JP5592890B2 - ピロロトリアジンキナーゼ阻害剤 - Google Patents

ピロロトリアジンキナーゼ阻害剤 Download PDF

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Publication number
JP5592890B2
JP5592890B2 JP2011531165A JP2011531165A JP5592890B2 JP 5592890 B2 JP5592890 B2 JP 5592890B2 JP 2011531165 A JP2011531165 A JP 2011531165A JP 2011531165 A JP2011531165 A JP 2011531165A JP 5592890 B2 JP5592890 B2 JP 5592890B2
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Japan
Prior art keywords
substituted
methyl
pyrazol
piperazinyl
pyrrolo
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Expired - Fee Related
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JP2011531165A
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English (en)
Japanese (ja)
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JP2012505234A5 (OSRAM
JP2012505234A (ja
Inventor
アショク・ブイ・プランデア
デイビッド・ビー・フレンネソン
ムソニ・ジー・カマウ
ラルグディ・エス・ハリクリシュナン
マーク・ジー・ソールニアー
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication date
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011531165A 2008-10-08 2009-10-08 ピロロトリアジンキナーゼ阻害剤 Expired - Fee Related JP5592890B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10362008P 2008-10-08 2008-10-08
US61/103,620 2008-10-08
PCT/US2009/059945 WO2010042684A1 (en) 2008-10-08 2009-10-08 Pyrrolotriazine kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2012505234A JP2012505234A (ja) 2012-03-01
JP2012505234A5 JP2012505234A5 (OSRAM) 2012-11-08
JP5592890B2 true JP5592890B2 (ja) 2014-09-17

Family

ID=41664941

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011531165A Expired - Fee Related JP5592890B2 (ja) 2008-10-08 2009-10-08 ピロロトリアジンキナーゼ阻害剤

Country Status (5)

Country Link
US (1) US8445676B2 (OSRAM)
EP (1) EP2344504B1 (OSRAM)
JP (1) JP5592890B2 (OSRAM)
CN (1) CN102245610B (OSRAM)
WO (1) WO2010042684A1 (OSRAM)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011513419A (ja) * 2008-03-06 2011-04-28 ブリストル−マイヤーズ スクイブ カンパニー ピロロトリアジンキナーゼ阻害剤
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
US9050345B2 (en) * 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2015051500A1 (zh) * 2013-10-08 2015-04-16 上海创诺制药有限公司 吡咯并三嗪类衍生物及其制法和用途
CN104016983B (zh) * 2013-10-08 2018-11-02 上海创诺制药有限公司 吡咯并三嗪类衍生物及其制法和用途
CA2933927C (en) * 2013-12-17 2021-11-16 Merck Patent Gmbh N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase
CN104974163B (zh) * 2014-04-14 2017-11-07 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
US10550125B2 (en) * 2015-10-20 2020-02-04 Bristol-Myers Squibb Company Prodrugs of imidazotriazine compounds as CK2 inhibitors
MX380776B (es) * 2016-07-14 2025-03-12 Lilly Co Eli Derivados de pirazolilaminobenzimidazol como inhibidores de jak.
US11753413B2 (en) 2020-06-19 2023-09-12 Incyte Corporation Substituted pyrrolo[2,1-f][1,2,4]triazine compounds as JAK2 V617F inhibitors
US11691971B2 (en) 2020-06-19 2023-07-04 Incyte Corporation Naphthyridinone compounds as JAK2 V617F inhibitors
US11767323B2 (en) 2020-07-02 2023-09-26 Incyte Corporation Tricyclic pyridone compounds as JAK2 V617F inhibitors
SI4175719T1 (sl) 2020-07-02 2025-07-31 Incyte Corporation Triciklične sečninske spojine kot zaviralci jak2 v617f
US11661422B2 (en) 2020-08-27 2023-05-30 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
WO2022140231A1 (en) 2020-12-21 2022-06-30 Incyte Corporation Deazaguaine compounds as jak2 v617f inhibitors
US11958861B2 (en) 2021-02-25 2024-04-16 Incyte Corporation Spirocyclic lactams as JAK2 V617F inhibitors
US12084430B2 (en) 2022-03-17 2024-09-10 Incyte Corporation Tricyclic urea compounds as JAK2 V617F inhibitors
AU2023249795A1 (en) 2022-04-08 2024-10-17 Shy Therapeutics, Llc Compounds that interact with ras superfamily proteins for treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ516292A (en) * 1999-05-21 2004-01-30 Bristol Myers Squibb Co Pyrrolotriazine inhibitors of kinases
MXPA05008183A (es) * 2003-02-05 2005-10-05 Bristol Myers Squibb Co Proceso para preparar pirrolotriazina como inhibidores de cinasa.
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
CN1993130B (zh) * 2004-06-28 2010-06-23 布里斯托尔-迈尔斯斯奎布公司 用于制备稠合杂环激酶抑制剂的方法和中间体
US7713973B2 (en) * 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
US7442700B2 (en) * 2005-07-01 2008-10-28 Bristol-Myers Squibb Company Pyrrolotriazine compounds useful as kinase inhibitors and methods of treating kinase-associated conditions therewith
US7514435B2 (en) * 2005-11-18 2009-04-07 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
KR20130141706A (ko) * 2005-12-02 2013-12-26 바이엘 헬스케어 엘엘씨 과다-증식성 장애 및 맥관형성과 관련된 질환의 치료에 유용한 치환된 4-아미노-피롤로트리아진 유도체
EP2041138B1 (en) * 2006-07-07 2014-06-25 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7531539B2 (en) * 2006-08-09 2009-05-12 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP2081936B1 (en) * 2006-11-03 2014-04-02 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2008131050A1 (en) * 2007-04-18 2008-10-30 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
JP5678661B2 (ja) * 2007-09-25 2015-03-04 バイエル ヘルスケア エルエルシー オーロラキナーゼの阻害による癌の治療に有用なピロロトリアジン誘導体
JP2011513419A (ja) * 2008-03-06 2011-04-28 ブリストル−マイヤーズ スクイブ カンパニー ピロロトリアジンキナーゼ阻害剤

Also Published As

Publication number Publication date
EP2344504B1 (en) 2014-06-04
CN102245610A (zh) 2011-11-16
US8445676B2 (en) 2013-05-21
WO2010042684A4 (en) 2010-07-08
WO2010042684A1 (en) 2010-04-15
JP2012505234A (ja) 2012-03-01
CN102245610B (zh) 2014-04-30
US20110294816A1 (en) 2011-12-01
EP2344504A1 (en) 2011-07-20

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