JP5576362B2 - 乳癌を治療するための組成物および方法 - Google Patents

乳癌を治療するための組成物および方法 Download PDF

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Publication number
JP5576362B2
JP5576362B2 JP2011507559A JP2011507559A JP5576362B2 JP 5576362 B2 JP5576362 B2 JP 5576362B2 JP 2011507559 A JP2011507559 A JP 2011507559A JP 2011507559 A JP2011507559 A JP 2011507559A JP 5576362 B2 JP5576362 B2 JP 5576362B2
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cdb
progesterone
breast cancer
tumor
compound
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Japanese (ja)
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JP2011518883A5 (cg-RX-API-DMAC7.html
JP2011518883A (ja
Inventor
エス． ポドルスキ，ジョセフ
ディー． ウィエール，ロナルド
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レプロス セラピューティクス インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011507559A 2008-04-28 2009-04-27 乳癌を治療するための組成物および方法 Expired - Fee Related JP5576362B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4845208P 2008-04-28 2008-04-28
US61/048,452 2008-04-28
PCT/US2009/041836 WO2009134723A1 (en) 2008-04-28 2009-04-27 Pregesteron antagonists such as cdb-4124 in the treatment of breast cancer

Publications (3)

Publication Number Publication Date
JP2011518883A JP2011518883A (ja) 2011-06-30
JP2011518883A5 JP2011518883A5 (cg-RX-API-DMAC7.html) 2012-06-07
JP5576362B2 true JP5576362B2 (ja) 2014-08-20

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JP2011507559A Expired - Fee Related JP5576362B2 (ja) 2008-04-28 2009-04-27 乳癌を治療するための組成物および方法

Country Status (21)

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US (2) US20110053900A1 (cg-RX-API-DMAC7.html)
EP (2) EP2293798A1 (cg-RX-API-DMAC7.html)
JP (1) JP5576362B2 (cg-RX-API-DMAC7.html)
KR (1) KR101349737B1 (cg-RX-API-DMAC7.html)
CN (1) CN102099040B (cg-RX-API-DMAC7.html)
AR (1) AR071419A1 (cg-RX-API-DMAC7.html)
AU (1) AU2009241360B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0911112A2 (cg-RX-API-DMAC7.html)
CA (1) CA2722637C (cg-RX-API-DMAC7.html)
CL (1) CL2009001011A1 (cg-RX-API-DMAC7.html)
EA (1) EA019224B1 (cg-RX-API-DMAC7.html)
IL (2) IL208845A (cg-RX-API-DMAC7.html)
ME (1) ME01122B (cg-RX-API-DMAC7.html)
MX (1) MX2010011273A (cg-RX-API-DMAC7.html)
MY (1) MY161549A (cg-RX-API-DMAC7.html)
NI (1) NI201000184A (cg-RX-API-DMAC7.html)
NZ (1) NZ589534A (cg-RX-API-DMAC7.html)
TW (1) TWI539953B (cg-RX-API-DMAC7.html)
UA (1) UA101192C2 (cg-RX-API-DMAC7.html)
WO (1) WO2009134723A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201007648B (cg-RX-API-DMAC7.html)

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UA113283C2 (xx) * 2010-12-23 2017-01-10 19-норстероїди і їх застосування для лікування прогестеронзалежних станів
PH12014500683A1 (en) * 2011-10-04 2014-05-12 Invivis Pharmaceuticals Inc Methods and systems for identfying and treating anti-progestin sensitive tumors
FR2997628B1 (fr) * 2012-11-08 2015-01-16 Hra Pharma Lab Produit de co-micronisation comprenant un modulateur selectif des recepteurs a la progesterone
AU2014228990B2 (en) * 2013-03-15 2017-02-02 Aprecia Pharmaceuticals LLC Rapid disperse dosage form containing levetiracetam
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
HU230381B1 (hu) * 2014-02-17 2016-03-29 Richter Gedeon Nyrt Ipari eljárás szteroid intermedier előállítására
MX391191B (es) 2014-11-17 2025-03-21 Context Biopharma Inc Composiciones de liberación extendida de onapristona y métodos.
WO2017053793A1 (en) 2015-09-25 2017-03-30 Arno Therapeutics, Inc. Methods of making onapristone intermediates
MX2018007154A (es) 2015-12-15 2019-01-10 Context Biopharma Inc Composiciones de onapristona amorfa y metodos para hacer las mismas.
KR102558066B1 (ko) 2016-03-28 2023-07-25 인사이트 코포레이션 Tam 억제제로서 피롤로트리아진 화합물
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
WO2018106914A1 (en) * 2016-12-09 2018-06-14 Repros Therapeutics Inc. Oral pharmaceutical compositions comprising an unmicronized selective progesterone receptor as active agent
IL273579B2 (en) 2017-09-27 2025-10-01 Incyte Corp Salts of pyrrolizidine derivatives used as Tm inhibitors.
HRP20250676T1 (hr) 2018-06-29 2025-08-01 Incyte Corporation Formulacije inhibitora axl/mer
RU2679625C1 (ru) * 2018-11-08 2019-02-12 Ильясов Шамиль Сионович ПРИМЕНЕНИЕ 3-О-СУЛЬФАМОИЛОКСИ-6-ОКСА-7β-МЕТИЛ-D-ГОМО-8α-ЭСТРА-1,3,5(10)-ТРИЕН-17а-ОНА ДЛЯ ЛЕЧЕНИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ, ВКЛЮЧАЯ ТРИЖДЫ-НЕГАТИВНУЮ ФОРМУ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
CN115697343A (zh) 2020-03-06 2023-02-03 因赛特公司 包含axl/mer和pd-1/pd-l1抑制剂的组合疗法

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Also Published As

Publication number Publication date
NI201000184A (es) 2011-08-10
CN102099040B (zh) 2013-06-19
TWI539953B (zh) 2016-07-01
US20110053900A1 (en) 2011-03-03
IL208845A (en) 2016-08-31
KR101349737B1 (ko) 2014-02-07
EP2293798A1 (en) 2011-03-16
IL247093A0 (en) 2016-09-29
ZA201007648B (en) 2011-07-27
AU2009241360B2 (en) 2012-03-08
CL2009001011A1 (es) 2009-09-25
MY161549A (en) 2017-04-28
EA019224B1 (ru) 2014-02-28
AR071419A1 (es) 2010-06-16
HK1155084A1 (en) 2012-05-11
CA2722637C (en) 2015-03-10
EP2974772A1 (en) 2016-01-20
KR20110003553A (ko) 2011-01-12
NZ589534A (en) 2012-08-31
TW201002330A (en) 2010-01-16
WO2009134723A9 (en) 2010-01-21
IL208845A0 (en) 2011-01-31
BRPI0911112A2 (pt) 2015-10-06
AU2009241360A1 (en) 2009-11-05
US20140343022A1 (en) 2014-11-20
CA2722637A1 (en) 2009-11-05
WO2009134723A1 (en) 2009-11-05
JP2011518883A (ja) 2011-06-30
ME01122B (me) 2013-03-20
EA201071250A1 (ru) 2011-04-29
UA101192C2 (uk) 2013-03-11
MX2010011273A (es) 2010-12-21
CN102099040A (zh) 2011-06-15

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