JP5599610B2 - Ｈｓｐ９０の阻害による神経変性疾患の処置 - Google Patents
Ｈｓｐ９０の阻害による神経変性疾患の処置 Download PDFInfo
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| CA3004867C (fr) | 2008-06-26 | 2020-09-15 | Orphazyme Aps | Utilisation du hsp70 en tant que regulateur de l'activite enzymatique |
| CN102458402B (zh) | 2009-06-12 | 2013-10-02 | 百时美施贵宝公司 | 用作激酶调节剂的烟酰胺化合物 |
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| EP2694505B1 (fr) | 2011-04-05 | 2022-04-27 | Sloan-kettering Institute For Cancer Research | Inhibiteurs de la hsp90 |
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| US20140079636A1 (en) | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| EP2879675B1 (fr) | 2012-08-06 | 2019-11-13 | Duke University | Composés et procédés pour le ciblage de hsp90 |
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| US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| BR112016003201A2 (pt) * | 2013-08-16 | 2017-11-21 | Memorial Sloan Kettering Cancer Center | inibidores de grp94 seletivos e usos dos mesmos |
| AU2014318826B2 (en) | 2013-09-10 | 2019-10-10 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| WO2015066053A2 (fr) | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Thérapies ciblées |
| TWI673279B (zh) | 2013-12-23 | 2019-10-01 | 美國紀念斯隆-凱特琳癌症中心 | 用於放射性標記之方法及試劑 |
| JP2017505777A (ja) | 2014-01-29 | 2017-02-23 | シンタ ファーマスーティカルズ コーポレーション | 標的化治療薬 |
| AU2015224576A1 (en) | 2014-03-03 | 2016-09-22 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| EP3131586A4 (fr) | 2014-03-18 | 2017-10-25 | Madrigal Pharmaceuticals, Inc. | Agents thérapeutiques cibles |
| PL3193840T3 (pl) | 2014-09-15 | 2021-12-06 | Orphazyme A/S | Preparat arimoklomolu |
| MA40535A (fr) | 2014-09-17 | 2016-03-24 | Memorial Sloan Kettering Cancer Center | Imagerie et thérapie d'une inflammation et d'une infection ciblant hsp90 |
| MA47474A (fr) | 2015-10-05 | 2019-12-25 | Memorial Sloan Kettering Cancer Center | Polythérapie rationelle pour le traitement du cancer |
| WO2017178029A1 (fr) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Protéines de choc thermique et homéostasie du cholestérol |
| WO2017184956A1 (fr) | 2016-04-22 | 2017-10-26 | Duke University | Composés et procédés de ciblage de hsp90 |
| PT3448382T (pt) | 2016-04-29 | 2020-11-20 | Orphazyme As C/O Cobis As | Arimoclomol para o tratamento de distúrbios associados à glucocerebrosidase |
| KR102296703B1 (ko) | 2017-03-20 | 2021-09-01 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물 |
| AU2018257901A1 (en) * | 2017-04-24 | 2019-11-14 | Samus Therapeutics, Inc. | Hsp90 inhibitor oral formulations and related methods |
| JP2020524156A (ja) | 2017-06-20 | 2020-08-13 | マドリガル ファーマシューティカルズ インコーポレイテッドＭａｄｒｉｇａｌ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 標的治療薬を含む併用療法 |
| KR20200016875A (ko) | 2017-06-20 | 2020-02-17 | 마드리갈 파마슈티칼스 인코포레이티드 | 표적화 치료제 |
| CN111683658A (zh) * | 2017-06-23 | 2020-09-18 | 萨缪斯治疗股份有限公司 | 用于创伤性脑损伤及其后遗症的多蛋白复合物抑制剂疗法 |
| PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
| WO2020010003A1 (fr) | 2018-07-02 | 2020-01-09 | Incyte Corporation | DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ |
| US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| BR112021005188A2 (pt) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | tratamento de anemia falciforme com um composto de ativação de piruvato cinase r |
| MX2023005954A (es) | 2020-11-19 | 2023-09-04 | Zevra Denmark As | Procesos para preparar citrato de arimoclomol e intermediarios del mismo. |
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| WO2000061578A1 (fr) | 1999-04-09 | 2000-10-19 | Sloan-Kettering Institute For Cancer Research | Procedes et compositions permettant la degradation et/ou l'inhibition des tyrosine kinases appartenant a la famille her |
