JP5616065B2 - 抗微生物テルペン組成物 - Google Patents
抗微生物テルペン組成物 Download PDFInfo
- Publication number
- JP5616065B2 JP5616065B2 JP2009536764A JP2009536764A JP5616065B2 JP 5616065 B2 JP5616065 B2 JP 5616065B2 JP 2009536764 A JP2009536764 A JP 2009536764A JP 2009536764 A JP2009536764 A JP 2009536764A JP 5616065 B2 JP5616065 B2 JP 5616065B2
- Authority
- JP
- Japan
- Prior art keywords
- terpene
- composition
- preparation
- acid
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Description
アスコルビン酸、ショウノウ酸、及び亜鉛を主成分とする第1の調製を、常温且つ常圧、すなわち、298.15K且つ105Paのもとで行った。ただし、ある段階では、混合物は僅かに加熱されて撹拌される。
148mgの桂皮酸を1gのエタノールに溶解し、それに500mgの超純水を加える。上述した方法にしたがって得られる132.65mgのショウノウ酸亜鉛を、このようにして調製された溶液中に加える。溶解の後、沈殿物が形成されるが、この沈殿物は、桂皮・ショウノウ酸亜鉛(zinc cinnamo-camphorate)に相当する。桂皮・ショウノウ酸亜鉛は、1000倍希釈(1000重量部の水あたり1重量部)を意味する1/1000の割合で水に溶け、回収される。
Claims (4)
- 抗HIV剤として使用されるテルペン組成物であって、
ショウノウ酸である環状テルペン化合物と、
前記環状テルペン化合物とエステル結合を形成しているアスコルビン酸、桂皮酸から選ばれるベクター形成有機物質とからなり、
前記ベクター形成有機物質と会合した前記環状テルペン化合物が亜鉛カチオンと結合していることを特徴とするテルペン組成物。 - 請求項1に記載のテルペン組成物の製造方法であって、
アスコルビン酸、桂皮酸から選ばれるベクター形成有機物質がショウノウ酸である環状テルペン化合物と会合され、前記環状テルペン化合物が亜鉛カチオンと結合されることを特徴とするテルペン組成物の製造方法。 - 抗HIV剤の調製のための、請求項1に記載のテルペン組成物の使用。
- 成人で1日あたり1mgから3000mgの投与量にしたがって投与可能な薬剤を調製するための、請求項3に記載のテルペン組成物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0610073A FR2908660B1 (fr) | 2006-11-17 | 2006-11-17 | Composition terpenique anti-microorganisme |
FR0610073 | 2006-11-17 | ||
PCT/FR2007/001895 WO2008068427A2 (fr) | 2006-11-17 | 2007-11-16 | Composition terpénique anti-microorganisme |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010510199A JP2010510199A (ja) | 2010-04-02 |
JP5616065B2 true JP5616065B2 (ja) | 2014-10-29 |
Family
ID=38197735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009536764A Expired - Fee Related JP5616065B2 (ja) | 2006-11-17 | 2007-11-16 | 抗微生物テルペン組成物 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8198321B2 (ja) |
EP (1) | EP2086586A2 (ja) |
JP (1) | JP5616065B2 (ja) |
CN (1) | CN101583378A (ja) |
AP (1) | AP2767A (ja) |
BR (1) | BRPI0721551A2 (ja) |
CA (1) | CA2669871A1 (ja) |
FR (1) | FR2908660B1 (ja) |
WO (1) | WO2008068427A2 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104803853B (zh) * | 2014-01-29 | 2017-02-22 | 中国科学院海洋研究所 | 一种抗海洋弧菌单萜衍生物及其制备方法和应用 |
FR3110396B1 (fr) | 2020-05-20 | 2023-03-17 | M G B Pharma | Composition comprenant un composé ascorbo-camphorate métallique pour son utilisation dans le traitement des infections causées par herpèsvirus |
FR3110395A1 (fr) | 2020-05-20 | 2021-11-26 | M.G.B. Pharma | Composition comprenant un composé ascorbo-camphorate métallique pour son utilisation dans le traitement des infections causées par papillomavirus |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB266727A (ja) * | 1926-02-26 | 1927-09-15 | Chemische Fabrik Auf Actien | |
