JP5579079B2 - 黄斑浮腫治療用ジフルプレドナート点眼剤 - Google Patents

黄斑浮腫治療用ジフルプレドナート点眼剤 Download PDF

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Publication number
JP5579079B2
JP5579079B2 JP2010545305A JP2010545305A JP5579079B2 JP 5579079 B2 JP5579079 B2 JP 5579079B2 JP 2010545305 A JP2010545305 A JP 2010545305A JP 2010545305 A JP2010545305 A JP 2010545305A JP 5579079 B2 JP5579079 B2 JP 5579079B2
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administration
weeks
eye drop
difluprednate
day
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JP2012533517A5 (enExample
JP2012533517A (ja
Inventor
英俊 山下
禎子 山本
早紀子 後藤
さち 阿部
枝里子 桐井
敦司 奥村
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Yamagata University NUC
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Yamagata University NUC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2010545305A 2009-07-14 2010-07-14 黄斑浮腫治療用ジフルプレドナート点眼剤 Expired - Fee Related JP5579079B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2010545305A JP5579079B2 (ja) 2009-07-14 2010-07-14 黄斑浮腫治療用ジフルプレドナート点眼剤

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2009165924 2009-07-14
JP2009165924 2009-07-14
JP2010545305A JP5579079B2 (ja) 2009-07-14 2010-07-14 黄斑浮腫治療用ジフルプレドナート点眼剤
PCT/JP2010/062289 WO2011007893A1 (en) 2009-07-14 2010-07-14 Eye drop with difluprednate for macular edema treatment

Publications (3)

Publication Number Publication Date
JP2012533517A JP2012533517A (ja) 2012-12-27
JP2012533517A5 JP2012533517A5 (enExample) 2013-07-18
JP5579079B2 true JP5579079B2 (ja) 2014-08-27

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JP2010545305A Expired - Fee Related JP5579079B2 (ja) 2009-07-14 2010-07-14 黄斑浮腫治療用ジフルプレドナート点眼剤

Country Status (13)

Country Link
US (3) US20110190250A1 (enExample)
EP (1) EP2340014B1 (enExample)
JP (1) JP5579079B2 (enExample)
KR (1) KR101689847B1 (enExample)
CN (3) CN102170865A (enExample)
BR (1) BRPI1005380A2 (enExample)
CA (1) CA2738151C (enExample)
ES (1) ES2405779T3 (enExample)
MX (1) MX2011005043A (enExample)
PL (1) PL2340014T3 (enExample)
RU (1) RU2572707C2 (enExample)
TW (1) TW201105363A (enExample)
WO (1) WO2011007893A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5902100B2 (ja) * 2011-01-14 2016-04-13 株式会社エス・ディー・エス バイオテック 4−(3−ブチニル)アミノピリミジン誘導体を含む農園芸用有害生物防除剤組成物
US20140018402A1 (en) * 2011-03-30 2014-01-16 Catholic University Industry Academic Cooperation Foundation Pharmaceutical composition for preventing or treating macular degeneration
CN103130857A (zh) * 2011-11-30 2013-06-05 天津金耀集团有限公司 二氟泼尼酯ⅱ晶型及其制备方法
CN103130859B (zh) * 2011-11-30 2015-12-02 天津金耀集团有限公司 二氟泼尼酯晶型i及其制备方法
KR20150119315A (ko) * 2013-02-15 2015-10-23 센주 세이야꾸 가부시키가이샤 아연을 함유하는 디플루프레드네이트 유액 조성물
GB2516561B (en) * 2013-03-15 2016-03-09 Aerpio Therapeutics Inc Compositions, formulations and methods for treating ocular diseases
WO2015197594A2 (de) 2014-06-23 2015-12-30 Schott Ag Elektrisches speichersystem enthaltend ein scheibenförmiges diskretes element, scheibenförmiges diskretes element sowie verfahren zu dessen herstellung und dessen verwendung
JP2018505515A (ja) 2014-12-01 2018-02-22 ショット アクチエンゲゼルシャフトSchott AG シート状の独立した部材を有する蓄電システム、独立したシート状の部材、その製造方法、およびその使用
EP4566638A3 (en) * 2015-05-29 2025-08-27 Allergan, Inc. Implant for treatment of an ocular condition
RU2661621C2 (ru) * 2016-12-19 2018-07-17 Александр Николаевич Епихин Способ пролонгации и усиления терапевтического эффекта действия ингибиторов ангиогенеза при лечении неоваскулярных форм макулярных дегенераций
CN108014172A (zh) * 2017-12-29 2018-05-11 广州仁恒医药科技股份有限公司 一种含有二氟泼尼酯的药物组合物及其制备方法
KR20210012346A (ko) 2019-07-25 2021-02-03 심낙범 미세먼지 눈꺼풀 세정스틱
US20210100856A1 (en) * 2019-09-11 2021-04-08 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept
WO2021050649A1 (en) * 2019-09-11 2021-03-18 Adverum Biotechnologies, Inc. Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3781792B2 (ja) 1993-12-27 2006-05-31 千寿製薬株式会社 ジフルプレドナート含有点眼用懸濁液剤
AU684115B2 (en) 1993-12-27 1997-12-04 Mitsubishi Chemical Corporation Ophthalmic suspension containing diflupredonate
US6114319A (en) 1997-05-14 2000-09-05 Senju Pharmaceutical Co., Ltd. Compositions containing difluprednate
JP3410364B2 (ja) 1997-05-14 2003-05-26 千寿製薬株式会社 ジフルプレドナート含有組成物
US20050048099A1 (en) * 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
MXPA05008561A (es) * 2003-02-20 2005-11-04 Alcon Inc Uso de esteroides para tratar personas que sufren de trastornos oculares.
US20050226814A1 (en) * 2004-04-13 2005-10-13 Bausch & Lomb Incorporated Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid
US20060009498A1 (en) * 2004-07-12 2006-01-12 Allergan, Inc. Ophthalmic compositions and methods for treating ophthalmic conditions
EP1848541A4 (en) * 2005-02-07 2013-01-16 Pharmalight Inc METHOD AND DEVICE FOR THE OPHTHALMIC ADMINISTRATION OF PHARMACEUTICAL ACTIVE SUBSTANCES
US20070049568A1 (en) 2005-08-25 2007-03-01 Psivida Inc. Control of induced elevated intraocular pressure
US20090105245A1 (en) * 2006-12-21 2009-04-23 Bingaman David P Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor

Also Published As

Publication number Publication date
ES2405779T3 (es) 2013-06-03
US20110190250A1 (en) 2011-08-04
EP2340014B1 (en) 2013-04-24
KR20120040683A (ko) 2012-04-27
CN103705524A (zh) 2014-04-09
CN102170865A (zh) 2011-08-31
RU2011125640A (ru) 2013-08-20
CN107569494A (zh) 2018-01-12
EP2340014A1 (en) 2011-07-06
CA2738151C (en) 2017-02-28
US20180133153A1 (en) 2018-05-17
US9949926B2 (en) 2018-04-24
WO2011007893A1 (en) 2011-01-20
JP2012533517A (ja) 2012-12-27
KR101689847B1 (ko) 2016-12-26
PL2340014T3 (pl) 2013-09-30
RU2572707C2 (ru) 2016-01-20
BRPI1005380A2 (pt) 2016-02-10
US10092514B2 (en) 2018-10-09
US20150190340A1 (en) 2015-07-09
MX2011005043A (es) 2011-06-01
TW201105363A (en) 2011-02-16
CA2738151A1 (en) 2011-01-20

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