JP5558587B2 - 共鳴非線形光信号を検出するための方法およびその方法を実装するための装置 - Google Patents
共鳴非線形光信号を検出するための方法およびその方法を実装するための装置 Download PDFInfo
- Publication number
- JP5558587B2 JP5558587B2 JP2012549334A JP2012549334A JP5558587B2 JP 5558587 B2 JP5558587 B2 JP 5558587B2 JP 2012549334 A JP2012549334 A JP 2012549334A JP 2012549334 A JP2012549334 A JP 2012549334A JP 5558587 B2 JP5558587 B2 JP 5558587B2
- Authority
- JP
- Japan
- Prior art keywords
- optical signal
- nonlinear optical
- resonant
- medium
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000003287 optical effect Effects 0.000 title claims description 103
- 238000000034 method Methods 0.000 title claims description 55
- 230000005284 excitation Effects 0.000 claims description 68
- 238000001514 detection method Methods 0.000 claims description 57
- 230000005855 radiation Effects 0.000 claims description 23
- 238000012545 processing Methods 0.000 claims description 21
- 238000001069 Raman spectroscopy Methods 0.000 claims description 19
- 230000003993 interaction Effects 0.000 claims description 12
- 238000001228 spectrum Methods 0.000 claims description 11
- 210000001747 pupil Anatomy 0.000 claims description 9
- 230000000295 complement effect Effects 0.000 claims description 7
- 239000000523 sample Substances 0.000 description 53
- 230000008569 process Effects 0.000 description 16
- 238000001237 Raman spectrum Methods 0.000 description 9
- 239000002904 solvent Substances 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 7
- 239000011324 bead Substances 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 5
- 239000013307 optical fiber Substances 0.000 description 5
- 238000004611 spectroscopical analysis Methods 0.000 description 5
- 229910052779 Neodymium Inorganic materials 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229910052691 Erbium Inorganic materials 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 229910052769 Ytterbium Inorganic materials 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000028161 membrane depolarization Effects 0.000 description 3
- 230000003534 oscillatory effect Effects 0.000 description 3
- 230000010363 phase shift Effects 0.000 description 3
- 230000010287 polarization Effects 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 229910052594 sapphire Inorganic materials 0.000 description 3
- 239000010980 sapphire Substances 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 230000003595 spectral effect Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 3
- 238000004566 IR spectroscopy Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910009372 YVO4 Inorganic materials 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000009022 nonlinear effect Effects 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 239000004038 photonic crystal Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000001845 vibrational spectrum Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/653—Coherent methods [CARS]
Landscapes
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1000244A FR2955663B1 (fr) | 2010-01-22 | 2010-01-22 | Methode pour la detection d'un signal optique non lineaire resonant et dispositif pour la mise en oeuvre de ladite methode |
| FR10/00244 | 2010-01-22 | ||
| PCT/EP2011/050622 WO2011089119A1 (fr) | 2010-01-22 | 2011-01-18 | Methode pour la detection d'un signal optique non lineaire resonant et dispositif pour la mise en oeuvre de ladite methode |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013517491A JP2013517491A (ja) | 2013-05-16 |
