 attgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtaggtaacc tgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatgaacaacg cttaaaagatggcttctcgctatcacttctggatggacctgcgctgcattagcttgttggtggggtaatggcctacca aggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggcccatactcctacg ggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgcgtgagtgaagaagg gtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatacgttgacggtatttaacca gaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttattgggc gtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaaccggagaagtgcatcggaaact ggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtggaatgcgtagatatatggaagaac accagtggcgaaggcggctacctggtctgcaactgacgctgagactcgaaagcatgggtagcgaacaggatt agataccctggtagtccatgccgtaaacgatgagtgctaggtgttggagggtttccgcccttcagtgccggagcta acgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggcccgcac aagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttaccaggtcttgacatcttgcgccaacccta gagatagggcgtttccttcgggaacgcaatgacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgg gttaagtcccgcaacgagcgcaacccttgttactagttgccagcattaagttgggcactctagtgagactgccggt gacaaaccggaggaaggtggggacgacgtcagatcatcatgccccttatgacctgggctacacacgtgctaca atggacggtacaacgagtcgcgaactcgtgagggcaagcaaatctcttaaaaccgttctcagttcggactgcag gctgcaactcgcctgcacgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgg gccttgtacacaccgcccgtcacaccatgagagtttgtaacacccaaagtcggtggggtaaccttttaggagcca gccgcctaaggtgggacagatgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatc acctcctt Bacteroides_theta SEQ ID NO: ctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatgggaataaagttttccac iotaomicron 239 gtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatc cgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtgaaagtttgcggctca accgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggtgtagcggtgaaat gcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactgatgctcgaaagtg tgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgcgatatacagt aagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattg acgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaa ttgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgctgcatggttgtcgtcagctcgtgc cgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagttactaacaggtcatgctgaggactcta gagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggct acacacgtgttacaatggggggtacagaaggcagctacctggtgacaggatgctaatcccaaaagcctctctca gttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtg aatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgc aaggagcgtcctagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggct ggaacacctcctt Bacteroides_theta SEQ ID NO: ctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatgggaataaagttttccac iotaomicron 240 gtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatc cgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtgaaagtttgcggctca accgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggtgtagcggtgaaat gcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactgatgctcgaaagtg tgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttgcgatatacagt aagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattg acgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaa ttgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgctgcatggttgtcgtcagctcgtgc cgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagttactaacaggtcatgctgaggactcta gagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggct acacacgtgttacaatggggggtacagaaggcagctacctggtgacaggatgctaatcccaaaagcctctctca gttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtg aatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgc aaggagcgtcctagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggct ggaacacctcctt Bacteroides_theta SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatttc iotaomicron 241 agtttgcttgcaaactggagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataactcggg gatagcctttcgaaagaaagattaatacccgatagtataattagaccgcatggtcttattattaaagaatttcggttat cgatggggatgcgttccattaggcagttggtgaggtaacggctcaccaaaccttcgatggataggggttctgaga ggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtc aatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatggg aataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtga aagtttgcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggt gtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactg atgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtt tgcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaa ctcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacctt acccgggcttaaattgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgctgcatggttgt cgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagttactaacaggtcat gctgaggactctagagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccct tacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacctggtgacaggatgctaatccc aaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcag ccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctga agtacgtaaccgcaaggagcgtcctagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtacc ggaaggtgcggctggaacacctcctt Bacteroides_theta SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcatttc iotaomicron 242 agtttgcttgcaaactggagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataactcggg gatagcctttcgaaagaaagattaatacccgatggtataattagaccgcatggtcttgttattaaagaatttcggttat cgatggggatgcgttccattaggcagttggtgaggtaacggctcaccaaaccttcgatggataggggttctgaga ggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtc aatgggcgcaggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatggg aataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcgg taatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtga aagtttgcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggt gtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactg atgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtt tgcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggtgaaa ctcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaacctt acccgggcttaaattgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgctgcatggttgt cgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagttactaacaggtcat gctgaggactctagagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccct tacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacctggtgacaggatgctaatccc aaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcag ccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctga agtacgtaaccgcaaggagcgtcctagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtacc ggaaggtgcggctggaacacctcctt Sutterella_wadsw SEQ ID NO: taaagagtttgatcctggctcagattgaacgctggcggcatgctttacacatgcaagtcgaacggcagcgcggg orthensis 243 gagcttgctccctggcggcgagtggcgcacgggtgagtaatacatcggaacgtgtcttctagtgggggataactg cccgaaagggcagctaataccgcatgagacctgagggtgaaagcgggggatcgcaagacctcgcgctgga agagcggccgatgtccgattagctagttggtgaggtaaaggctcaccaaggcgacgatcggtagctggtctgag aggacgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaattttgg acaatgggggcaaccctgatccagccatgccgcgtgcaggatgaaggtcttcggattgtaaactgcttttgtcag ggacgaaaagggatgcgataacaccgtattccgctgacggtacctgaagaataagcaccggctaactacgtg ccagcagccgcggtaatacgtagggtgcaagcgttaatcggaattactgggcgtaaagcgtgcgcaggcggtt ctgtaagatagatgtgaaatccccgggctcaacctgggaattgcatatatgactgcaggacttgagtttgtcagag gagggtggaattccacgtgtagcagtgaaatgcgtagatatgtggaagaacaccgatggcgaaggcagccctc tggggcatgactgacgctcatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccc taaacgatgtctactagttgttggggacgatagtccttggtaacgcagctaacgcgtgaagtagaccgcctgggg agtacggtcgcaagattaaaactcaaaggaattgacggggacccgcacaagcggtggatgatgtggattaatt cgatgcaacgcgaaaaaccttacctagccttgacatgccaggaaggtctgagagatcagaccgtgcccgcaa gggaatctggacacaggtgctgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgag cgcaacccttgtcattagttgctacgaaagggcactctaatgagactgccggtgacaaaccggaggaaggtgg ggatgacgtcaagtcctcatggcccttatggctagggcctcacacgtcatacaatggtcggaacagagggaagc gaagccgcgaggtgaagccaatcccagaaaaccgatcgtagtccggattgcagtctgcaactcgactgcatga agtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtc acaccatgggagtggggttcaccagaagacgtttgcccaaccgaaaggaaggcggcgtccacggtgggcttc atgactggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Sutterella_wadsw SEQ ID NO: taaagagtttgatcctggctcagattgaacgctggcggcatgctttacacatgcaagtcgaacggcagcgcggg orthensis 244 gagcttgctccctggcggcgagtggcgcacgggtgagtaatacatcggaacgtgtcttctagtgggggataactg cccgaaagggcagctaataccgcatgagacctgagggtgaaagcgggggatcgcaagacctcgcgctgga agagcggccgatgtccgattagctagttggtgaggtaaaggctcaccaaggcgacgatcggtagctggtctgag aggacgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaattttgg acaatgggggcaaccctgatccagccatgccgcgtgcaggatgaaggtcttcggattgtaaactgcttttgtcag ggacgaaaagggatgcgataacaccgtattccgctgacggtacctgaagaataagcaccggctaactacgtg ccagcagccgcggtaatacgtagggtgcaagcgttaatcggaattactgggcgtaaagcgtgcgcaggcggtt ctgtaagatagatgtgaaatccccgggctcaacctgggaattgcatatatgactgcaggacttgagtttgtcagag gagggtggaattccacgtgtagcagtgaaatgcgtagatatgtggaagaacaccgatggcgaaggcagccctc tgggacatgactgacgctcatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccc taaacgatgtctactagttgttggggacgatagtccttggtaacgcagctaacgcgtgaagtagaccgcctgggg agtacggtcgcaagattaaaactcaaaggaattgacgggn Sutterella_wadsw SEQ ID NO: taaagagtttgatcctggctcagattgaacgctggcggcatgctttacacatgcaagtcgaacggcagcgcggg orthensis 245 gagcttgctccctggcggcgagtggcgcacgggtgagtaatacatcggaacgtgtcttctagtgggggataactg tccgaaagggcagctaataccgcatgagacctgagggtgaaagcgggggatcgcaagacctcgcgctggaa gagcggccgatgtccgattagctagttggtgaggtaaaggctcaccaaggcgacgatcggtagctggtctgaga ggacgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaattttgga caatgggggcaaccctgatccagccatgccgcgtgcaggatgaaggtcttcggattgtaaactgcttttgtcagg gacgaaaagggatgcgataacaccgtattccgctgacggtacctgaagaataagcaccggctaactacgtgcc agcagccgcggtaatacgtagggtgcaagcgttaatcggaattactgggcgtaaagcgtgcgcaggcggttctg taagatagatgtgaaatccccgggctcaacctgggaattgcatatatgactgcaggacttgagtttgtcagagga gggtggaattccacgtgtagcagtgaaatgcgtagatatgtggaagaacaccgatggcgaaggcagccctctg ggacatgactgacgctcatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgcccta aacgatgtctactagttgttggggacgatagtccttggtaacgcagctaacgcgtgaagtagaccgcctggggag tacggtcgcaagattaaaactcaaaggaattgacggggacccgcacaagcggtggatgatgtggattaattcg atgcaacgcgaaaacccttccctagccttgacatgccaggaaggtctgagagatcagaccgtgcccgcaagg gaatctggacacaggtgctgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcg caacccttgtcattagttgctacgaaagggcactctaatgagactgccggtgacaaaccggaggaaggtgggg atgacgtcaagtcctcatggcccttatggctagggcctcacacgtcatacaatggtcggaacagagggaagcga agccgcgaggtgaagccaatcccagaaaaccgatcgtagtccggattgcagtctgcaactcgactgcatgaag tcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcac accatgggagtggggttcaccagaagacgtttgcccaaccgaaaggaaggcggcgtccacggtgggcttcat gactggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Sutterella_wadsw SEQ ID NO: taaagagtttgatcctggctcagattgaacgctggcggcatgctttacacatgcaagtcgaacggcagcgcggg orthensis 246 gagcttgctccctggcggcgagtggcgcacgggtgagtaatacatcggaacgtgtcttctagtgggggataactg cccgaaagggcagctaataccgcatgagacctgagggtgaaagcgggggatcgcaagacctcgcgctgga agagcggccgatgtccgattagctagttggtgaggtaaaggctcaccaaggcgacgatcggtagctggtctgag aggacgaccagccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaattttgg acaatgggggcaaccctgatccagccatgccgcgtgcaggatgaaggtcttcggattgtaaactgcttttgtcag ggacgaaaagggatgcgataacaccgtattccgctgacggtacctgaagaataagcaccggctaactacgtg ccagcagccgcggtaatacgtagggtgcaagcgttaatcggaattactgggcgtaaagcgtgcgcaggcggtt ctgtaagatagatgtgaaatccccgggctcaacctgggaattgcatatatgactgcaggacttgagtttgtcagag gagggtggaattccacgtgtagcagtgaaatgcgtagatatgtggaagaacaccgatggcgaaggcagccctc tgggacatgactgacgctcatgcacgaaagcgtggggagcaaacaggattagataccctggtagtccacgccc taaacgatgtctactagttgttggggacgatagtccttggtaacgcagctaacgcgtgaagtagaccgcctgggg agtacggtcgcaagattaaaactcaaaggaattgacggggacccgcacaagcggtggatgatgtggattaatt cgatgcaacgcgaaaaaccttacctagccttgacatgccaggaaggcctgagagatcaggccgtgcccgcaa gggaatctggacacaggtgctgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgag cgcaacccttgtcattagttgctacgaaagggcactctaatgagactgccggtgacaaaccggaggaaggtgg ggatgacgtcaagtcctcatggcccttatggctagggcctcacacgtcatacaatggtcggaacagagggaagc gaagccgcgaggtgaagccaatcccagaaaaccgatcgtagtccggattgcagtctgcaactcgactgcatga agtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtc acaccatgggagtggggttcaccagaagacgtttgcccaaccgaaaggaaggcggcgtccacggtgggcttc atgactggggtgaagtcgtaacaaggtagccgtaccggaaggtgcggctggatcacctccttt Clostridium_sp_K SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacggagttatgcag LE_1755 247 aggaagttttcggatggaatcggcgtaacttagtggcggacgggtgagtaacgcgtgggaaacctgccctgtac cgggggataacacttagaaataggtgctaataccgcataagcgcacagcttcacatgaggcagtgtgaaaaac tccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcagt agccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatgacaagccag atgtgaaaacccagggctcaaccctgggactgcatttggaactgccaggctggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt aactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgat gattgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaagtcttgacatcccaatgacgtgcccgtaacggggcattctcttcggagcattgg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctta tccttagtagccagcaggtaaagctgggcactctagggagactgccggggataacccggaggaaggcgggg atgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcga gacagtgatgttgagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagttggaaatgcccgaagcctgtgacctaaccgtaaggaaggagcagtcgaaggcaggtctaataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_symbi SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcgattta osum 248 acggaagttttcggatggaagttgaattgactgagtggcggacgggtgagtaacgcgtgggtaacctgccttgta ctgggggacaacagttagaaatgactgctaataccgcataagcgcacagtattgcatgatacagtgtgaaaaac tccggtggtacaagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtaaagcaagtctgaa gtgaaagcccgcggctcaactgcgggactgctttggaaactgtttaactggagtgtcggagaggtaagtggaatt cctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcgacttactggacgataact gacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaat actaggtgttggggagcaaagctcttcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgc aagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacg cgaagaaccttaccaggtcttgacatcgatccgacgggggagtaacgtccccttcccttcggggcggagaaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattct aagtagccagcggttcggccgggaactcttgggagactgccagggataacctggaggaaggtggggatgacg tcaaatcatcatgccccttatgatctgggctacacacgtgctacaatggcgtaaacaaagagaagcaagaccgc gaggtggagcaaatctcaaaaataacgtctcagttcggactgcaggctgcaactcgcctgcacgaagctggaa tcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcgggaccgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_ram SEQ ID NO: gttctgtgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacacagggggataacagttggaa ulus 249 acgactgctaataccgcataagcgcacagcaccgcatggtgcagtgtgaaaaactccggtggtgtgagatgga tccgcgtctgattagcttgttggcggggtaacggcccaccaaggcgacgatcagtagccggcctgagagggcg accggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcacaatgg gggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgtaaagctctatcagcagggaag ataatgacggtacctgactaagaagctccggctaaatacgtgccagcagccgcggtaatacgtatggagcaag cgttatccggatttactgggtgtaaagggagcgtaggcggtcctgcaagtctgatgtgaaaggccggggctcaac cccgggactgcattggaaactgtaggactagagtgtcggaggggtaagtggaattcctagtgtagcggtgaaat gcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgactactgacgctgaggctcgaaag cgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgttggcaggtaa gacctgtcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgcaagaatgaaactcaaag gaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagt cttgacatcccggtgacagaacatgtaatgtgttttcccttcggggcaccggtgacaggtggtgcatggttgtcgtc agctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatccccagtagccagcatttcggatg ggcactctgtggagactgccagggacaacctggaggaaggtggggatgacgtcaaatcatcatgccccttatg acttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagaccgcgaggtggagcaaatcccaa aaataacgtcccagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcagatcag aatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcggaaatgcccgaag ccggtggcctaaccgcaaggaaggagccgtcgaaggcaggtctgataactggggtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcactttt avus 250 gcggatttcttcggattgaagcaattgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtaccgtgtgaaaa actccggtggtatgagatggacccgcgtctgattagctagttggtggggtaacggcctaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgta aagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcca gatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggaaagc ggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacga tgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttacctggtcttgacatccccctgaccgctctttaatcggagctttccttcgggacagggga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcatttcggatgggcactctagagagactgccagggataacctggaggaaggtggggatgac gtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcgagccc gcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgataac tggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacctt avus 251 gacggatttcttcggattgaagccttggtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaa aactccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatc agtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcc agatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggaaag cggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatccctctgaccgctctttaatcggagctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atctttagtagccagcattttggatgggcactctagagagactgccagggataacctggaggaaggtggggatg acgtcaaatcatcatgccccttatgatcagggctacacacgtgctacaatggcgtaaacaaagggaagcgagc ccgcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacctt avus 252 gacggatttcttcggattgaagccttggtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaa aactccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatc agtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcc agatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggaaag cggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatccccctgaccgctctttaatcggagctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atctttagtagccagcattttggatgggcactctagagagactgccagggataacctggaggaaggtggggatg acgtcaaatcatcatgccccttatgatcagggctacacacgtgctacaatggcgtaaacaaagggaagcgagc ccgcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: ncgacgatcagtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacg avus 253 ggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagt atttcggtatgtaaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgt gccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggc atggcaagccagatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcgg agaggaaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcgg ctttctggacgatgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccac gccgtaaacgatgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattcca cctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtg gtttaattcgaagcaacgcgaagaaccttacctggtcttgacatccctctgaccgctctttaatcggaactttccttcg ggacagaggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagc gcaacccctatctttagtagccagcattttggatgggcactctagagagactgccagggataacctggaggaag gtggggatgacgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagg gaagcgagcccgcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgacta catgaagctggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgc ccgtcacaccatgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtg ggaccgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacctt avus 254 gacggatttcttcggattgaagccttggtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaa aactccggtggtatgagatggacccgcgtctgattaggtagttggtggggtaacggcctaccaagccgacgatc agtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagc agtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgt aaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagcc gcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcc agatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggaaag cggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacg atgactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacg atgaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttacctggtcttgacatccctctgaccgctctttaatcggagctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atctttagtagccagcatttcggatgggcactctagagagactgccagggataacctggaggaaggtggggatg acgtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcgagc ccgcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagtcagtaacgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggtgggaccgata actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_wexlerae SEQ ID NO: tcagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggaaatattt 255 cattgagacttcggtggatttgatctatttctagtggcggacgggtgagtaacgcgtgggtaacctgccttatacagg gggataacagtcagaaatggctgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaactcc ggtggtataagatggacccgcgttggattagctagttggtggggtaacggcccaccaaggcgacgatccatagc cggcctgagagggtgaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgtaaactt ctatcagcagggaagatagtgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggta atacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggtgtggcaagtctgatgtga aaggcatgggctcaacctgtggactgcattggaaactgtcatacttgagtgccggaggggtaagcggaattccta gtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggtaactgacg ttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatacta ggtgtcgggtggcagagccattcggtgccgtcgcaaacgcagtaagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatccgcctgaccgatccttaaccggatctttccttcgggacaggcgagacaggt ggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcctcagta gccagcatttaaggtgggcactctggggagactgccagggataacctggaggaaggcggggatgacgtcaaa tcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgagattgtgagatg gagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatcgcta gtaatcgcggatcagaatgccgcggtgaatacgttcccggg Gemmiger_formici SEQ ID NO: aaaggatttattcgcttcaggatggactcgcgtccaattagctagttggtgaggtaacggcccaccaaggcgacg lis 256 attggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggca gcagtgggggatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggttttcgga ttgtaaactcctgtcgttagggacgataatgacggtacctaacaagaaagcaccggctaactacgtgccagcag ccgcggtaaaacgtagggtgcaagcgttgtccggaattactgggtgtaaagggagcgcaggcggaccggcaa gttggaagtgaaatccatgggctcaacccgtgaattgctttcaaaactgctggccttgagtagtgcagaggtaggt ggaattcccggtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcgacctactgggc accaactgacgctgaggctcgaaagcatgggtagcaaacaggattagataccctggtagtccatgccgtaaac gatgattactaggtgttggaggattgaccccttcagtgccgcagttaacacaataagtaatccacctggggagtac gaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaag caacgcgaagaaccttaccaggtcttgacatccgatgcatagtgcagagatgcatgaagtccttcgggacatcg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctta ttgccagttactacgcaagaggactctggcgagactgccgttgacaaaacggaggaaggtggggatgacgtca aatcatcatgccctttatgacctgggctacacacgtactacaatggcgtttaacaaagagaagcaagaccgcga ggtggagcaaaactcagaaacaacgtctcagttcagattgcaggctgcaactcgcctgcatgaagtcggaattg ctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgag agccggggggacccgaagtcggtagtctaaccgcaaggaggacgccgccgaaggtaaaactggtgattggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eisenbergiella_ma SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacggagttatgcag ssiliensis 257 aggaagttttcggatggaatcggcgtaacttagtggcggacgggtgagtaacgcgtgggaaacctgccctgtac cgggggataacacttagaaataggtgctaataccgcataagcgcacagcttcacatgaggcagtgtgaaaaac tccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcagt agccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatgacaagccag atgtgaaaacccagggctcaaccctgggactgcatttggaactgccaggctggagtgcaggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgt aactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcggtaaacgat gattgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaagtcttgacatcccaatgacgtgtccgtaacggggcattctcttcggagcattgg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctta tccttagtagccagcaggtaaagctgggcactctagggagactgccggggataacccggaggaaggcgggg atgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcga gacagtgatgttgagcaaatcccagaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctg gaatcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagttggaaatgcccgaagcctgtgacctaaccgcaagggaggagcagtcgaaggcaggtctaataac tggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatg Ruminococcus_sp SEQ ID NO: ctaaagagtttgatcctggctcaggacgaacgctggcggcgcgcctaacacatgcaagtcgaacggagaaat . 258 gctgagcttgctttgcatttcttagtggcggacgggtgagtaacacgtgagcaacctgcctttgtgaggggaataac gtctggaaacggacgctaataccgcataacgtcaaggaaccgcatggttttttgaccaaagattttatcgcacaa agatgggctcgcggctgattagctagttggcggggtaacggcccaccaaggcgacgatcagtagccggactg agaggttgatcggccacattgggactgagacacggcccagactcctacgggaggcagcagtgggggatattg cacaatgggggaaaccctgatgcagcgacgccgcgtgagggaagacggttttcggattgtaaacctctgtcttc agggacgaaatcaatgacggtacctgaggaggaagccacggctaactacgtgccagcagccgcggtaatac gtaggtggcaagcgttgtccggaattactgggtgtaaagggagcgtaggcgggaatgcaagttgaatgtttaaac tatcggctcaactgataatcgcgttcaaaactgcatttcttgagtggagtagaggcaggcggaattcctagtgtagc ggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcctgctgggctctaactgacgctgaggc tcgaaagcgtgggtagcaaacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgtggg gggactgaccccttccgtgccggagttaacacaataagtaatccacctggggagtacggtcgcaagactgaaa ctcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcgtgcgcataccgtagagatacgggaagtccttcgggacgcatagacaggtggtgcatg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattattagttgctacgcaa gagcactctaatgagactgccgttgacaaaacggaggaaggtggggatgacgtcaaatcatcatgccccttatg acctgggctacacacgtactacaatggcacttaacagagggaagcaagaccgcgaggtggagcaaaccccc aaaaagtgtctcagttcggattgcaggctgcaacccgcctgtatgaagtcggaattgctagtaatcgcggatcag catgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggtaacacccgaa gtcagtagcctaaccgcaaggagggcgctgccgaaggtgggattggtgattagggtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Roseburia_faecis SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcactctat 259 ttgattttcttcggaaatgaagattttgtgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcatac agggggataacagttggaaacgactgctaataccgcataagcgcacaggattgcatgatccggtgtgaaaaac tccggtggtatgggatggacccgcgtctgattagccagttggcagggtaacggcctaccaaagcgacgatcagt agccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagt ggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgaagaagtatttcggtatgtaa agctctatcagcaggaaagaaaaatgacggtacctgactaagaagcaccggctaaatacgtgccagcagcc gcggtaatacgtatggtgcaagcgttatccggatttactgggtgtaaagggagcgcaggcggtgcggcaagtct gatgtgaaagcccggggctcaaccccggtactgcattggaaactgtcgtactagagtgtcggaggggtaagtgg aattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgata actgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatactaggtgtcggggagcattgctcttcggtgccgcagcaaacgcaataagtattccacctggggagtacgt tcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatcccgatgacagagtatgtaatgtactttctcttcggagcatcggtgac aggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctgttctt agtagccagcggttcggccgggcactctagggagactgccagggataacctggaggaaggcggggatgacg tcaaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagggaagcggagccgt gaggccgagcaaatctcaaaaataacgtctcagttcggactgtagtctgcaacccgactacacgaagctggaat cgctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggaaatgcccgaagtcagtgacccaaccgcaaggagggagctgccgaaggcaggttcgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Butyrivibrio_sp.

