JP5599610B2 - Ｈｓｐ９０の阻害による神経変性疾患の処置 - Google Patents
Ｈｓｐ９０の阻害による神経変性疾患の処置 Download PDFInfo
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| EP2038041A4 (fr) * | 2006-05-12 | 2010-02-17 | Myriad Genetics Inc | Composés thérapeutiques et leur utilisation contre le cancer |
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| US20090258869A1 (en) * | 2008-02-08 | 2009-10-15 | The Regents Of The University Of California | Methods and compounds for treatment or prevention of substance-related disorders |
| PL2318032T3 (pl) | 2008-06-26 | 2012-08-31 | Orphazyme Aps | Zastosowanie hsp70 jako regulatora aktywności enzymatycznej |
| WO2010144647A1 (fr) | 2009-06-12 | 2010-12-16 | Bristol-Myers Squibb Company | Composés de nicotinamide utiles en tant que modulateurs de kinases |
| AU2013204109B2 (en) * | 2009-10-07 | 2016-05-05 | Sloan-Kettering Institute For Cancer Research | Purine derivatives useful as hsp90 inhibitors |
| ES2733131T3 (es) * | 2009-10-07 | 2019-11-27 | Sloan Kettering Inst Cancer Res | Derivados de purina útiles como inhibidores de hsp90 |
| US9662375B2 (en) | 2010-11-30 | 2017-05-30 | Orphazyme Aps | Methods for increasing intracellular activity of Hsp70 |
| CN103582642B (zh) * | 2011-04-05 | 2021-05-11 | 索隆-基特林癌症研究协会 | Hsp90抑制剂 |
| EA024647B1 (ru) * | 2011-04-05 | 2016-10-31 | Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч | ИНГИБИТОРЫ Hsp90 |
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| US20140079636A1 (en) | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| US9738643B2 (en) | 2012-08-06 | 2017-08-22 | Duke University | Substituted indazoles for targeting Hsp90 |
| CN104936953B (zh) | 2013-01-23 | 2017-03-08 | 阿斯利康(瑞典)有限公司 | 化合物 |
| CA2905509A1 (fr) | 2013-03-15 | 2014-09-18 | Memorial Sloan-Kettering Cancer Center | Imagerie cardiaque a ciblage hsp90 et traitement associe |
| AU2014306417C1 (en) * | 2013-08-16 | 2019-07-25 | Memorial Sloan-Kettering Cancer Center | Selective Grp94 inhibitors and uses thereof |
| WO2015038649A1 (fr) | 2013-09-10 | 2015-03-19 | Synta Pharmaceuticals Corp. | Thérapeutique ciblée |
| WO2015066053A2 (fr) | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Thérapies ciblées |
| RU2016128528A (ru) | 2013-12-23 | 2018-01-30 | Мемориал Слоун-Кеттеринг Кэнсэ Сентр | Способы и реактивы для введения радиоактивной метки |
| WO2015116774A1 (fr) | 2014-01-29 | 2015-08-06 | Synta Pharmaceuticals Corp. | Agents thérapeutiques cibles |
| CN106456795A (zh) | 2014-03-03 | 2017-02-22 | 辛塔医药品有限公司 | 靶向治疗学 |
| MA39483A (fr) | 2014-03-18 | 2015-09-24 | Synta Pharmaceuticals Corp | Agents thérapeutiques cibles |
| EP3193840B1 (fr) | 2014-09-15 | 2021-05-19 | Orphazyme A/S | Formulation arimoclomol |
| CN107110869B (zh) | 2014-09-17 | 2021-08-10 | 纪念斯隆-凯特琳癌症中心 | Hsp90-靶向炎症和感染成像及治疗 |
| KR20180058824A (ko) | 2015-10-05 | 2018-06-01 | 메모리얼 슬로안-케터링 캔서 센터 | 암 치료를 위한 합리적 병용 요법 |
| WO2017178029A1 (fr) | 2016-04-13 | 2017-10-19 | Orphazyme Aps | Protéines de choc thermique et homéostasie du cholestérol |
| US11261187B2 (en) | 2016-04-22 | 2022-03-01 | Duke University | Compounds and methods for targeting HSP90 |
| AU2017255959B2 (en) | 2016-04-29 | 2020-10-15 | Zevra Denmark A/S | Arimoclomol for treating glucocerebrosidase associated disorders |