| JP2013517491A5 JP2013517491A5 (enExample) | 2014-01-16 |
| JP5558587B2 true JP5558587B2 (ja) | 2014-07-23 |
Family
ID=42562452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012549334A Expired - Fee Related JP5558587B2 (ja) | 2010-01-22 | 2011-01-18 | 共鳴非線形光信号を検出するための方法およびその方法を実装するための装置 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8804117B2 (enExample) |
| EP (1) | EP2526408B1 (enExample) |
| JP (1) | JP5558587B2 (enExample) |
| FR (1) | FR2955663B1 (enExample) |
| WO (1) | WO2011089119A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066447A1 (en) | 2011-08-01 | 2013-05-10 | The Trustees Of Columbia University In The City Of New York | Lens-free planar imager and wireless transmitter |
| WO2013059665A1 (en) | 2011-10-19 | 2013-04-25 | The Trustees Of Columbia University In The City Of New York | Ultracompact fabry-perot array for ultracompact hyperspectral imaging |
| WO2013176759A1 (en) * | 2012-03-30 | 2013-11-28 | The Trustees Of Columbia University In The City Of New York | Systems and methods for chip-integrated infrared silicon detector |
| WO2013148349A1 (en) | 2012-03-30 | 2013-10-03 | The Trustees Of Columbia University In The City Of New York | Graphene photonics for resonator-enhanced electro-optic devices and all-optical interactions |
| US9212948B2 (en) | 2012-11-07 | 2015-12-15 | The Trustees Of Columbia University In The City Of New York | Lossless hyperspectral imaging |
| US9927397B1 (en) * | 2013-11-26 | 2018-03-27 | Stc.Unm | Innovative nanopore sequencing technology including a self-assembled porous membrane |
| CN104185353B (zh) * | 2014-09-05 | 2016-08-24 | 中国人民解放军陆军军官学院 | 一种基于汤姆逊散射弱相干技术的聚变堆等离子体密度温度诊断方法 |
| JP6340474B2 (ja) * | 2015-03-11 | 2018-06-06 | 株式会社日立ハイテクノロジーズ | 光計測装置及び光計測方法 |
| JP6765648B2 (ja) * | 2016-07-13 | 2020-10-07 | 国立大学法人東京農工大学 | 光検出装置、光検出方法および光検出プログラム |
| JP7567112B2 (ja) * | 2020-05-18 | 2024-10-16 | 株式会社エーティーエー | 差分検出共役補償ｃａｒｓ計測装置 |
| JP7568210B2 (ja) * | 2020-05-22 | 2024-10-16 | 国立大学法人山梨大学 | 分析システム及び分析方法 |
| WO2022165276A1 (en) | 2021-01-29 | 2022-08-04 | Armonica Technologies, Inc. | Enhancement structures for surface-enhanced raman scattering |
| CN113252085B (zh) * | 2021-06-30 | 2021-09-17 | 中国人民解放军国防科技大学 | 含非线性机械振子的光机械微腔结构、测量系统及方法 |
| CN113948944B (zh) * | 2021-10-15 | 2024-04-09 | 复旦大学 | 一种基于共振四波混频产生相干太赫兹脉冲的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5042952A (en) * | 1984-05-21 | 1991-08-27 | Therma-Wave, Inc. | Method and apparatus for evaluating surface and subsurface and subsurface features in a semiconductor |
| US5303710A (en) * | 1992-11-03 | 1994-04-19 | The United States Of America As Represented By The Secretary Of The Navy | Apparatus for imaging an object in or through a scattering medium using coherent anti-Stokes Raman scattering |
| DE4243144B4 (de) * | 1992-12-19 | 2008-08-21 | BRUKER OPTICS, Inc., Billerica | Objektiv für ein FT-Raman-Mikroskop |
| ATE543080T1 (de) | 2000-07-13 | 2012-02-15 | Harvard College | System und verfahren für die epidetektions- kohärenz-anti-stokes-raman-streumikroskopie |
| JP4854878B2 (ja) * | 2001-07-03 | 2012-01-18 | オリンパス株式会社 | レーザー顕微鏡 |
| US6789507B1 (en) | 2002-09-03 | 2004-09-14 | Paul Davis Slate | Oxygen flow control process for hatchery hatchers |
| EP1754047A1 (en) * | 2004-06-09 | 2007-02-21 | The President And Fellows Of Havard College | Phase sensitive heterodyne coherent anti-stokes raman scattering micro-spectroscopy and microscopy systems and methods. |
