JP5598894B2 - 生物活性を強化した抗体改変体 - Google Patents

生物活性を強化した抗体改変体 Download PDF

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Publication number
JP5598894B2
JP5598894B2 JP2008502861A JP2008502861A JP5598894B2 JP 5598894 B2 JP5598894 B2 JP 5598894B2 JP 2008502861 A JP2008502861 A JP 2008502861A JP 2008502861 A JP2008502861 A JP 2008502861A JP 5598894 B2 JP5598894 B2 JP 5598894B2
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antibody
domain
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variant
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JP2008502861A
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Japanese (ja)
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JPWO2007100083A1 (ja
Inventor
安彦 増保
弘明 長島
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Chemo Sero Therapeutic Research Institute Kaketsuken
Tokyo University of Science
Teijin Pharma Ltd
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Chemo Sero Therapeutic Research Institute Kaketsuken
Tokyo University of Science
Teijin Pharma Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008502861A 2006-03-03 2007-03-02 生物活性を強化した抗体改変体 Expired - Fee Related JP5598894B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008502861A JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006057475 2006-03-03
JP2006057475 2006-03-03
JP2008502861A JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体
PCT/JP2007/054018 WO2007100083A1 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体

Related Child Applications (1)

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JP2012004674A Division JP5901299B2 (ja) 2006-03-03 2012-01-13 生物活性を強化した抗体改変体

Publications (2)

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JPWO2007100083A1 JPWO2007100083A1 (ja) 2009-07-23
JP5598894B2 true JP5598894B2 (ja) 2014-10-01

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JP2008502861A Expired - Fee Related JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体
JP2012004674A Expired - Fee Related JP5901299B2 (ja) 2006-03-03 2012-01-13 生物活性を強化した抗体改変体

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US (2) US20090304715A1 (https=)
EP (2) EP2006305B1 (https=)
JP (2) JP5598894B2 (https=)
CA (1) CA2638804C (https=)
ES (1) ES2602439T3 (https=)
WO (1) WO2007100083A1 (https=)

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US20090304715A1 (en) * 2006-03-03 2009-12-10 Tokyo University Of Science Modified antibodies with enhanced biological activities
CN101835802B (zh) 2007-06-01 2014-04-09 马里兰大学巴尔的摩分校 免疫球蛋白恒定区Fc受体结合剂
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
WO2010065578A2 (en) * 2008-12-04 2010-06-10 Leukosight Inc. POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME
WO2012002562A1 (en) * 2010-06-30 2012-01-05 Tokyo University Of Science Educational Foundation Administrative Organization Modified protein therapeutics
WO2012016073A2 (en) 2010-07-28 2012-02-02 Gliknik Inc. Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
JP5768147B2 (ja) 2011-02-28 2015-08-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 一価抗原結合タンパク質
WO2012116926A1 (en) * 2011-02-28 2012-09-07 F. Hoffmann-La Roche Ag Antigen binding proteins
JP2015527366A (ja) * 2012-08-20 2015-09-17 グリックニック インコーポレイテッド 抗原結合および多価ｆｃガンマ受容体結合活性を有する分子
WO2014115893A1 (ja) 2013-01-28 2014-07-31 株式会社イーベック ヒト・メタニューモウイルスに特異的なヒト抗体もしくはその抗原結合性断片
WO2015005960A1 (en) 2013-07-12 2015-01-15 Emd Millipore Corporation Removal of fragments from a sample containing a target protein using activated carbon
ES2935274T3 (es) * 2014-12-05 2023-03-03 Merck Patent Gmbh Anticuerpo con intercambio de dominios
LT3325011T (lt) 2015-07-24 2021-01-25 Gliknik Inc. Iš žmogaus baltymo fragmentų sulieti baltymai, siekiant sukurti tvarkingai multimerizuoto imunoglobulino fc kompozicijas su padidintu komplemento surišimu
US11466093B2 (en) 2015-07-27 2022-10-11 The General Hospital Corporation Antibody derivatives with conditionally enabled effector function
WO2017214321A1 (en) 2016-06-07 2017-12-14 Gliknik Inc. Cysteine-optimized stradomers
CA3043251A1 (en) 2016-12-09 2018-06-14 Gliknik Inc. Methods of treating inflammatory disorders with multivalent fc compounds
CN110177802A (zh) 2016-12-09 2019-08-27 格利克尼克股份有限公司 多聚化stradomer GL-2045的制造优化
RU2019124709A (ru) * 2017-01-06 2021-02-08 Момента Фармасьютикалз, Инк. КОМПОЗИЦИИ И СПОСОБЫ, СВЯЗАННЫЕ СО СКОНСТРУИРОВАННЫМИ КОНСТРУКЦИЯМИ НА ОСНОВЕ Fc-АНТИГЕНСВЯЗЫВАЮЩЕГО ДОМЕНА
BR112021000391A2 (pt) * 2018-07-11 2021-04-06 Momenta Pharmaceuticals, Inc. Composições e métodos relacionados a construtos do domínio de ligação fc-antígeno manipulado direcionado a ccr4
CN119421953A (zh) 2022-01-28 2025-02-11 株式会社伊贝克 具有突变株交叉性的抗SARS－CoV－2人中和抗体及其抗原结合片段

Citations (2)

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WO2004029207A2 (en) * 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
WO2005077981A2 (en) * 2003-12-22 2005-08-25 Xencor, Inc. Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES

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GB8824869D0 (en) 1988-10-24 1988-11-30 Stevenson G T Synthetic antibody
DE3908834A1 (de) 1989-03-17 1990-09-20 Hollingsworth Gmbh Vorrichtung zur ausscheidung von verunreinigungen eines faserverbandes an einer karde
US7511121B2 (en) * 2001-03-09 2009-03-31 Arnason Barry G W Polymeric immunoglobulin fusion proteins that target low-affinity Fcγreceptors
PL1706428T3 (pl) * 2004-01-22 2010-02-26 Merck Patent Gmbh Przeciwciała przeciwnowotworowe o zredukowanym wiązaniu dopełniacza
WO2006085967A2 (en) * 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
US20090304715A1 (en) * 2006-03-03 2009-12-10 Tokyo University Of Science Modified antibodies with enhanced biological activities

Patent Citations (2)

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WO2004029207A2 (en) * 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
WO2005077981A2 (en) * 2003-12-22 2005-08-25 Xencor, Inc. Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES

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JPN6012050545; ＷＥＮＧ，　Ｗ．-Ｋ．　ａｎｄ　ＬＥＶＹ，　Ｒ．: Ｊ．　Ｃｌｉｎ．　Ｏｎｃｏｌ． Ｖｏｌ．２１，　Ｎｏ．２１, 2003, ｐｐ．３９４０-３９４７ *

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Publication number Publication date
US20190367630A1 (en) 2019-12-05
CA2638804C (en) 2017-02-28
US20090304715A1 (en) 2009-12-10
EP2006305A9 (en) 2009-07-15
JP2012136519A (ja) 2012-07-19
CA2638804A1 (en) 2007-09-07
ES2602439T3 (es) 2017-02-21
JPWO2007100083A1 (ja) 2009-07-23
EP2610268A1 (en) 2013-07-03
EP2006305A4 (en) 2010-06-30
EP2006305B1 (en) 2016-08-10
JP5901299B2 (ja) 2016-04-06
EP2006305A2 (en) 2008-12-24
WO2007100083A1 (ja) 2007-09-07

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