SEQ ID NO: ttgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggacggattgga 260 gcttgctccatgaagttagtggcggacgggtgagtaacgcgtgggtaacctgccctatgcagggggataacgttt ggaaacgaacgctaataccgcataacctagttggttcgcatgaaccgactagcaaagattttatcggcataggat ggacccgcgttggattagctagttggtgagataacagcccaccaaggcaacgatccatagccggcctgagagg gtgaacggccacactgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcaca atgggcgcaagcctgatgcagcgacgccgcgtgaaggatgaaggtcttcggatcgtaaacttctatcagcagg gaagaaaccatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcggtaatacgtagg gggcaagcgttatccggaattactgggtgtaaagggtgcgtaggcggcgatttaagtcagatgtgaaaactcag ggctcaaccttgagactgcatctgaaactgagttgctagagtgcaggagaggaaagcggaattccgagtgtagc ggtgaaatgcgtagagattcggaggaacaccagtagcgaaggcggctttctggactgtaactgacgctgaggc acgaaagcgtggggagcgaacaggattagataccctggtagtccacgccgtaaacgatgaatactaggtgtcg gggcttacgggtctcggtgccgcagctaacgcattaagtattccacctgggaagtacgaccgcaaggttgaaact caaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctta cctaaacttgacatccctttgaccggtccttaatcggatctttactagcttgctagtacaaaggtgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatctttagtagccatcat tcagttgggcactctagagagactgccagggataacctggaggaaggtggggatgacgtcaaatcatcatgcc ccttatgtttagggctacacacgtgctacaatgggtgctacaaagggaagcaaatccgcgaggccgagcaaat ctcaaaaaagcactcccagttcggattgtagtctgcaactcgactacatgaagttggaatcgctagtaatcgcga atcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttgggggggcc caacgccagtgacctaacccgcaagggaaggagctgtctaaggcaaaaccaatgactggggtgaagtcgta acaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_sp_CAG_ SEQ ID NO: acagagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggggattatttt 257 261 gacagagacttcggttgaagtcgttataatcctagtggcggacgggtgagtaacgcgtgggtaacctgcctcaca ctgggggataacagtcagaaatgactgctaataccgcataagcgcacagagctgcatggctcagtgtgaaaaa ctccggtggtgtgagatggacccgcgttggattagccagttggcagggtaacggcctaccaaagcgacgatcca tagccggcctgagagggtggacggccacattgggactgagacacggcccagactcctacgggaggcagcag tggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatctcggtatgta aacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggagcagcaagtct gatgtgaaaggcgggggctcaacccccggactgcattggaaactgttgatcttgagtaccggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacggt aactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatactaggtgtcgggtggcagagccattcggtgccgcagcaaacgcagtaagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaagtcttgacatccctctgaccggtgagtaacgtcacctttccttcgggacagagg agacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccct atccttagtagccagcggtttggccgggcactctgaggagactgccagggataacctggaggaaggcggggat gacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaga gtgtgagcttaagcaaatcccaaaaataacgtcccagttcggactgcagtctgcaactcgactgcacgaagctg gaatcgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacacc atgggagtcagtaacgcccgaagtcagtgaccgaaccgaaaggacggagctgccgaaggcgggacggatg actggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_sp_ SEQ ID NO: gaacggccacattgggactgagacacggcccagactcctacgggaggcagcagtggggaatattgcgcaat 3_1_31 262 gggggaaaccctgacgcagcaacgccgcgtgattgaagaaggccttcgggttgtaaagatctttaattggggac gaaaaatgacggtacccaaagaataagctccggctaactacgtgccagcagccgcggtaatacgtagggag caagcgttatccggatttactgggtgtaaagggcgagtaggcgggctggcaagttgggagtgaaatcccgggg cttaaccccggaactgctttcaaaactgctggtcttgagtgatggagaggcaggcggaattccgtgtgtagcggtg aaatgcgtagatatacggaggaacaccagtggcgaaggcggcctgctggacattaactgacgctgaggagcg aaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatggatactaggtgtggga ggtattgaccccttccgtgccggagttaacacaataagtatcccacctggggagtacggccgcaaggttgaaact caaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagcaacgcgaagaaccttac caggtcttgacatccctctgaccgccctagagatagggtttcccttcggggcagaggtgacaggtggtgcatggtt gtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttacggttagttgatacgcaag atcactctagccggactgccgttgacaaaacggaggaaggtggggacgacgtcaaatcatcatgccccttatga cctgggctacacacgtactacaatggcagtcatacagagggaagcaaaacagtgatgtggagcaaatcccta aaagctgtcccagttcagattgcaggctgcaactcgcctgcatgaagtcggaattgctagtaatcgcggatcagc atgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagccggtaatacccgaagt ccgtagcctaaccgcaaggagggcgcggccgaaggtaggactggtaattagggtgaagtcgtaacaaggtag ccgtatcggaaggtgcggctggatcacctccttt Gemmiger_formici SEQ ID NO: aaaaggatttattcgctttaggatggactcgcgtccaattagctagttggtgaggtaacggcccaccaaggcgac lis 263 gattggtagccggactgagaggttgaacggccacattgggactgagacacggcccagactcctacgggaggc agcagtgggggatattgcacaatgggggaaaccctgatgcagcgacgccgcgtggaggaagaaggttttcgg attgtaaactcctgtcgttagggacgataatgacggtacctaacaagaaagcaccggctaactacgtgccagca gccgcggtaaaacgtagggtgcaagcgttgtccggaattactgggtgtaaagggagcgcaggcgggaagac aagttggaagtgaaaaccatgggctcaacccatgaattgctttcaaaactgtttttcttgagtagtgcagaggtaga tggaattcccggtgtagcggtggaatgcgtagatatcgggaggaacaccagtggcgaaggcggtctactgggc accaactgacgctgaggctcgaaagcatgggtagcaaacaggattagataccctggtagtccatgccgtaaac gatgattactaggtgttgggggattgaccccctcagtgccgcagttaacacaataagtaatccacctggggagta cgaccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaa gcaacgcgaagaaccttaccaggtcttgacatccgatgcatagcacagagatgtgtgaaatccttcgggacatc gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt attgccagttactacgttaagaggactctggcgagactgccgttgacaaaacggaggaaggtggggatgacgtc aaatcatcatgccctttatgacctgggctacacacgtactacaatggcgttaaacaaagagaagcaagaccgcg aggtggagcaaaactcaaaaacaacgtctcagttcagattgcaggctgcaactcgcctgcatgaagtcggaatt gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatga gagccggggggacccgaagtcgatagtctaaccgcaaggaggacgtcgccgaaggtaaaactggtgattgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Intestinimonas_bu SEQ ID NO: ggctcaccaaggcgacgatcagtagccggactgagaggttggccggccacattgggactgagacacggccc tyriciproducens 264 agactcctacgggaggcagcagtggggaatattgggcaatgggcgaaagcctgacccagcaacgccgcgtg aaggaagaaggccctcgggttgtaaacttcttttgtcagggacgaagcaagtgacggtacctgacgaataagcc acggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggatttactgggtgtaaagg gcgtgtaggcgggagtgcaagtcagatgtgaaaactatgggctcaacccatagcctgcatttgaaactgtacttct tgagtgatggagaggcaggcggaattccctgtgtagcggtgaaatgcgtagatatagggaggaacaccagtgg cgaaggcggcctgctggacattaactgacgctgaggcgcgaaagcgtggggagcaaacaggattagatacc ctggtagtccacgccgtaaacgatggatactaggtgtggggggtctgaccccctccgtgccgcagttaacacaat aagtatcccacctggggagtacgatcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggt ggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggacttgacatcctactaacgaagcagagat gcataaggtgcccttcggggaaagtagagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggt taagtcccgcaacgagcgcaacccttattgttagttgctacgcaagagcactctagcgagactgccgttgacaaa acggaggaaggtggggacgacgtcaaatcatcatgccccttatgtcctgggccacacacgtactacaatggcg gtcaacagagggaagcaaagccgcgaggtggagcaaatccctaaaagccgtcccagttcggattgcaggct gaaactcgcctgtatgaagtcggaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggcct tgtacacaccgcccgtcacaccatgagagtcgggaacacccgaagtccgtagcctaacagcaatgggggcgc ggccgaaggtgggttcgataattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcac ctccttt Oscillospiraceae_ SEQ ID NO: tatagagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacggagcaccc bacterium_VE202 265 ttgactgaggtttcggccaaatgataggaatgcttagtggcggactggtgagtaacgcgtgaggaacctaccttcc _24 agagggggacaacagttggaaacgactgctaataccgcatgacgcatgaccggggcatcccgggcatgtca aagattttatcgctggaagatggcctcgcgtctgattagctagatggtggggtaacggcccaccatggcgacgat cagtagccggactgagaggttgaccggccacattgggactgagatacggcccagactcctacgggaggcagc agtggggaatattgggcaatggacgcaagtctgacccagcaacgccgcgtgaaggaagaaggctttcgggttg taaacttcttttgtcagggaagagtagaagacggtacctgacgaataagccacggctaactacgtgccagcagc cgcggtaatacgtaggtggcaagcgttgtccggatttactgggtgtaaagggcgtgcagccgggccggcaagtc agatgtgaaatctggaggcttaacctccaaactgcatttgaaactgtaggtcttgagtaccggagaggttatcgga attccttgtgtagcggtgaaatgcgtagatataaggaagaacaccagtggcgaaggcggataactggacggca actgacggtgaggcgcgaaagcgtggggagcaaacaggattagataccctggtagtccacgctgtaaacgat ggatactaggtgtgcggggactgaccccctgcgtgccgcagttaacacaataagtatcccacctggggagtacg atcgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcggtggattatgtggtttaattcgaagca acgcgaagaaccttaccagggcttgacatcctactaacgaagtagagatacatcaggtgcccttcggggaaag tagagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacc cctattgttagttgctacgcaagagcactctagcgagactgccgttgacaaaacggaggaaggtggggacgac gtcaaatcatcatgccccttatgtcctgggctacacacgtaatacaatggcggtcaacagagggaggcaaagcc gcgaggcagagcaaacccccaaaagccgtcccagttcggatcgcaggctgcaacccgcctgcgtgaagtcg gaatcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac catgagagtcgggaacacccgaagtccgtagcctaaccgcaaggagggcgcggccgaaggtgggttcgata attggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp_C SEQ ID NO: tagtggcggacgggtgagtaacgcgtgggtaacctgccttgtactgggggacaacagttggaaacgactgctaa AG_91 266 taccgcataagcgcacagcttcgcatgaagcagtgtgaaaaactccggtggtacaagatggacccgcgtctgat tagctggttggtgaggtaacggcccaccaaggcgacgatcagtagccggcctgagagggtgaacggccacat tgggactgagacacggcccaaactcctacgggaggcagcagtggggaatattgcacaatgggggaaaccct gatgcagcaacgccgcgtgagtgaagaagtatttcggtatgtaaagctctatcagcaggaaagaaaatgacgg tacctgactaagaagccccggctaactacgtgccagcagccgcggtaatacgtagggggcaagcgttatccgg atttactgggtgtaaagggagcgtagacggttttgcaagtctgaagtgaaagcccggggcttaaccccgggactg ctttggaaactgtagaactagagtgcaggagaggtaagtggaattcctagtgtagcggtgaaatgcgtagatatt aggaggaacaccagtggcgaaggcggcttactggactgtaactgacgttgaggctcgaaagcgtggggagca aacaggattagataccctggtagtccacgccgtaaacgatgattactaggtgttggtgggtacgacccatcggtg ccgcagcaaacgcaataagtaatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggg gacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttacctggtcttgacatcccta tgaataacgggcaatgccgttagtacttcggtacataggagacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccttatctttagtagccagcagtaagatgggcactctagaga gactgccggggataacccggaggaaggtggggatgacgtcaaatcatcatgccccttatgaccagggctacac acgtgctacaatggcgtaaacaaagagaagcgaagtcgtgaggcagagcgaatctcaaaaataacgtctcag ttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcagatcagaatgctgcggtgaat acgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcggaaatgcccgaagtcggtgacctaaccg caaggaaggagccgccgaaggcaggtctgataactggggtgaagtcgtaacaaggtagccgtatcggaagg tgcggctggatcacctccttt Ruminococcus_ob SEQ ID NO: cctacgggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaagga eum 267 agaagtatctcggtatgtaaacttctatcagcagggaagatagtgacggtacctgactaagaagccccggctaa ctacgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtag acggactggcaagtctgatgtgaaaggcgggggctcaacccctggactgcattggaaactgttagtcttgagtgc cggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaagg cggcttactggacggtaactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtc cacgccgtaaacgatgaatactaggtgttggggagcaaagctcttcggtgccgccgcaaacgcattaagtattcc acctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgt ggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccctctgaccgactcttaaccgagtctttcctt cgggacagaggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacga gcgcaacccctatccccagtagccagcggttcggccgggcactctgaggagactgccagggataacctggag gaaggcggggatgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaa agggaagcaagcctgcgaaggtaagcaaatcccaaaaataacgtcccagttcggactgcagtctgcaactcg actgcacgaagctggaatcgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacaca ccgcccgtcacaccatgggagtcagtaacgcccgaagtcagtgacctaaccgcaagggaggagctgccgaa ggcgggaccgatgactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_sp.

SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcaatttaa 268 gtgaagttttcggatggatcttagattgactgagcggcggacgggtgagtaacgcgtggataacctgcctcacac agggggataacagttagaaatgactgctaataccgcataagcgcacggtaccgcatggtacagtgtgaaaaac tccggtggtgtgagatggatccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggcgaaagcctgatgcagcaacgccgcgtgagtgaagaagtatctcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgcagacggcactgcaagtctga agtgaaagcccggggctcaaccccgggactgctttggaaactgtagagctagagtgctggagaggcaagcgg aattcctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttgctggacagta actgacgttcaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg aatactaggtgttggtgggcaaagcccatcggtgccgccgcaaacgcaataagtattccacctggggagtacgt tcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatcgtgatgaccggaacttaaccgttccttcccttcggggcatcataga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcct cagtagccagcagtaagatgggcactctggggagactgccagggataacctggaggaaggtggggatgacg tcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagagggt gacctggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaa tcgctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatg ggagtcagcaacgcccgaagtcagtgactcaaccgcaaggagagagctgccgaaggcggggcaggtaact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_sp.

SEQ ID NO: atgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcaatttaa 269 gtgaagttttcggatggatcttagattgactgagcggcggacgggtgagtaacgcgtggataacctgcctcacac agggggataacagttagaaatgactgctaataccgcataagcgcacggtaccgcatggtacagtgtgaaaaac tccggtggtgtgagatggatccgcgtctgattaggtagttggtgaggtaacggcccaccaagccgacgatcagta gccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtg gggaatattgcacaatgggcgaaagcctgatgcagcaacgccgcgtgagtgaagaagtatctcggtatgtaaa gctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccgcg gtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgcagacggcactgcaagtctga agtgaaagcccggggctcaaccccgggactgctttggaaactgtagagctagagtgctggagaggcaagcgg aattcctagtgtagcggtgaaatgcgtagatattaggaagaacaccagtggcgaaggcggcttgctggacagta actgacgttcaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatg aatactaggtgttggtgggcaaagcccatcggtgccgccgcaaacgcaataagtattccacctggggagtacgt tcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatcgtgatgaccggaacttaaccgttccttcccttcggggcatcataga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcct cagtagccagcagtaagatgggcactctgtggagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcaagagggtg acctggagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaat cgctagtaatcgcagatcagaatgctgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagtcagcaacgcccgaagtcagtgactcaaccgcaaggagagagctgccgaaggcggggcaggtaactg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospira_pecti SEQ ID NO: ttatgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagcatttgc noschiza 270 gacagatttcttcggattgaagttgcttatgactgagtggcggacgggtgagtaacgcgtgggtaacctgcctcac acagggggatagcagttggaaacggctgataataccgcataagcgcacagtaccgcatggtacagtgtgaaa aactccggtggtgtgagatggacccgcgtctgattagcttgttggcagggtaacggcctaccaaggcaacgatc agtagccgacctgagagggtgaccggccacattgggactgagacacggcccagactcctacgggaggcagc agtggggaatattgcacaatggaggaaactctgatgcagcgacgccgcgtgagtgaagaagtaattcgttatgt aaagctctatcagcagggaagatagtgacggtacctgactaagaagctccggctaaatacgtgccagcagcc gcggtaatacgtatggagcaagcgttatccggatttactgggtgtaaagggagtgtaggtggcatcacaagtcag aagtgaaagcccggggctcaaccccgggactgcttttgaaactgtggagctggagtgcaggagaggcaagtg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttgctggactgt aactgacactgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatactaggtgtcggggctcataagagcttcggtgccgcagcaaacgcaataagtattccacctggggagta cgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaa gcaacgcgaagaaccttaccaagtcttgacatcctcttgcccggtcagtaatgtgaccttttcttcggaacaagagt gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat tcttagtagccagcatttaaggtgggcactctaggaagactgccagggataacctggaggaaggtggggatga cgtcaaatcatcatgccccttatgacttgggctacacacgtgctacaatggcgtaaacaaagtgaagcgagagt gtgagcttaagcaaatcacaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagtcggaaatgcccgaagtcggtgacctaacgaaagaaggagccgccgaaggcaggtctgataactgggg tgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lactonifactor_long SEQ ID NO: ctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcagtggggaat oviformis 271 attgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggaagaagtatttcggtatgtaaacttctatc agcagggaagaaaatgacggtacctgactaagaagccccggctaattacgtgccagcagccgcggtaatac gtaaggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcagtgcaagtctgatgtgaaag cccggggctcaaccccgggactgcattggaaactgtgcagctagagtgtcggagaggtaagtggaattcctagt gtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgataactgacgtt gaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatactag gtgtcgggcgccaaaggcgttcggtgccgcagcaaacgcaataagtattccacctggggagtacgttcgcaag aatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaacgcga agaaccttaccaagtcttgacatctgcctgaccggtccgtaacaggacccttccttcgggacaggcaagacagg tggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatccttagta gccagcaggtagagctgggcactctagggagactgccagggacaacctggaggaaggtggggatgacgtca aatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaggcgaaggggtgac ctggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgct agtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagt cggatatgcccgaagccggtgaccgaacccgaaagggaaggagccgtcgaaggtggagccgataactggg gtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_cont SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgcttt ortum 272 acttagatttcttcggattgaagagttttgcgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacagtaccgcatggtaccgtgggaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgta aacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttatgtaagtctgat gtgaaaacccggggctcaaccccgggactgcattggaaactatgtaactagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgca tactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtatgccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatccccctgaccggcgcgtaatggtgcctttccttcgggacaggggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttt agtagccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaggcgaagccg cgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_cont SEQ ID aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgcttt ortum NO:273 acttagatttcttcggattgaagagttttgcgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggacaacagttagaaatgactgctaataccgcataagaccacggtaccgcatggtacagtgggaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgta aacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttatgtaagtctgat gtgaaaacccggggctcaaccccgggactgcattggaaactatgtaactagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgca tactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtatgccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatccccctgaccggcgcgtaatggtgcctttccttcgggacaggggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttt agtagccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaggcgaagccg cgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_cont SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgcttt ortum 274 acttagatttcttcggattgaagagttttgcgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcat acagggggataacagttagaaatgactgctaataccgcataagaccacggtaccgcatggtacagtgggaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgta aacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttatgtaagtctgat gtgaaaacccggggctcaaccccgggactgcattggaaactatgtaactagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgca tactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtatgccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatccccctgaccggcgcgtaatggtgcctttccttcgggacaggggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttt agtagccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaggcgaagccg cgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eubacterium_cont SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcacttt ortum 275 acttagatttcttcggaatgaagagtgttgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctca tacagggggataacagttagaaatgactgctaataccgcataagaccacggtaccgcatggtacagtgggaaa aactccggtggtatgagatggacccgcgtctgattagctagttggtaaggtaacggcttaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaaggatgaagtatttcggtatgta aacttctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggttatgtaagtctgat gtgaaaacccggggctcaaccccgggactgcattggaaactatgtaactagagtgtcggagaggtaagtggaa ttcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgatgac tgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatgca tactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtatgccacctggggagtacgttc gcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagcaa cgcgaagaaccttacctgctcttgacatccccctgaccggcgcgtaatggtgcctttccttcgggacaggggaga caggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcttt agtagccagcggttcggccgggcactctagagagactgccagggataacctggaggaaggtggggatgacgt caaatcatcatgccccttatgagcagggctacacacgtgctacaatggcgtaaacaaagggaggcgaagccg cgaggtggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaat cgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgg gagttggtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataactgg ggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Eisenbergiella_tay SEQ ID NO: ggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggc i 276 ggcttactggactgtaactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtcc acgcggtaaacgatgattgctaggtgtaggtgggtatggacccatcggtgccgcagctaacgcaataagcaatc cacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcat gtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccccctgaatatctcgtaaaagggatag gccttcgggacaggggagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgca acgagcgcaacccttattcttagtagccagcaggtaaagctgggcactctaaggagactgccggggataaccc ggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaa acaaagggaagcgagacagtgatgtggagcaaatcccagaaataacgtctcagttcggattgtagtctgcaact cgactacatgaagctggaatcgctagtaatcgcgaatcagcatgtcgcggtgaatacgttcccgggtcttgtacac accgcccgtcacaccatgggagttggaaatgcccgaagtctgtgacctaaccgaaagggaggagcagccga aggcaggtctgataactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Ruminococcus_gn SEQ ID NO: aacgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgaagcgctttt avus_sp 277 gcggatttcttcggattgaagcaactgtgactgagcggcggacgggtgagtaacgcgtgggtaacctgcctcata cagggggataacagttggaaacggctgctaataccgcataagcgcacagtaccgcatggtaccgtgtgaaaa actccggtggtatgagatggacccgcgtctgattagctagttggtggggtaacggcctaccaaggcgacgatca gtagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagca gtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagcgatgaagtatttcggtatgta aagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagcca gatgtgaaagcccggggctcaaccccgggactgcatttggaactgtcaggctagagtgtcggagaggtaagcg gaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggacgat gactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgat gaatactaggtgtcgggtggcaaagccattcggtgccgcagcaaacgcaataagtattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttacctggtcttgacatccctatgaccgctctttaatcggagctttccttcgggacagagga gacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat ctttagtagccagcattttggatgggcactctagagagactgccagggataacctggaggaaggtggggatgac gtcaaatcatcatgccccttatgaccagggctacacacgtgctacaatggcgtaaacaaagggaagcgaacct gcgagggggagcaaatcccaaaaataacgtctcagttcggattgtagtctgcaactcgactacatgaagctgga atcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccat gggagtcagtaacgcccgaagtcagtgacccaaccgtaaggagggagctgccgaaggtgggaccgataact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_alden SEQ ID NO: tttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcgattag ense_sp 278 gatgaagttttcggatggattcctggttgactgagtggcggacgggtgagtaacgcgtggataacctgcctcacac tgggggataacagttagaaatggctgctaataccgcataagcgcacagtaccgcatggtacggtgtgaaaaac ccaggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcag tggggaatattgcacaatgggcggaagcctgatgcagcgacgccgcgtgagtgaagaagtatctcggtatgta aagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaactacgtgccagcagccg cggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcgacgcaagtct ggagtgaaagcccggggcccaaccccgggactgctttggaaactgtgctgctggagtgcaggagaggtaagt ggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactg taactgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacga tgaatgctaggtgtcggggggcaaagcccttcggtgccgccgctaacgcaataagcattccacctggggagtac gttcgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaag caacgcgaagaaccttaccaagtcttgacatccccctgaccggcgcgtaacggtgcccttccttcgggacaggg gagacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaaccctt atccttagtagccagcacgtcgtggtgggcactctagggagactgccagggataacctggaggaaggtgggga tgacgtcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaggcgacc ctgcgaaggtaagcaaatcccaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagct ggaatcgctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcaca ccatgggagtcagcaacgcccgaagtcagtgacccaaccttaacaggagggagctgccgaaggcggggca ggtaactggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_sp.

SEQ ID NO: acgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaacacatgcaagtcgaacgagaatctttg 279 aacagatcttttcggagtgacgttcaaagaggaaagtggcggacgggcgagtaacgcgtgagtaacctgccca taagagggggataatccatggaaacgtggactaataccgcatattgtagttaagttgcatgacttgattatgaaag atttatcgcttatggatggactcgcgtcagattagatagttggtgaggtaacggctcaccaagtcaacgatctgtag ccgaactgagaggttgatcggccgcattgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcgcaatgggggcaaccctgacgcagcaacgccgcgtgcaggaagaaggtcttcggattgtaaact gttgtcgcaagggaagaagacagtgacggtaccttgtgagaaagtcacggctaactacgtgccagcagccgc ggtaatacgtaggtgacaagcgttgtccggatttactgggtgtaaagggcgcgtaggcggactgtcaagtcagtc gtgaaataccggggcttaaccccggggctgcgattgaaactgacagccttgagtatcggagaggaaagcgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggctttctggacgacaa ctgacgctgaggcgcgaaagtgtggggagcaaacaggattagataccctggtagtccacaccgtaaacgatg gatactaggtgtaggaggtatcgaccccttctgtgccgcagttaacacaataagtatcccacctggggagtacga ccgcaaggttgaaactcaaaggaattgacgggggcccgcacaagcagtggagtatgtggtttaattcgaagca acgcgaagaaccttacctgggcttgacatccctggaatcgagtagagatacttgagtgccttcgggaatcaggtg acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatt gtcagttgccatcattaagttgggcactctggcgagactgccggtgacaaatcggaggaaggtggggacgacgt caaatcatcatgccccttatgcccagggctacacacgtactacaatggccgataacaaagtgcagcgaaaccg tgaggtggagcgaatcacaaaactcggtctcagttcagattgcaggctgcaactcgcctgcatgaagttggaatt gctagtaatcgcggatcagaatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatga gagtcgataacacccgaagcctgtgagctaacctttaggaggcagcagtcgaaggtggggttgatgattggggt gaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Clostridium_lavale SEQ ID NO: tttgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagcatttca nse 280 gatgaagttttcggatggattctgagatgactgagtggcggacgggtgagtaacacgtggataacctgcctcaca ctgggggacaacagttagaaatgactgctaataccgcataagcgcacagtaccgcatggtacagtgtgaaaaa ctccggtggtgtgagatggatccgcgtctgattagccagttggcggggtaacggcccaccaaagcgacgatcag tagccgacctgagagggtgaccggccacattgggactgagacacggcccaaactcctacgggaggcagcag tggggaatattgcacaatgggcgaaagcctgatgcagcgacgccgcgtgagtgaagaagtatttcggtatgtaa agctctatcagcagggaagataatgacggtacctgactaagaagccccggctaactacgtgccagcagccgc ggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgtagacggcatggcaagtctga agtgaaaacccagggctcaaccctgggactgctttggaaactgtcaagctagagtgcaggagaggtaagtgga attcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtggcgaaggcggcttactggactgtaa ctgacgttgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgccgtaaacgatga gtgctaggtgttggggggcaaagcccttcggtgccgtcgcaaacgcaataagcactccacctggggagtacgtt cgcaagaatgaaactcaaaggaattgacggggacccgcacaagcggtggagcatgtggtttaattcgaagca acgcgaagaaccttaccaagtcttgacatcctcttgaccggcgtgtaacggcgcctttccttcgggacaagggag acaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatcc ttagtagccagcattaagatgggcactctagggagactgccagggacaacctggaggaaggtggggatgacg tcaaatcatcatgccccttatgatttgggctacacacgtgctacaatggcgtaaacaaagggaagcgaccctgcg aaggtgagcaaatctcaaaaataacgtcccagttcggactgtagtctgcaacccgactacacgaagctggaatc gctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatggg agtcagcaacgcccgaagtcagtgacccaactcgcaagagagggagctgccgaaggcggggcaggtaact ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Blautia_producta SEQ ID NO: AGAGTTTGATCCTGGCTCAGGATGAACGCTGGCGGCGTGCTTAACACATGC 281 AAGTCGAGCGAAGCACTAAGACGGATTTCTTCGGATTGAAGTCTTTGTGACT

GAGCGGCGGACGGGTGAGTAACGCGTGGGTAACCTGCCTCATACAGGGGG ATAACAGTTAGAAATGACTGCTAATACCGCATAAGCGCACAGGACCGCATGG TCTGGTGTGAAAAACTCCGGTGGTATGAGATGGACCCGCGTCTGATTAGCTA GTTGGAGGGGTAACGGCCCACCAAGGCGACGATCAGTAGCCGGCCTGAGA GGGTGAACGGCCACATTGGGACTGAGACACGGCCCAGACTCCTACGGGAG GCAGCAGTGGGGAATATTGCACAATGGGGGAAACCCTGATGCAGCGACGC CGCGTGAAGGAAGAAGTATCTCGGTATGTAAACTTCTATCAGCAGGGAAGAA AATGACGGTACCTGACTAAGAAGCCCCGGCTAACTACGTGCCAGCAGCCGC GGTAATACGTAGGGGGCAAGCGTTATCCGGATTTACTGGGTGTAAAGGGAG CGTAGACGGAAGAGCAAGTCTGATGTGAAAGGCTGGGGCTTAACCCCAGGA CTGCATTGGAAACTGTTGTTCTAGAGTGCCGGAGAGGTAAGCGGAATTCCTA GTGTAGCGGTGAAATGCGTAGATATTAGGAGGAACACCAGTGGCGAAGGCG GCTTACTGGACGGTAACTGACGTTGAGGCTCGAAAGCGTGGGGAGCAAACA GGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGAATACTAGGTGTCG GGTGGCAAAGCCATTCGGTGCCGCAGCAAACGCAATAAGTATTCCACCTGG GGAGTACGTTCGCAAGAATGAAACTCAAAGGAATTGACGGGGACCCGCACA AGCGGTGGAGCATGTGGTTTAATTCGAAGCAACGCGAAGAACCTTACCAAG TCTTGACATCCCTCTGACCGTCCCGTAACGGGGACTTCCCTTCGGGGCAGA GGAGACAGGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTGGGT TAAGTCCCGCAACGAGCGCAACCCTTATCCTTAGTAGCCAGCACATGATGGT GGGCACTCTAGGGAGACTGCCGGGGATAACCCGGAGGAAGGCGGGGACG ACGTCAAATCATCATGCCCCTTATGATTTGGGCTACACACGTGCTACAATGG CGTAAACAAAGGGAAGCGAGACAGCGATGTTGAGCGAATCCCAAAAATAAC GTCCCAGTTCGGACTGCAGTCTGCAACTCGACTGCACGAAGCTGGAATCGC TAGTAATCGCGGATCAGAATGCCGCGGTGAATACGTTCCCGGGTCTTGTAC ACACCGCCCGTCACACCATGGGAGTCAGTAACGCCCGAAGTCAGTGACCTA ACCGAAAGGAAGGAGCTGCCGAAGGCGGGACCGATAACTGGGGTGAAGTC

GTAACAAGGTAACC Clostridium_nexile SEQ ID NO: NNNNNNNGAGATTTGATCCTGGCTCAGGATGAACGCTGGCCGGCCGTGCTT 282 ACACATGCAGTCGAACGAAGCGCTTAAACTGGATTTCTTCGGATTGAAGTTT

TTGCTGACTGAGTGGCGGACGGGTGAGTAACGCGTGGGTAACCTGCCTCAT ACAGGGGGATAACAGTTAGAAATGACTGCTAATACCNNATAAGCGCACAGTG CTGCATGGCACAGTGTAAAAACTCCGGTGGTATGAGATGGACCCGCGTCTG ATTAGCTAGTTGGTGGGGTAACGGCCTACCAAGGCGACGATCAGTAGCCGG CCTGAGAGGGTGAACGGCCACATTGGGACTGAGACACGGNCCAAACTCCTA CGGGAGGCAGCAGTGGGGAATATTGCACAATGGGGGAAACCCTGATGCAG CGACGCCGCGTGAGCGAAGAAGTATTTNGGTATGTAAAGCTCTATCAGCAG GGAAGAAAATGACGGTACCTGACTAAGAAGCACCGGCTAAATACGTGCCAG CAGCCGCGGTAATACGTAGGTGCAAGCGTTATCCGGATTTACTGGGTGTAA AGGGAGCGTAGACGGTTGTGTAAGTCTGATGTGAAAGCCCGGGGCTCAACC CCGGACTGCATTGGAAACTATGTAACTAGAGTGTCGGAGAGGTAAGCGGAA TTCCTAGTGTAGCGGTGAAATGCGTAGATATTAGGAGGAACACCAGTGGCG AAGGCGGCTTACTGGACGATCACTGACGTTGAGGCTCGAAAGCGTGGGGA GCAAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGACTACTAG GTGTCGGGGAGCAAAGCTCTTCGGTGCCGCAGCAAACGCAATAAGTAGTCC ACCTGGGGAGTACGTTCGCAAGAATGAAACTCAAAGGAATTGACGGGGACC CGCACAAGCGTGGAGCATGTGGTTTAATTCGAGCAACGCGAAGACCTTACC TGGTCTTGACATCCCGGTGACCGGTCCAGTAATGGGACCTTTCCTTCGGGA CACGGTGACAGGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTG GGTTAAGTCCCGCAACGAGCGCAACCCCTATCTTCAGTAGCCAGCATTTAAG GTGGGCACTCTGGAGAGACTGCCAGGGATAACCTGGAGGAAGGTGGGGAT GACGTCAAATCATCATGCCCCTTATGACCAGGGCTACACACGTGCTACAATG GCGTAAACAAAGGGAAGCGAACCTGTGAGGGGAAGCAAATCTCAAAAATAA CGTCTCAGTTCGGATTGTAGTCTGCAACTCGACTACATGAAGCTGGAATCGC TAGTAATCGCGAATCAGCATGTCGCGGTGAATACGTTCCCGGGTCTTGTACA CACCGCCCGTCACACCATGGGAGTCAGTAACGCCCGAAGTCAGTGACCCAA CCGTAAGGAGGGAGCTGCCGAAGGTGGGACCGATAACTGGGGTGAAGTCG

TAACAAGGTAGCCGTATCGGAAGGTGCGGCTGGATCACCTCC Roseburia_inuliniv SEQ ID NO: TTGATCCTGGCTCAGGATGAACGCTGGCGGCGTGCTTAACACATGCAAGTC orans 283 GAACGAAGCACTTTTACAGATTTCTTCGGAATGAAGTTTTAGTGACTGAGTG

GCGGACGGGTGAGTAACGCGTGGGTAACCTGCCTCACACAGGGGGATAAC AGTTGGAAACGGCTGCTAATACCGCATAAGCGCACAGTACCGCATGGTACA GTGTGAAAAACTCCGGTGGTGTGAGATGGACCCGCGTCTGATTAGCTAGTT GGCAGGGCAACGGCCTACCAAGGCGACGATCAGTAGCCGACCTGAGAGGG TGACCGGCCACATTGGGACTGAGACACGGCCCAAACTCCTACGGGAGGCA GCAGTGGGGAATATTGCACAATGGGGGAAACCCTGATGCAGCGACGCCGC GTGAGCGAAGAAGTATTTCGGTATGTAAAGCTCTATCAGCAGGGAAGAAGAA ATGACGGTACCTGACTAAGAAGCACCGGCTAAATACGTGCCAGCAGCCGCG GTAATACGTATGGTGCAAGCGTTATCCGGATTTACTGGGTGTAAAGGGAGC GCAGGCGGAAGGCTAAGTCTGATGTGAAAGCCCGGGGCTCAACCCCGGTA CTGCATTGGAAACTGGTCATCTAGAGTGTCGGAGGGGTAAGTGGAATTCCTA GTGTAGCGGTGAAATGCGTAGATATTAGGAGGAACACCAGTGGCGAAGGCG GCTTACTGGACGATAACTGACGCTGAGGCTCGAAAGCGTGGGGAGCAAACA GGATTAGATACCCTGGTAGTCCACGCCGTAAACGATGAATACTAGGTGTCG GAAAGCACAGCTTTTCGGTGCCGCCGCAAACGCATTAAGTATTCCACCTGG GGAGTACGTTCGCAAGAATGAAACTCAAAGGAATTGACGGGGACCCGCACA AGCGGTGGAGCATGTGGTTTAATTCGAAGCAACGCGAAGAACCTTACCAAG TCTTGACATCCTTCTGACCGGACAGTAATGTGTCCTTTCCTTCGGGACAGAA GTGACAGGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTT AAGTCCCGCAACGAGCGCAACCCTTATCCCCAGTAGCCAGCGGTTCGGACG GGCACTCTGAGGAGACTGCCAGGGATAACCTGGAGGAAGGTGGGGATGAC GTCAAATCATCATGCCCCTTATGACTTGGGCTACACACGTGCTACAATGGCG TAAACAAAGGGAAGCGAGACCGTGAGGTGGAGCAAATCCCAAAAATAACGT CTCAGTTCGGACTGTAGTCTGCAACCCGACTACACGAAGCTGGAATCGCTA GTAATCGCAGATCAGAATGCTGCGGTGAATACGTTCCCGGGTCTTGTACACA CCGCCCGTCACACCATGGGAGTTGGAAATGCCCGAAGTCAGTGACCCAACC

GCAAGGAGGGAGCTGCGAAGGCAGGT Streptococcus_inf SEQ ID NO: GAACGGGTGAGTAACGCGTAGGTAACCTGCCTGGTAGCGGGGGATAACTAT antis 284 TGGAAACGATAGCTAATACCGCATAACAGTAGATATCGCATGATAGCTGCTT

GAAAGGTGCAATTGCACCACTACCAGATGGACCTGCGTTGTATTAGCTAGTT GGTGAGGTAACGGCTCACCAAGGCRACGATACATAGCCGACCTGAGAGGGT GATCGGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGGAGGCAG CAGTAGGGAATCTTCGGCAATGGACGGAAGTCTGACCGAGCAACGCCGCGT GAGTGAAGAAGGTTTTCGGATCGTAAAGCTCTGTTGTAAGAGAAGAACGAGT GTGAGAGTGGAAAGTTCACACTGTGACGGTATCTTACCAGAAAGGGACGGC TAACTACGTGCCAGCAGCCGCGGTAATACGTAGGTCCCGAGCGTTGTCCGG ATTTATTGGGCGTAAAGCGAGCGCAGGCGGTTAGATAAGTCTGAAGTTAAAG GCTGTGGCTTAACCATAGTACGCTTTGGAAACTGTTTAACTTGAGTGCAAGA GGGGAGAGTGGAATTCCATGTGTAGCGGTGAAATGCGTAGATATATGGAGG AACACCGGTGGCGAAAGCGGCTCTCTGGCTTGTAACTGACGCTGAGGCTCG AAAGCGTGGGGAGCAAACAGGATTAGATACCCTGGTAGTCCACGCCGTAAA CGATGAGTGCTAGGTGTTAGACCCTTTCCGGGGTTTAGTGCCGAAGCTAAC GCATTAAGCACTCCGCCTGGGGAGTACGACCGCAAGGTTGAAACTCAAAGG AATTGACGGGGGCCCGCACAAGCGGTGGAGCATGTGGTTTAATTCGAAGCA ACGCGAAGAACCTTACCAGGTCTTGACATCCCTCTGACCGCTCTAGAGATAG AGTTTTCCTTCGGGACAGAGGTGACAGGTGGTGCATGGTTGTCGTCAGCTC GTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCCTATTGTTA GTTGCCATCATTYAGTTGGGCACTCTAGCGAGACTGCCGGTAATAAACCGGA GGAAGGTGGGGATGACGTCAAATCATCATGCCCCTTATGACCTGGGCTACA CACGTGCTACAATGGTTGGTACAACGAGTCGCAAGCCGGTGACGGCAAGCT AATCTCTTAAAGCCAATCTCAGTTCGGATTGTAGGCTGCAACTCGCCTACAT GAAGTCGGAATCGCTAGTAATCGCGGATCAGCACGCCGCGGTGAATACGTT

CCCGGGCCTTGTACACACCGCCCGTCACACCACGAGAGTTTGTAAC Streptococcus_inf SEQ ID NO: TGCCTAATACATGCAAGTAGAACGCTGAAGGAGGAGCTTGCTCTTCTGGATG antis 285 AGTTGCGAACGGGTGAGTAACGCGTAGGTAACCTGCCTGGTAGCGGGGGA

TAACTATTGGAAACGATAGCTAATACCGCATAACAGTAGATATCGCATGATAG CTGCTTGAAAGGTGCAATTGCACCACTACCAGATGGACCTGCGTTGTATTAG CTAGTTGGTGAGGTAACGGCTCACCAAGGCAACGATACATAGCCGACCTGA GAGGGTGATCGGCCACACTGGGACTGAGACACGGCCCAGACTCCTACGGG AGGCAGCAGTAGGGAATCTTCGGCAATGGACGGAAGTCTGACCGAGCAACG CCGCGTGAGTGAAGAAGGTTTTCGGATCGTAAAGCTCTGTTGTAAGAGAAGA ACGAGTGTGAGAGTGGAAAGTTCACACTGTGACGGTATCTTACCAGAAAGG GACGGCTAACTACGTGCCAGCAGCCGCGGTAATACGTAGGTCCCGAGCGTT GTCCGGATTTATTGGGCGTAAAGCGAGCGCAGGCGGTTAGATAAGTCTGAA GTTAAAGGCTGTGGCTTAACCATAGTACGCTTTGGAAACTGTTTAACTTGAGT GCAAGAGGGGAGAGTGGAATTCCATGTGTAGCGGTGAAATGCGTAGATATA TGGAGGAACACCGGTGGCGAAAGCGGCTCTCTGGCTTGTAACTGACGNGA GGCTCGAAAGCGTGGGGAGCAAACAGGATTAGATACCCTGGTAGTCCACGC CGTAAACGATGAGTGCTAGGTGTTAGACCCTTTCCGGGGTTTAGTGCCGTA GCTAACGCATTAAGCACTCCGCCTGGGGAGTACGACCGCAAGGTTGAAACT CAAAGGAATTGACGGGGGCCCGCACAAGCGGTGGAGCATGTGGTTTAATTC GAAGCAACGCGAAGAACCTTACCAGGTCTTGACATCCCTCTGACCGCTCTA GAGATAGAGTTTTCCTTCGGGACAGAGGTGACAGGTGGTGCATGGTTGTCG TCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCC TATTGTTAGTTGCCATCATTCAGTTGGGCACTCTAGCGAGACTGCCGGTAAT AAACCGGAGGAAGGTGGGGATGACGTCAAATCATCATGCCCCTTATGACCT GGGCTACACACGTGCTACAATGGTTGGTACAACGAGTCGCAAGCCGGTGAC GGCAAGCTAATCTCTTAAAGCCAATCTCAGTTCGGATTGTAGGCTGCAACTC GCCTACATGAAGTCGGAATCGCTAGTAATCGCGGATCAGCACGCCGCGGTG

AATACG Streptococcus_inf SEQ ID NO: GACGAACGCTGGCGGCGTGCCTAATACATGCAAGTAGAACGCTGAAGGAGG antis 286 AGCTTGCTCTTCTGGATGAGTTGCGAACGGGTGAGTAACGCGTAGGTAACC

TGCCTGGTAGCGGGGGATAACTATTGGAAACGATAGCTAATACCGCATAACA GTAGATATCGCATGATAGCTGCTTGAAAGGTGCAATTGCACCACTACCAGAT GGACCTGCGTTGTATTAGCTAGTTGGTGAGGTAACGGCTCACCAAGGCAAC GATACATAGCCGACCTGAGAGGGTGATCGGCCACACTGGGACTGAGACACG GCCCAGACTCCTACGGGAGGCAGCAGTAGGGAATCTTCGGCAATGGACGG AAGTCTGACCGAGCAACGCCGCGTGAGTGAAGAAGGTTTTCGGATCGTAAA GCTCTGTTGTAAGAGAAGAACGAGTGTGAGAGTGGAAAGTTCACACTGTGA CGGTATCTTACCAGAAAGGGACGGCTAACTACGTGCCAGCAGCCGCGGTAA TACGTAGGTCCCGAGCGTTGTCCGGATTTATTGGGCGTAAAGCGAGCGCAG GCGGTTAGATAAGTCTGAAGTTAAAGGCTGTGGCTTAACCATAGTACGCTTT GGAAACTGTTTAACTTGAGTGCAAGAGGGGAGAGTGGAATTCCATGTGTAG CGGTGAAATGCGTAGATATATGGAGGAACACCGGTGGCGAAAGCGGCTCTC TGGCTTGTAACTGACGCTGAGGCTCGAAAGCGTGGGGAGCAAACAGGATTA GATACCCTGGTAGTCCACGCCGTAAACGATGAGTGCTAGGTGTTAGACCCTT TCCGGGGTTTAGTGCCGAAGCTAACGCATTAAGCACTCCGCCTGGGGAGTA CGACCGCAAGGTTGAAACTCAAAGGAATTGACGGGGGCCCGCACAAGCGG TGGAGCATGTGGTTTAATTCGAAGCAACGCGAAGAACCTTACCAGGTCTTGA CATCCCTCTGACCGCTCTAGAGATAGAGTTTTCCTTCGGGACAGAGGTGACA GGTGGTGCATGGTTGTCGTCAGCTCGTGTCGTGAGATGTTGGGTTAAGTCC CGCAACGAGCGCAACCCCTATTGTTAGTTGCCATCATTTAGTTGGGCACTCT AGCGAGACTGCCGGTAATAAACCGGAGGAAGGTGGGGATGACGTCAAATCA TCATGCCCCTTATGACCTGGGCTACACACGTGCTACAATGGTTGGTACAACG AGTCGCAAGCCGGTGACGGCAAGCTAATCTCTTAAAGCCAATCTCAGTTCG GATTGTAGGCTGCAACTCGCCTACATGAAGTCGGAATCGCTAGTAATCGCG GATCAGCACGCCGCGGTGAATACGTTCCCGGGCCTTGTACACACCGCCCGT CACACCACGAGAGTTTGTAACACCCGAAGTCGGTGAGGTAACCATTTGGAG

CCAGCCGCCTAAGGTGGGATAGATGATT Clostridium_sp_C SEQ ID NO: GCGATGAAGCCCTTCGGGGTGGATTAGCGGCGGACGGGTGAGTAACACGT L_6 287 GGGTAACCTGCCTTGTAGAGGGGGATAGCCTTCCGAAAGGAAGATTAATAC

CGCATAACATCTTTTTATCGCATGGTAGAAAGATCAAAGGAGCAATCCGCTA CAAGATGGACCCGCGGCGCATTAGCTAGTTGGTGAGGTAACGGCTCACCAA GGCGACGATGCGTAGCCGACCTGAGAGGGTGATCGGCCACATTGGAACTG AGACACGGTCCAGACTCCTACGGGAGGCAGCAGTGGGGAATATTGCGCAAT GGGGGAAACCCTGACGCAGCAACGCCGCGTGAATGAAGAAGGCCTTAGGG TTGTAAAGTTCTGTTTACGGGGACGATAATGACGGTACCCGTGGGGAAGCC ACGGCTAACTACGTGCCAGCAGCCGCGGTAATACGTAGGTGGCAAGCGTTG TCCGGATTTACTGGGCGTAAAGGATGCGTAGGCGGATGTTTAAGTGAGATG TGAAATACCCGGGCTCAACTTGGGTGCTGCATTTCAAACTGGACATCTAGAG TGCGGGAGAGGAAAGCGGAATTCCTAGTGTAGCGGTGAAATGCGTAGAGAT TAGGAAGAACACCAGTGGCGAAGGCGGCTTTCTGGACCGTAACTGACGCTG AGGCATGAAAGCGTGGGGAGCAAACAGGATTAGATACCCTGGTAGTCCACG CCGTAAACGATGAATACTAGGTGTAGGAGGTATCGACTCCTTCTGTGCCGCA GTTAACACAATAAGTATTCCGCCTGGGAAGTACGATCGCAAGATTAAAACTC AAAGGAATTGACGGGGGCCCGCACAAGCAGCGGAGCATGTGGTTTAATTCG AAGCAACGCGAAGAACCTTACCTAGACTTGACATCTCCTGAATTACTCTTAAT CGAGGAAGCCCTTCGGGGCAGGAAGACAGGTGGTGCATGGTTGTCGTCAG CTCGTGTCGTGAGATGTTGGGTTAAGTCCCGCAACGAGCGCAACCCTTATC ATTAGTTGCTACCATTAAGTTGAGCACTCTAGTGAGACTGCCACGGTTAACG TGGAGGAAGGTGGGGATGACGTCAAATCATCATGCCCCTTATGTCTAGGGC TACACACGTGCTACAATGGTGAATACAAATAGATGCAATACCGCGAGGTGGA GCCAAACTATAAAATTCATCCCAGTTCGGATTGCAGTCTGAAACTCGACTGC ATGAAGCCGGAGTTGCTAGTAATCGCGAATCAGCATGTCGCGGTGAATACG TTCCCGGGCCTTGTACACACCGCCCGTCACACCATGAGAGCTGGTAACACC CGAAGTTCCGTGAGGTAACCGCA