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| US7241890B2 (en) * | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
| EP1450784A4 (fr) | 2001-11-09 | 2005-02-09 | Conforma Therapeutics Corp | Composes de zearalanol inhibant hsp90 et leurs procedes de production et d'utilisation |
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| WO2005028434A2 (fr) | 2003-09-18 | 2005-03-31 | Conforma Therapeutics Corporation | Nouveaux composes heterocycliques utilises en tant qu'inhibiteurs de la proteine hsp90 |
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| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
| EP2380879B1 (fr) * | 2005-02-25 | 2017-07-12 | Esanex, Inc. | Dérivés de tetrahydroindolone et de tetrahydroindazolone |
| WO2006130469A1 (fr) | 2005-05-27 | 2006-12-07 | Oregon Health & Science University | Stimulation de la croissance des neurites au moyen de molecules de petite taille |
| WO2007117466A2 (fr) | 2006-03-31 | 2007-10-18 | Massachusetts Institute Of Technology | Celastrol, gédunine, et dérivés de ceux-ci, utilisés comme inhibiteurs de hsp90 |
| CA2652263A1 (fr) | 2006-05-12 | 2007-11-22 | Myriad Genetics, Inc. | Composes therapeutiques et leur utilisation contre le cancer |
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| US20100204093A1 (en) | 2006-07-27 | 2010-08-12 | University Of Florida Research Foundation, Inc | Use of heat shock activators for tissue regeneration |
| EP2061772A4 (fr) * | 2006-09-11 | 2011-06-29 | Curis Inc | Petites molécules multifonctionnelles servant d'agents anti-prolifératifs |
| CL2007002994A1 (es) * | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| WO2008070472A2 (fr) | 2006-11-27 | 2008-06-12 | University Of Maryland, Baltimore | Utilisation de plasma hsp90 lié à une malignité |
| BRPI0808301B1 (pt) * | 2007-03-20 | 2022-05-03 | Curis, Inc | Composto e composição farmacêutica |
| US20080234297A1 (en) * | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| EP2183221A1 (fr) | 2007-07-12 | 2010-05-12 | Crystax Pharmaceuticals S.L. | Nouveaux composés inhibiteurs de la hsp90 |
| WO2009042646A1 (fr) | 2007-09-24 | 2009-04-02 | Curis, Inc. | Agents antiprolifératifs |
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2007
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- 2007-07-02 DK DK07812557.2T patent/DK2034839T3/en active
- 2007-07-02 ES ES07812557.2T patent/ES2645095T3/es active Active
- 2007-07-02 CA CA2656202A patent/CA2656202C/fr active Active
- 2007-07-02 AU AU2007269144A patent/AU2007269144B2/en not_active Ceased
- 2007-07-02 EP EP07812557.2A patent/EP2034839B1/fr active Active
- 2007-07-02 EP EP17177927.5A patent/EP3305297A1/fr not_active Withdrawn
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2013
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2019
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2007269144A1 (en) | 2008-01-10 |
| US10336757B2 (en) | 2019-07-02 |
| ES2645095T3 (es) | 2017-12-04 |
| JP2009542716A (ja) | 2009-12-03 |
| US20190389864A1 (en) | 2019-12-26 |
| WO2008005937A2 (fr) | 2008-01-10 |
| EP2034839B1 (fr) | 2017-08-23 |
| EP2034839A4 (fr) | 2012-08-29 |
| EP3305297A1 (fr) | 2018-04-11 |
| US20140378452A1 (en) | 2014-12-25 |
| JP6427227B2 (ja) | 2018-11-21 |
| JP6585266B2 (ja) | 2019-10-02 |
| CA2656202A1 (fr) | 2008-01-10 |
| JP2013177389A (ja) | 2013-09-09 |
| AU2007269144B2 (en) | 2013-05-16 |
| JP2016028063A (ja) | 2016-02-25 |
| US20240158397A1 (en) | 2024-05-16 |
| JP5824698B2 (ja) | 2015-11-25 |
| JP2019038829A (ja) | 2019-03-14 |
| EP2034839A2 (fr) | 2009-03-18 |
| JP2017214379A (ja) | 2017-12-07 |
| DK2034839T3 (en) | 2017-12-04 |
| WO2008005937A3 (fr) | 2008-12-11 |
| US20230060990A1 (en) | 2023-03-02 |
| CA2656202C (fr) | 2018-01-16 |
| US20090298857A1 (en) | 2009-12-03 |
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