JP5598894B2 - 生物活性を強化した抗体改変体 - Google Patents

生物活性を強化した抗体改変体 Download PDF

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Publication number
JP5598894B2
JP5598894B2 JP2008502861A JP2008502861A JP5598894B2 JP 5598894 B2 JP5598894 B2 JP 5598894B2 JP 2008502861 A JP2008502861 A JP 2008502861A JP 2008502861 A JP2008502861 A JP 2008502861A JP 5598894 B2 JP5598894 B2 JP 5598894B2
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antibody
domain
minutes
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variant
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Japanese (ja)
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JPWO2007100083A1 (ja
Inventor
安彦 増保
弘明 長島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Tokyo University of Science
Teijin Pharma Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Tokyo University of Science
Teijin Pharma Ltd
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Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Tokyo University of Science, Teijin Pharma Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2008502861A 2006-03-03 2007-03-02 生物活性を強化した抗体改変体 Expired - Fee Related JP5598894B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008502861A JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2006057475 2006-03-03
JP2006057475 2006-03-03
JP2008502861A JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体
PCT/JP2007/054018 WO2007100083A1 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体

Related Child Applications (1)

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JP2012004674A Division JP5901299B2 (ja) 2006-03-03 2012-01-13 生物活性を強化した抗体改変体

Publications (2)

Publication Number Publication Date
JPWO2007100083A1 JPWO2007100083A1 (ja) 2009-07-23
JP5598894B2 true JP5598894B2 (ja) 2014-10-01

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JP2008502861A Expired - Fee Related JP5598894B2 (ja) 2006-03-03 2007-03-02 生物活性を強化した抗体改変体
JP2012004674A Expired - Fee Related JP5901299B2 (ja) 2006-03-03 2012-01-13 生物活性を強化した抗体改変体

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JP2012004674A Expired - Fee Related JP5901299B2 (ja) 2006-03-03 2012-01-13 生物活性を強化した抗体改変体

Country Status (6)

Country Link
US (2) US20090304715A1 (cg-RX-API-DMAC10.html)
EP (2) EP2610268A1 (cg-RX-API-DMAC10.html)
JP (2) JP5598894B2 (cg-RX-API-DMAC10.html)
CA (1) CA2638804C (cg-RX-API-DMAC10.html)
ES (1) ES2602439T3 (cg-RX-API-DMAC10.html)
WO (1) WO2007100083A1 (cg-RX-API-DMAC10.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090304715A1 (en) * 2006-03-03 2009-12-10 Tokyo University Of Science Modified antibodies with enhanced biological activities
SI2185589T1 (sl) 2007-06-01 2016-04-29 University Of Maryland Baltimore Vezavna sredstva za Fc receptor konstantne regije imunoglobulina
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
WO2010065578A2 (en) * 2008-12-04 2010-06-10 Leukosight Inc. POLYPEPTIDES COMPRISING Fc FRAGMENTS OF IMMUNOGLOBULIN G (IgG) AND METHODS OF USING THE SAME
WO2012002562A1 (en) * 2010-06-30 2012-01-05 Tokyo University Of Science Educational Foundation Administrative Organization Modified protein therapeutics
WO2012016073A2 (en) 2010-07-28 2012-02-02 Gliknik Inc. Fusion proteins of natural human protein fragments to create orderly multimerized immunoglobulin fc compositions
JP5768147B2 (ja) 2011-02-28 2015-08-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 一価抗原結合タンパク質
WO2012116926A1 (en) * 2011-02-28 2012-09-07 F. Hoffmann-La Roche Ag Antigen binding proteins
KR20150058236A (ko) 2012-08-20 2015-05-28 글리크닉 인코포레이티드 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자
CN104955839A (zh) 2013-01-28 2015-09-30 株式会社伊贝克 对人偏肺病毒具有特异性的人抗体或其抗原结合性片段
US10519194B2 (en) 2013-07-12 2019-12-31 Merck Patent Gmbh Removal of fragments from a sample containing a target protein using activated carbon
ES2935274T3 (es) * 2014-12-05 2023-03-03 Merck Patent Gmbh Anticuerpo con intercambio de dominios
IL309260B2 (en) 2015-07-24 2025-01-01 Gliknik Inc Fusion proteins of human protein fragments to create ordered multimeric immunoglobulin FC preparations with enhanced complement binding
US11466093B2 (en) 2015-07-27 2022-10-11 The General Hospital Corporation Antibody derivatives with conditionally enabled effector function
CA3026420A1 (en) 2016-06-07 2017-12-14 Gliknik Inc. Cysteine-optimized stradomers
BR112019009484A2 (pt) 2016-12-09 2019-07-30 Gliknik Inc otimização de fabricação de gl-2045, um stradomer multimerizador
BR112019009495A2 (pt) 2016-12-09 2019-08-06 Gliknik Inc métodos de tratamento de distúrbios inflamatórios com compostos de fc multivalentes
US20200040084A1 (en) * 2017-01-06 2020-02-06 Momenta Pharmaceuticals, Inc. Compositions and methods related to engineered fc-antigen binding domain constructs
WO2020014429A2 (en) * 2018-07-11 2020-01-16 Kurtagic Elma Compositions and methods related to engineered fc-antigen binding domain constructs targeted to ccr4
KR20240137083A (ko) 2022-01-28 2024-09-19 에베크 인코포레이티드 변이주 교차성을 갖는 항SARS-CoV-2 인간 중화 항체 및 그의 항원 결합성 단편