| RS60209B1 (sr) | 2017-03-20 | 2020-06-30 | Forma Therapeutics Inc | Kompozicije pirolopirola kao aktivatori piruvat kinaze (pkr) |
| CN110996918A (zh) * | 2017-04-24 | 2020-04-10 | 萨缪斯治疗股份有限公司 | Hsp90抑制剂口服配制品和相关方法 |
| EP3641647A4 (fr) | 2017-06-20 | 2021-05-05 | Madrigal Pharmaceuticals, Inc. | Agents thérapeutiques ciblés |
| EP3641782A4 (fr) | 2017-06-20 | 2021-03-24 | Madrigal Pharmaceuticals, Inc. | Thérapies combinées comprenant des thérapeutiques ciblées |
| US20210161902A1 (en) * | 2017-06-23 | 2021-06-03 | Samus Therapeutics, Inc. | Epichaperome inhibitor therapy for traumatic brain injury and sequelae thereof |
| HUE057970T2 (hu) | 2018-03-08 | 2022-06-28 | Incyte Corp | Aminopirazindiol-vegyületek mint PI3K-Y inhibitorok |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| US20220031671A1 (en) | 2018-09-19 | 2022-02-03 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| WO2020061255A1 (fr) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activation de la pyruvate kinase r |
| CA3202568A1 (fr) | 2020-11-19 | 2022-05-27 | Zevra Denmark A/S | Procedes de preparation de citrate d'arimoclomol et intermediaires associes |
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| US7439359B2 (en) * | 2000-11-02 | 2008-10-21 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to hsp90 |
| US20040235813A1 (en) * | 2001-05-03 | 2004-11-25 | Erich Wanker | Compounds that inhibit hsp90 and stimulate hsp70 and hsp40, useful in the prevention or treatment of diseases associated with protein aggregation and amyloid formation |
| EP2336133A1 (fr) | 2001-10-30 | 2011-06-22 | Conforma Therapeutics Corporation | Analogues de purine présentant une activité inhibitrice de HSP90 |
| WO2003041643A2 (fr) | 2001-11-09 | 2003-05-22 | Conforma Therapeutics Corporation | Composes de zearalanol inhibant hsp90 et leurs procedes de production et d'utilisation |
| BR0308056A (pt) | 2002-02-28 | 2004-12-07 | Astrazeneca Ab | Composto, pró-droga, método para a produção de um efeito antibacteriano em um animal de sangue quente, uso de um composto, composição farmacêutica, e, processo para a preparação de um composto |
| US7592143B2 (en) | 2003-04-18 | 2009-09-22 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
| GB0315111D0 (en) | 2003-06-27 | 2003-07-30 | Cancer Rec Tech Ltd | Substituted 5-membered ring compounds and their use |
| WO2005012482A2 (fr) | 2003-06-30 | 2005-02-10 | Sloan-Kettering Institute For Cancer Research | Essai d'identification de composes bioactifs qui interagissent avec la proteine du stress 90 |
| BRPI0414533A (pt) | 2003-09-18 | 2006-11-07 | Conforma Therapeutics Corp | composto, composição farmacêutica, e, métodos para inibir um hsp90 e para tratar um indivìduo tendo um distúrbio mediado por hsp90 |
| US9403828B2 (en) | 2005-02-01 | 2016-08-02 | Sloan-Kettering Institute For Cancer Research | Small-molecule Hsp90 inhibitors |
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| BRPI0607739A2 (pt) | 2005-02-25 | 2009-09-29 | Serenex Inc | derivados de tetraidroindolona e tetraidroindazolona, composição compreendendo os mesmos e uso relacionado |
| WO2006130469A1 (fr) | 2005-05-27 | 2006-12-07 | Oregon Health & Science University | Stimulation de la croissance des neurites au moyen de molecules de petite taille |