[0126] Tabela 6 - Sequências de 16S rDNA Completas das Espécies (Correlatos Positivos) Nome da Espécie Identificador de Sequência Sequência de 16S Streptococcus_mitis SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag _oralis_pneumoniae 288 gaggagcttgcttctctggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcggggga taactattggaaacgatagctaataccgcataagagtggatgttgcatgacatttgcttaaaaggtgcacttgc atcactaccagatggacctgcgttgtattagctagttggtggggtaacggctcaccaaggcgacgatacatag ccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagt agggaatcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgt aaagctctgttgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaaag ggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgta aagcgagcgcaggcggttagataagtctgaagttaaaggctgtggcttaaccatagtaggctttggaaactgt ttaacttgagtgcaagaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaaca ccggtggcgaaagcggctctctggcttgtaactgacgctgaggctcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgagtgctaggtgttagaccctttccggggtttagtgccgtagct aacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggccc gcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctg accgctctagagatagagttttccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctagcga gactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggctac acacgtgctacaatggctggtacaacgagtcgcaagccggtgacggcaagctaatctcttaaagccagtctc agttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgcg gtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtga ggtaaccgtaaggagccagccgcctaaggtgggatagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Streptococcus_mitis SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag _oralis_pneumoniae 289 gaggagcttgcttctctggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcggggga taactattggaaacgatagctaataccgcataagagtggatgttgcatgacatttgcttaaaaggtgcacttgc atcactaccagatggacctgcgttgtattagctagttggtggggtaacggctcaccaaggcgacgatacatag ccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagt agggaatcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgt aaagctctgttgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaaag ggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgta aagcgagcgcaggcggttagataagtctgaagttaaaggctgtggcttaaccatagtaggctttggaaactgt ttaacttgagtgcaagaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaaca ccggtggcgaaagcggctctctggcttgtaactgacgctgaggctcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgagtgctaggtgttagaccctttccggggtttagtgccgtagct aacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggccc gcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctg accgctctagagatagagttttccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctagcga gactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggctac acacgtgctacaatggctggtacaacgagtcgcaagccggtgacggcaagctaatctcttaaagccagtctc agttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgcg gtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtga ggtaaccgtaaggagccagccgcctaaggtgggatagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Streptococcus_mitis SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag _oralis_pneumoniae 290 gaggagcttgcttctctggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcggggga taactattggaaacgatagctaataccgcataagagtggatgttgcatgacatttgcttaaaaggtgcacttgc atcactaccagatggacctgcgttgtattagctagttggtggggtaacggctcaccaaggcgacgatacatag ccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagt agggaatcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgt aaagctctgttgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaaag ggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgta aagcgagcgcaggcggttagataagtctgaagttaaaggctgtggcttaaccatagtaggctttggaaactgt ttaacttgagtgcaagaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaaca ccggtggcgaaagcggctctctggcttgtaactgacgctgaggctcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgagtgctaggtgttagaccctttccggggtttagtgccgtagct aacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggccc gcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctg accgctctagagatagagttttccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctagcga gactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggctac acacgtgctacaatggctggtacaacgagtcgcaagccggtgacggcaagctaatctcttaaagccagtctc agttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgcg gtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtga ggtaaccgtaaggagccagccgcctaaggtgggatagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Streptococcus_mitis SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag _oralis_pneumoniae 291 gaggagcttgcttctctggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcggggga taactattggaaacgatagctaataccgcataagagtggatgttgcatgacatttgcttaaaaggtgcacttgc atcactaccagatggacctgcgttgtattagctagttggtggggtaacggctcaccaaggcgacgatacatag ccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagt agggaatcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgt aaagctctgttgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaaag ggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgta aagcgagcgcaggcggttagataagtctgaagttaaaggctgtggcttaaccatagtaggctttggaaactgt ttaacttgagtgcaagaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaaca ccggtggcgaaagcggctctctggcttgtaactgacgctgaggctcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgagtgctaggtgttagaccctttccggggtttagtgccgtagct aacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggggccc gcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccctctg accgctctagagatagagttttccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctagcga gactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggctac acacgtgctacaatggctggtacaacgagtcgcaagccggtgacggcaagctaatctcttaaagccagtctc agttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgcg gtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtga ggtaaccgtaaggagccagccgcctaaggtgggatagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 292 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttgtcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtaatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 293 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttgtcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtgatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 294 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttgtcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtaatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 295 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttatcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtaatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 296 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttgtcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtgatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 297 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttatcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttctggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtaatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_mirabilis SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 298 gagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gataactactggaaacggtggctaataccgcataatgtctacggaccaaagcaggggctcttcggaccttgc actatcggatgaacccatatgggattagctagtaggtggggtaaaggctcacctaggcgacgatctctagctg gtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaaag tactttcagcggggaggaaggtgataaggttaatacccttatcaattgacgttacccgcagaagaagcaccg gctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagc gcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggttg gctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggaggaataccg gtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggatt agataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcgaatc ctttagagatagaggagtgccttctggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcacgtaatggtgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Pediococcus_acidila SEQ ID NO: atgagagtttgatcttggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgaacttccgtt ctici 299 aattgatcaggacgtgcttgcactgaatgagattttaacacgaagtgagtggcggacgggtgagtaacacgt gggtaacctgcccagaagcaggggataacacctggaaacagatgctaataccgtataacagagaaaacc gcctggttttcttttaaaagatggctctgctatcacttctggatggacccgcggcgcattagctagttggtgaggta acggctcaccaaggcgatgatgcgtagccgacctgagagggtaatcggccacattgggactgagacacg gcccagactcctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgcc gcgtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacgtgggtgagagtaactgttca cccagtgacggtatttaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggc aagcgttatccggatttattgggcgtaaagcgagcgcaggcggtcttttaagtctaatgtgaaagccttcggctc aaccgaagaagtgcattggaaactgggagacttgagtgcagaagaggacagtggaactccatgtgtagcg gtgaaatgcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgagg ctcgaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgattactaagtgtt ggagggtttccgcccttcagtgctgcagctaacgcattaagtaatccgcctggggagtacgaccgcaaggttg aaactcaaaagaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaag aaccttaccaggtcttgacatcttctgccaacctaagagattaggcgttcccttcggggacagaatgacaggtg gtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattactagtt gccagcattcagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtcaa atcatcatgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgaaaccgcga ggtttagctaatctcttaaaaccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgc tagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatga gagtttgtaacacccaaagccggtggggtaaccttttaggagctagccgtctaaggtgggacagatgattag ggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Bifidobacterium_den SEQ ID NO: tatggagggttcgattctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacgggatcc tium 300 cgggggttcgctcccgggtgagagtggcgaacgggtgagtaatgcgtgaccgacctgccccatacaccgg aatagctcctggaaacgggtggtaatgccggatgctccggttggatgcatgtccttccgggaaagattccatc ggtatgggatggggtcgcgtcctatcagcttgatggcggggtaacggcccaccatggcttcgacgggtagcc ggcctgagagggcgaccggccacattgggactgagatacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgcgggatggaggccttcgggttgtaa accgcttttgatcgggagcaagcccttcggggtgagtgtacctttcgaataagcaccggctaactacgtgcca gcagccgcggtaatacgtagggtgcaagcgttatccggaattattgggcgtaaagggctcgtaggcggttcgt cgcgtccggtgtgaaagcccatcgcttaacggtgggtctgcgccgggtacgggcgggctggagtgcggtag gggagactggaattcccggtgtaacggtggaatgtgtagatatcgggaagaacaccaatggcgaaggcag gtctctgggccgtcactgacgctgaggagcgaaagcgtggggagcgaacaggattagataccctggtagtc cacgccgtaaacggtggatgctggatgtggggcccgttccacgggttccgtgtcggagctaacgcgttaagc atcccgcctggggagtacggccgcaaggctaaaactcaaagaaattgacgggggcccgcacaagcggc ggagcatgcggattaattcgatgcaacgcgaagaaccttacctgggcttgacatgttcccgacagccgtaga gatatggcctcccttcggggcgggttcacaggtggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgggtt aagtcccgcaacgagcgcaaccctcgccctgtgttgccagcacgtcatggtgggaactcacgggggaccg ccggggtcaactcggaggaaggtggggatgacgtcagatcatcatgccccttacgtccagggcttcacgcat gctacaatggccggtacagcgggatgcgacatggcgacatggagcggatccctgaaaaccggtctcagttc ggattggagtctgcaacccgactccatgaaggcggagtcgctagtaatcgcggatcagcaacgccgcggtg aatgcgttcccgggccttgtacacaccgcccgtcaagtcatgaaagtgggcagcacccgaagccggtggcc taaccccttgcgggatggagccgtctaaggtgaggctcgtgattgggactaagtcgtaacaaggtagccgta ccggaaggtgcggctggatcacctccttt Proteus_penneri SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtaacag 301 aagaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagagggg gagtaactactggaaacggtggctaataccgcatgacgtctacggaccaaagcaggggctcttcggacctt gcgctatcggatgaacccatatgggattagctagtaggtgaggtaaaggctcacctaggcgacgatctctag ctggtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagcagtg gggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttgtaa agtactttcagcggggaggaaggtgataaagttaatacctttatcaattgacgttacccgcagaagaagcacc ggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaag cgcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaactggtt ggctagagtcttgtagaggggggtagaattccatctgtagcggtgaaatgcgtagagatgtggaggaatacc ggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggat tagataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctggagcta acgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgc acaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagcggatc ctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaa atgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcgcgtgatggcgggaactcaaag gagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggct acacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcataaagtct gtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgct acggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtag gtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgt aggggaacctgcggttggatcacctcctt Proteus_penneri SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacgcatgcaagtcgaccggaaaca 302 gaggaaagcttgctttcttgctgacgagcggcggacgggtgagtaatgtatggggatctgcccgatagaggg gggtaactattggaaaaagggggggtaaataccgcttgacgtctacggccaaaagccggggcgcttcgga cctttcgctattggatgaacccatatgggattagctagtaggtgaggtaaaggctcacctaggcgacgatctct agctggtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagca gtggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttagggttg taaagtactttcagcggggaggaaggtgataaagttaatacctttatcaattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtcaattaagtcagatgtgaaagccccgagcttaacttgggaattgcatctgaaact ggttggctagagtcttgtagagggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggagga ataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaac aggattagataccctggtagtccacgctgtaaacgatgtcgatttagaggttgtggtcttgaaccgtggcttctgg agctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacggggg cccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagc gaatcctttagagatagaggagtgccttcgggaacgctgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcgcgtgatggcgggaactc aaaggagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggcccttacgagta gggctacacacgtgctacaatggcagatacaaagagaagcgacctcgcgagagcaagcggaactcata aagtctgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcag aatgctacggtgaatacg Lactobacillus_salivar SEQ ID NO: atgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgaaactttct ius 303 tacaccgaatgcttgcattcatcgtaagaagttgagtggcggacgggtgagtaacacgtgggtaacctgccta aaagaaggggataacacttggaaacaggtgctaataccgtatatctctaaggatcgcatgatccttagatga aagatggttctgctatcgcttttagatggacccgcggcgtattaactagttggtggggtaacggcctaccaaggt gatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaactcctacgg gaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtgaagaag gtcttcggatcgtaaaactctgttgttagagaagaacacgagtgagagtaactgttcattcgatgacggtatcta accagcaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggattta ttgggcgtaaagggaacgcaggcggtcttttaagtctgatgtgaaagccttcggcttaaccggagtagtgcatt ggaaactggaagacttgagtgcagaagaggagagtggaactccatgtgtagcggtgaaatgcgtagatat atggaagaacaccagtggcgaaagcggctctctggtctgtaactgacgctgaggttcgaaagcgtgggtag caaacaggattagataccctggtagtccacgccgtaaacgatgaatgctaggtgttggagggtttccgccctt cagtgccgcagctaacgcaataagcattccgcctggggagtacgaccgcaaggttgaaactcaaaggaat tgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtct tgacatcctttgaccacctaagagattaggnn Veillonella_dispar SEQ ID NO: ttggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagagc 304 gatggaagcttgcttctatcaatcttagtggcgaacgggtgagtaacgcgtaatcaacctgcccttcagaggg ggacaacagttggaaacgactgctaataccgcatacgatctaacctcggcatcgaggatagatgaaaggtg gcctctatttataagctatcactgaaggaggggattgcgtctgattagctagttggaggggtaacggcccacca aggcgatgatcagtagccggtctgagaggatgaacggccacattgggactgagacacggcccagactcct acgggaggcagcagtggggaatcttccgcaatggacgaaagtctgacggagcaacgccgcgtgagtgat gacggccttcgggttgtaaagctctgttaatcgggacgaaaggccttcttgcgaatagttagaaggattgacg gtaccggaatagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgt ccggaattattgggcgtaaagcgcgcgcaggcggattggtcagtctgtcttaaaagttcggggcttaaccccg tgatgggatggaaactgccaatctagagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcg tagatattaggaagaacaccagtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagc caggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgtaggaggt atcgaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacgaccgcaaggttgaaact caaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaacctt accaggtcttgacattgatggacagaactagagatagttcctcttcttcggaagccagaaaacaggtggtgca cggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttatgttgcca gcactttgggtgggaactcatgagagactgccgcagacaatgcggaggaaggcggggatgacgtcaaatc atcatgccccttatgacctgggctacacacgtactacaatgggagttaatagacggaagcaataccgcgag gtggagcaaacccgagaaacactctctcagttcggatcgtaggctgcaactcgcctacgtgaagtcggaatc gctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggaagtgcccaaagccggtggggtaaccttcgggagccagccgtctaaggtaaagtcgatgatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggattacctccttt Veillonella_dispar SEQ ID NO: ttggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagagc 305 gatggaagcttgcttctatcaatcttagtggcgaacgggtgagtaacgcgtaatcaacctgcccttcagaggg ggacaacagttggaaacgactgctaataccgcatacgatccaatctcggcatcgaggatagatgaaaggtg gcctctatttataagctatcactgaaggaggggattgcgtctgattagctagttggaggggtaacggcccacca aggcgatgatcagtagccggtctgagaggatgaacggccacattgggactgagacacggcccagactcct acgggaggcagcagtggggaatcttccgcaatggacgaaagtctgacggagcaacgccgcgtgagtgat gacggccttcgggttgtaaagctctgttaatcgggacgaaaggccttcttgcgaatagttagaaggattgacg gtaccggaatagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgt ccggaattattgggcgtaaagcgcgcgcaggcggattggtcagtctgtcttaaaagttcggggcttaaccccg tgatgggatggaaactgccaatctagagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcg tagatattaggaagaacaccagtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagc caggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgtaggaggt atcgaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacgaccgcaaggttgaaact caaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaacctt accaggtcttgacattgatggacagaactagagatagttcctcttcttcggaagccagaaaacaggtggtgca cggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttatgttgcca gcactttgggtgggaactcatgagagactgccgcagacaatgcggaggaaggcggggatgacgtcaaatc atcatgccccttatgacctgggctacacacgtactacaatgggagttaatagacggaagcaataccgcgag gtggagcaaacccgagaaacactctctcagttcggatcgtaggctgcaactcgcctacgtgaagtcggaatc gctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggaagtgcccaaagccggtggggtaaccttcgggagccagccgtctaaggtaaagtcgatgatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Veillonella_dispar SEQ ID NO: ttggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagagc 306 gatggaagcttgcttctatcaatcttagtggcgaacgggtgagtaacgcgtaatcaacctgcccttcagaggg ggacaacagttggaaacgactgctaataccgcatacgatctaacctcggcatcgaggatagatgaaaggtg gcctctatttataagctatcactgaaggaggggattgcgtctgattagctagttggaggggtaacggcccacca aggcgatgatcagtagccggtctgagaggatgaacggccacattgggactgagacacggcccagactcct acgggaggcagcagtggggaatcttccgcaatggacgaaagtctgacggagcaacgccgcgtgagtgat gacggccttcgggttgtaaagctctgttaatcgggacgaaaggccttcttgcgaatagttagaaggattgacg gtaccggaatagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgt ccggaattattgggcgtaaagcgcgcgcaggcggattggtcagtctgtcttaaaagttcggggcttaaccccg tgatgggatggaaactgccaatctagagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcg tagatattaggaagaacaccagtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagc caggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgtaggaggt atcgaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacgaccgcaaggttgaaact caaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaacctt accaggtcttgacattgatggacagaactagagatagttcctcttcttcggaagccagaaaacaggtggtgca cggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttatgttgcca gcactttgggtgggaactcatgagagactgccgcagacaatgcggaggaaggcggggatgacgtcaaatc atcatgccccttatgacctgggctacacacgtactacaatgggagttaatagacggaagcaataccgcgag gtggagcaaacccgagaaacactctctcagttcggatcgtaggctgcaactcgcctacgtgaagtcggaatc gctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggaagtgcccaaagccggtggggtaaccttcgggagccagccgtctaaggtaaagtcgatgatt ggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Rothia_dentocariosa SEQ ID NO: acggagagtttgattctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgatgaag 307 cctagcttgctaggtggattagtggcgaacgggtgagtaatacgtgagtgacctacctttgactctgggataag cctgggaaactgggtctaataccggatacgaccaatctccgcatggggtgttggtggaaagcgttatggagtg gttttagatgggctcacggcctatcagcttgttggtgaggtaatggcttaccaaggcgacgacgggtagccgg cctgagagggtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgagggatgacggccttcgggttgtaaa cctctgttagcatcgaagaagcgaaagtgacggtaggtgcagagaaagcgccggctaactacgtgccagc agccgcggtaatacgtagggcgcgagcgttgtccggaattattgggcgtaaagagcttgtaggcggttggtc gcgtctgctgtgaaaggctggggcttaaccctggttttgcagtgggtacgggctaactagagtgcagtagggg agactggaattcctggtgtagcggtggaatgcgcagatatcaggaggaacaccgatggcgaaggcaggtc tctgggctgtaactgacgctgagaagcgaaagcatggggagcgaacaggattagataccctggtagtccat gccgtaaacgttgggcactaggtgtgggggacattccacgttttccgcgccgtagctaacgcattaagtgccc cgcctggggagtacggccgcaaggctaaaactcaaagaaattgacgggggcccgcacaagcggcgga gcatgcggattaattcgatgcaacgcgaagaaccttaccaaggcttgacatatactggactgcgtcagagat ggcgtttcccttcggggctggtatacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaaccctcgttctatgttgccagcacgtgatggtggggactcataggagactgccggggt caactcggaggaaggtggggatgacgtcaaatcatcatgccccttatgtcttgggcttcacgcatgctacaat ggccggtacagagggttgcgatactgtgaggtggagctaatccctaaaagccggtctcagttcggattggggt ctgcaactcgaccccatgaagtcggagtcgctagtaatcgcagatcagcaacgctgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagtcacgaaagttggtaacacccgaagccggtggcctaaccctggtg gggggagccgtcgaaggtgggactggcgattgggactaagtcgtaacaaggtagccgtaccggaaggtg cggctggatcacctccttt Rothia_dentocariosa SEQ ID NO: acggagagtttgattctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgatgaag 308 cctagcttgctaggtggattagtggcgaacgggtgagtaatacgtgagtgacctacctttgactctgggataag cctgggaaactgggtctaataccggatacgaccaatctccgcatggggtgttggtggaaagcgttatggagtg gttttagatgggctcacggcctatcagcttgttggtgaggtaatggcttaccaaggcgacgacgggtagccgg cctgagagggtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgagggatgacggccttcgggttgtaaa cctctgttagcatcgaagaagcgaaagtgacggtaggtgcagagaaagcgccggctaactacgtgccagc agccgcggtaatacgtagggcgcgagcgttgtccggaattattgggcgtaaagagcttgtaggcggttggtc gcgtctgctgtgaaaggctggggcttaaccctggttttgcagtgggtacgggctaactagagtgcagtagggg agactggaattcctggtgtagcggtggaatgcgcagatatcaggaggaacaccgatggcgaaggcaggtc tctgggctgtaactgacgctgagaagcgaaagcatggggagcgaacaggattagataccctggtagtccat gccgtaaacgttgggcactaggtgtgggggacattccacgttttccgcgccgtagctaacgcattaagtgccc cgcctggggagtacggccgcaaggctaaaactcaaagaaattgacgggggcccgcacaagcggcgga gcatgcggattaattcgatgcaacgcgaagaaccttaccaaggcttgacatatactggactgcgtcagagat ggcgtttcccttcggggctggtatacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaaccctcgttctatgttgccagcacgtgatggtggggactcataggagactgccggggt caactcggaggaaggtggggatgacgtcaaatcatcatgccccttatgtcttgggcttcacgcatgctacaat ggccggtacagagggttgcgatactgtgaggtggagctaatccctaaaagccggtctcagttcggattggggt ctgcaactcgaccccatgaagtcggagtcgctagtaatcgcagatcagcaacgctgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagtcacgaaagttggtaacacccgaagccggtggcctaaccctggtg gggggagccgtcgaaggtgggactggcgattgggactaagtcgtaacaaggtagccgtaccggaaggtg cggctggatcacctccttt Rothia_dentocariosa SEQ ID NO: acggagagtttgattctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgatgaag 309 cctagcttgctaggtggattagtggcgaacgggtgagtaatacgtgagtgacctacctttgactctgggataag cctgggaaactgggtctaataccggatacgaccaatctccgcatggggtgttggtggaaagcgttatggagtg gttttagatgggctcacggcctatcagcttgttggtgaggtaatggcttaccaaggcgacgacgggtagccgg cctgagagggtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtggg gaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgagggatgacggccttcgggttgtaaa cctctgttagcatcgaagaagcgaaagtgacggtaggtgcagagaaagcgccggctaactacgtgccagc agccgcggtaatacgtagggcgcgagcgttgtccggaattattgggcgtaaagagcttgtaggcggttggtc gcgtctgctgtgaaaggctggggcttaaccctggttttgcagtgggtacgggctaactagagtgcagtagggg agactggaattcctggtgtagcggtggaatgcgcagatatcaggaggaacaccgatggcgaaggcaggtc tctgggctgtaactgacgctgagaagcgaaagcatggggagcgaacaggattagataccctggtagtccat gccgtaaacgttgggcactaggtgtgggggacattccacgttttccgcgccgtagctaacgcattaagtgccc cgcctggggagtacggccgcaaggctaaaactcaaagaaattgacgggggcccgcacaagcggcgga gcatgcggattaattcgatgcaacgcgaagaaccttaccaaggcttgacatatactggactgcgtcagagat ggcgtttcccttcggggctggtatacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaaccctcgttctatgttgccagcacgtgatggtggggactcataggagactgccggggt caactcggaggaaggtggggatgacgtcaaatcatcatgccccttatgtcttgggcttcacgcatgctacaat ggccggtacagagggttgcgatactgtgaggtggagctaatccctaaaagccggtctcagttcggattggggt ctgcaactcgaccccatgaagtcggagtcgctagtaatcgcagatcagcaacgctgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagtcacgaaagttggtaacacccgaagccggtggcctaaccctggtg gggggagccgtcgaaggtgggactggcgattgggactaagtcgtaacaaggtagccgtaccggaaggtg cggctggatcacctccttt Megasphaera_micro SEQ ID NO: atggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgagagcg nuciformis 310 tagagaaagcttgctttttctacaatctagtggcaaacgggtgagtaacgcgtaaacaacctgccctacggat ggggacaacagctggaaacggctgctaataccgaatacgttccgaaagtcgcatgactgtcggaagaaag gatggcctctatttataagctatcgccggaggaggggtttgcgtctgattagctagttggaggggtaacggccc accaaggcgacgatcagtagccggtctgagaggatgaacggccacattggaactgagacacggtccaga ctcctacgggaggcagcagtggggaatcttccgcaatgggcgaaagcctgacggagcaacgccgcgtga gtgaagacggccttcgggttgtaaagctctgttatacgggacgaataatcttgtggttaatacccataagaagt gacggtaccgtaagagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagc gttgtccggaattattgggcgtaaagggcgcgcaggcggcttcttaagtctgtcttaaaagtgcggggcttaac cccgtgatgggatggaaactgggaagctcagagtatcggagaggaaagcggaattcctagtgtagcggtg aaatgcgtagatattaggaggaacaccagtggcgaaagcggctttctggacgaaaactgacgctgaggcg cgaaagccaggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgt aggaggtatcgaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacggccgcaagg ttgaaactcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcga agaaccttaccaagccttgacattgatcgcaaggagtagagatactctgttcttcttcggaagacgagaaaac aggtggtgcacggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctat cttctgttaccagcacgtaacggtggggactcaggagagactgccgcagacaatgcggaggaaggcggg gatgacgtcaagtcatcatgccccttatggcttgggctacacacgtactacaatggctcttaatagagggagg cgaaggagcgatccggagcaaaccccaaaaacagagtctcagttcggattgtaggctgcaactcgcctac atgaagcaggaatcgctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacacc gcccgtcacaccacgaaagtcattcacacccgaagccggtgaggtaaccgcaaggagccagccgtcgaa ggtgggggcgatgattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctgg Veillonella_atypica SEQ ID NO: ttggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagagc 311 gatggaagcttgcttctatcaatcttagtggcgaacgggtgagtaacgcgtaatcaacctgcccttcagaggg ggacaacagttggaaacgactgctaataccgcatacgatccaatctcggcatcgagactggatgaaaggtg gcctctatttataagctatcactgaaggaggggattgcgtctgattagctagttggaggggtaacggcccacca aggcgatgatcagtagccggtctgagaggatgaacggccacattgggactgagacacggcccagactcct acgggaggcagcagtggggaatcttccgcaatggacgaaagtctgacggagcaacgccgcgtgagtgat gacggccttcgggttgtaaagctctgttaatcgggacgaatggttcttgtgcgaatagtgcgaggatttgacggt accggaatagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtcc ggaattattgggcgtaaagcgcgcgcaggcggattagttagtctgtcttaaaagttcggggcttaaccccgtga tgggatggaaactgctgatctagagtatcggagaggaaagtggaattcctagtgtagcggtgaaatgcgtag atattaggaagaacaccagtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaaagcca ggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgtaggaggtatc gaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacgaccgcaaggttgaaactca aaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaaccttac caggtcttgacattgatggacagaactagagatagttcctcttcttcggaagccagaaaacaggtggtgcacg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttatgttgccagc acttcgggtgggaactcatgagagactgccgcagacaatgcggaggaaggcggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtactacaatgggagttaatagacggaagcgaaaccgcgaggt ggagcaaacccgagaaacactctctcagttcggatcgtaggctgcaactcgcctacgtgaagtcggaatcg ctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacg aaagtcggaagtgcccaaagccggtggggtaaccttcgggagccagccgtctaaggtaaagtcgatgattg gggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Streptococcus_ther SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag mophilus 312 agaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcggggg ataactattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattg ctccactacaagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacata gccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagca gtagggaatcttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaagctctgttgtaagtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggcgggttgataagtctgaagttaaaggctggggctcaaccatagttcgctttggaaac tgtcaaacttgagtgcagaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggagga acaccggtggcgaaagcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacag gattagataccctggtagtccacgccgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccg aagctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccc gatgctatttctagagatagaaagttacttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctag cgagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggc tacacacgtgctacaatggttggtacaacgagttgcgagtcggtgacggcgagctaatctcttaaagccaatc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtg aggtaaccttttggagccagccgcctaaggtgggacagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctgggtcacctcctt Streptococcus_ther SEQ ID NO: atgaaagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaaga mophilus 313 gaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcggggga taactattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattgc tccactacaagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacatag ccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagcagt agggaatcttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcgt aaagctctgttgtaagtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaaag ggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcgta aagcgagcgcaggcggtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaactgt caaacttgagtgcagaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaac accggtggcgaaagcggctcactggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacagg attagataccctggtagtccacgccgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccgc agctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacggggg cccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccg atgctatttctagagatagaaagttacttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtcg tgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctagc gagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggct acacacgtgctacaatggttggtacaacgagttgcgagtcggtgacggcgagctaatctcttaaagccaatct cagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtg aggtaaccttttggagccagccgcctaaggtgggacagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Streptococcus_ther SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag mophilus 314 agaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcggggg ataactattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattg ctccactacaagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacata gccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagca gtagggaatcttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaagctctgttgtaagtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggcggtttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaact gtcaaacttgagtgcagaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggagga acaccggtggcgaaagcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacag gattagataccctggtagtccacgccgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccg cagctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccc gatgctatttctagagatagaaagttacttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctag cgagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggc tacacacgtgctacaatggttggtacaacgagttgcgagtcggtgacggcgagctaatctcttaaagccaatc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtg aggtaaccttttggagccagccgcctaaggtgggacagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggatcacctcctt Streptococcus_ther SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag mophilus 315 agaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcggggg ataactattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattg ctccactacaagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacata gccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagca gtagggaatcttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaagctctgttgtaagtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggcgggttgataagtctgaagttaaaggctggggctcaaccatagttcgctttggaaac tgtcaaacttgagtgcagaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggagga acaccggtggcgaaagcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacag gattagataccctggtagtccacgccgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccg cagctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccc gatgctatttctagagatagaaagttacttcggtacatcggtgacaggtggtgcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctag cgagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggc tacacacgtgctacaatggttggtacaacgagttgcgagtcggtgacggcgagctaatctcttaaagccaatc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtg aggtaaccttttggagccagccgcctaaggtgggacagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctggtcacctcctt Streptococcus_ther SEQ ID NO: aatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag mophilus 316 agaggagcttgctcttcttggatgagttgcgaacgggtgagtaacgcgtaggtaacctgccttgtagcggggg ataactattggaaacgatagctaataccgcataacaatggatgacacatgtcatttatttgaaaggggcaattg ctccactacaagatggacctgcgttgtattagctagtaggtgaggtaatggctcacctaggcgacgatacata gccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagca gtagggaatcttcggcaatgggggcaaccctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaagctctgttgtaagtcaagaacgggtgtgagagtggaaagttcacactgtgacggtagcttaccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggcgggttgataagtctgaagttaaaggctgtggctcaaccatagttcgctttggaaact gtcaaacttgagtgcagaaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggagga acaccggtggcgaaagcggctctctggtctgtaactgacgctgaggctcgaaagcgtggggagcgaacag gattagataccctggtagtccacgccgtaaacgatgagtgctaggtgttggatcctttccgggattcagtgccg cagctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccc gatgctatttctagagatagaaagttacttcggtacatcggtgacaggtgggcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattcagttgggcactctag cgagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggc tacacacgtgctacaatggttggtacaacgagttgcgagtcggtgacggcgagctaatctcttaaagccaatc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcggtg aggtaaccttttggagccagccgcctaaggtgggacagatgattggggtgaagtcgtaacaaggtagccgt atcggaaggtgcggctgggtcacctcctt Lactobacillus_anima SEQ ID NO: attgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgaaacttctt lis 317 tatcaccgagtgcttgcactcaccgataaagagttgagtggcgaacgggtgagtaacacgtgggcaacctg cccaaaagagggggataacacttggaaacaggtgctaataccgcataaccatagttaccgcatggtaacta tgtaaaaggtggctatgctaccgcttttggatgggcccgcggcgcattagctagttggtgaggtaaaggcttac caaggcaatgatgcgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaactc ctacgggaggcagcagtagggaatcttccacaatgggcgaaagcctgatggagcaacgccgcgtgggtg aagaaggtcttcggatcgtaaaaccctgttgttagagaagaaagtgcgtgagagtaactgttcacgtttcgac ggtatctaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttat ccggatttattgggcgtaaagggaacgcaggcggtcttttaagtctgatgtgaaagccttcggcttaaccgga gtagtgcattggaaactgggagacttgagtgcagaagaggagagtggaactccatgtgtagcggtgaaatg cgtagatatatggaagaacaccagtggcgaaagcggctctctggtctgtaactgacgctgaggttcgaaagc gtgggtagcaaacaggattagataccctggtagtccacgccgtaaacgatgaatgctaagtgttggagggttt ccgcccttcagtgctgcagctaacgcaataagcattccgcctggggagtacgaccgcaaggttgaaactca aaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctta ccaggtcttgacatcttctgacaatcctagagataggactttcccttcggggacagaatgacaggtggtgcatg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattgttagttgccagc attaagttgggcactctagcaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatc atgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcaagaccgcgaggttta gcaaatctcttaaagccgttctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagta atcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagtt tgtaacacccaaagccggtggggtaaccttttggagccagccgtctaaggtgggacagatgattggggtga agtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Bilophila_wadsworth SEQ ID NO: ctggagagtttgattctggctcagattgaacgctggcggcgtgcttaacacatgcaagtcgaacgtgaaagtc ia 318 cttcggggcgagtaaagtggcgcacgggtgagtaacgcgtggataatctacccttaagatggggataacgg ctggaaacggtcgctaataccgaatacgctcccgattttatcattggggggaaagatggcctctgcttgcaag ctatcgcttaaggatgagtccgcgtcccattagctagttggcggggtaacggcccaccaaggcgacgatgg gtagccggtctgagaggatgaccggccacactggaactggaacacggtccagactcctacgggaggcag cagtggggaatattgcgcaatgggcgaaagcctgacgcagcgacgccgcgtgagggatgaaggttctcgg atcgtaaacctctgtcaggggggaagaaaccccctcgtgtgaataatgcgagggcttgacggtacccccaa aggaagcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaatca ctgggcgtaaagcgcacgtaggcggcttggtaagtcaggggtgaaatcccacagcccaactgtggaactg cctttgatactgccaggcttgagtaccggagagggtggcggaattccaggtgtaggagtgaaatccgtagat atctggaggaacaccggtggcgaaggcggccacctggacggtaactgacgctgaggtgcgaaagcgtgg gtagcaaacaggattagataccctggtagtccacgctgtaaacgatgggtgctgggtgctgggatgtatgtct cggtgccgtagctaacgcgataagcaccccgcctggggagtacggtcgcaaggctgaaactcaaagaaa ttgacgggggcccgcacaagcggtggagtatgtggtttaattcgatgcaacgcgaagaaccttacccaggct tgacatctagggaacccttcggaaatgaaggggtgcccttcggggagccctaagacaggtgctgcatggct gtcgtcagctcgtgccgtgaggtgttgggttaagtcccgcaacgagcgcaacccctatcttcagttgccagca ggtaaggctgggcactctggagagaccgccccggtcaacggggaggaaggtggggacgacgtcaagtc atcatggcccttacgcctggggctacacacgtactacaatggcgcgcacaaagggtagcgagaccgcgag gtggagccaatcccaaaaaacgcgtcccagtccggattggagtctgcaactcgactccatgaagtcggaat cgctagtaattcgagatcagcatgctcgggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggttttacccgaagccggtgagctaactcgcaagaggagcagccgtctacggtagggccgatg attggggtgaagtcgtaacaaggtagccgtaggggaacctgcggctggatcacctccttt Bilophila_wadsworth SEQ ID NO: ctggagagtttgattctggctcagattgaacgctggcggcgtgcttaacacatgcaagtcgaacgtgaaagtc ia 319 cttcggggcgagtaaagtggcgcacgggtgagtaacgcgtggataatctacccttaagatggggataacgg ctggaaacggtcgctaataccgaatacgctcccgattttatcgttggggggaaagatggcctctgcttgcaag ctatcgcttaaggatgagtccgcgtcccattagctagttggcggggtaacggcccaccaaggcgacgatgg gtagccggtctgagaggatgaccggccacactggaactggaacacggtccagactcctacgggaggcag cagtggggaatattgcgcaatgggcgaaagcctgacgcagcgacgccgcgtgagggatgaaggttctcgg atcgtaaacctctgtcaggggggaagaaaccccctcgtgtgaataatgcgagggcttgacggtacccccaa aggaagcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaatca ctgggcgtaaagcgcacgtaggcggcttggtaagtcaggggtgaaatcccacagcccaactgtggaactg cctttgatactgccaggcttgagtaccggagagggtggcggaattccaggtgtaggagtgaaatccgtagat atctggaggaacaccggtggcgaaggcggccacctggacggtaactgacgctgaggtgcgaaagcgtgg gtagcaaacaggattagataccctggtagtccacgctgtaaacgatgggtgctgggtgctgggatgtatgtct cggtgccgtagctaacgcgataagcaccccgcctggggagtacggtcgcaaggctgaaactcaaagaaa ttgacgggggcccgcacaagcggtggagtatgtggtttaattcgatgcaacgcgaagaaccttacccaggct tgacatctagggaacccttcggaaatgaaggggtgcccttcggggagccctaagacaggtgctgcatggct gtcgtcagctcgtgccgtgaggtgttgggttaagtcccgcaacgagcgcaacccctatcttcagttgccagca ggtaaggctgggcactctggagagaccgccccggtcaacggggaggaaggtggggacgacgtcaagtc atcatggcccttacgcctggggctacacacgtactacaatggcgcgcacaaagggtagcgagaccgcgag gtggagccaatcccaaaaaacgcgtcccagtccggattggagtctgcaactcgactccatgaagtcggaat cgctagtaattcgagatcagcatgctcgggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggttttacccgaagccggtgagctaactcgcaagaggagcagccgtctacggtagggccgatg attggggtgaagtcgtaacaaggtagccgtaggggaacctgcggctggatcacctccttt Bilophila_wadsworth SEQ ID NO: ctggagagtttgattctggctcagattgaacgctggcggcgtgcttaacacatgcaagtcgaacgtgaaagtc ia 320 cttcggggcgagtaaagtggcgcacgggtgagtaacgcgtggataatctacccttaagatggggataacgg ctggaaacggtcgctaataccgaatacgctcccgattttatcattggggggaaagatggcctctgcttgcaag ctatcgcttaaggatgagtccgcgtcccattagctagttggcggggtaacggcccaccaaggcgacgatgg gtagccggtctgagaggatgaccggccacactggaactggaacacggtccagactcctacgggaggcag cagtggggaatattgcgcaatgggcgaaagcctgacgcagcgacgccgcgtgagggatgaaggttctcgg atcgtaaacctctgtcaggggggaagaaaccccctcgtgtgaataatgcgagggcttgacggtacccccaa aggaagcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaatca ctgggcgtaaagcgcacgtaggcggcttggtaagtcaggggtgaaatcccacagcccaactgtggaactg cctttgatactgccaggcttgagtaccggagagggtggcggaattccaggtgtaggagtgaaatccgtagat atctggaggaacaccggtggcgaaggcggccacctggacggtaactgacgctgaggtgcgaaagcgtgg gtagcaaacaggattagataccctggtagtccacgctgtaaacgatgggtgctgggtgctgggatgtatgtct cggtgccgtagctaacgcgataagcaccccgcctggggagtacggtcgcaaggctgaaactcaaagaaa ttgacgggggcccgcacaagcggtggagtatgtggtttaattcgatgcaacgcgaagaaccttacccaggct tgacatctagggaacccttcggaaatgaaggggtgcccttcggggagccctaagacaggtgctgcatggct gtcgtcagctcgtgccgtgaggtgttgggttaagtcccgcaacgagcgcaacccctatcttcagttgccagca ggtaaggctgggcactctggagagaccgccccggtcaacggggaggaaggtggggacgacgtcaagtc atcatggcccttacgcctggggctacacacgtactacaatggcgcgcacaaagggtagcgagaccgcgag gtggagccaatcccaaaaaacgcgtcccagtccggattggagtctgcaactcgactccatgaagtcggaat cgctagtaattcgagatcagcatgctcgggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggttttacccgaagccggtgagctaactcgcaagaggagcagccgtctacggtagggccgatg attggggtgaagtcgtaacaaggtagccgtaggggaacctgcggctggatcacctccttt Bilophila_wadsworth SEQ ID NO: ctggagagtttgattctggctcagattgaacgctggcggcgtgcttaacacatgcaagtcgaacgtgaaagtc ia 321 cttcggggcgagtaaagtggcgcacgggtgagtaacgcgtggataatctacccttaagatggggataacgg ctggaaacggtcgctaataccgaatacgctcccgattttatcgttggggggaaagatggcctctgcttgcaag ctatcgcttaaggatgagtccgcgtcccattagctagttggcggggtaacggcccaccaaggcgacgatgg gtagccggtctgagaggatgaccggccacactggaactggaacacggtccagactcctacgggaggcag cagtggggaatattgcgcaatgggcgaaagcctgacgcagcgacgccgcgtgagggatgaaggttctcgg atcgtaaacctctgtcaggggggaagaaaccccctcgtgtgaataatgcgagggcttgacggtacccccaa aggaagcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaatca ctgggcgtaaagcgcacgtaggcggcttggtaagtcaggggtgaaatcccacagcccaactgtggaactg cctttgatactgccaggcttgagtaccggagagggtggcggaattccaggtgtaggagtgaaatccgtagat atctggaggaacaccggtggcgaaggcggccacctggacggtaactgacgctgaggtgcgaaagcgtgg gtagcaaacaggattagataccctggtagtccacgctgtaaacgatgggtgctgggtgctgggatgtatgtct cggtgccgtagctaacgcgataagcaccccgcctggggagtacggtcgcaaggctgaaactcaaagaaa ttgacgggggcccgcacaagcggtggagtatgtggtttaattcgatgcaacgcgaagaaccttacccaggct tgacatctagggaacccttcggaaatgaaggggtgcccttcggggagccctaagacaggtgctgcatggct gtcgtcagctcgtgccgtgaggtgttgggttaagtcccgcaacgagcgcaacccctatcttcagttgccagca ggtaaggctgggcactctggagagaccgccccggtcaacggggaggaaggtggggacgacgtcaagtc atcatggcccttacgcctggggctacacacgtactacaatggcgcgcacaaagggtagcgagaccgcgag gtggagccaatcccaaaaaacgcgtcccagtccggattggagtctgcaactcgactccatgaagtcggaat cgctagtaattcgagatcagcatgctcgggtgaatgcgttcccgggccttgtacacaccgcccgtcacaccac gaaagtcggttttacccgaagccggtgagctaactcgcaagaggagcagccgtctacggtagggccgatg attggggtgaagtcgtaacaaggtagccgtaggggaacctgcggctggatcacctccttt Veillonella_parvula SEQ ID NO: ttggagagtttgatcctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgaagagc 322 gatggaagcttgcttctatcaatcttagtggcgaacgggtgagtaacgcgtaatcaacctgcccttcagaggg ggacaacagttggaaacgactgctaataccgcatacgatctaatctcggcatcgaggatagatgaaaggtg gcctctacatgtaagctatcactgaaggaggggattgcgtctgattagctagttggaggggtaacggcccacc aaggcgatgatcagtagccggtctgagaggatgaacggccacattgggactgagacacggcccagactc ctacgggaggcagcagtggggaatcttccgcaatggacgaaagtctgacggagcaacgccgcgtgagtg atgacggccttcgggttgtaaagctctgttaatcgggacgaaaggccttcttgcgaacagttagaaggattga cggtaccggaatagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtt gtccggaattattgggcgtaaagcgcgcgcaggcggatcagtcagtctgtcttaaaagttcggggcttaaccc cgtgatgggatggaaactgctgatctagagtatcggagaggaaagtggaattcctagtgtagcggtgaaatg cgtagatattaggaagaacaccagtggcgaaggcgactttctggacgaaaactgacgctgaggcgcgaa agccaggggagcgaacgggattagataccccggtagtcctggccgtaaacgatgggtactaggtgtagga ggtatcgaccccttctgtgccggagttaacgcaataagtaccccgcctggggagtacgaccgcaaggttgaa actcaaaggaattgacgggggcccgcacaagcggtggagtatgtggtttaattcgacgcaacgcgaagaa ccttaccaggtcttgacattgatggacagaactagagatagttcctcttcttcggaagccagaaaacaggtggt gcacggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccctatcttatgttg ccagcacgtaatggtgggaactcatgagagactgccgcagacaatgcggaggaaggcggggatgacgtc aaatcatcatgccccttatgacctgggctacacacgtactacaatgggagttaatagacggaagcgagatcg cgagatggagcaaacccgagaaacactctctcagttcggatcgtaggctgcaactcgcctacgtgaagtcg gaatcgctagtaatcgcaggtcagcatactgcggtgaatacgttcccgggccttgtacacaccgcccgtcac accacgaaagtcggaagtgcccaaagccggtggggtaaccttcgggagccagccgtctaaggtaaagtc gatgattggggtgaagtcgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_b SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttaca acterium_3_1_57FA 323 cggaggaagttttcggatggaatcggtataacttagtggcggacgggtgagtaacgcgtgggaaacctgcc A_CT1 ctgtaccgggggataacacttagaaataggtgctaataccgcataagcgcacggaaccgcatggttccgtgt gaaaaactccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagc gacgatcagtagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacg ggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaaga agtatttcggtatgtaaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaac tacgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgt agacggcatggcaagccagatgtgaaaacccagggctcaaccttgggattgcatttggaactgccaggctg gagtgcaggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagt ggcgaaggcggcttactggactgtaactgacgttgaggctcgaaagcgtggggagcaaacaggattagat accctggtagtccacgcggtaaacgatgattgctaggtgtaggtgggtatggacccatcggtgccgcagcta acgcaataagcaatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccg cacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccccctga atatcttgtaaaaaagagatgccttcgggacaggggagacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttattcttagtagccagcaggtaaggctgggcactct aaggagactgccggggataacccggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttgg gctacacacgtgctacaatggcgtaaacaaagggaagcgagacagtgatgtggagcaaatcccagaaat aacgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcgaatcagcat gtcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttggaaatgcccgaagt ctgtgacctaaccgaaagggaggagcagccgaaggcaggtctgataactggggtgaagtcgtaacaagg tagccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_b SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttatat acterium_3_1_57FA 324 cgaggaagttttcggatggaatcagtataacttagtggcggacgggtgagtaacgcgtgggaaacctgccct A_CT1 gtaccgggggataacacttagaaataggtgctaataccgcataagcgcacagcttcacatgaagcagtgtg aaaaactccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagcg acgatcagtagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgg gaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaagaa gtatttcggtatgtaaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaact acgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgta gacggcatggcaagccagatgtgaaaacccagggctcaaccttgggattgcatttggaactgtcaggctgg agtgcaggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagtg gcgaaggcggcttactggactgtaactgacgttgaggctcgaaagcgtggggagcaaacaggattagata ccctggtagtccacgcggtaaacgatgattgctaggtgtaggtgggtatggacccatcggtgccgcagctaa cgcaataagcaatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccgc acaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccccctgac tctcctgtaaaagagtgaggccttcgggacattggagacaggtggtgcatggttgtcgtcagctcgtgtcgtga gatgttgggttaagtcccgcaacgagcgcaacccttattcttagtagccagcaggtaaagctgggcactctaa ggagactgccggggataacccggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttgggc tacacacgtgctacaatggcgtaaacaaagggaagcgagacagtgatgtggagcaaatcccagaaataa cgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcgaatcagcatgt cgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttggaaatgcccgaagtct gtgacctaaccgaaagggaggagcagccgaaggcaggtctgataactggggtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Lachnospiraceae_b SEQ ID NO: agagagtttgatcctggctcaggatgaacgctggcggcgtgcctaacacatgcaagtcgaacgaagttaca acterium_3_1_57FA 325 cagaggaagttttcggatggaatcggtataacttagtggcggacgggtgagtaacgcgtgggaaacctgcc A_CT1 ctgtaccgggggataacacttagaaataggtgctaataccgcataagcgcacggattcacatgaagcagtgt gaaaaactccggtggtacaggatggtcccgcgtctgattagccagttggcagggtaacggcctaccaaagc gacgatcagtagccggcctgagagggtgaacggccacattgggactgagacacggcccaaactcctacg ggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgagtgaaga agtatttcggtatgtaaagctctatcagcagggaagaaaatgacggtacctgactaagaagccccggctaac tacgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaagggagcgt agacggcatggcaagccagatgtgaaaacccagggctcaaccttgggattgcatttggaactgtcaggctg gagtgcaggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacaccagt ggcgaaggcggcttactggactgtaactgacgttgaggctcgaaagcgtggggagcaaacaggattagat accctggtagtccacgcggtaaacgatgattgctaggtgtaggtgggtatggacccatcggtgccgcagcta acgcaataagcaatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccg cacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatcccaatga cgcacctgtaaagaggtgttcccttcggggcattggagacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccttattcttagtagccagcaggtaaagctgggcactcta aggagactgccggggataacccggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttggg ctacacacgtgctacaatggcgtaaacaaagggaagcgagacagtgatgtggagcaaatcccagaaata acgtctcagttcggattgtagtctgcaactcgactacatgaagctggaatcgctagtaatcgcgaatcagcatg tcgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagttggaaatgcccgaagtct gtgacctaaccgaaagggaggagcagccgaaggcaggtctgataactggggtgaagtcgtaacaaggta gccgtatcggaaggtgcggctggatcacctccttt Erysipelotrichaceae SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagcttc _bacterium_2_2_44 326 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgtccg A ggataactgctggaaacggtagctaaaaccggataggtatacagagcgcatgctcagtatattaaagcgcc catcaaggcgtgaacatggatggacctgcggcgcattagctagttggtgaggtaacggcccaccaaggcg atgatgcgtagccggcctgagagggtaaacggccacattgggactgagacacggcccaaactcctacgg gaggcagcagtagggaattttcgtcaatgggggaaaccctgaacgagcaatgccgcgtgagtgaagaag gtcttcggatcgtaaagctctgttgtaagtgaagaacggctcatagaggaaatgctatgggagtgacggtagc ttaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccgga atcattgggcgtaaagggtgcgtaggtggcgtactaagtctgtagtaaaaggcaatggctcaaccattgtaag ctatggaaactggtatgctggagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagat atatggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgaggcacgaaagcgtggg gagcaaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggaggaattcagt gctgcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgg gggcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacat ggaaacaaataccctagagatagggggataattatggatcacacaggtggtgcatggttgtcgtcagctcgt gtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtcgcatgttaccagcatcaagttggggac tcatgcgagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcc tgggctacacacgtactacaatggcgaccacaaagagcagcgacttggtgacaagaagcgaatctcataa aggtcgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagc atgctgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagtcagtaatacccgaa gccggtggcataaccgtaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaag gtatccctacgggaacgtggggatggatcacctccttt Rothia_mucilaginos SEQ ID NO: acggagagtttgattctggctcaggacgaacgctggcggcgtgcttaacacatgcaagtcgaacgatgaag a 327 cctagcttgctaggtggattagtggcgaacgggtgagtaatacgtgagtaacctacctttaactctgggataag cctgggaaactgggtctaataccggatacgaccaatctccgcatggggtgttggtggaaagcgttatgtagtg gttatagatgggctcacggcctatcagcttgttggtgaggtaacggctcaccaaggcgacgacgggtagccg gcctgagagggtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgagggatgacggccttcgggttgtaa acctctgttagcagggaagaagagaaattgacggtacctgcagagaaagcgccggctaactacgtgccag cagccgcggtaatacgtagggcgcgagcgttgtccggaattattgggcgtaaagagcttgtaggcggtttgtc gcgtctgctgtgaaaggccggggcttaactccgtgtattgcagtgggtacgggcagactagagtgcagtagg ggagactggaattcctggtgtagcggtggaatgcgcagatatcaggaggaacaccgatggcgaaggcag gtctctgggctgtaactgacgctgagaagcgaaagcatggggagcgaacaggattagataccctggtagtc catgccgtaaacgttgggcactaggtgtgggggacattccacgttttccgcgccgtagctaacgcattaagtg ccccgcctggggagtacggccgcaaggctaaaactcaaagaaattgacgggggcccgcacaagcggcg gagcatgcggattaattcgatgcaacgcgaagaaccttaccaaggcttgacatatactggaccgcatcaga gatggtgtttcccttcggggctggtatacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaa gtcccgcaacgagcgcaaccctcgttctatgttgccagcacgttatggtggggactcataggagactgccgg ggtcaactcggaggaaggtggggatgacgtcaaatcatcatgccccttatgtcttgggcttcacgcatgctac aatggccggtacagagggttgcgatactgtgaggtggagctaatccctaaaagccggtctcagttcggattg gggtctgcaactcgaccccatgaagtcggagtcgctagtaatcgcagatcagcaacgctgcggtgaatacg ttcccgggccttgtacacaccgcccgtcaagtcacgaaagttggtaacacccaaagccggtggcctaaccct tcggggagggagccgtctaaggtgggattggcgattgggactaagtcgtaacaaggtagccgtaccggaa ggtgcggctggatcacctccttt Lactobacillus_rhamn SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctgat osus 328 tattgaaaggtgcttgcatcttgatttgattttgaacgagtggcggacgggtgagcaacacgtgggtaactgcc cttagtgggggatacatttggaaacagatgctaataccgcataaatccaagaaccgcatggttcttggctgaa agatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaacggctcaccaag gcaatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaactcctac gggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtgaaga aggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgacggtat ccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccgg atttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgaggaagt gcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaatgcgta gatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaagcatg ggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggagggtttccg cccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactcaaag gaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttacca ggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgtatggttgt cgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgccagcattt agttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgcc ccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtcaagcta atctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagtaatcg cggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagtttgta acacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagggtgaa gtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_rhamn SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctgat osus 329 tattgaaaggtgcttgcatcttgatttaattttgaacgagtggcggacgggtgagtaacacgtgggtaacctgcc cttaagtgggggataacatttggaaacagatgctaataccgcataaatccaagaaccgcatggttcttggctg aaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaacggctcacca aggcaatgaatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaactcc tacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtgaa gaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgacggt atccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatcc ggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgagga agtgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaatgc gtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaagc atgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggagggttt ccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactca aaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctta ccaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgtatgg ttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgccagc atttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcat gccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtcaag ctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagtaat cgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagtttg taacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagggtg aagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Klebsiella_oxytoca SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtagcac 330 agagagcttgctctcgggtgacgagtggcggacgggtgagtaatgtctgggaaactgcccgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttagggcctc ttgccatcggatgtgcccagatgggattagcttgtaggtgaggtaacggctcacctaggcgacgatccctagc tggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagtg gggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgtaa agtactttcagcggggaggaagggagtgaggttaataaccttattcattgacgttacccgcagaagaagcac cggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaa gcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaactg gcaggctggagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgctgtaaacgatgtcgacttggaggttgttcccttgaggagtggcttccgg agctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacggggg cccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatc Clostridium_perfring SEQ ID NO: attgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgagcgatgaagtt ens 331 tccttcgggaaacggattagcggcggacgggtgagtaacacgtgggtaacctgcctcatagagtggaatag ccttccgaaaggaagattaataccgcataatgttgaaagatggcatcatcattcaaccaaaggagcaatccg ctatgagatggacccgcggcgcattagctagttggtggggtaacggcctaccaaggcgacgatgcgtagcc gacctgagagggtgatcggccacattgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggggaaaccctgatgcagcaacgccgcgtgagtgatgaaggttttcggatcgtaa agctctgtctttggggaagataatgacggtacccaaggaggaagccacggctaactacgtgccagcagcc gcggtaatacgtaggtggcgagcgttatccggatttactgggcgtaaagggagcgtaggcggatgattaagt gggatgtgaaatacccgggctcaacttgggtgctgcattccaaactggttatctagagtgcaggagaggaga gtggaattcctagtgtagcggtgaaatgcgtagagattaggaagaacaccagtggcgaaggcgactctctg gactgtaactgacgctgaggctcgaaagcgtggggagcaaacaggattagataccctggtagtccacgcc gtaaacgatgaatactaggtgtgggggtttcaacacctccgtgccgccgctaacgcattaagtattccgcctg gggagtacggtcgcaagattaaaactcaaaggaattgacggggacccgcacaagtagcggagcatgtgg tttaattcgaagcaacgcgaagaaccttacctacacttgacatcccttgcattactcttaatcgaggaaatccctt cggggacaaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaac gagcgcaacccttgtcgttagttactaccattaagttgaggactctagcgagactgcctgggttaaccaggag gaaggtggggatgacgtcaaatcatcatgccccttatgtgtagggctacacacgtgctacaatggctggtaca gagagatgcaataccgcgaggtggagccaaacttaaaaaccagtctcagttcggattgtaggctgaaactc gcctacatgaagctggagttactagtaatcgcgaatcagaatgtcgcggtgaatacgttcccgggtcttgtaca caccgcccgtcacaccatgagagttggcaatacccgaagtccgtgagctaaccgcaaggaggcagcggc cgaaggtagggtcagcgattggggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcac ctccttt Streptococcus_mitis SEQ ID NO: taatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtagaacgctgaag _oralis_pneumoniae 332 gaggagcttgcttctccggatgagttgcgaacgggtgagtaacgcgtaggtaacctgcctggtagcggggg ataactattggaaacgatagctaataccgcataacagtagatgttgcatgacatttgcttaaaaggtgcaattg catcactaccagatggacctgcgttgtattagctagttggtggggtaacggctcaccaaggcgacgatacata gccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctacgggaggcagca gtagggaatcttcggcaatggacggaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatc gtaaagctctgttgtaagagaagaacgagtgtgagagtggaaagttcacactgtgacggtatcttaccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggcggttagataagtctgaagttaaaggctgtggcttaaccatagtacgctttggaaact gtttaacttgagtgcaagaggggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaa caccggtggcgaaagcggctctctggcttgtaactgacgctgaggctcgaaagcgtggggagcaaacagg attagataccctggtagtccacgccgtaaacgatgagtgctaggtgttagaccctttccggggtttagtgccgc agctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacggggg cccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatccct ctgaccgctctagagatagagttttccttcgggacagaggtgacaggtggtgcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcatttagttgggcactctag cgagactgccggtaataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctgggc tacacacgtgctacaatggctggtacaacgagtcgcaagccggtgacggcaagctaatctcttaaagccag tctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgcc gcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgtaacacccgaagtcg gtgaggtaaccgtaaggagccagccgcctaaggtgggatagatgattggggtgaagtcgtaacaaggtag ccgtatcggaaggtgcggctggatcacctcctt Bacteroides_ovatus SEQ ID NO: cgatggataggggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacggga 333 ggcagcagtgaggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgaaggc tctatgggtcgtaaacttcttttatatgggaataaagttttccacgtgtggaattttgtatgtaccatatgaataagg atcggctaactccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaa gggagcgtaggtggattgttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgaaactggca gtcttgagtacagtagaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccg attgcgaaggcagctcactagactgtcactgacactgatgctcgaaagtgtgggtatcaaacaggattagat accctggtagtccacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaag cattaagtattccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcaca agcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcaacagaatat attggaaacagtatagccgtaaggctgttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtc ggcttaagtgccataacgagcgcaacccttatctttagttactaacaggtcatgctgaggactctagagagact gccgtcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggccccttacgtccggggctacac acgtgttacaatggggggtacagaaggcggctacctggtgacaggatgctaatcccaaaaacctctctcagt tcggatcgaagtctgcaacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtg aatacgttcccgggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaacc gcaaggagcgtcctagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtg cggctggaacacctcctt Bacteroides_ovatus SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat 334 tttagtttgcttgcaaactgaagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataact ccggaatagcctttcgaaagaaagattaataccggatagcatacgaatatcgcatgatatttttattaaagaatt tcggttatcgatggggatgcgttccattagtttgttggcggggtaacggcccaccaagactacgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgta aacttcttttatatgggaataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactcc gtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggt ggattgttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgaaactggcagtcttgagtacag tagaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggca gctcactagactgtcactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtcc acacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattcca cctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaac atgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcaacagaatatattggaaacagta tagccgtaaggctgttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccat aacgagcgcaacccttatctttagttactaacaggttatgctgaggactctagagagactgccgtcgtaagatg tgaggaaggtggggatgacgtcaaatcagcacggccccttacgtccggggctacacacgtgttacaatggg gggtacagaaggcggctacctggtgacaggatgctaatcccaaaaacctctctcagttcggatcgaagtctg caacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtgaatacgttcccggg ccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcc tagggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacct cctt Bacteroides_ovatus SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat 335 tttagtttgcttgcaaactgaagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataact ccggaatagcctttcgaaagaaagattaataccggatagcatacgaatatcgcatgatatttttattaaagaatt tcggttatcgatggggatgcgttccattagtttgttggcggggtaacggcccaccaagactacgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgaaggctctatgggtcgta aacttcttttatatgggaataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactcc gtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggt ggattgttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgaaactggcagtcttgagtacag tagaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggca gctcactagactgtcactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtcc acacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattcca cctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaac atgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcaacagaatatattggaaacagta tagccgtaaggctgttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccat aacgagcgcaacccttatctttagttactaacaggttatgctgaggactctagagagactgccgtcgtaagatg tgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatgggg ggtacagaaggcagctacacggcgacgtgatgctaatcccaaaaacctctctcagttcggatcgaagtctgc aacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggc cttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcct agggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacct cctt Bacteroides_ovatus SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat 336 tttagtttgcttgcaaactaaagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataact cggggatagcctttcgaaagaaagattaatatccgatggtatattttctccgcatggtgagaatattaaagaattt cggttatcgatggggatgcgttccattagtttgttggcggggtaacggcccaccaagaccacgatggataggg gttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtgag gaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaa cttcttttatatgggaataaagtgttccacgtgtgggattttgtatgtaccatatgaataaggatcggctaactccgt gccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtgg attgttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgaaactggcagtcttgagtacagta gaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcag ctcactagactgttactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccac acagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattccacct ggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgt ggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcaacagaatatattggaaacagtatag ccgtaaggctgttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataac gagcgcaacccttatctttagttactaacaggtcatgctgaggactctagagagactgccgtcgtaagatgtga ggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatggggggt acagaaggcggctacctggtgacaggatgctaatcccaaaaacctctctcagttcggatcgaagtctgcaac ccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgt acacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcctaggg taaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_uniform SEQ ID NO: actgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaatggacgagagtctgaa is 337 ccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacgggaataaagtgaggcac gtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcggtaatacggagga tccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtgaaagtttgcgg ctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtggtgtagcg gtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgctgatgct cgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttg cgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaa ctcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaac cttacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgca tggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttacc atcaggttatgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatc agcacggcccttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgac gtgatgctaatcccgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgct agtaatcgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatg aaagccgggggtacctgaagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaa gtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_uniform SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat is 338 gaacttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactc ggggatagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtggaactattaaagaatt tcggtcatcgatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatacgggaataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactc cgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagg cggacgcttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtaca gtagaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaagg cagcttgctggactgtaactgacgctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaactgaatgatgtggagacatg tcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgcc ataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcgagactgccgtcgtaag atgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatg gggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttcggattggagt ctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaaggagc gccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaa cacctcctt Bacteroides_uniform SEQ ID NO: actgagacacggtccaaactcctacgggaggcagcagtgaggaatattggtcaatggacgagagtctgaa is 339 ccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatacgggaataaagtgaggcac gtgtgcctttttgtatgtaccgtatgaataaggatcggctaactccgtgccagcagccgcggtaatacggagga tccgagcgttatccggatttattgggtttaaagggagcgtaggcggacgcttaagtcagttgtgaaagtttgcgg ctcaaccgtaaaattgcagttgatactgggtgtcttgagtacagtagaggcaggcggaattcgtggtgtagcg gtgaaatgcttagatatcacgaagaactccgattgcgaaggcagcttgctggactgtaactgacgctgatgct cgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgctgtttg cgatatacagtaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaa ctcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaac cttacccgggcttgaattgcaactgaatgatgtggagacatgtcagccgcaaggcagttgtgaaggtgctgca tggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatcgatagttacc atcaggttatgctggggactctgtcgagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaaatc agcacggcccttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacacggcgac gtgatgctaatcccgaaagcctctctcagttcggattggagtctgcaacccgactccatgaagctggattcgct agtaatcgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatg aaagccgggggtacctgaagtgcgtaaccgcaaggagcgccctagggtaaaactggtgattggggctaa gtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_uniform SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat is 340 gaacttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactc ggggatagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatt tcggtcatcgatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatacgggaataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactc cgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagg cggacgcttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtaca gtagaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaagg cagcttgctggactgtaactgacgctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaactgaatgatgtggagacatg tcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgcc ataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcgagactgccgtcgtaag atgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatg gggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttcggattggagt ctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaaggagc gccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaa cacctcctt Bacteroides_uniform SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat is 341 gaacttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactc ggggatagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtggaactattaaagaatt tcggtcatcgatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatacgggaataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactc cgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagg cggacgcttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtaca gtagaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaagg cagcttgctggactgtaactgacgctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaactgaatgatgtggagacatg tcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgcc ataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcgagactgccgtcgtaag atgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatg gggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttcggattggagt ctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaaggagc gccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaa cacctcctt Bacteroides_uniform SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat is 342 gaacttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactc ggggatagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatt tcggtcatcgatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatacgggaataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactc cgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagg cggacgcttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtaca gtagaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaagg cagcttgctggactgtaactgacgctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaactgaatgatgtggagacatg tcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgcc ataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcgagactgccgtcgtaag atgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatg gggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttcggattggagt ctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaaggagc gccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaa cacctcctt Bacteroides_uniform SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat is 343 gaacttagcttgctaagtttgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgatgactc ggggatagcctttcgaaagaaagattaatacccgatggcatagttcttccgcatggtagaactattaaagaatt tcggtcatcgatggggatgcgttccattaggttgttggcggggtaacggcccaccaagccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatacgggaataaagtgaggcacgtgtgcctttttgtatgtaccgtatgaataaggatcggctaactc cgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtagg cggacgcttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactgggtgtcttgagtaca gtagaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaagg cagcttgctggactgtaactgacgctgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaattgcaactgaatgatgtggagacatg tcagccgcaaggcagttgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgcc ataacgagcgcaacccttatcgatagttaccatcaggttatgctggggactctgtcgagactgccgtcgtaag atgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatg gggggtacagaaggcagctacacggcgacgtgatgctaatcccgaaagcctctctcagttcggattggagt ctgcaacccgactccatgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttccc gggccttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtgcgtaaccgcaaggagc gccctagggtaaaactggtgattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaa cacctcctt Bacteroides_vulgatu SEQ ID NO: tttgcatgtactttatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccgagcg s 344 ttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgtgaaagtttgcggctcaaccgt aaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgtggtgtagcggtgaaatgct tagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgacattgaggctcgaaagtgt gggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgctgtttgcgatatacg gcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaaagg aattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgg gcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcatggttgtcg tcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaacaggttct gctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagcacggc ccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggatgcca atcccaaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagtaatcg cgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccg ggggtacctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgtaac aaggtagccgtaccggaaggtgcggctggaacacctccttt Bacteroides_vulgatu SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat s 345 ggtcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactct tggacagccttctgaaaggaagattaatacaagatggcatcatgagttcacatgttcacatgattaaaggtatt ccggtagacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggatag gggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtg aggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgt aaacttcttttataaaggaataaagtcgggtatggatacccgtttgcatgtactttatgaataaggatcggctaac tccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtag atggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgca gttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggc agcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacggtaaacgatgaatactcgctgtttgcgatatacggcaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagatgaattacggtgaaagcc gtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgc cataacgagcgcaacccttgttgtcagttactaacaggttctgctgaggactctgacaagactgccatcgtaa gatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaat ggggggtacagagggccgctaccacgcgagtggatgccaatcccaaaaacctctctcagttcggactgga gtctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttc ccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcgagga gcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgg aacacctcctt Bacteroides_vulgatu SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat s 346 ggtcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactct tggacagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtatt ccggtaggcgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggatag gggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtg aggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgt aaacttcttttataaaggaataaagtcgggtatgtatacccgtttgcatgtactttatgaataaggatcggctaact ccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtag atggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgca gttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggc agcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacggtaaacgatgaatactcgctgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagatgaattacggtgaaagcc gtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgc cataacgagcgcaacccttgttgtcagttactaacaggttctgctgaggactctgacaagactgccatcgtaa gatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaat ggggggtacagagggccgctaccacgcgagtggatgccaatcccaaaaacctctctcagttcggactgga gtctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttc ccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcgagga gcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgg aacacctcctt Bacteroides_vulgatu SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat s 347 ggtcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactct tggacagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtatt ccggtagacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggatag gggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtg aggaatattggtcaatgggcgcaggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgt aaacttcttttataaaggaataaagtcgggtatgcatacccgtttgcatgtactttatgaataaggatcggctaac tccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtag atggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgca gttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggc agcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacggtaaacgatgaatactcgctgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagatgaattacggtgaaagcc gtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgc cataacgagcgcaacccttgttgtcagttactaacaggttccgctgaggactctgacaagactgccatcgtaa gatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaat ggggggtacagagggtcgctaccacgcgagtggatgccaatccccaaaacctctctcagttcggactggag tctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttcc cgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcgaggag cgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgga acacctcctt Bacteroides_vulgatu SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat s 348 ggtcttagcttgctaaggccgatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgtctactct tggacagccttctgaaaggaagattaatacaagatggcatcatgagtccgcatgttcacatgattaaaggtatt ccggtagacgatggggatgcgttccattagatagtaggcggggtaacggcccacctagtcttcgatggatag gggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtg aggaatattggtcaatgggcgagagcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgt aaacttcttttataaaggaataaagtcgggtatggatacccgtttgcatgtactttatgaataaggatcggctaac tccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtag atggatgtttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggatatcttgagtgca gttgaggcaggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggc agcctgctaagctgcaactgacattgaggctcgaaagtgtgggtatcaaacaggattagataccctggtagtc cacacggtaaacgatgaatactcgctgtttgcgatatacagcaagcggccaagcgaaagcgttaagtattcc acctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaa catgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcagatgaattacggtgaaagcc gtaagccgcaaggcatctgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgc cataacgagcgcaacccttgttgtcagttactaacaggttctgctgaggactctgacaagactgccatcgtaa gatgtgaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaat ggggggtacagagggccgctaccacgcgagtggatgccaatcccaaaaacctctctcagttcggactgga gtctgcaacccgactccacgaagctggattcgctagtaatcgcgcatcagccacggcgcggtgaatacgttc ccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtgcgtaaccgcgagga gcgccctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctgg aacacctcctt Bacteroides_vulgatu SEQ ID NO: ccgtttgcatgtactttatgaataaggatcggctaactccgtgccagcagccgcggtaatacggaggatccga s 349 gcgttatccggatttattgggtttaaagggagcgtagatggatgtttaagtcagttgtgaaagtttgcggctcaac cgtaaaattgcagttgatactggatatcttgagtgcagttgaggcaggcggaattcgtggtgtagcggtgaaat gcttagatatcacgaagaactccgattgcgaaggcagcctgctaagctgcaactgacattgaggctcgaaa gtgtgggtatcaaacaggattagataccctggtagtccacacggtaaacgatgaatactcgctgtttgcgatat acagcaagcggccaagcgaaagcgttaagtattccacctggggagtacgccggcaacggtgaaactcaa aggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgaggaaccttacc cgggcttaaattgcagatgaattacggtgaaagccgtaagccgcaaggcatctgtgaaggtgctgcatggtt gtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttgttgtcagttactaacag gttctgctgaggactctgacaagactgccatcgtaagatgtgaggaaggtggggatgacgtcaaatcagca cggcccttacgtccggggctacacacgtgttacaatggggggtacagagggccgctaccacgcgagtggat gccaatccccaaaacctctctcagttcggactggagtctgcaacccgactccacgaagctggattcgctagta atcgcgcatcagccacggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggag ccgggggtacctgaagtgcgtaaccgcgaggagcgccctagggtaaaactggtgactggggctaagtcgt aacaaggtagccgtaccggaaggtgcggctggaacacctccttt Eubacterium_sp_3_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttt 1_31 350 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgccc gggataactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcac cttcgggtgtgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatg atgcgtagccgacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggag gcagcagtagggaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtctt cggatcgtaaagcactgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttac cagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatca ttgggcgtaaagggtgcgtaggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgcttt ggaaactgtcgagctagagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatata tggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggag caaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggagagattcagtgct gcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggg gcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacatgg atataaatgttctagagatagaaagatagctatatatcacacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttgtcttctgttaccagcattaggttggggactcagga gagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcctgggct acacacgtactacaatggcgcctacaaagagcagcgacaccgcgaggtggagcgaatctcataaaggg cgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagcatgc tgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagttggtaatacccgaagccg gtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaaggtat ccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_3_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttt 1_31 351 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgccc gggataactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcac cttcgggtgtgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatg atgcgtagccgacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggag gcagcagtagggaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtctt cggatcgtaaagcactgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttac cagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatca ttgggcgtaaagggtgcgtaggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgcttt ggaaactgtcgagctagagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatata tggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggag caaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggagagattcagtgct gcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggg gcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacatgg atataaatgttctagagatagaaagatagctatatatcacacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttgtcttctgttaccagcattaggttggggactcagga gagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcctgggct acacacgtactacaatggcgcctacaaagagcagcgacaccgcgaggtggagcgaatctcataaaggg cgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagcatgc tgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagttggtaatacccgaagccg gtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaaggtat ccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_3_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttt 1_31 352 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgccc gggataactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcac cttcgggtgtgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatg atgcgtagccgacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggag gcagcagtagggaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtctt cggatcgtaaagcactgttgtaagtgaagaatgccatatagaggaaatgctatgtgggtgacggtagcttacc agaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcatt gggcgtaaagggtgcgtaggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttg gaaactgtcgagctagagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatat ggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggag caaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggagagattcagtgct gcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggg gcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacatgg atataaatgttctagagatagaaagatagctatatatcacacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttgtcttctgttaccagcattaggttggggactcagga gagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcctgggct acacacgtactacaatggcgcctacaaagagcagcgacaccgcgaggtgaagcgaatctcataaaggg cgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagcatgc tgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagttggtaatacccgaagccg gtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaaggtat ccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_3_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttt 1_31 353 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgccc gggataactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcac cttcgggtgtgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatg atgcgtagccgacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggag gcagcagtagggaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtctt cggatcgtaaagcactgttgtaagtgaagaatgccacatagaggaaatgctatgtgggtgacggtagcttac cagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatca ttgggcgtaaagggtgcgtaggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgcttt ggaaactgtcgagctagagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatata tggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggag caaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggagagattcagtgct gcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggg gcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacatgg atataaatgttctagagatagaaagatagctatatatcacacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttgtcttctgttaccagcattaagttggggactcagga gagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcctgggct acacacgtactacaatggcgcctacaaagagcagcgacaccgcgaggtggagcgaatctcataaaggg cgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagcatgc tgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagttggtaatacccgaagccg gtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaaggtat ccctacgggaacgtggggatggatcacctccttt Eubacterium_sp_3_ SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctggcggcatgcctaatacatgcaagtcgaacgaagtcttt 1_31 354 aggaagcttgcttccaaagagacttagtggcgaacgggtgagtaacacgtaggtaacctgcccatgtgccc gggataactgctggaaacggtagctaaaaccggataggtatgagggaggcatcttcctcatattaaagcac cttcgggtgtgaacatggatggacctgcggcgcattagctggttggtgaggtaacggcccaccaaggcgatg atgcgtagccgacctgagagggtgaacggccacattgggactgagacacggcccaaactcctacgggag gcagcagtagggaattttcgtcaatggggggaaccctgaacgagcaatgccgcgtgtgtgaagaaggtctt cggatcgtaaagcactgttgtaagtgaagaatgccatatagaggaaatgctatgtgggtgacggtagcttacc agaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatccggaatcatt gggcgtaaagggtgcgtaggtggcacgataagtctgaagtaaaaggcaacagctcaactgttgtatgctttg gaaactgtcgagctagagtgcagaagagggcgatggaattccatgtgtagcggtaaaatgcgtagatatat ggaggaacaccagtggcgaaggcggtcgcctggtctgtaactgacactgatgcacgaaagcgtggggag caaataggattagataccctagtagtccacgccgtaaacgatgagaactaagtgttggagagattcagtgct gcagttaacgcaataagttctccgcctggggagtatgcacgcaagtgtgaaactcaaaggaattgacgggg gcccgcacaagcggtggagtatgtggtttaattcgaagcaacgcgaagaaccttaccaggccttgacatgg atataaatgttctagagatagaaagatagctatatatcacacaggtggtgcatggttgtcgtcagctcgtgtcgt gagatgttgggttaagtcccgcaacgagcgcaacccttgtcttctgttaccagcattaggttggggactcagga gagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatggcctgggct acacacgtactacaatggcgcctacaaagagcagcgacaccgcgaggtggagcgaatctcataaaggg cgtctcagttcggattgaagtctgcaactcgacttcatgaagtcggaatcgctagtaatcgcagatcagcatgc tgcggtgaatacgttctcgggccttgtacacaccgcccgtcaaaccatgggagttggtaatacccgaagccg gtggcataaccgcaaggagtgagccgtcgaaggtaggaccgatgactggggttaagtcgtaacaaggtat ccctacgggaacgtggggatggatcacctccttt Morganella_morgani SEQ ID NO: ggggataactactggaaacggtagctaataccgcataatgtcttcggaccaaagcgggggacctccgggc i 355 ctcgcgccatcagatgaacccatatgggattagctagtaggtgaggtaacggcttacctaggcgacgatccc tagctggtctgagaggatgatcagccacactgggactgagacacggcccagactcctacgggaggcagc agtggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggtt gtaaagtactttcagtcgggaggaaggtgtcaaggttaataaccttggcaattgacgttaccgacagaagaa gcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggc gtaaagcgcacgcaggcggttgattgagtcagatgtgaaatccccgggcttaacccgggaattgcatctgat actggtcagctagagtcttgtagaggggggtagaattccatgtgtagcggtgaaatgcgtagagatgtggag gaataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaa acaggattagataccctggtagtccacgctgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggctt ccggagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacg ggggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacat ccagagaacttagcagagatgctttggtgccttcgggaactctgagacaggtgctgcatggctgtcgtcagct cgtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcgcgtgatggcgg gaactcaaaggagactgccggtgataaaccggaggaaggtggggatgacgtcaagtcatcatggccctta cgagtagggctacacacgtgctacaatggcgtatacaaagggaagcgaccccgcgagggcaagcggaa ctcataaagtacgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgta gatcagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgc aaaagaagtaggtagcttaacctccgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaa caaggtaaccgtaggggaacctgcggttggatcacctcctt Parabacteroides_dis SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagca tasonis 356 caggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggg gataacccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagatt catcgctgatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatgga taggggttctgagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagca gtgaggaatattggtcaatgggcgtaagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatc gtaaacctcttttataagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggcta actccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgt aggcggccttttaagtcagcggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttga gtatgtttgaggcaggcggaatgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcg aaggcagcctgccaagccatgactgacgctgatgcacgaaagcgtggggatcaaacaggattagatacc ctggtagtccacgcagtaaacgatgatcactagctgtttgcgatacagtgtaagcggcacagcgaaagcgtt aagtgatccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaag cggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggtttgaacgcattcggaccgaggt ggaaacaccttttctagcaatagccgtttgcgaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgg cttaagtgccataacgagcgcaacccttgccactagttactaacaggtaaagctgaggactctggtgggact gccagcgtaagctgcgaggaaggcggggatgacgtcaaatcagcacggcccttacatccggggcgacac acgtgttacaatggcgtggacaaagggaggccacctggcgacagggagcgaatccccaaaccacgtctc agttcggatcggagtctgcaacccgactccgtgaagctggattcgctagtaatcgcgcatcagccatggcgc ggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtccgt aaccgcgaggatcggcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaa ggtgcggctggaacacctccttt Parabacteroides_dis SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagca tasonis 357 caggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttgcctatcagagggg gataacccggcgaaagtcggactaataccgcatgaagcaggggccccgcatggggatatttgctaaagatt catcgctgatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatgga taggggttctgagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagca gtgaggaatattggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatggat cgtaaacctcttttataagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggct aactccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcg taggcggccttttaagtcagcggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttg agtatgtttgaggcaggcggaatgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgc gaaggcagcctgccaagccatgactgacgctgatgcacgaaagcgtggggatcaaacaggattagatac cctggtagtccacgcagtaaacgatgatcactagctgtttgcgatacagtgtaagcggcacagcgaaagcgt taagtgatccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaag cggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggtttgaacgcattcggaccgaggt ggaaacaccttttctagcaatagccgtttgcgaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgg cttaagtgccataacgagcgcaacccttgccactagttactaacaggtaaagctgaggactctggtgggact gccagcgtaagctgcgaggaaggcggggatgacgtcaaatcagcacggcccttacatccggggcgacac acgtgttacaatggcgtggacaaagggatgccacctggcgacagggagcgaatccccaaaccacgtctca gttcggatcggagtctgcaacccgactccgtgaagctggattcgctagtaatcgcgcatcagccatggcgcg gtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtccgta accgaaaggatcggcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaa ggtgcggctggaacacctccttt Parabacteroides_dis SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagca tasonis 358 caggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggg gataacccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagatt catcgctgatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatgga taggggttctgagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagca gtgaggaatattggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatggat cgtaaacctcttttataagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggct aactccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcg taggcggccttttaagtcagcggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttg agtatgtttgaggcaggcggaatgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgc gaaggcagcctgccaagccatgactgacgctgatgcacgaaagcgtggggatcaaacaggattagatac cctggtagtccacgcagtaaacgatgatcactagctgtttgcgatacagtgtaagcggcacagcgaaagcgt taagtgatccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaag cggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggtttgaacgcattcggaccgaggt ggaaacaccttttctagcaatagccgtttgcgaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgg cttaagtgccataacgagcgcaacccttgccactagttactaacaggtgatgctgaggactctggtgggactg ccagcgtaagctgcgaggaaggcggggatgacgtcaaatcagcacggcccttacatccggggcgacaca cgtgttacaatggcgtggacaaagggaagccacctggcgacagggagcgaatccccaaaccacgtctca gttcggatcggagtctgcaacccgactccgtgaagctggattcgctagtaatcgcgcatcagccatggcgcg gtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtccgta accgaaaggatcggcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaa ggtgcggctggaacacctccttt Parabacteroides_dis SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagcg tasonis 359 ggggtagcaatacccgccggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagaggg ggataacccggcgaaagtcggactaataccgcatgaagcaggggccccgcatggggatatttgctaaaga ttcatcgctgatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatgg ataggggttctgagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagc agtgaggaatattggtcaatgggcgcgagcctgaaccagccaagtcgcgtgagggatgaaggttctatgga tcgtaaacctcttttataagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggct aactccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcg taggcggccttttaagtcagcggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttg agtatgtttgaggcaggcggaatgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgc gaaggcagcctgccaagccatgactgacgctgatgcacgaaagcgtggggatcaaacaggattagatac cctggtagtccacgcagtaaacgatgatcactagctgtttgcgatacagtgtaagcggcacagcgaaagcgt taagtgatccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaag cggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggtttgaacgcattcggaccgaggt ggaaacaccttttctagcaatagccgtttgcgaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgg cttaagtgccataacgagcgcaacccttgccactagttactaacaggtaatgctgaggactctggtgggactg ccagcgtaagctgcgaggaaggcggggatgacgtcaaatcagcacggcccttacatccggggcgacaca cgtgttacaatggcgtggacaaagggaggccacctggcgacagggagcgaatccccaaaccacgtctca gttcggatcggagtctgcaacccgactccgtgaagctggattcgctagtaatcgcgcatcagccatggcgcg gtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtccgta accgcgaggatcggcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaag gtgcggctggaacacctccttt

