JP5588864B2 - 密閉膜を用いる貯留槽システム - Google Patents
密閉膜を用いる貯留槽システム Download PDFInfo
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- JP5588864B2 JP5588864B2 JP2010513646A JP2010513646A JP5588864B2 JP 5588864 B2 JP5588864 B2 JP 5588864B2 JP 2010513646 A JP2010513646 A JP 2010513646A JP 2010513646 A JP2010513646 A JP 2010513646A JP 5588864 B2 JP5588864 B2 JP 5588864B2
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- skin
- transdermal administration
- sealing layer
- active substance
- administration according
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Description
Claims (16)
- 少なくとも1種類の活性物質を含む貯留槽と、該活性物質の貯留槽を画する活性物質−透過性膜と、密閉層とを含み、該密閉層の密閉材は30℃ないし35℃の範囲の融解温度 を有し、該密閉層は、少なくとも1種類の活性物質を皮膚温度よりも低い温度では透過できないが、皮膚温度又はそれよりも高い温度では透過できることを特徴とする、皮膚投与又は経皮投与の治療システム。
- 前記密閉材の融解温度は、31℃ないし33℃の範囲であることを特徴とする、請求項 1に記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉材の融解温度は、32℃であることを特徴とする、請求項1又は2に記載の皮 膚投与又は経皮投与の治療システム。
- 密閉材が、植物性脂肪と、動物性脂肪と、アルカノールと、脂肪酸と、長鎖飽和脂肪酸のモノグリセリド、ジグリセリド及びトリグリセリド(C12H24O2ないしC18H36O2)及び中鎖トリグリセリド(C6H12O2ないしC10H20O2)と、長鎖アルカノール及び酸のエステルと、天然樹脂と、高分子パラフィンと、水和ヒマシ油のポリエチレングリコール誘導体と、トコフェロールのポリエチレングリコール誘導体と、多糖類と、アクリル酸の重合体と、これらの混合物とのグループからの物質から選択されることを特徴とする、請求項1ないし3のうちの1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉材は、カカオバター及びクプアスバターと、鯨蝋の代用品と、蜜蝋と、硬質脂肪と、中性油と、ドデカノールと、セチルアルコールと、ウンデセン酸と、パルミチン酸ミリシルエステルと、コロフォニーと、トコフェルソランと、グア粉末及びカルボポールと、これらの混合物とのうちから選択されることを特徴とする、請求項1ないし4のうち の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層の材料は均一な混合物からなることを特徴とする、請求項1ないし5のうちの1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層は、植物性脂肪及び動物性脂肪の混合物のうちから選択されることを特徴とする、請求項1ないし6のうちの1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記混合物は、蜜蝋及びカルナバワックスからなり、蜜蝋の割合は重量比40%ないし95%の範囲であり、かつ、カルナバワックスの割合は重量比5%ないし60%の範囲であることを特徴とする、請求項6又は7に記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層の物質は、長鎖飽和脂肪酸のモノグリセリド、ジグリセリド及びトリグリセリド(C12H24O2ないしC18H36O2)と、中鎖トリグリセリド(C6H12O2ないしC10H20O2)との均一の混合物であることを特徴とする、請求項1ないし8の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記混合物は、硬質脂肪及び中性油からなり、前記硬質脂肪が重量比60%ないし90%の割合で含まれ、かつ、前記中性油が重量比10%ないし40%の割合で含まれることを特徴とする、請求項6ないし9の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層は重量比0.1%ないし10%の抗酸化剤を含むことを特徴とする、請求項1ないし10の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記抗酸化剤は、トコフェロールのポリエチレングリコール誘導体であることを特徴とする、請求項11に記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層は、皮膚温度又はそれよりも高い温度で透過性を増大する特性を有することを特徴とする、請求項1ないし12の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層は、感圧接着の特性を有することを特徴とする、請求項1ないし13の1つに記載の皮膚投与又は経皮投与の治療システム。
- 前記密閉層の厚さは、50μmないし600μmの範囲であることを特徴とする、請求項1ないし14の1つに記載の皮膚投与又は経皮投与の治療システム。
- 少なくとも1種類の活性物質を含む前記密閉層は、固体、半固体又は液体の貯留槽として形成されることを特徴とする、請求項1ないし15の1つに記載の皮膚投与又は経皮投与の治療システム。
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DE102007030965.3 | 2007-07-04 | ||
PCT/DE2008/001112 WO2009003466A1 (de) | 2007-07-04 | 2008-07-04 | Reservoirsystem mit verschlossener membran |
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EP (1) | EP2173330B1 (ja) |
JP (1) | JP5588864B2 (ja) |
AT (1) | ATE551994T1 (ja) |