| US20110263693A1 (en) | 2006-03-31 | 2011-10-27 | Dana-Farber Cancer Institute, Inc. | Celastrol, gedunin, and derivatives thereof as hsp90 inhibitors |
| EP2038041A4 (fr) | 2006-05-12 | 2010-02-17 | Myriad Genetics Inc | Composés thérapeutiques et leur utilisation contre le cancer |
| AU2007269144B2 (en) * | 2006-06-30 | 2013-05-16 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibition of HSP90 |
| US20100204093A1 (en) | 2006-07-27 | 2010-08-12 | University Of Florida Research Foundation, Inc | Use of heat shock activators for tissue regeneration |
| EP2061772A4 (fr) | 2006-09-11 | 2011-06-29 | Curis Inc | Petites molécules multifonctionnelles servant d'agents anti-prolifératifs |
| CL2007002994A1 (es) | 2006-10-19 | 2008-02-08 | Wyeth Corp | Compuestos derivados heterociclicos que contienen sulfamoilo, inhibidores de hsp90; composicion farmaceutica; y uso para el tratamiento del cancer, tal como cancer de mama, de colon y prostata, entre otros. |
| GB0622084D0 (en) | 2006-11-06 | 2006-12-13 | Chroma Therapeutics Ltd | Inhibitors of HSP90 |
| US8580519B2 (en) | 2006-11-27 | 2013-11-12 | University Of Maryland, Baltimore | Use of plasma HSP90 related to malignancy |
| WO2008115719A1 (fr) | 2007-03-20 | 2008-09-25 | Curis, Inc. | Aminopyridine fondue inhibiteur de hsp90 |
| US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
| EP2183221A1 (fr) | 2007-07-12 | 2010-05-12 | Crystax Pharmaceuticals S.L. | Nouveaux composés inhibiteurs de la hsp90 |
| WO2009042646A1 (fr) | 2007-09-24 | 2009-04-02 | Curis, Inc. | Agents antiprolifératifs |
| JP2011503206A (ja) | 2007-11-14 | 2011-01-27 | ミレクシス， インコーポレイテッド | 疾患および障害の治療における治療化合物およびその使用方法 |
| ES2733131T3 (es) | 2009-10-07 | 2019-11-27 | Sloan Kettering Inst Cancer Res | Derivados de purina útiles como inhibidores de hsp90 |
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- 2007-07-02 WO PCT/US2007/072671 patent/WO2008005937A2/fr active Application Filing
- 2007-07-02 JP JP2009518602A patent/JP5599610B2/ja not_active Expired - Fee Related
- 2007-07-02 US US12/307,063 patent/US10336757B2/en active Active
- 2007-07-02 CA CA2656202A patent/CA2656202C/fr active Active
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- 2007-07-02 EP EP07812557.2A patent/EP2034839B1/fr active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2034839B1 (fr) | 2017-08-23 |
| JP2009542716A (ja) | 2009-12-03 |
| JP2019038829A (ja) | 2019-03-14 |
| US20240158397A1 (en) | 2024-05-16 |
| ES2645095T3 (es) | 2017-12-04 |
| AU2007269144A1 (en) | 2008-01-10 |
| US20140378452A1 (en) | 2014-12-25 |
| WO2008005937A2 (fr) | 2008-01-10 |
| US20090298857A1 (en) | 2009-12-03 |
| JP6585266B2 (ja) | 2019-10-02 |
| CA2656202C (fr) | 2018-01-16 |
| JP2016028063A (ja) | 2016-02-25 |
| CA2656202A1 (fr) | 2008-01-10 |
| US20190389864A1 (en) | 2019-12-26 |
| EP2034839A2 (fr) | 2009-03-18 |
| JP2017214379A (ja) | 2017-12-07 |
| JP5824698B2 (ja) | 2015-11-25 |
| JP2013177389A (ja) | 2013-09-09 |
| DK2034839T3 (en) | 2017-12-04 |
| US20230060990A1 (en) | 2023-03-02 |
| WO2008005937A3 (fr) | 2008-12-11 |
| US10336757B2 (en) | 2019-07-02 |
| EP3305297A1 (fr) | 2018-04-11 |
| EP2034839A4 (fr) | 2012-08-29 |
| AU2007269144B2 (en) | 2013-05-16 |
| JP6427227B2 (ja) | 2018-11-21 |
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