Parabacteroides_dis SEQ ID NO: cgaagagtttgatcctggctcaggatgaacgctagcgacaggcttaacacatgcaagtcgaggggcagca tasonis 360 caggtagcaataccgggtggcgaccggcgcacgggtgagtaacgcgtatgcaacttacctatcagagggg gataacccggcgaaagtcggactaataccgcatgaagcaggggtcccgcatggggatatttgctaaagatt catcgctgatagataggcatgcgttccattaggcagttggcggggtaacggcccaccaaaccgacgatgga taggggttctgagaggaaggtcccccacattggtactgagacacggaccaaactcctacgggaggcagca gtgaggaatattggtcaatgggcgtaagcctgaaccagccaagtcgcgtgagggatgaaggttctatggatc gtaaacctcttttataagggaataaagtgcgggacgtgtcctgttttgtatgtaccttatgaataaggatcggcta actccgtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggtgcgt aggcggccttttaagtcagcggtgaaagtctgtggctcaaccatagaattgccgttgaaactggggggcttga gtatgtttgaggcaggcggaatgcgtggtgtagcggtgaaatgcttagatatcacgcagaaccccgattgcg aaggcagcctgccaagccatgactgacgctgatgcacgaaagcgtggggatcaaacaggattagatacc ctggtagtccacgcagtaaacgatgatcactagctgtttgcgatacagtgtaagcggcacagcgaaagcgtt aagtgatccacctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaag cggaggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggtttgaacgcattcggaccgaggt ggaaacaccttttctagcaatagccgtttgcgaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgg cttaagtgccataacgagcgcaacccttgccactagttactaacaggtaaagctgaggactctggtgggact gccagcgtaagctgcgaggaaggcggggatgacgtcaaatcagcacggcccttacatccggggcgacac acgtgttacaatggcgtggacaaagggaagccacctggcgacagggagcgaatccccaaaccacgtctc agttcggatcggagtctgcaacccgactccgtgaagctggattcgctagtaatcgcgcatcagccatggcgc ggtgaatacgttcccgggccttgtacacaccgcccgtcaagccatgggagccgggggtacctgaagtccgt aaccgcgaggatcggcctagggtaaaactggtgactggggctaagtcgtaacaaggtagccgtaccggaa ggtgcggctggaacacctccttt Citrobacter_freundii SEQ ID NO: attggagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgagcgagtccc 361 ttcgggggctagcggcggacgggtgagtaacacgtaggcaacctgcctctcagactgggataacataggg aaacttatgctaataccggataggtttttggatcgcatgatctgaaaagaaaagatggcttttcgctatcactgg gagatgggcctgcggcgcattagctagttggtggggtaacggcctaccaaggcgacgatgcgtagccgac ctgagagggtgaccggccacactgggactgagacacggcccagactcctacgggaggcagcagtaggg aattttccacaatggacgaaagtctgatggagcaacgccgcgtgaacgatgaaggtcttcggattgtaaagtt ctgttgtcagggacgaacacgtaccgttcgaatagggcggtaccttgacggtacctgacgagaaagccacg gctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccggatttattgggcgtaaagcg cgcgcaggcggctatgtaagtctggtgttaaagcccggggctcaaccccggttcgcatcggaaactgtgtag cttgagtgcagaagaggaaagcggtattccacgtgtagcggtgaaatgcgtagagatgtggaggaacacc agtggcgaaggcggctttctggtctgtaactgacgctgaggcgcgaaagcgtggggagcaaacaggatta gataccctggtagtccacgccgtaaacgatgagtgctaggtgttgggggtttcaataccctcagtgccgcagc taacgcaataagcactccgcctggggagtacgctcgcaagagtgaaactcaaaggaattgacgggggcc cgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatcccgct gaccgctctggagacagagcttcccttcggggcagcggtgacaggtggtgcatggttgtcgtcagctcgtgtc gtgagatgttgggttaagtcccgcaacgagcgcaacccttatctttagttgccagcattcagttgggcactctag agagactgccgtcgacaagacggaggaaggcggggatgacgtcaaatcatcatgccccttatgacctggg ctacacacgtgctacaatggttggtacaacgggacgctacctcgcgagaggacgccaatctcttaaaacca atctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcatgc cgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgggagtttgcaacacccgaagtc ggtgaggtaaccgcaaggagccagccgccgaaggtggggtagatgactggggtgaagtcgtaacaaggt atccgtaccggaaggtgcggatggatcacctccttt Citrobacter_freundii SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtagcac 362 agaggagcttgctccttgggtgacgagtggcggacgggtgagtaatgtctgggaaactgcccgatggaggg ggataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcct cttgccatcggatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatcccta gctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcag tggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgt aaagtactttcagcgaggaggaaggcgttgtggttaataaccgcagcgattgacgttactcgcagaagaag caccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgt aaagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcatccgaa actggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctgga ggaataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagca aacaggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggc ttccggagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgac gggggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctactcttgaca tccagagaacttagcagagatgctttggtgccttcgggaactctgagacaggtgctgcatggctgtcgtcagct cgtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggttcggccggg aactcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttac gagtagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacct cataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtgga tcagaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaa aagaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaaca aggtaaccgtaggggaacctgcggttggatcacctcctt Lactococcus_lactis SEQ ID NO: atttgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagttgagcgctgaagg 363 ttggtacttgtaccgactggatgagcagcgaacgggtgagtaacgcgtggggaatctgcctttgagcggggg acaacatttggaaacgaatgctaataccgcataaaaactttaaacacaagttttaagtttgaaagatgcaattg catcactcaaagatgatcccgcgttgtattagctagttggtgaggtaaaggctcaccaaggcgatgatacata gccgacctgagagggtgatcggccacattgggactgagacacggcccaaactcctacgggaggcagcag tagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcg taaaactctgttggtagagaagaacgttggtgagagtggaaagctcatcaagtgacggtaactacccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggtggtttattaagtctggtgtaaaaggcagtggctcaaccattgtatgcattggaaactg gtagacttgagtgcaggagaggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaa caccggtggcgaaagcggctctctggcctgtaactgacactgaggctcgaaagcgtggggagcaaacag gattagataccctggtagtccacgccgtaaacgatgagtgctagatgtagggagctataagttctctgtatcgc agctaacgcaataagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatact cgtgctattcctagagataggaagttccttcgggacacgggatacaggtggtgcatggttgtcgtcagctcgtgt cgtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattaagttgggcactcta acgagactgccggtgataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctggg ctacacacgtgctacaatggatggtacaacgagtcgcgagacagtgatgtttagctaatctcttaaaaccattc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgggagttgggagtacccgaagtaggtt gcctaaccgcaaggagggcgcttcctaaggtaagaccgatgactggggtgaagtcgtaacaaggtagccg tatcggaaggtgcggctggatcacctcctt Lactococcus_lactis SEQ ID NO: atttgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagttgagcgctgaagg 364 ttggtacttgtaccgactggatgagcagcgaacgggtgagtaacgcgtggggaatctgcctttgagcggggg acaacatttggaaacgaatgctaataccgcataaaaactttaaacacaagttttaagtttgaaagatgcaattg catcactcaaagatgatcccgcgttgtattagctagttggtgaggtaaaggctcaccaaggcgatgatacata gccgacctgagagggtgatcggccacattgggactgagacacggcccaaactcctacgggaggcagcag tagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaagaaggttttcggatcg taaaactctgttggtagagaagaacgttggtgagagtggaaagctcatcaagtgacggtaactacccagaa agggacggctaactacgtgccagcagccgcggtaatacgtaggtcccgagcgttgtccggatttattgggcg taaagcgagcgcaggtggtttattaagtctggtgtaaaaggcagtggctcaaccattgtatgcattggaaactg gtagacttgagtgcaggagaggagagtggaattccatgtgtagcggtgaaatgcgtagatatatggaggaa caccggtggcgaaagcggctctctggcctgtaactgacactgaggctcgaaagcgtggggagcaaacag gattagataccctggtagtccacgccgtaaacgatgagtgctagatgtagggagctataagttctctgtatcgc agctaacgcaataagcactccgcctggggagtacgaccgcaaggttgaaactcaaaggaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaggtcttgacatact cgtgctattcctagagataggaagttccttcgggacacgggatacaggtggtgcatggttgtcgtcagctcgtgt cgtgagatgttgggttaagtcccgcaacgagcgcaacccctattgttagttgccatcattaagttgggcactcta acgagactgccggtgataaaccggaggaaggtggggatgacgtcaaatcatcatgccccttatgacctggg ctacacacgtgctacaatggatggtacaacgagtcgcgagacagtgatgtttagctaatctcttaaaaccattc tcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcgcggatcagcacgccgc ggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgggagttgggagtacccgaagtaggtt gcctaaccgcaaggagggcgcttcctaaggtaagaccgatgactggggtgaagtcgtaacaaggtagccg tatcggaaggtgcggctggatcacctcctt Alistipes_onderdonki SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctagcggcaggcctaacacatgcaagtcgaggggcatcg i 365 ggattgaagcttgcttcaattgccggcgaccggcgcacgggtgcgtaacgcgtatgtaacctacctataaca ggggcataacactgagaaattggtactaattccccataatattcggagaggcatctctccgggttgaaaactc cggtggttatagatggacatgcgttgtattagctagttggtgaggtaacggctcaccaaggcaacgatacata gggggactgagaggttaaccccccacactggtactgagacacggaccagactcctacgggaggcagcag tgaggaatattggtcaatggacgcaagtctgaaccagccatgccgcgtgcaggaagacggctctatgagttg taaactgcttttgtacgagggtaaactcacctacgtgtaggtgactgaaagtatcgtacgaataaggatcggct aactccgtgccagcagccgcggtaatacggaggattcaagcgttatccggatttattgggtttaaagggtgcgt aggcggtttgataagttagaggtgaaatcccggggcttaactccggaactgcctctaatactgttagactaga gagtagttgcggtaggcggaatgtatggtgtagcggtgaaatgcttagagatcatacagaacaccgattgcg aaggcagcttaccaaactatatctgacgttgaggcacgaaagcgtggggagcaaacaggattagataccct ggtagtccacgcagtaaacgatgataactcgttgtcggcgatacacagtcggtgactaagcgaaagcgata agttatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacgggggcccgcacaagcgg aggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaaagttactgacgattctggaa acaggatttcccttcggggcaggaaactaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgggtt aagtcccataacgagcgcaacccctaccgttagttgccatcaggtcaagctgggcactctggcgggactgc cggtgtaagccgagaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacac gtgttacaatggtaggtacagagggtcgctaccccgcgaggggatgccaatctcgaaagcctatctcagttc ggattggaggctgaaacccgcctccatgaagttggattcgctagtaatcgcgcatcagccatggcgcggtga atacgttcccgggccttgtacacaccgcccgtcaagccatggaagctgggggtgcctgaagttcgtgaccgc aaggagcgacctagggcaaaaccggtaactggggctaagtcgtaacaaggtagccgtaccggaaggtgc ggctggaacacctccttt Alistipes_onderdonki SEQ ID NO: atggagagtttgatcctggctcaggatgaacgctagcggcaggcctaacacatgcaagtcgaggggcatcg i 366 ggattgaagcttgcttcaattgccggcgaccggcgcacgggtgcgtaacgcgtatgtaacctacctataaca ggggcataacactgagaaattggtactaattccccataatattcggagaggcatctctccgggttgaaaactc cggtggttatagatggacatgcgttgtattagctagttggtgaggtaacggctcaccaaggcaacgatacata gggggactgagaggttaaccccccacactggtactgagacacggaccagactcctacgggaggcagcag tgaggaatattggtcaatggacgcaagtctgaaccagccatgccgcgtgcaggaagacggctctatgagttg taaactgcttttgtacgagggtaaactcacctacgtgtaggtgactgaaagtatcgtacgaataaggatcggct aactccgtgccagcagccgcggtaatacggaggattcaagcgttatccggatttattgggtttaaagggtgcgt aggcggtttgataagttagaggtgaaatcccggggcttaactccggaactgcctctaatactgttagactaga gagtagttgcggtaggcggaatgtatggtgtagcggtgaaatgcttagagatcatacagaacaccgattgcg aaggcagcttaccaaactatatctgacgttgaggcacgaaagcgtggggagcaaacaggattagataccct ggtagtccacgcagtaaacgatgataactcgttgtcggcgatacacagtcggtgactaagcgaaagcgata agttatccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacgggggcccgcacaagcgg aggaacatgtggtttaattcgatgatacgcgaggaaccttacccgggcttgaaagttactgacgattctggaa acaggatttcccttcggggcaggaaactaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcgggtt aagtcccataacgagcgcaacccctaccgttagttgccatcaggtcaagctgggcactctggcgggactgc cggtgtaagccgagaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacac gtgttacaatggtaggtacagagggtcgctaccccgcgaggggatgccaatctcgaaagcctatctcagttc ggattggaggctgaaacccgcctccatgaagttggattcgctagtaatcgcgcatcagccatggcgcggtga atacgttcccgggccttgtacacaccgcccgtcaagccatggaagctgggggtgcctgaagttcgtgaccgc aaggagcgacctagggcaaaaccggtaactggggctaagtcgtaacaaggtagccgtaccggaaggtgc ggctggaacacctccttt Campylobacter_curv SEQ ID NO: atggagagtttgatcctggctcagagtgaacgctggcggcgtgcctaatacatgcaagtcgaacggacaagt us 367 aagagcttgctcttatgagttagtggcgcacgggtgagtaatgtatagctaatctgccccatagtggaggaca acagttggaaacgactgctaatactccatactccatttatatataagtataaatgggaaagtcgaaccctatat attgtttatttatcaaatacctacggcgcaaccgaaagttgcggtgtgctttaggtgggtcaagggagcgtagct ccttgtcgcaaagacggactttgttcgtctgcgaagtaaataatatatagggtttctcgctatgggatgaggctat atcgtatcagctagttggtaaggtaatggcttaccaaggctatgacgcgtaactggtctgagaggatgatcagt cacactggaactgagacacggtccagactcctacgggaggcagcagtagggaatattgctcaatggggga aaccctgaagcagcaacgccgcgtggaggatgacacttttcggagcgtaaactccttttcttggggaagaaa tttgacggtacccaaggaataagcaccggctaactccgtgccagcagccgcggtaatacggagggtgcaa gcgttactcggaatcactgggcgtaaaggacgcgtaggcggattatcaagtctcttgtgaaatccaatggctta accattgaactgcttgagaaactgataatctagagtgagggagaggtagatggaattggtggtgtaggggta aaatccgtagagatcaccaggaatacccattgcgaaggcgatctgctggaactcaactgacgctaatgcgt gaaagcgtggggagcaaacaggattagataccctggtagtccacgccctaaacgatgtatactagttgttgct gagctagtcttggcagtaatgcacctaacggattaagtataccgcctggggagtacggtcgcaagattaaaa ctcaaaggaatagacggggacccgcacaagcggtggagcatgtggtttaattcgaagatacgcgaagaa ccttacccggacttgatatctaacaaatcatctagagatagaagagtgtctgcttgcagaaatgttaagacag gtgctgcacggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccacgtca ttagttgctaacggttcggccgagcactctaatgagactgccttcgcaaggaggaggaaggtgtggacgacg tcaagtcatcatggcccttatgtccggggcgacacacgtgctacaatggcgtatacaatgagacgcaatatc gcgagatggagcaaatctataaaatacgtcccagttcggattggagtctgcaactcgactccatgaagccgg aatcgctagtaatcgtagatcagccatgctacggtgaatacgttcccgggtcttgtactcaccgcccgtcacac catgggagttgatttcactcgaagcccaaataccaaaccggttatggtccacagtggaatcagcgactgggg tgaagtcgtaacaaggtaaccgtaggagaacctgcggttggatcacctcctt Lactobacillus_ferme SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggcc ntum 368 cgattgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtagg taacctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatg aacaacgcttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaa cggcctaccaaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacgg cccatactcctacgggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccg cgtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcata cgttgacggtatttaaccagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaa gcgttatccggatttattgggcgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaa ccggagaagtgcatcggaaactggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtg gaatgcgtagatatatggaagaacaccagtggcgaaggcggctacctggtctgcaactgacgctgagactc gaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaggtgttgg agggtttccgcccttcagtgccggagctaacgcattaagcactccgcctggggagtacgaccgcaaggttga aactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaaga accttaccaggtcttgacatcttgcgccaaccctagagatagggcgtttccttcgggaacgcaatgacaggtg gtgcatggtcgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgttactagt tgccagcattaagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtca gatcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcgaactcgcg agggcaagcaaatctcttaaaaccgttctcagttcggactgcaggctgcaactcgcctgcacgaagtcggaa tcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc atgagagtttgtaacacccaaagtcggtggggtaaccttttaggagccagccgcctaaggtgggacagatg attagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Lactobacillus_ferme SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggcc ntum 369 caattgattgacggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtag gtaacctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcat gaacaacgcttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggta acggcctaccaaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacg gcccatactcctacgggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacacc gcgtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcat acgttgacggtatttaaccagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggca agcgttatccggatttattgggcgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggctta accggagaagtgcatcggaaactggataacttgagtgcagaagagggtagtggaactccatgtgtagcggt ggaatgcgtagatatatggaagaacaccagtggcgaaggcggctacctggtctgcaactgacgctgagact cgaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaggtgttg gagggtttccgcccttcagtgccggagctaacgcattaagcactccgcctggggagtacgaccgcaaggttg aaactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaag aaccttaccaggtcttgacatcttgcgccaaccctagagatagggcgtttccttcgggaacgcaatgacaggt ggtgcatggtcgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgttacta gttgccagcattaagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtc agatcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcgaactcgc gagggcaagcaaatctcttaaaaccgttctcagttcggactgcaggctgcaactcgcctgcacgaagtcgga atcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacac catgagagtttgtaacacccaaagtcggtggggtaaccttttaggagccagccgcctaaggtgggacagatg attagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Lactobacillus_ferme SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggcc ntum 370 caattgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtagg taacctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatg aacaacgcttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggtaa cggcctaccaaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacgg cccatactcctacgggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccg cgtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcata cgttgacggtatttaaccagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaa gcgttatccggatttattgggcgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaa ccggagaagtgcatcggaaactggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtg gaatgcgtagatatatggaagaacaccagtggcgaaggcggctacctggtctgcaactgacgctgagactc gaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaggtgttgg agggtttccgcccttcagtgccggagctaacgcattaagcactccgcctggggagtacgaccgcaaggttga aactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaaga accttaccaggtcttgacatcttgcgccaaccctagagatagggcgtttccttcgggaacgcaatgacaggtg gtgcatggtcgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgttactagt tgccagcattaagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtca gatcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcgaactcgcg agggcaagcaaatctcttaaaaccgttctcagttcggactgcaggctgcaactcgcctgcacgaagtcggaa tcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc atgagagtttgtaacacccaaagtcggtggggtaaccttttaggagccagccgcctaaggtgggacagatg attagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Lactobacillus_ferme SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggtc ntum 371 caattgattgacggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtag gtaacctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcat gaacaacgtttaaaagatggcttctcgctatcacttctggatggacctgcggtgcattagcttgttggtggggta atggcctaccaaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacgg cccatactcctacgggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccg cgtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcata cgttgacggtatttaaccagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaa gcgttatccggatttattgggcgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaa ccggagaagtgcatcggaaactggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtg gaatgcgtagatatatggaagaacaccagtggcgaaggcggctacctggtctgcaactgacgctgagactc gaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaggtgttgg agggtttccgcccttcagtgccggagctaacgcattaagcactccgcctggggagtacgaccgcaaggttga aactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaaga accttaccaggtcttgacatcttgcgccaaccctagagatagggcgtttccttcgggaacgcaatgacaggtg gtgcatggtcgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgttactagt tgccagcattaagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtca gatcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcaaactcgcg agggcaagcaaatctcttaaaaccgttctcagttcggactgcaggctgcaactcgcctgcacgaagtcggaa tcgctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacacc atgagagtttgtaacacccaaagtcggtggggtaaccttttaggagccagccgcctaaggtgggacagatg attagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_ferme SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgccggcggtgtgcctaatacatgcaagtcgaacgcgttggcc ntum 372 caattgattgatggtgcttgcacctgattgattttggtcgccaacgagtggcggacgggtgagtaacacgtagg taacctgcccagaagcgggggacaacatttggaaacagatgctaataccgcataacaacgttgttcgcatg aacaacgcttaaaagatggcttctcgctatcacttctggatggacctgcgctgcattagcttgttggtggggtaat ggcctaccaaggcgatgatgcatagccgagttgagagactgatcggccacaatgggactgagacacggc ccatactcctacgggaggcagcagtagggaatcttccacaatgggcgcaagcctgatggagcaacaccgc gtgagtgaagaagggtttcggctcgtaaagctctgttgttaaagaagaacacgtatgagagtaactgttcatac gttgacggtatttaaccagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaag cgttatccggatttattgggcgtaaagagagtgcaggcggttttctaagtctgatgtgaaagccttcggcttaac cggagaagtgcatcggaaactggataacttgagtgcagaagagggtagtggaactccatgtgtagcggtgg aatgcgtagatatatggaagaacaccagtggcgaaggcggctacctggtctgcaactgacgctgagactcg aaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaggtgttgga gggtttccgcccttcagtgccggagctaacgcattaagcactccgcctggggagtacgaccgcaaggttgaa actcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaagaa ccttaccaggtcttgacatcttgcgccaaccctagagatagggcgtttccttcgggaacgcaatgacaggtggt gcatggtcgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgttactagttg ccagcattaagttgggcactctagtgagactgccggtgacaaaccggaggaaggtggggacgacgtcaga tcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagtcgcgaactcgtgag ggcaagcaaatctcttaaaaccgttctcagttcggactgcaggctgcaactcgcctgcacgaagtcggaatc gctagtaatcgcggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccat gagagtttgtaacacccaaagtcggtggggtaaccttttaggagccagccgcctaaggtgggacagatgatt agggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Bacteroides_thetaiot SEQ ID NO: ctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatgggaataaagttttc aomicron 373 cacgtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcggtaatacgg aggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtgaaagttt gcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggtgta gcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactg atgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgct gtttgcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggt gaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgag gaaccttacccgggcttaaattgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagtta ctaacaggtcatgctgaggactctagagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaa atcagcacggcccttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacctggtg acaggatgctaatcccaaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattc gctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagcca tgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcctagggtaaaactggtaattggggcta agtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_thetaiot SEQ ID NO: ctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaaacttcttttatatgggaataaagttttc aomicron 374 cacgtgtggaattttgtatgtaccatatgaataaggatcggctaactccgtgccagcagccgcggtaatacgg aggatccgagcgttatccggatttattgggtttaaagggagcgtaggtggacagttaagtcagttgtgaaagttt gcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacagtagaggtgggcggaattcgtggtgta gcggtgaaatgcttagatatcacgaagaactccgattgcgaaggcagctcactggactgcaactgacactg atgctcgaaagtgtgggtatcaaacaggattagataccctggtagtccacacagtaaacgatgaatactcgct gtttgcgatatacagtaagcggccaagcgaaagcattaagtattccacctggggagtacgccggcaacggt gaaactcaaaggaattgacgggggcccgcacaagcggaggaacatgtggtttaattcgatgatacgcgag gaaccttacccgggcttaaattgcatttgaatatattggaaacagtatagccgtaaggcaaatgtgaaggtgct gcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccataacgagcgcaacccttatctttagtta ctaacaggtcatgctgaggactctagagagactgccgtcgtaagatgtgaggaaggtggggatgacgtcaa atcagcacggcccttacgtccggggctacacacgtgttacaatggggggtacagaaggcagctacctggtg acaggatgctaatcccaaaagcctctctcagttcggatcgaagtctgcaacccgacttcgtgaagctggattc gctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggccttgtacacaccgcccgtcaagcca tgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcctagggtaaaactggtaattggggcta agtcgtaacaaggtagccgtaccggaaggtgcggctggaacacctcctt Bacteroides_thetaiot SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat aomicron 375 ttcagtttgcttgcaaactggagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataac tcggggatagcctttcgaaagaaagattaatacccgatagtataattagaccgcatggtcttattattaaagaat ttcggttatcgatggggatgcgttccattaggcagttggtgaggtaacggctcaccaaaccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatggacgagagtctgaaccagccaagtagcgtgaaggatgactgccctatgggttgtaa acttcttttatatgggaataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactccg tgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggtg gacagttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacagt agaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggca gctcactggactgcaactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtcc acacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattcca cctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaac atgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcatttgaatatattggaaacagtata gccgtaaggcaaatgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccata acgagcgcaacccttatctttagttactaacaggtcatgctgaggactctagagagactgccgtcgtaagatgt gaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatgggg ggtacagaaggcagctacctggtgacaggatgctaatcccaaaagcctctctcagttcggatcgaagtctgc aacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggc cttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcct agggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacct cctt Bacteroides_thetaiot SEQ ID NO: atgaagagtttgatcctggctcaggatgaacgctagctacaggcttaacacatgcaagtcgaggggcagcat aomicron 376 ttcagtttgcttgcaaactggagatggcgaccggcgcacgggtgagtaacacgtatccaacctgccgataac tcggggatagcctttcgaaagaaagattaatacccgatggtataattagaccgcatggtcttgttattaaagaat ttcggttatcgatggggatgcgttccattaggcagttggtgaggtaacggctcaccaaaccttcgatggatagg ggttctgagaggaaggtcccccacattggaactgagacacggtccaaactcctacgggaggcagcagtga ggaatattggtcaatgggcgcaggcctgaaccagccaagtagcgtgaaggatgactgccctatgggttgta aacttcttttatatgggaataaagttttccacgtgtggaattttgtatgtaccatatgaataaggatcggctaactcc gtgccagcagccgcggtaatacggaggatccgagcgttatccggatttattgggtttaaagggagcgtaggt ggacagttaagtcagttgtgaaagtttgcggctcaaccgtaaaattgcagttgatactggctgtcttgagtacag tagaggtgggcggaattcgtggtgtagcggtgaaatgcttagatatcacgaagaactccgattgcgaaggca gctcactggactgcaactgacactgatgctcgaaagtgtgggtatcaaacaggattagataccctggtagtcc acacagtaaacgatgaatactcgctgtttgcgatatacagtaagcggccaagcgaaagcattaagtattcca cctggggagtacgccggcaacggtgaaactcaaaggaattgacgggggcccgcacaagcggaggaac atgtggtttaattcgatgatacgcgaggaaccttacccgggcttaaattgcatttgaatatattggaaacagtata gccgtaaggcaaatgtgaaggtgctgcatggttgtcgtcagctcgtgccgtgaggtgtcggcttaagtgccata acgagcgcaacccttatctttagttactaacaggtcatgctgaggactctagagagactgccgtcgtaagatgt gaggaaggtggggatgacgtcaaatcagcacggcccttacgtccggggctacacacgtgttacaatgggg ggtacagaaggcagctacctggtgacaggatgctaatcccaaaagcctctctcagttcggatcgaagtctgc aacccgacttcgtgaagctggattcgctagtaatcgcgcatcagccatggcgcggtgaatacgttcccgggc cttgtacacaccgcccgtcaagccatgaaagccgggggtacctgaagtacgtaaccgcaaggagcgtcct agggtaaaactggtaattggggctaagtcgtaacaaggtagccgtaccggaaggtgcggctggaacacct cctt Lactobacillus_gasse SEQ ID NO: atgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgagcgagcttgcc ri 377 tagatgaatttggtgcttgcaccaaatgaaactagatacaagcgagcggcggacgggtgagtaacacgtgg gtaacctgcccaagagactgggataacacctggaaacagatgctaataccggataacaacactagacgc atgtctagagtttaaaagatggttctgctatcactcttggatggacctgcggtgcattagctagttggtaaggtaa cggcttaccaaggcaatgatgcatagccgagttgagagactgatcggccacattgggactgagacacggc ccaaactcctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgc gtgagtgaagaagggtttcggctcgtaaagctctgttggtagtgaagaaagatagaggtagtaactggccttt atttgacggtaattacttagaaagtcacggctaactacgtgccagcagccgcggtaatacgtaggtggcaag cgttgtccggatttattgggcgtaaagcgagtgcaggcggttcaataagtctgatgtgaaagccttcggctcaa ccggagaattgcatcagaaactgttgaacttgagtgcagaagaggagagtggaactccatgtgtagcggtg gaatgcgtagatatatggaagaacaccagtggcgaaggcggctctctggtctgcaactgacgctgaggctc gaaagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgagtgctaagtgttgg gaggtttccgcctctcagtgctgcagctaacgcattaagcactccgcctggggagtacgaccgcaaggttga aactcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaag aaccttaccaggtcttgacatccagtgcaaacctaagagattaggagttcccttcggggacgctgagacagg tggtgcatggctgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttgtcatta gttgccatcattaagttgggcactctaatgagactgccggtgacaaaccggaggaaggtggggatgacgtc aagtcatcatgccccttatgacctgggctacacacgtgctacaatggacggtacaacgagaagcgaacctg cgaaggcaagcggatctctgaaagccgttctcagttcggactgtaggctgcaactcgcctacacgaagctgg aatcgctagtaatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcaca ccatgagagtctgtaacacccaaagccggtgggataacctttataggagtcagccgtctaaggtaggacag atgattagggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 378 tgatgatcggtgcttgcaccgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctca ccaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaact cctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtg aagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgac ggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtta tccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgag gaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaat gcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaa gcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggaggg tttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactc aaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcca gcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 379 tgatgatcggtgcttgcaccgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctca ccaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaact cctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtg aagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgac ggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtta tccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgag gaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaat gcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaa gcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggaggg tttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactc aaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcca gcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Enterococcus_faeci SEQ ID NO: tatgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgctttttcttt um 380 caccggagcttgctccaccgaaagaaaaagagtggcgaacgggtgagtaacacgtgggtaacctgccca tcagaaggggataacacttggaaacaggtgctaataccgtataacactattttccgcatggaagaaagttga aaggcgcttttgcgtcactgatggatggacccgcggtgcattagctagttggtgaggtaacggctcaccaagg caacgatgcatagccgacctgagagggtgatcggccacactgggactgagacacggcccagactcctac gggaggcagcagtagggaatcttcggcaatggacgaaagtctgaccgagcaacgccgcgtgagtgaag aaggttttcggatcgtaaaactctgttgttagagaagaacaaggatgagagtagaacgttcatcccttgacggt atctaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccg gatttattgggcgtaaagcgagcgcaggcggtttcttaagtctgatgtgaaagcccccggctcaaccgggga gggtcattggaaactgggagacttgagtgcagaagaggagagtggaattccatgtgtagcggtgaaatgcg tagatatatggaggaacaccagtggcgaaggcggctctctggtctgtaactgacgctgaggctcgaaagcgt ggggagcgaacaggattagataccctggtagtccacgccgtaaacgatgagtgctaagtgttggagggtttc cgcccttcagtgctgcagcaaacgcattaagcactccgcctggggagtacgaccgcaaggttgaaactcaa aggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttac caggtcttgacatcctttgaccactctagagatagagcttccccttcgggggcaaagtgacaggtggtgcatg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattgttagttgccatca tttagttgggcactctagcgagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcat gccccttatgacctgggctacacacgtgctacaatgggaagtacaacgagttgcgaagtcgcgaggctaag ctaatctcttaaagcttctctcagttcggattgtaggctgcaactcgcctacatgaagccggaatcgctagtaatc gcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccacgagagtttgt aacacccgaagtcggtgaggtaacctttttggagccagccgcctaaggtgggatagatgattggggtgaagt cgtaacaaggtagccgtatcggaaggtgcggctggatcacctccttt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 381 tgatgatcggtgcttgcaccgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctca ccaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaact cctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtg aagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgac ggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtta tccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgag gaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaat gcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaa gcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggaggg tttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactc aaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcca gcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 382 tgatgatcggtgcttgcaccgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaacggctc accaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaa ctcctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgag tgaagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtga cggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtt atccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccga ggaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaa atgcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcga aagcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggag ggtttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaa ctcaaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaac cttaccaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgc atggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcc agcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatca tcatgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtt aagctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctag taatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgaga gtttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattag ggtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 383 tgatgatcggtgcttgcactgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacct gcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttgg ctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctcac caaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaactc ctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtga agaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgacg gtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttatc cggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgagg aagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaatg cgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaag catgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggagggtt tccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactca aaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctta ccaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcatg gttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgccag catttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatc atgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 384 tgatgatcggtgcttgcaccgagattcaacatggaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcttg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctca ccaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaact cctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtg aagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgac ggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtta tccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgag gaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaat gcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaa gcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggaggg tttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactc aaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcca gcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Lactobacillus_casei_ SEQ ID NO: tatgagagtttgatcctggctcaggatgaacgctggcggcgtgcctaatacatgcaagtcgaacgagttctcgt paracasei 385 tgatgatcggtgcttgcaccgagattcaacatagaacgagtggcggacgggtgagtaacacgtgggtaacc tgcccttaagtgggggataacatttggaaacagatgctaataccgcatagatccaagaaccgcatggttcctg gctgaaagatggcgtaagctatcgcttttggatggacccgcggcgtattagctagttggtgaggtaatggctca ccaaggcgatgatacgtagccgaactgagaggttgatcggccacattgggactgagacacggcccaaact cctacgggaggcagcagtagggaatcttccacaatggacgcaagtctgatggagcaacgccgcgtgagtg aagaaggctttcgggtcgtaaaactctgttgttggagaagaatggtcggcagagtaactgttgtcggcgtgac ggtatccaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgtta tccggatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccctcggcttaaccgag gaagcgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaat gcgtagatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaa gcatgggtagcgaacaggattagataccctggtagtccatgccgtaaacgatgaatgctaggtgttggaggg tttccgcccttcagtgccgcagctaacgcattaagcattccgcctggggagtacgaccgcaaggttgaaactc aaaggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaacctt accaggtcttgacatcttttgatcacctgagagatcaggtttccccttcgggggcaaaatgacaggtggtgcat ggttgtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttatgactagttgcca gcatttagttgggcactctagtaagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcat catgccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgagaccgcgaggtca agctaatctcttaaagccattctcagttcggactgtaggctgcaactcgcctacacgaagtcggaatcgctagt aatcgcggatcagcacgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagag tttgtaacacccgaagccggtggcgtaacccttttagggagcgagccgtctaaggtgggacaaatgattagg gtgaagtcgtaacaaggtagccgtaggagaacctgcggctggatcacctccttt Lactobacillus_planta SEQ ID NO: tttgagagtttgatcctggctcaggacgaacgctggcggcgtgcctaatacatgcaagtcgaacgaactctgg rum 386 tattgattggtgcttgcatcatgatttacatttgagtgagtggcgaactggtgagtaacacgtgggaaacctgcc cagaagcgggggataacacctggaaacagatgctaataccgcataacaacttggaccgcatggtccgagt ttgaaagatggcttcggctatcacttctggatggtcccgcggcgtattagctagatggtggggtaacggctcac catggcaatgatacgtagccgacctgagagggtaatcggccacattgggactgagacacggcccaaactc ctacgggaggcagcagtagggaatcttccacaatggacgaaagtctgatggagcaacgccgcgtgagtga agaagggtttcggctcgtaaaactctgttgttaaagaagaacatatctgagagtaactgttcaggtattgacggt atttaaccagaaagccacggctaactacgtgccagcagccgcggtaatacgtaggtggcaagcgttgtccg gatttattgggcgtaaagcgagcgcaggcggttttttaagtctgatgtgaaagccttcggctcaaccgaagaa gtgcatcggaaactgggaaacttgagtgcagaagaggacagtggaactccatgtgtagcggtgaaatgcgt agatatatggaagaacaccagtggcgaaggcggctgtctggtctgtaactgacgctgaggctcgaaagtat gggtagcaaacaggattagataccctggtagtccataccgtaaacgatgaatgctaagtgttggagggtttcc gcccttcagtgctgcagctaacgcattaagcattccgcctggggagtacggccgcaaggctgaaactcaaa ggaattgacgggggcccgcacaagcggtggagcatgtggtttaattcgaagctacgcgaagaaccttacca ggtcttgacatactatgcaaatctaagagattagacgttcccttcggggacatggatacaggtggtgcatggtt gtcgtcagctcgtgtcgtgagatgttgggttaagtcccgcaacgagcgcaacccttattatcagttgccagcatt aagttgggcactctggtgagactgccggtgacaaaccggaggaaggtggggatgacgtcaaatcatcatg ccccttatgacctgggctacacacgtgctacaatggatggtacaacgagttgcgaactcgcgagagcaagct aatctcttaaagccattctcagttcggattgtaggctgcaactcgcctacatgaagtcggaatcgctagtaatcg cggatcagcatgccgcggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgagagtttgta acacccaaagtcggtggggtaaccttttaggaaccagccgcctaaggtgggacagatgattagggtgaagt cgtaacaaggtagccgtaggagaacctgcggctggatcacctcctt Enterobacter_cloaca SEQ ID NO: agcggcggacgggtgagtaatgtctgggaaactgcctgatggagggggataactactggaaacggtagct e 387 aataccgcataacgtcgcaagaccaaagagggggaccttcgggcctcttgccatcagatgtgcccagatgg gattagctagtaggtggggtaacggctcacctaggcgacgatccctagctggtctgagaggatgaccagcc acactggaactgagacacggtccagactcctacgggaggcagcagtggggaatattgcacaatgggcgc aagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgtaaagtactttcagcggggaggaa ggcgttgaggttaataacctcagcgattgacgttacccgcagaagaagcaccggctaactccgtgccagca gccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaagcgcacgcaggcggtctgtc aagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaactggcaggctagagtcttgtagag gggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaataccggtggcgaaggcggcc ccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaacaggattagataccctggtagtcc acgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccggagctaacgcgttaagtcgac cgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggggcccgcacaagcggtggagc atgtggtttaattcgatgcaacgcgaagaaccttacctactcttgacatccagagaactttccagagatggattg gtgccttcgggaactctgagacaggtgctgcatggctgtcgtcagctcgtgttgtgaaatgttgggttaagtccc gcaacgagcgcaacccttatcctttgttgccagcggttcggccgggaactcaaaggagactgccagtgataa actggaggaaggtggggatgacgtcaagtcatcatggcccttacgagtagggctacacacgtgctacaatg gcgcatacaaagagaagcgacctcgcgagagcaagcggacctcataaagtgcgtcgtagtccggattgg agtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcagaatgctacggtgaatacgttcc cgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaagtaggtagcttaaccttcgg gagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaaccgtaggggaacctgcgg ttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 388 gaatcagcttgctgattcgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaaccttgtagagatacgagggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtg ttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaact caaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacc agggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcat aaagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatc agaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 389 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaactc aaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacca gggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcata aagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatca gaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaa gaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaag gtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 390 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaactc aaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacca gggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcata aagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatca gaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaa gaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaag gtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 391 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaactc aaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacca gggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcata aagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatca gaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaa gaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaag gtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 392 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaactc aaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacca gggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcata aagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatca gaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaa gaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaag gtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 393 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaaccttgtagagatacgagggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtg ttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaact caaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacc agggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcat aaagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatc agaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Escherichia_coli SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgaacggtaacag 394 gaagaagcttgcttctttgctgacgagtggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagagggggaccttcgggcctc ttgccatcggatgtgcccagatgggattagctagtaggtggggtaaaggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtatgaagaaggccttcgggttgta aagtactttcagcggggaggaagggagtaaagttaatacctttgctcattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtttgttaagtcagatgtgaaatccccgggctcaacctgggaactgcatctgatactg gcaagcttgagtctcgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacgaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgacttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaagtcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaaccttgtagagatacgagggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtg ttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaact caaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacc agggctacacacgtgctacaatggcgcatacaaagagaagcgacctcgcgagagcaagcggacctcat aaagtgcgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtggatc agaatgccacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 395 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagtgggggaccttcgggcctc atgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgta aagcactttcagcggggaggaaggcggtgaggttaataacctcatcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggcttaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 396 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagtgggggaccttcgggcctc atgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgta aagcactttcagcggggaggaaggcgttaaggttaataaccttggcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 397 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataatgtcgcaagaccaaagtgggggaccttcgggcctca tgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctagc tggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagtg gggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgtaa agcactttcagcggggaggaaggcggtgaggttaataacctcatcgattgacgttacccgcagaagaagca ccggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaa agcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaact ggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagga ataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaac aggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttcc ggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacggg ggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatcc acagaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgt gttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaac tcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacc agggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctcata aagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcag aatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaaga agtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggta accgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 398 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagtgggggaccttcgggcctc atgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgta aagcactttcagcggggaggaaggcgttaaggttaataaccttggcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggttcggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 399 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataatgtcgcaagaccaaagtgggggaccttcgggcctca tgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctagc tggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagtg gggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgtaa agcactttcagcggggaggaaggcggtgaggttaataaccttggcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaacttagcagagatgctttggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 400 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagtgggggaccttcgggcctc atgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgta aagcactttcagcggggaggaaggcggtgaggttaataacctcatcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggcttaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaactttccagagatggattggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 401 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataatgtcgcaagaccaaagtgggggaccttcgggcctca tgccatcagatgtgcccagatgggattagcttgtaggtggggtaacggctcacctaggcgacgatccctagct ggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgtaaa gcactttcagcggggaggaaggcggtgaggttaataacctcatcgattgacgttacccgcagaagaagcac cggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgtaaa gcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaactg gcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggaggaa taccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaaca ggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttccg gagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgggg gcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatccac agaacttagcagagatgctttggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctcgtgtt gtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccgggaactc aaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacgacca gggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctcataa agtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagatcaga atgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaaagaa gtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaaggtaa ccgtaggggaacctgcggttggatcacctcctt Klebsiella_pneumoni SEQ ID NO: ttgaagagtttgatcatggctcagattgaacgctggcggcaggcctaacacatgcaagtcgagcggtagcac ae 402 agagagcttgctctcgggtgacgagcggcggacgggtgagtaatgtctgggaaactgcctgatggagggg gataactactggaaacggtagctaataccgcataacgtcgcaagaccaaagtgggggaccttcgggcctc atgccatcagatgtgcccagatgggattagctagtaggtggggtaacggctcacctaggcgacgatccctag ctggtctgagaggatgaccagccacactggaactgagacacggtccagactcctacgggaggcagcagt ggggaatattgcacaatgggcgcaagcctgatgcagccatgccgcgtgtgtgaagaaggccttcgggttgta aagcactttcagcggggaggaaggcgttaaggttaataacctcatcgattgacgttacccgcagaagaagc accggctaactccgtgccagcagccgcggtaatacggagggtgcaagcgttaatcggaattactgggcgta aagcgcacgcaggcggtctgtcaagtcggatgtgaaatccccgggctcaacctgggaactgcattcgaaac tggcaggctagagtcttgtagaggggggtagaattccaggtgtagcggtgaaatgcgtagagatctggagg aataccggtggcgaaggcggccccctggacaaagactgacgctcaggtgcgaaagcgtggggagcaaa caggattagataccctggtagtccacgccgtaaacgatgtcgatttggaggttgtgcccttgaggcgtggcttc cggagctaacgcgttaaatcgaccgcctggggagtacggccgcaaggttaaaactcaaatgaattgacgg gggcccgcacaagcggtggagcatgtggtttaattcgatgcaacgcgaagaaccttacctggtcttgacatc cacagaacttagcagagatgctttggtgccttcgggaactgtgagacaggtgctgcatggctgtcgtcagctc gtgttgtgaaatgttgggttaagtcccgcaacgagcgcaacccttatcctttgttgccagcggtccggccggga actcaaaggagactgccagtgataaactggaggaaggtggggatgacgtcaagtcatcatggcccttacg accagggctacacacgtgctacaatggcatatacaaagagaagcgacctcgcgagagcaagcggacctc ataaagtatgtcgtagtccggattggagtctgcaactcgactccatgaagtcggaatcgctagtaatcgtagat cagaatgctacggtgaatacgttcccgggccttgtacacaccgcccgtcacaccatgggagtgggttgcaaa agaagtaggtagcttaaccttcgggagggcgcttaccactttgtgattcatgactggggtgaagtcgtaacaa ggtaaccgtaggggaacctgcggttggatcacctcctt Fusobacterium_nucl SEQ ID NO: gctcaccaaggcgatgatgggtagccggcctgagagggtgatcggccacaaggggactgagacacggc eatum 403 ccttactcctacgggaggcagcagtggggaatattggacaatggaccaagagtctgatccagcaattctgtgt gcacgatgaagtttttcggaatgtaaagtgctttcagttgggaagaaaaaaatgacggtaccaacagaaga agtgacggctaaatacgtgccagcagccgcggtaatacgtatgtcacaagcgttatccggatttattgggcgt aaagcgcgtctaggtggttatgtaagtctgatgtgaaaatgcagggctcaactctgtattgcgttggaaactgtg taactagagtactggagaggtaagcggaactacaagtgtagaggtgaaattcgtagatatttgtaggaatgc cgatggggaagccagcttactggacagatactgacgctgaagcgcgaaagcgtgggtagcaaacaggat tagataccctggtagtccacgccgtaaacgatgattactaggtgttgggggtcgaacctcagcgcccaagca aacgcgataagtaatccgcctggggagtacgtacgcaagtatgaaactcaaaggaattgacggggacccg cacaagcggtggagcatgtggtttaattcgacgcaacgcgaggaaccttaccagcgtttgacatcttaggaat gagacagagatgtttcagtgtcccttcggggaaacctaaagacaggtggtgcatggctgtcgtcagctcgtgt cgtgagatgttgggttaagtcccgcaacgagcgcaacccctttcgtatgttaccatcattaagttggggactcat gcgatactgcctgcgatgagcaggaggaaggtggggatgacgtcaagtcatcatgccccttatacgctggg ctacacacgtgctacaatgggtagtacagagagtcgcaaagccgtgaggtggagctaatctcagaaaacta ttcttagttcggattgtactctgcaactcgagtacatgaagttggaatcgctagtaatcgcgaatcagcaatgtcg cggtgaatacgttctcgggtcttgtacacaccgcccgtcacaccacgagagttggttgcacctgaagtagcag gcctaaccgtaaggagggatgctccgagggtgtgattagcgattggggtgaagtcgtaacaaggtatccgta cgggaacgtgcggatggatcacctcctt Butyrivibrio_sp.