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029207A2 (en) * 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
WO2005077981A2 (en) * 2003-12-22 2005-08-25 Xencor, Inc. Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8824869D0 (en) 1988-10-24 1988-11-30 Stevenson G T Synthetic antibody
DE3908834A1 (de) 1989-03-17 1990-09-20 Hollingsworth Gmbh Vorrichtung zur ausscheidung von verunreinigungen eines faserverbandes an einer karde
CA2437958C (en) * 2001-03-09 2018-10-30 University Of Chicago Polymeric immunoglobulin fusion proteins that target low-affinity fc.gamma.receptors
CA2553883C (en) * 2004-01-22 2013-04-02 Merck Patent Gesellschaft Mit Beschraenkter Haftung Anti-cancer antibodies with reduced complement fixation
WO2006085967A2 (en) * 2004-07-09 2006-08-17 Xencor, Inc. OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
US20090304715A1 (en) * 2006-03-03 2009-12-10 Tokyo University Of Science Modified antibodies with enhanced biological activities

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004029207A2 (en) * 2002-09-27 2004-04-08 Xencor Inc. Optimized fc variants and methods for their generation
WO2005077981A2 (en) * 2003-12-22 2005-08-25 Xencor, Inc. Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN5010008747; ＳＴＥＶＥＮＳＯＮ　Ｇ　Ｔ: ＪＯＵＲＮＡＬ　ＯＦ　ＩＭＭＵＮＯＬＯＧＹ Ｖ１５８, 19970101, Ｐ２２４２-２２５０, ＡＭＥＲＩＣＡＮ　ＡＳＳＯＣＩＡＴＩＯＮ　ＯＦ　ＩＭＭＵＮＯＬＯＧＩＳＴＳ *
JPN5010008943; ＧＲＥＥＮＷＯＯＤ　Ｊ: ＴＨＥＲＡＰＥＵＴＩＣ　ＩＭＭＵＮＯＬＯＧＹ Ｖ１　Ｎ５, 19941001, Ｐ２４７-２５５, ＢＬＡＣＫＷＥＬＬ　ＳＣＩＥＮＴＩＦＩＣ　ＰＵＢＬ． *
JPN6011059765; 田村隆明，　山本雅　編: 分子生物学イラストレイテッド 第２刷, 1998, 第１５９-１６０頁 *
JPN6011059767; 長島弘明，　増保安彦: 薬学雑誌 Ｖｏｌ．１３０，　Ｎｏ．１, 2010, ｐｐ．４９-５４ *
JPN6011059770; ＫＡＮ，　Ｋ．Ｓ．　ｅｔ　ａｌ．: Ｊ．　Ｉｍｍｕｎｏｌ． Ｖｏｌ．１６６, 2001, ｐｐ．１３２０-１３２６ *
JPN6012050543; ＣＡＲＴＲＯＮ，　Ｇ．　ｅｔ　ａｌ．: Ｂｌｏｏｄ Ｖｏｌ．９９, 2002, ｐｐ．７５４-７５８ *
JPN6012050545; ＷＥＮＧ，　Ｗ．-Ｋ．　ａｎｄ　ＬＥＶＹ，　Ｒ．: Ｊ．　Ｃｌｉｎ．　Ｏｎｃｏｌ． Ｖｏｌ．２１，　Ｎｏ．２１, 2003, ｐｐ．３９４０-３９４７ *

Also Published As

Publication number Publication date
EP2006305A4 (en) 2010-06-30
EP2610268A1 (en) 2013-07-03
US20190367630A1 (en) 2019-12-05
US20090304715A1 (en) 2009-12-10
CA2638804A1 (en) 2007-09-07
EP2006305B1 (en) 2016-08-10
JP2012136519A (ja) 2012-07-19
CA2638804C (en) 2017-02-28
JP5901299B2 (ja) 2016-04-06
JPWO2007100083A1 (ja) 2009-07-23
EP2006305A2 (en) 2008-12-24
EP2006305A9 (en) 2009-07-15
WO2007100083A1 (ja) 2007-09-07
ES2602439T3 (es) 2017-02-21

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