CH201766A (fr) * | 1937-09-30 | 1938-12-15 | Roger Dr Fischer | Procédé de préparation d'une substance bactéricide. |
GB753742A (en) * | 1953-07-23 | 1956-08-01 | Upjohn Co | Erythromycin acid esters |
DE1492341A1 (de) * | 1964-12-18 | 1969-12-11 | Bayer Ag | Antimikrobielle Mittel |
FR5651M (ja) * | 1966-07-29 | 1967-12-26 | ||
FR2303537A1 (fr) * | 1975-03-13 | 1976-10-08 | Byk Gulden Lomberg Chem Fab | Nouveau medicament contenant des monomethylesters de l'acide camphorique |
IT1079112B (it) * | 1976-04-01 | 1985-05-08 | Zambeletti L Dr Spa | Esteri dell acido canforico ad azione coleretica |
DE3801900A1 (de) * | 1988-01-23 | 1989-09-07 | Nink Karl Heinz | Verwendung von terpen-haltigen aetherischen oelen zur bekaempfung von aids und arc, sowie sie enthaltende pharmazeutische zubereitungen |
LU87394A1 (fr) * | 1988-11-22 | 1990-06-12 | Oreal | Sels de metaux polyvalents de derives sulfones du benzylidene-camphre et leur utilisation pour la protection de la peau contre le rayonnement ultraviolet |
JP4487096B2 (ja) * | 1998-12-22 | 2010-06-23 | 有限会社サンテクノ久我 | 水虫治療用軟膏 |
US6638915B1 (en) * | 2000-06-30 | 2003-10-28 | Harold Killam | Anti-viral composition |
AU2002227913B2 (en) * | 2000-11-09 | 2007-08-02 | Jorg P. Schur | Synergistic medicament containing aromatic agents and having an antagonistic, regenerative and/or protagonist decontamination effect |
-
2006
- 2006-11-17 FR FR0610073A patent/FR2908660B1/fr active Active
-
2007
- 2007-11-16 AP AP2009004854A patent/AP2767A/xx active
- 2007-11-16 CA CA002669871A patent/CA2669871A1/fr not_active Abandoned
- 2007-11-16 BR BRPI0721551-7A2A patent/BRPI0721551A2/pt not_active IP Right Cessation
- 2007-11-16 US US12/515,057 patent/US8198321B2/en not_active Expired - Fee Related
- 2007-11-16 JP JP2009536764A patent/JP5616065B2/ja not_active Expired - Fee Related
- 2007-11-16 EP EP07870301A patent/EP2086586A2/fr not_active Withdrawn
- 2007-11-16 WO PCT/FR2007/001895 patent/WO2008068427A2/fr active Application Filing
- 2007-11-16 CN CNA2007800500617A patent/CN101583378A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2086586A2 (fr) | 2009-08-12 |
US8198321B2 (en) | 2012-06-12 |
US20100286413A1 (en) | 2010-11-11 |
FR2908660A1 (fr) | 2008-05-23 |
CN101583378A (zh) | 2009-11-18 |
CA2669871A1 (fr) | 2008-06-12 |
AP2009004854A0 (en) | 2009-06-30 |
WO2008068427A2 (fr) | 2008-06-12 |
JP2010510199A (ja) | 2010-04-02 |
BRPI0721551A2 (pt) | 2014-02-18 |
WO2008068427A3 (fr) | 2008-07-24 |
AP2767A (en) | 2013-09-30 |
FR2908660B1 (fr) | 2013-02-08 |
WO2008068427A8 (fr) | 2009-07-02 |
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