SEQ ID NO: ttgagagtttgatcctggctcaggatgaacgctggcggcgtgcttaacacatgcaagtcgaacggacggattg 404 gagcttgctccatgaagttagtggcggacgggtgagtaacgcgtgggtaacctgccctatgcagggggata acgtttggaaacgaacgctaataccgcataacctagttggttcgcatgaaccgactagcaaagattttatcgg cataggatggacccgcgttggattagctagttggtgagataacagcccaccaaggcaacgatccatagccg gcctgagagggtgaacggccacactgggactgagacacggcccagactcctacgggaggcagcagtgg ggaatattgcacaatgggcgcaagcctgatgcagcgacgccgcgtgaaggatgaaggtcttcggatcgtaa acttctatcagcagggaagaaaccatgacggtacctgactaagaagccccggctaactacgtgccagcag ccgcggtaatacgtagggggcaagcgttatccggaattactgggtgtaaagggtgcgtaggcggcgatttaa gtcagatgtgaaaactcagggctcaaccttgagactgcatctgaaactgagttgctagagtgcaggagagg aaagcggaattccgagtgtagcggtgaaatgcgtagagattcggaggaacaccagtagcgaaggcggctt tctggactgtaactgacgctgaggcacgaaagcgtggggagcgaacaggattagataccctggtagtccac gccgtaaacgatgaatactaggtgtcggggcttacgggtctcggtgccgcagctaacgcattaagtattccac ctgggaagtacgaccgcaaggttgaaactcaaaggaattgacggggacccgcacaagcggtggagcatg tggtttaattcgaagcaacgcgaagaaccttacctaaacttgacatccctttgaccggtccttaatcggatcttta ctagcttgctagtacaaaggtgacaggtggtgcatggttgtcgtcagctcgtgtcgtgagatgttgggttaagtc ccgcaacgagcgcaacccctatctttagtagccatcattcagttgggcactctagagagactgccagggata acctggaggaaggtggggatgacgtcaaatcatcatgccccttatgtttagggctacacacgtgctacaatgg gtgctacaaagggaagcaaatccgcgaggccgagcaaatctcaaaaaagcactcccagttcggattgtag tctgcaactcgactacatgaagttggaatcgctagtaatcgcgaatcagaatgtcgcggtgaatacgttcccg ggtcttgtacacaccgcccgtcacaccatgggagttgggggggcccaacgccagtgacctaacccgcaag ggaaggagctgtctaaggcaaaaccaatgactggggtgaagtcgtaacaaggtagccgtatcggaaggtg cggctggatcacctccttt Ruminococcus_obe SEQ ID NO: cctacgggaggcagcagtggggaatattgcacaatgggggaaaccctgatgcagcgacgccgcgtgaag um 405 gaagaagtatctcggtatgtaaacttctatcagcagggaagatagtgacggtacctgactaagaagccccg gctaactacgtgccagcagccgcggtaatacgtagggggcaagcgttatccggatttactgggtgtaaaggg agcgtagacggactggcaagtctgatgtgaaaggcgggggctcaacccctggactgcattggaaactgtta gtcttgagtgccggagaggtaagcggaattcctagtgtagcggtgaaatgcgtagatattaggaggaacacc agtggcgaaggcggcttactggacggtaactgacgttgaggctcgaaagcgtggggagcaaacaggatta gataccctggtagtccacgccgtaaacgatgaatactaggtgttggggagcaaagctcttcggtgccgccgc aaacgcattaagtattccacctggggagtacgttcgcaagaatgaaactcaaaggaattgacggggacccg cacaagcggtggagcatgtggtttaattcgaagcaacgcgaagaaccttaccaagtcttgacatccctctga ccgactcttaaccgagtctttccttcgggacagaggagacaggtggtgcatggttgtcgtcagctcgtgtcgtg agatgttgggttaagtcccgcaacgagcgcaacccctatccccagtagccagcggttcggccgggcactct gaggagactgccagggataacctggaggaaggcggggatgacgtcaaatcatcatgccccttatgatttgg gctacacacgtgctacaatggcgtaaacaaagggaagcaagcctgcgaaggtaagcaaatcccaaaaat aacgtcccagttcggactgcagtctgcaactcgactgcacgaagctggaatcgctagtaatcgcggatcaga atgccgcggtgaatacgttcccgggtcttgtacacaccgcccgtcacaccatgggagtcagtaacgcccga agtcagtgacctaaccgcaagggaggagctgccgaaggcgggaccgatgactggggtgaagtcgtaaca aggtagccgtatcggaaggtgcggctggatcacctccttt Exemplo 3: Estudos em Humanos - Colite Ulcerativa

[0127] Os sujeitos humanos com colite ulcerativa leve a moderada receberam apenas placebo (Braço A), doses semanais de esporos enriquecidos e purificados, preparadas a partir das fezes de humanos saudáveis e examinados (Braço B), um curso curto de vancomicina seguido pela administração semanal dos esporos (Braço D), ou um curso curto de vancomicina, seguido pela administração diária dos esporos (Braço C).

[0128] Uma vez que os antibióticos não são o padrão de tratamento para a colite ulcerativa, é menos provável que essa população de sujeitos tenha sido tratada com antibióticos em comparação com a população de C. difficile multiplicada e recorrente (Exemplo 1, acima). Portanto, os microbiomas de sujeitos com colite ulcerativa sofreram menos períodos de forte seleção para resistência a antibióticos. Na amostra basal pré-antibiótico (Visita 1, Figura 3), observamos uma baixa abundância de genes de resistência a antibióticos.

[0129] Os resultados mostram que a abundância do gene AbxR é menor nos períodos de tempo pós-tratamento em comparação com as amostras de referência pós-antibióticos (Visita 4, dia 8). Nos braços C e D, o tratamento com vancomicina resulta em um aumento nos genes de resistência a antibióticos após o tratamento (Visita 4, dia 8). O tratamento com esporos diariamente ou semanalmente resultou em uma redução significativa nos genes de resistência a antibióticos na Visita 5 (dia 15, 7 dias após o início da administração dos esporos) em relação à referência pós-antibiótico (Visita 4, Tabela 7).

[0130] Tabela 7. Abundâncias do Gene AbxR São Menores Nos Períodos de Tempo Pós-tratamento em Comparação com As Amostras de Referência Pós- antibiótico (Visita 4, dia 8). Braço Dia 11 (3 dias após o Dia 15 tratamento) <Dia 8 (7 dias após o tratamento) (pós vancomicina) <Dia 8 (pós-vancomicina) p-valores do teste de D (esporos 0,01367 0,03223 Wilcox (teste pareado semanalmente unilateral) após vancomicina) p-valor do Teste de C (esporos 0,6562 0,009766 Wilcox diariamente (teste pareado após unilateral) vancomicina)

[0131] A abundância do gene AbxR é menor nos períodos de tempo pós- tratamento, em comparação com as amostras de referência pré-antibióticos (Visita 1). Nos Braços C e D, o tratamento com esporos resultou em redução nos genes de resistência a antibióticos em relação à referência pré-antibiótico (Visita 1, Tabela 8, Figura 3). O tratamento diário com esporos resultou em uma redução significativa nos genes de resistência a antibióticos na Visita 5 e Visita 6 (dia 18, dia 28, respectivamente) em relação à referência pré-antibiótico (Visita 1, Tabela 8).

[0132] Tabela 8. O Tratamento com Esporos Resultou na Redução da Abundância do Gene AbxR em Relação à Referência Pré-antibiótico (Por Exemplo, Visita 1 (Pré-antibiótico) vs (Visita 5 ou Visita 6)). Braços Visita 5 (dia 18) Visita 6 D (esporos 0,1826 0,1902 p-valores do teste de semanalmente Wilcox (teste após pareado unilateral) vancomicina) p-valor do Teste de C (esporos 0,01367 0,04199 Wilcox diariamente (teste pareado após unilateral) vancomicina)

[0133] Os resultados mostram que o enxerto de esporos reduz a resistência a antibióticos. No Braço D (dosagem semanal), os esporos enxertaram rapidamente em um subconjunto de sujeitos (Enxertos Precoces Rápidos = Verdadeiro, Figura 4). Nos demais sujeitos, o enxerto foi reduzido em magnitude ou tempo (Enxertos Precoces Rápidos = Falso, Figura 4). Os “Enxertos Precoces Rápido” foram definidos como sujeitos com mais de 6 formadores de esporos doseados detectados na Visita 5 (Dia 15). Observamos que esses sujeitos com enxertia precoce rápida exibiram abundâncias de genes AbxR significativamente mais baixos na Visita 5 (Dia 15) em comparação com aqueles que não foram identificados como enxertos precoces rápidos na Visita 5 (Dia 15, 7 dias após a primeira dose de esporos).

[0134] Tabela 9. Dentro do Mesmo Período, As Abundâncias do Gene AbxR São Mais Baixas em Sujeitos com Enxertos Rápidos em Comparação com Os Enxertos Não Rápidos, o Braço D (Dosagem Semanal). Dia 8 (pré- Dia 11 (3 dias Dia 15 tratamento) após o (6 dias após o tratamento) tratamento) p-valor do Teste 0,6548 0,3312 0,07343 de Wilcox (alternativa = "menos") Exemplo 4: Modelos de Animais

[0135] Um método para testar uma composição ROAR quanto à capacidade de reduzir a resistência a antibióticos usa camundongos convencionais (cepas de laboratório que possuem um microbioma). Os camundongos são tratados com antibióticos selecionados e depois colonizados com bactérias que abrigam um ou mais genes de resistência a antibióticos, por exemplo, bactérias resistentes à vancomicina (Enterococcus resistente a vancomicina; VRE) ou bactérias resistentes à vancomicina e carbapenem (Enterobacteriaceae resistente a carbapenem; CRE). Após a colonização, os ratos são tratados com uma composição ROAR, transplante fecal ou controle. Os títulos de bactérias resistentes a antibióticos (por exemplo, bactérias resistentes à vancomicina e resistentes a carbapenêmicos) são monitorados através de placas de fezes coletadas de animais tratados.

[0136] Os depositantes estabeleceram um modelo de colonização reprodutível e robusto para enterococos resistentes à vancomicina (VRE) em camundongos com base em um modelo publicado (Caballero e Pamer, 2015, Ann Rev Immunol 33: 227-256). Antes da inoculação do VRE, os ratos livres de patógenos específicos (SPF) são pré-condicionados com ampicilina para interromper a resistência à colonização e permitir a colonização por VRE. Após o tratamento com ampicilina, os camundongos são expostos a VRE e atingem um alto título (107 a 1010 CFU/g de fezes) no trato GI, uma condição estável por várias semanas. Uma vez colonizados com VRE, os camundongos são tratados com uma composição de resistência a FMT ou a ROAR humano via gavagem oral diária por 3 dias. As amostras fecais frescas são coletadas ao longo do estudo para avaliar a capacidade das composições de remover o VRE dos camundongos e restaurar um microbioma intestinal saudável. Os títulos viáveis de VRE nas fezes antes e após o tratamento são determinados por meio de placas em meio seletivo que contém ágar bile esculina azida com vancomicina e estreptomicina. O modelo de colonização do VRE é capaz de detectar uma diferença> 4 log na colonização ao longo de 3 semanas em camundongos tratados com FMT humana em comparação com camundongos tratados apenas com PBS. A capacidade de detectar uma diferença> 4 log nos títulos de VRE durante a janela de estudo também distinguiu composições microbianas projetadas com potência diferencial. Além disso, a abundância de genes de resistência a antibióticos pode ser analisada. A resistência a Enterobacteriaceae resistente a carbapenêmicos (CRE) pode ser testada de maneira semelhante, substituindo o meio seletivo apropriado pelo CRE.

[0137] Usando esses modelos, uma composição ROAR pode ser testada quanto a seus efeitos na abundância de genes de resistência a antibióticos. Uma composição ROAR que pode reduzir a abundância de um ou mais genes de resistência a antibióticos neste modelo é útil para os métodos descritos neste documento.

[0138] Várias modalidades da invenção estão dentro dos seguintes parágrafos numerados.

1. Um método para reduzir a abundância de pelo menos um gene de resistência a antibióticos no microbioma de um sujeito, o método compreendendo a administração de uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo bactérias formadoras de esporos.

2. Um método para tratar um sujeito em risco ou diagnosticado com um nível ou população indesejável de bactérias resistentes a medicamentos, o método compreendendo a administração de uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo Firmicutes derivados de um ou mais sujeitos humanos saudáveis.

3. Um método para reduzir a abundância de bactérias resistentes a antibióticos no microbioma de um sujeito, compreendendo o método a administração de uma quantidade terapeuticamente eficaz de uma composição ROAR.

4. Um método para interromper um ciclo de transmissão de genes de resistência a antibióticos, o método compreendendo a administração de uma composição ROAR a pelo menos dois sujeitos com uma alta probabilidade de contato direto ou indireto, incluindo o contato com um fluido ou resíduo corporal.

5. O método, de acordo com o parágrafo 1, em que os genes de resistência a antibióticos são selecionado dentre os listados na Tabela 1.

6. O método, de acordo com o parágrafo 5, em que a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é reduzida.

7. O método, de acordo com qualquer um dos parágrafos 1 a 6, em que o medicamento ou antibiótico é de uma classe de medicamentos listados na Tabela

2.

8. O método, de acordo com qualquer um dos parágrafos 1 a 7, compreendendo ainda reduzir a abundância de 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 ou mais genes ou classes de medicamentos de resistência a antibióticos.

9. O método, de acordo com qualquer um dos parágrafos 1 a 8, em que a composição administrada compreende uma ou mais espécies listadas na Tabela 3.

10. O método, de acordo com o parágrafo 9, em que a composição administrada compreende 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais espécies listadas na Tabela 3.

11. O método, de acordo com os parágrafos 9 ou 10, em que as espécies administradas compreendem uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade.

12. O método, de acordo com qualquer um dos parágrafos 1 a 11, em que a composição administrada não compreende uma ou mais espécies da Tabela 4.

13. O método, de acordo com qualquer um dos parágrafos 1 a 12, em que as bactérias na composição estão na forma de esporos.

14. O método, de acordo com qualquer um dos parágrafos 1 a 13, em que as bactérias na composição são cultivadas.

15. O método, de acordo com qualquer um dos parágrafos 1 a 14, em que a composição compreende Firmicutes e uma ou mais espécies de Bacteroides.

16. O método, de acordo com qualquer um dos parágrafos 1 a 15, em que o sujeito tem uma abundância reduzida de uma, duas ou três bactérias selecionadas do grupo que consiste em bactérias resistentes a quinolona, resistentes a beta- lactâmicos e resistentes a carbapenêmicos.

17. O método, de acordo com qualquer um dos parágrafos 1 a 16, em que o sujeito não respondeu ao tratamento com antibióticos.

18. O método, de acordo com qualquer um dos parágrafos 1 a 17, em que o sujeito tem ou está em risco de desenvolver infecção por C. difficile .

19. O método, de acordo com qualquer um dos parágrafos 1 a 18, em que o sujeito tem ou está em risco de desenvolver uma colite.

20. O método, de acordo com o parágrafo 19, em que a colite é doença de Crohn ou colite ulcerativa.

21. O método, de acordo com o parágrafo 20, em que a colite é colite ulcerativa leve a moderada.

22. Uma composição compreendendo espécies bacterianas associadas a uma diminuição na abundância de pelo menos um gene de resistência a antibióticos em um sujeito.

23. A composição, de acordo com o parágrafo 22, em que os genes de resistência a antibióticos são selecionado dentre os listados na Tabela 1.

24. A composição, de acordo com o parágrafo 23, em que a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é diminuída.

25. A composição, de acordo com qualquer um dos parágrafos 22 a 24, em que o antibiótico é de uma classe listada na Tabela 2.

26. A composição, de acordo com qualquer um dos parágrafos 22 a 25, em que a composição compreende uma ou mais espécies listadas na Tabela 3.

27. A composição, de acordo com o parágrafo 26, em que a composição compreende 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais, espécies listadas na Tabela 3.

28. A composição, de acordo com os parágrafos 20 ou 27, em que a espécie compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade.

29. A composição, de acordo com qualquer um dos parágrafos 22 a 28, em que a composição não compreende uma ou mais espécies da Tabela 4 e, opcionalmente, a uma ou mais espécies da Tabela 4 compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6, ou uma sequência com pelo menos 95% de identidade.

30. A composição, de acordo com qualquer um dos parágrafos 22 a 29, em que a composição compreende uma ou mais espécies de Firmicutes.

31. A composição, de acordo com qualquer um dos parágrafos 22 a 30, em que a composição compreende uma ou mais espécies de Bacteroides.

32. A composição, de acordo com qualquer um dos parágrafos 22 a 31, em que as bactérias na composição estão na forma de esporos.

33. A composição, de acordo com qualquer um dos parágrafos 22 a 32, em que as bactérias na composição são obtidas a partir de uma fração de esporos derivada de fezes de um sujeito saudável.

34. A composição, de acordo com qualquer um dos parágrafos 22 a 33, em que a composição compreende uma ou mais espécies de Firmicutes e, opcionalmente, uma ou mais espécies de Bacteroides, como a única espécie bacteriana na composição.

35. A composição, de acordo com qualquer um dos parágrafos 22 a 34, em que as bactérias na composição são cultivadas.

36. Uma composição compreendendo bactérias para uso na diminuição da abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada.

37. A composição, de acordo com o parágrafo 36, em que as bactérias na composição são obtidas a partir de uma fração de esporos derivada de fezes de um sujeito saudável.

38. A composição, de acordo com o parágrafo 36, em que as bactérias são selecionadas por serem associadas a uma diminuição na abundância de um ou mais genes de resistência a antibióticos em um sujeito.

39. A composição, de acordo com qualquer um dos parágrafos 36 a 38, em que os genes de resistência a antibióticos são selecionados na Tabela 1.

40. A composição, de acordo com qualquer um dos parágrafos 36 a 39, em que a composição compreende pelo menos uma espécie selecionada da Tabela 3.

41. A composição, de acordo com qualquer um dos parágrafos 36 a 40, em que a composição não compreende uma espécie da Tabela 4.

42. Um método para identificar uma composição bacteriana útil para diminuir a abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada, o método compreendendo a triagem da composição quanto à presença de uma ou mais espécies bacterianas da Tabela 3, em que a detecção de uma ou mais espécies da Tabela 3 na composição bacteriana indica a identificação de uma composição que pode ser usada para diminuir a abundância de pelo menos um gene de resistência a antibióticos.

43. O método, de acordo com o parágrafo 42, em que a triagem compreende a detecção de uma ou mais sequências de 16S rDNA, V4 e/ou V6 da Tabela 5 na composição, ou uma sequência com pelo menos 95% de identidade.

44. O método, de acordo com os parágrafos 42 ou 43, compreendendo ainda a triagem quanto à presença de uma ou mais espécies bacterianas da Tabela 4 e, opcionalmente, a uma ou mais espécies da Tabela 4 compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6 ou uma sequência com pelo menos 95% de identidade.

45. Um método para realizar a triagem de um potencial doador de fezes para uso em métodos terapêuticos, o método compreendendo testar uma amostra de fezes do potencial doador para a presença de uma espécie bacteriana da Tabela 3 ou Tabela 4, em que a detecção de uma ou mais espécies da Tabela 3 indica que o potencial doador pode continuar a se tornar um doador, enquanto a detecção de uma ou mais espécies da Tabela 4 indica que o potencial doador não deve se tornar um doador.

46. Um método para determinar se um sujeito pode se beneficiar do tratamento com uma composição ROAR, o método compreendendo determinar se uma amostra do sujeito inclui uma ou mais espécies de bactérias da Tabela 4, em que a detecção de uma ou mais espécies da Tabela 4 indica que o sujeito pode se beneficiar do tratamento com uma composição ROAR.

47. Uma composição, de acordo com qualquer um dos parágrafos 22 a 41, em que as bactérias na composição demonstram a capacidade de diminuir a abundância de um ou mais genes de resistência a antibióticos em um modelo de animal de resistência a antibióticos.

48. A composição, de acordo com o parágrafo 47, em que o modelo de animal compreende um camundongo tratado com um ou mais antibióticos e depois colonizado com uma ou mais bactérias que abrigam um ou mais genes de resistência a antibióticos.

49. A composição, de acordo com o parágrafo 48, em que os camundongos são colonizados com bactérias resistentes à vancomicina ou bactérias resistentes à vancomicina e carbapenem.

[0139] Outras modalidades estão dentro do escopo das seguintes reivindicações.

Claims (49)

REIVINDICAÇÕES

1. Composição caracterizada pelo fato de que compreende uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo bactérias formadoras de esporos para uso na redução da abundância de pelo menos um gene de resistência a antibióticos no microbioma de um sujeito.

2. Composição caracterizada pelo fato de que compreende uma quantidade terapeuticamente eficaz de uma composição de microbioma compreendendo Firmicutes derivados de um ou mais sujeitos humanos saudáveis para uso no tratamento de um sujeito em risco ou diagnosticado com um nível indesejável ou população de bactérias resistentes a medicamentos.

3. Composição ROAR caracterizada pelo fato de que consiste no uso que reduz a abundância de bactérias de resistência a antibióticos no microbioma de um sujeito.

4. Composição ROAR caracterizada pelo fato de que consiste no uso na interrupção de um ciclo de transmissão de genes de resistência a antibióticos, por administração a pelo menos dois sujeitos com uma alta probabilidade de contato direto ou indireto, incluindo contato opcional com um fluido ou resíduo corporal.

5. Composição para uso, de acordo com a reivindicação 1 ou 4, caracterizada pelo fato de que os genes de resistência a antibióticos é selecionado dentre os listados na Tabela 1.

6. Composição para uso, de acordo com a reivindicação 5, caracterizada pelo fato de que a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é reduzida.

7. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 6, caracterizada pelo fato de que o medicamento ou antibiótico é de uma classe de medicamentos listados na Tabela 2.

8. Composição, de acordo com qualquer uma das reivindicações 1 a 7, caracterizada pelo fato de que compreende ainda reduzir a abundância de 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25 ou mais genes ou classes de medicamentos de resistência a antibióticos.

9. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 8, caracterizada pelo fato de que a composição compreende uma ou mais espécies listadas na Tabela 3.

10. Composição para uso, de acordo com a reivindicação 9, caracterizada pelo fato de que a composição compreende 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais, espécies listadas na Tabela 3.

11. Composição, de acordo com as reivindicações 9 ou 10, caracterizada pelo fato de que a espécie compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade.

12. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 11, caracterizada pelo fato de que a composição não compreende uma ou mais espécies da Tabela 4.

13. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 12, caracterizada pelo fato de que as bactérias na composição estão na forma de esporos.

14. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 13, caracterizada pelo fato de que as bactérias na composição são cultivadas.

15. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 14, caracterizada pelo fato de que a composição compreende Firmicutes e uma ou mais espécies de Bacteroides.

16. Composição, de acordo com qualquer uma das reivindicações 1 a 15, caracterizada pelo fato de que o sujeito tem uma abundância reduzida de uma, duas ou três bactérias selecionadas do grupo que consiste em bactérias resistentes a quinolona, resistentes a beta-lactâmicos e resistentes a carbapenêmicos.

17. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 16, caracterizada pelo fato de que o sujeito não responde ao tratamento com antibióticos.

18. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 17, caracterizada pelo fato de que o sujeito tem ou está em risco de desenvolver infecção por C. difficile.

19. Composição para uso, de acordo com qualquer uma das reivindicações 1 a 18, caracterizada pelo fato de que o sujeito tem ou está em risco de desenvolver uma colite.

20. Composição para uso, de acordo com a reivindicação 19, caracterizada pelo fato de que a colite é a doença de Crohn ou colite ulcerativa.

21. Composição para uso, de acordo com a reivindicação 20, caracterizada pelo fato de que a colite é colite ulcerativa leve a moderada.

22. Composição caracterizada pelo fato de que compreende espécies bacterianas associadas a uma diminuição na abundância de pelo menos um gene de resistência a antibióticos em um sujeito.

23. Composição, de acordo com a reivindicação 22, caracterizada pelo fato de que os genes de resistência a antibióticos são selecionado dentre os listados na Tabela 1.

24. Composição, de acordo com a reivindicação 23, caracterizada pelo fato de que a abundância de pelo menos 2, 3, 4, 5, 6, 7, 8, 9, 10 ou mais genes de resistência a antibióticos da Tabela 1 é diminuída.

25. Composição, de acordo com qualquer uma das reivindicações 22 a 24, caracterizada pelo fato de que o antibiótico é de uma classe listada na Tabela 2.

26. Composição, de acordo com qualquer uma das reivindicações 22 a 25, caracterizada pelo fato de que a composição compreende uma ou mais espécies listadas na Tabela 3.

27. Composição, de acordo com a reivindicação 26, caracterizada pelo fato de que a composição compreende 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20 ou mais, espécies listadas na Tabela 3.

28. Composição, de acordo com qualquer uma das reivindicações 20 ou 27, caracterizada pelo fato de que a espécie compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 5, ou uma sequência com pelo menos 95% de identidade.

29. Composição, de acordo com qualquer uma das reivindicações 22 a 28, caracterizada pelo fato de que a composição não compreende uma ou mais espécies da Tabela 4 e, opcionalmente, a uma ou mais espécies da Tabela 4 compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6, ou uma sequência com pelo menos 95% de identidade.

30. Composição, de acordo com qualquer uma das reivindicações 22 a 29, caracterizada pelo fato de que a composição compreende uma ou mais espécies de Firmicutes.

31. Composição, de acordo com qualquer uma das reivindicações 22 a 30, caracterizada pelo fato de que a composição compreende uma ou mais espécies de Bacteroides.

32. Composição, de acordo com qualquer uma das reivindicações 22 a 31, caracterizada pelo fato de que as bactérias na composição estão na forma de esporos.

33. Composição, de acordo com qualquer uma das reivindicações 22 a 32, caracterizada pelo fato de que as bactérias na composição são obtidas a partir de uma fração de esporos derivada de fezes de um sujeito saudável.

34. Composição, de acordo com qualquer uma das reivindicações 22 a 33, caracterizada pelo fato de que a composição compreende uma ou mais espécies de Firmicutes e, opcionalmente, uma ou mais espécies de Bacteroides, como a única espécie bacteriana na composição.

35. Composição, de acordo com qualquer uma das reivindicações 22 a 34, caracterizada pelo fato de que as bactérias na composição são cultivadas.

36. Composição caracterizada pelo fato de que compreende bactérias para uso na diminuição da abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada.

37. Composição, de acordo com a reivindicação 36, caracterizada pelo fato de que as bactérias na composição são obtidas a partir de uma fração de esporos derivada de fezes de um sujeito saudável.

38. Composição, de acordo com a reivindicação 36, caracterizada pelo fato de que as bactérias são selecionadas por serem associadas a uma diminuição na abundância de um ou mais genes de resistência a antibióticos em um sujeito.

39. Composição, de acordo com qualquer uma das reivindicações 36 a 38, caracterizada pelo fato de que os genes de resistência a antibióticos são selecionados na Tabela 1.

40. Composição, de acordo com qualquer uma das reivindicações 36 a 39, caracterizada pelo fato de que a composição compreende pelo menos uma espécie selecionada da Tabela 3.

41. Composição, de acordo com qualquer uma das reivindicações 36 a 40, caracterizada pelo fato de que a composição não compreende uma espécie da Tabela 4.

42. Método para identificar uma composição bacteriana útil para diminuir a abundância de pelo menos um gene de resistência a antibióticos em um sujeito ao qual a composição é administrada, o método caracterizado pelo fato de que compreende a triagem da composição quanto à presença de uma ou mais espécies bacterianas da Tabela 3, em que a detecção de uma ou mais espécies da Tabela 3 na composição bacteriana indica a identificação de uma composição que pode ser usada para diminuir a abundância de pelo menos um gene de resistência a antibióticos.

43. Método, de acordo com a reivindicação 42, caracterizado pelo fato de que a triagem compreende a detecção de uma ou mais sequências de 16S rDNA, V4 e/ou V6 da Tabela 5 na composição, ou uma sequência com pelo menos 95% de identidade.

44. Método, de acordo com as reivindicações 42 ou 43, caracterizado pelo fato de que compreende ainda a triagem quanto à presença de uma ou mais espécies bacterianas da Tabela 4 e, opcionalmente, a uma ou mais espécies da Tabela 4 compreende uma sequência de 16S rDNA, V4 e/ou V6 listada na Tabela 6 ou uma sequência com pelo menos 95% de identidade.

45. Método para realizar a triagem de um potencial doador de fezes para uso em métodos terapêuticos, o método caracterizado pelo fato de que compreende testar uma amostra de fezes do potencial doador para a presença de uma espécie bacteriana da Tabela 3 ou Tabela 4, em que a detecção de uma ou mais espécies da Tabela 3 indica que o potencial doador pode continuar a se tornar um doador, enquanto a detecção de uma ou mais espécies da Tabela 4 indica que o potencial doador não deve se tornar um doador.

46. Método para determinar se um sujeito pode se beneficiar do tratamento com uma composição ROAR, o método caracterizado pelo fato de que determina se uma amostra do sujeito inclui uma ou mais espécies de bactérias da Tabela 4, em que a detecção de uma ou mais espécies da Tabela 4 indica que o sujeito pode se beneficiar do tratamento com uma composição ROAR.

47. Composição, de acordo com qualquer uma das reivindicações 22 a 41, caracterizada pelo fato de que as bactérias na composição demonstram a capacidade de diminuir a abundância de um ou mais genes de resistência a antibióticos em um modelo de animal de resistência a antibióticos.

48. Composição, de acordo com a reivindicação 47, caracterizada pelo fato de que o modelo de animal compreende um camundongo tratado com um ou mais antibióticos e depois colonizado com uma ou mais bactérias que abrigam um ou mais genes de resistência a antibióticos.

49. Composição, de acordo com a reivindicação 48, caracterizada pelo fato de que os camundongos são colonizados com bactérias resistentes à vancomicina ou bactérias resistentes à vancomicina e carbapenem.

antibiótico fluoroquinolona

Petição 870200147679, de 23/11/2020, pág. 171/175 Legenda

Todos os sujeitos tratados com esporos antibiótico Sujeitos com enxerto robusto 1/4 a antibióticos em Relação À Referência Pós- Fold Change de Log2 em Genes de Resistência Dias Após a Dosagem

B-Lactamas

Petição 870200147679, de 23/11/2020, pág. 172/175 Legenda

Todos os sujeitos tratados com esporos antibiótico 2/4

Sujeitos com enxerto robusto a antibióticos em Relação À Referência Pós- Fold Change de Log2 em Genes de Resistência Dias Após a Dosagem

Petição 870200147679, de 23/11/2020, pág. 173/175 Abundância de Genes de Resistência a antibióticos Visita 1 Visita 4 (Dia 8) Visita 4 (Dia 11) Visita 5 (Dia 15) Visita 5 (Dia 18) Visita 6 Visita 12 Visita 13 Visita 1 Visita 4 (Dia 8) Visita 4 (Dia 11) Visita 5 (Dia 15) Visita 5 (Dia 18) Visita 6 Visita 12 B: Esporos Semanalmente

Visita 13 Visita 1 Visita 4 (Dia 8) Visita 4 (Dia 11)

Ponto Temporal Visita 5 (Dia 15) Visita 5 (Dia 18) Visita 6 Visita 12 D: Vancomicina, Esporos Semanalmente

Visita 13 Visita 1 Visita 4 (Dia 8) Visita 4 (Dia 11) Visita 5 (Dia 15) Visita 5 (Dia 18) Visita 6 Visita 12 Visita 13 C: Vancomicina, Esporos Semanalmente 3/4

D: Vancomicina, Esporos Semanalmente

Petição 870200147679, de 23/11/2020, pág. 174/175 Enxertos Precoces Rápidos Falso Verdadeiro antibióticos 4/4

Abundância de Genes de Resistência a Visita 4 (Dia 8) Visita 4 (Dia 11) Visita 5 (Dia 15) Visita 5 (Dia 18) Ponto Temporal