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EP3131540B1 (en) * | 2014-04-18 | 2023-11-22 | Entrotech, Inc. | Methods of processing chlorhexidine-containing polymerizable compositions and antimicrobial articles formed thereby |
TWI670089B (zh) | 2017-03-24 | 2019-09-01 | 美商伊英克加利福尼亞有限責任公司 | 用於調節活性物投送速率之包含帶電或磁性粒子的微胞遞送系統 |
CN110461314A (zh) | 2017-03-24 | 2019-11-15 | 伊英克加利福尼亚有限责任公司 | 用于递送活性分子的微单元系统 |
JP6972334B2 (ja) | 2017-11-14 | 2021-11-24 | イー インク カリフォルニア, エルエルシー | 多孔性伝導電極層を含む電気泳動活性分子送達システム |
DE102018216244A1 (de) * | 2018-09-24 | 2020-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Barriereschicht |
CN110403921A (zh) * | 2019-08-29 | 2019-11-05 | 上海迦瑞生物医药有限公司 | 一种卡巴拉汀外用贴剂及其制备方法 |
JP7438346B2 (ja) | 2019-11-27 | 2024-02-26 | イー インク コーポレイション | 電気浸食シール層を有するマイクロセルを備えている有益剤送達システム |
CN116322881A (zh) | 2020-10-29 | 2023-06-23 | 伊英克加利福尼亚有限责任公司 | 用于递送有益剂的微单元系统 |
JP2023545106A (ja) | 2020-10-29 | 2023-10-26 | イー インク カリフォルニア, エルエルシー | 親水性活性分子を送達するためのマイクロセルシステム |
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US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
US4382886A (en) * | 1981-04-13 | 1983-05-10 | Sosnowski Zenon M | Method for extracting propolis and water soluble dry propolis powder |
DE3786998D1 (de) | 1986-11-20 | 1993-09-16 | Ciba Geigy Ag | Benutzer-aktivierte therapeutische systeme. |
US4943435A (en) | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
JP3240496B2 (ja) * | 1993-09-30 | 2001-12-17 | タキロン株式会社 | 経皮吸収製剤 |
PT1041975E (pt) * | 1997-12-22 | 2003-01-31 | Alza Corp | Membranas de controlo de taxa para dispositivos de fornecimento controlado de drogas |
US20020182260A1 (en) * | 1998-05-29 | 2002-12-05 | Cellegy Pharmaceuticals, Inc. | Anti-inflammatory agents and methods for their preparation and use |
EP1150675B1 (en) * | 1999-02-09 | 2006-02-01 | Samyang Corporation | A transdermal composition of an antivomiting agent and a preparation containing the same |
JP2002541094A (ja) * | 1999-04-01 | 2002-12-03 | アルザ・コーポレーション | ポリウレタン薬物貯蔵部を含んでなる経皮薬物送達装置 |
DE10137162A1 (de) | 2001-07-30 | 2003-02-20 | Hexal Ag | Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol |
AU2002329763B2 (en) * | 2001-08-17 | 2007-11-08 | Lavipharm Laboratories Inc. | Composition and transdermal drug delivery device |
GB0313999D0 (en) | 2003-06-17 | 2003-07-23 | Richards Peter W | Anti pyrexia patch |
WO2007112287A2 (en) * | 2006-03-24 | 2007-10-04 | Auxilium Pharmaceuticals, Inc. | Hme transdermal compositions containing testosterone |
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EP2173330A1 (de) | 2010-04-14 |
DE112008002414A5 (de) | 2010-06-10 |
PL2173330T3 (pl) | 2012-08-31 |
ES2385231T3 (es) | 2012-07-19 |
ATE551994T1 (de) | 2012-04-15 |
CA2692364C (en) | 2015-05-19 |
CA2692364A1 (en) | 2009-01-08 |
JP2010531684A (ja) | 2010-09-30 |
US8440222B2 (en) | 2013-05-14 |
EP2173330B1 (de) | 2012-04-04 |
US20100172959A1 (en) | 2010-07-08 |
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