| JP4954452B2 (ja) * | 2004-07-06 | 2012-06-13 | オリンパス株式会社 | 顕微鏡 |
| US7586618B2 (en) * | 2005-02-28 | 2009-09-08 | The Board Of Trustees Of The University Of Illinois | Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering |
| US7352458B2 (en) | 2005-10-26 | 2008-04-01 | President And Fellows Of Harvard College | System and method for high sensitivity vibrational imaging with frequency modulation coherent anti-stokes Raman scattering analyses |
| DE102007021378A1 (de) | 2007-05-04 | 2008-11-06 | Ape Angewandte Physik Und Elektronik Gmbh | Verfahren und optische Anordnung zum Erzeugen eines nicht-linearen optischen Signals an einem durch ein Anregungsfeld angeregten Material sowie Verwendung des Verfahrens und der optischen Anordnung |
| KR100929202B1 (ko) * | 2008-02-27 | 2009-12-01 | 광주과학기술원 | 가간섭성 반스토크스 라만 산란을 이용한 영상 획득 장치및 방법 |
-
2010
- 2010-01-22 FR FR1000244A patent/FR2955663B1/fr not_active Expired - Fee Related
-
2011
- 2011-01-18 WO PCT/EP2011/050622 patent/WO2011089119A1/fr not_active Ceased
- 2011-01-18 US US13/574,482 patent/US8804117B2/en not_active Expired - Fee Related
- 2011-01-18 EP EP11703623.6A patent/EP2526408B1/fr not_active Not-in-force
- 2011-01-18 JP JP2012549334A patent/JP5558587B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FR2955663B1 (fr) | 2014-09-12 |
| FR2955663A1 (fr) | 2011-07-29 |
| EP2526408A1 (fr) | 2012-11-28 |
| US20130021606A1 (en) | 2013-01-24 |
| JP2013517491A (ja) | 2013-05-16 |
| EP2526408B1 (fr) | 2014-03-19 |
| US8804117B2 (en) | 2014-08-12 |
| WO2011089119A1 (fr) | 2011-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5558587B2 (ja) | 共鳴非線形光信号を検出するための方法およびその方法を実装するための装置 | |
| JP5736325B2 (ja) | 光学装置 | |
| JP2013517491A5 (enExample) | ||
| JP4753947B2 (ja) | 位相感応性ヘテロダイン・コヒーレント・アンチ・ストークス・ラマン散乱顕微分光法、ならびに顕微鏡観察システムおよび方法 | |
| JP4499091B2 (ja) | シングルパルスアンチストークスラマン散乱顕微鏡法および分光法 | |
| US7582870B2 (en) | Imaging apparatus for IR four-wave mixing polarization microscopy | |
| JP5847821B2 (ja) | コヒーレント反ストークスラマン散乱（ｃａｒｓ）分光法における非共鳴バックグラウンド低減のための方法および装置 | |
| US9001321B2 (en) | Microscope and observation method | |
| JP6073484B2 (ja) | Ｃａｒｓ顕微鏡 | |
| JP5930220B2 (ja) | 非線形光学顕微鏡および非線形光学顕微鏡法 | |
| CN105247350A (zh) | 用于受激拉曼检测的设备和方法 | |
| JP2009513981A (ja) | 周波数変調コヒーレントアンチストークスラマン散乱分析による高感度振動イメージングのためのシステムおよび方法 | |
| JPWO2016143084A1 (ja) | 光計測装置及び光計測方法 | |
| JP5536908B2 (ja) | 共鳴非線形光信号を検出するための方法およびその方法を実装するための装置 | |
| JP2013517490A5 (enExample) | ||
| JP2009229714A (ja) | コヒーレント・ラマン顕微鏡の解像度評価用チャートおよびその製造方法、コヒーレント・ラマン顕微鏡用光源装置、並びに、コヒーレント・ラマン顕微鏡の調整法 | |
| WO2019142907A1 (ja) | 光学分析装置および光学分析方法 | |
| JP6923161B2 (ja) | 試料分析装置 | |
| JP2014126491A (ja) | 情報取得システム、情報取得装置、および情報取得方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130703 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130703 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20130703 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20130725 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130820 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20131120 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131217 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140317 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140325 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140417 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140513 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140604 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5558587 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |